Clinical and Experimental Dermatology最新文献

{"title":"Comment on 'Real-world outcomes of stapokibart-based combination therapy for bullous pemphigoid: a single-centre retrospective cohort': towards controlled comparisons, neurological profiling and long-term follow-up.","authors":"Yiying Xiao, Weikai Dong, Yuhong Zhu","doi":"10.1093/ced/llag303","DOIUrl":"10.1093/ced/llag303","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2155-2156"},"PeriodicalIF":2.8,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148454789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extrapulmonary tuberculosis despite preventive therapy during adalimumab treatment for psoriasis.","authors":"Tiago Torres, Martim Luz","doi":"10.1093/ced/llag323","DOIUrl":"10.1093/ced/llag323","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2161-2163"},"PeriodicalIF":2.8,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General dermatology and dermatology in primary healthcare.","authors":"Dalia Eid, Monika Beauchamp, Natalie Stone","doi":"10.1093/ced/llag247","DOIUrl":"10.1093/ced/llag247","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"2167-2168"},"PeriodicalIF":2.8,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardized Smartphone Photography for Severity Assessment in Pyoderma Gangrenosum: A Pilot Validation Study.","authors":"Morgan Vague, Martha Oberg, Laura Morales-Leon, Angelo V Marzano, William W Huang, Arash Mostaghimi, Robert I Kelly, Alex G Ortega-Loayza","doi":"10.1093/ced/llag453","DOIUrl":"https://doi.org/10.1093/ced/llag453","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149243403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Sites of Cutaneous Ulceration.","authors":"Alice Gore, Francesca Satchwell, Emanuel Odega, Uraida Mehmood, Kid Wan Shum","doi":"10.1093/ced/llag451","DOIUrl":"https://doi.org/10.1093/ced/llag451","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149263548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Upadacitinib After Anti-IL-13 Treatment Failure in Atopic Dermatitis: A 52-Week Real-World Case Series - IL-AD (Italian Landscape Atopic Dermatitis).","authors":"Luca Potestio, Silvia Mariel Ferrucci, Simone Ribero, Alessandra Narcisi, Mariateresa Rossi, Anna Graziella Burroni, Elena Pezzolo, Maddalena Napolitano, Diego Orsini","doi":"10.1093/ced/llag445","DOIUrl":"https://doi.org/10.1093/ced/llag445","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmented Actinic Lichen Planus Mimicking Chronic Photodermatitis in a Fair-Skinned Caucasian Woman: A Case Report.","authors":"Ludovica Ucci, Alessia Di Lorito, Fabrizio Panarese, Fabio Lobefaro, Paolo Amerio","doi":"10.1093/ced/llag440","DOIUrl":"https://doi.org/10.1093/ced/llag440","url":null,"abstract":"<p><p>Actinic lichen planus (ALP) is a rare photosensitive variant of lichen planus that typically affects young individuals with dark skin phototypes living in tropical and subtropical regions. Reports in fair-skinned Caucasian patients are exceptional, often making the diagnosis challenging. We describe the case of a 52-year-old Caucasian woman with Fitzpatrick skin phototype II who presented with a 2-year history of recurrent erythematous-violaceous reticulated plaques involving the lateral aspects of the neck. The lesions showed seasonal exacerbation following sun exposure and had initially been misdiagnosed as chronic photodermatitis. Dermoscopy revealed Wickham striae and gray peppering, suggestive of a lichenoid dermatosis. Histopathologic examination demonstrated a lichenoid interface dermatitis with basal vacuolar degeneration, cytoid bodies, compact hyperorthokeratosis, and marked pigment incontinence, confirming the diagnosis of pigmented actinic lichen planus. The patient was treated with topical clobetasol followed by tacrolimus, adapalene, and strict photoprotection, resulting in disease stabilization and partial improvement at 6-month follow-up. This case expands the clinical spectrum of ALP by documenting its occurrence in a fair-skinned Caucasian woman and highlights the importance of integrating clinical, dermoscopic, and histopathologic findings to establish the correct diagnosis in atypical presentations.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Inflammatory Disorders After Radiotherapy.","authors":"Ane Carrera Gabilondo, Isabel Jorques Belda, Marta Moreno Jiménez, Agustín España","doi":"10.1093/ced/llag430","DOIUrl":"https://doi.org/10.1093/ced/llag430","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Male Genital Dermatology in the Field of Andrology.","authors":"Mahmoud Ziada, Asif Muneer","doi":"10.1093/ced/llag448","DOIUrl":"https://doi.org/10.1093/ced/llag448","url":null,"abstract":"<p><strong>Background: </strong>Male genital dermatological conditions occupy a distinct clinical space at the intersection of dermatology and andrology. For much of the last century they were managed in isolation, often without accurate diagnosis, with surgery as the default response to anatomical sequelae. Over the past three decades, advances in male genital dermatology have fundamentally changed this landscape, with direct and measurable consequences for urological and andrological practice.</p><p><strong>Objectives: </strong>To review the impact of advances in male genital dermatology on the management of male genital lichen sclerosus (MGLSc), penile intraepithelial neoplasia (PeIN), penile squamous cell carcinoma (PSCC), and selected rare genital conditions, with a focus on how dermatological insights have altered urological and andrological practice.</p><p><strong>Methods: </strong>A review of the published literature was performed, incorporating primary studies, systematic reviews, clinical guidelines, and expert consensus documents relevant to male genital dermatology and its interface with andrology and urology.</p><p><strong>Results: </strong>Dermatological investigation established chronic occluded urinary exposure as the fundamental driver of MGLSc, providing the mechanistic basis for circumcision as definitive treatment where medical therapy fails. The refutation of HPV, Borrelia, and autoimmunity as aetiological agents, the characterisation of the LSc-dPeIN-PSCC carcinogenic sequence, and the reclassification of Zoon's balanitis as a manifestation of MGLSc have each had specific consequences for clinical decision making. The introduction of dermoscopy has improved lesion assessment and reduced unnecessary biopsy. An understanding of the triphasic age distribution of MGLSc, its association with urological procedures, and the psychosexual burden it imposes all reflect dermatologically derived knowledge with direct andrological and urological application. In rare conditions including penile melanoma, pseudoepitheliomatous keratotic and micaceous balanitis, and penoscrotal extramammary Paget's disease, multidisciplinary input from dermatology has improved diagnostic accuracy and reduced surgical morbidity.</p><p><strong>Conclusions: </strong>Advances in male genital dermatology have transformed the understanding, diagnosis, and management of male genital disease. Shared surveillance between dermatology and andrology, with agreed thresholds for surgical escalation, offers the most effective model of care and the greatest potential for organ preservation, prevention of malignant transformation, and improvement in quality of life.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extramammary Paget's Disease With Bilateral Sentinel Lymph Node Biopsy: a Multicenter Study of Lymphatic Patterns and Outcomes.","authors":"Yoshiki Sakai, Eiji Nakano, Ken Horisaki, Shoichiro Mori, Yuta Kage, Dai Ogata, Shusuke Yoshikawa, Masashi Akiyama, Naoya Yamazaki, Kenjiro Namikawa","doi":"10.1093/ced/llag436","DOIUrl":"https://doi.org/10.1093/ced/llag436","url":null,"abstract":"<p><strong>Background: </strong>Extramammary Paget's disease (EMPD) can metastasize to lymph nodes or distant sites. Sentinel lymph node biopsy (SLNB) is recommended for invasive EMPD without clinical nodal involvement.</p><p><strong>Objectives: </strong>Lesions near or across the midline may show bilateral lymphatic drainage, but the clinical significance of bilateral SLNB remains unclear. This study evaluated SLN metastatic distribution and its association with clinicopathological features, lymphatic drainage patterns, and survival in patients undergoing bilateral SLNB.</p><p><strong>Methods: </strong>We retrospectively reviewed 147 patients with EMPD who underwent bilateral SLNB at three institutions between 2015 and 2025. Tumor characteristics, SLN status, recurrence, and survival outcomes were analyzed. Patients were stratified as bilateral negative, unilateral positive, or bilateral positive. Clinicopathological features, lymphatic drainage patterns, and survival outcomes, including overall survival (OS), recurrence-free survival (RFS), and disease-free survival (DFS), were compared.</p><p><strong>Results: </strong>Bilateral SLN positivity was detected in eight male patients with genital nodular lesions; unilateral positivity occurred in 12 patients, and 127 were bilaterally negative. Contralateral SLNs were frequently negative despite lesions crossing the midline, although bilateral metastases developed in two patients. Four ectopic lower abdominal lesions were identified, two with irregular drainage. Patients with bilaterally negative SLNs had significantly better survival than those with SLN metastases. No significant differences in RFS or DFS were observed between the unilateral- and bilateral-positive groups.</p><p><strong>Conclusions: </strong>Bilateral SLN positivity is rare and limited to male genital cases. It was not associated with worse disease-related outcomes than unilateral positivity. Risk of bilateral metastasis appears to depend more on tumor location than intrinsic aggressiveness.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}