{"title":"Early detection of melanoma: evaluating the combined use of total body photography and sequential digital dermoscopic imaging in a national health service setting.","authors":"Tara Hodgkinson, Ciara Vereker, Ashley Spencer","doi":"10.1093/ced/llaf094","DOIUrl":"10.1093/ced/llaf094","url":null,"abstract":"<p><p>Early detection of thin, stage 1A melanoma is crucial in improving patient outcomes, but this can be clinically challenging in patients with multiple atypical naevi. We report an observational study evaluating the effectiveness of a UK-based clinical nurse specialist-led total body photography (TBP) and sequential digital dermoscopic imaging (SDDI) programme for patients at high risk of developing melanoma. In total, 1680 patients underwent 6890 TBP and SDDI sessions, with 345 excision biopsies of clinically suspicious melanocytic lesions being performed (5% of sessions); 21 pT1a and pT1b melanomas (6% of biopsies), 20 melanoma in situ (6% of biopsies) and 150 dysplastic naevi (43% of biopsies) were identified. Median (range) Breslow thickness was 0.5 (0.2-1) mm; 95% of melanomas had a Breslow thickness of < 0.8 mm without ulceration (pT1a) and the number needed to biopsy was 8.41. Our UK experience demonstrates that a nurse-led programme of TBP with SDDI can be a clinically effective strategy for detection of early melanoma and melanoma in situ.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1406-1408"},"PeriodicalIF":3.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huw W S Greenish, Hafsa Faarax Shirwac, Hannah Morgan, Harry Heath, Emma Porter, Sarah Carswell, Chloe White, Neha Kasaravalli, Alexander D G Anderson
{"title":"Are Skin Lesion Superclinics Associated With Decision Fatigue? A Controlled, Observational Study.","authors":"Huw W S Greenish, Hafsa Faarax Shirwac, Hannah Morgan, Harry Heath, Emma Porter, Sarah Carswell, Chloe White, Neha Kasaravalli, Alexander D G Anderson","doi":"10.1093/ced/llaf287","DOIUrl":"https://doi.org/10.1093/ced/llaf287","url":null,"abstract":"<p><p>Skin cancer superclinics have been proposed as an innovative solution to current capacity shortfalls. The aim of this study was to investigate whether this model was associated with decision fatigue. Consecutive patients with suspected skin cancer who attended a superclinic in 2022 were compared with those seen by the same clinician in standard clinics. Proxy markers of decision fatigue were cancer pickup rates and proportion of patients discharged without histology following initial clinic visit. 100/345 (29.0%) patients seen in superclinics had an ultimate diagnosis of skin malignancy, vs. 161/588 (27.4%) seen in standard clinic (p=0.598). 162 (47.0%) of superclinic patients were discharged without intervention vs. 294 (50.0%%) of patients in the standard clinic group (p=0.369). The superclinic model did not appear to be associated with decision fatigue in the one clinician studied and proved a safe and effective means of providing clinical care, improving capacity and delivering training.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Howard Jie Yang, Jennifer Nguyen, Ian Simpson, Senhong Lee, Francis Yi Xing Lai
{"title":"A Case of Angiolymphoid Hyperplasia with Eosinophilia Successfully Treated with Dupilumab.","authors":"Howard Jie Yang, Jennifer Nguyen, Ian Simpson, Senhong Lee, Francis Yi Xing Lai","doi":"10.1093/ced/llaf289","DOIUrl":"https://doi.org/10.1093/ced/llaf289","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Paediatrics and Genetics.","authors":"Dhanya Kuladeva, Puo Nen Lim, Gregory Parkins","doi":"10.1093/ced/llaf288","DOIUrl":"https://doi.org/10.1093/ced/llaf288","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetics and General Dermatology.","authors":"Mohammed Abbasi, Prajwal Pudasaini, Faisal Dubash","doi":"10.1093/ced/llaf270","DOIUrl":"https://doi.org/10.1093/ced/llaf270","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photosensitivity induced by Tribulus Terrestris extract supplement.","authors":"Chee Hian Tan, Robert S Dawe","doi":"10.1093/ced/llaf286","DOIUrl":"https://doi.org/10.1093/ced/llaf286","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pediatric Drug-Induced Epidermal Necrolysis: Insights from Real-World Evidence in Türkiye.","authors":"Esra Kiratli Nalbant, Burcu Ozkan Kirgin, Seda Sirin, Naim Ata, Suayip Birinci, Koray Harmanci, Zulfikar Akelma","doi":"10.1093/ced/llaf274","DOIUrl":"https://doi.org/10.1093/ced/llaf274","url":null,"abstract":"<p><strong>Background: </strong>Drug-induced epidermal necrolysis is a recently proposed entity designed to clearly differentiate medication-triggered Stevens-Johnson syndrome and toxic epidermal necrolysis from infection-related and idiopathic disease, particularly in pediatric patients.</p><p><strong>Objectives: </strong>This study aims to characterize the clinical features of pediatric drug-induced epidermal necrolysis, a condition with relatively limited data in the literature.</p><p><strong>Methods: </strong>This retrospective study analyzed the the electronic medical records of pediatric patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in Türkiye between 2018 and 2024. Cases were identified using ICD-10 codes from a national database, and only those with a confirmed drug-related etiology were included. Clinical characteristics, suspected causative drugs, disease severity, in-hospital complications, and treatment approaches were evaluated. Statistical analyses were performed to assess differences in clinical outcomes based on drug type and disease severity.</p><p><strong>Results: </strong>A total of 33 pediatric patients were included. Antibiotics (39.4%) and antiepileptic drugs (36.4%) were the most commonly implicated medications. In-hospital complications occurred in 66.7% of cases, with septicemia being the most frequent. The patients with toxic epidermal necrolysis had significantly longer hospital stays. Statistical analyses revealed differences in clinical presentation and disease course based mainly on the causative drug, with antiepileptic-induced cases exhibiting a later onset and fewer in-hospital complications.</p><p><strong>Conclusions: </strong>This study highlights the distinct clinical characteristics of pediatric drug-induced epidermal necrolysis, emphasizing the impact of causative drugs on disease course and outcomes, which may aid in improving diagnosis and treatment strategies.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}