Clinical and Experimental Dermatology最新文献

{"title":"Outcomes of ciclosporin treatment in paediatric patients with drug reaction with eosinophilia and systemic symptoms (DRESS): a retrospective cohort analysis.","authors":"Haleh Zabihi, Khalad Maliyar, Cathryn Sibbald, Ruud H J Verstegen","doi":"10.1093/ced/llaf026","DOIUrl":"10.1093/ced/llaf026","url":null,"abstract":"<p><p>Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but severe hypersensitivity reaction. In this retrospective cohort study, we compared the efficacy of systemic corticosteroids, the current first-line treatment, with ciclosporin, a treatment that is increasingly being used in paediatric patients with DRESS. We analysed the cases of 14 paediatric patients (aged < 18 years) admitted to the hospital between January 2016 and September 2023. Five patients received ciclosporin, while nine were treated with systemic corticosteroids. Ciclosporin treatment was associated with shorter hospital stays (median 6 days vs. 9 days) and more rapid normalization of alanine aminotransferase levels (25 days vs. 40 days) compared with corticosteroid treatment. While ciclosporin was well-tolerated, corticosteroid treatment was linked to adverse events, including corticosteroid-induced diabetes (n = 2), disease flares during tapering (n = 3) and the need for treatment intensification (n = 2). These findings suggest that ciclosporin may be a promising treatment for managing paediatric DRESS.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1183-1187"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sensitive skin on quality of life, anxiety and depression: a cross-sectional study.","authors":"Jinseo Park, Shona Cameron, Carsten Flohr, Mingyu Choi, Soyeon Lee, Boyoung Chung, Chunwook Park, Hyeone Kim","doi":"10.1093/ced/llaf028","DOIUrl":"10.1093/ced/llaf028","url":null,"abstract":"<p><strong>Background: </strong>Sensitive skin (SS) is a common condition reported by many people worldwide. Patient interviews reveal that individuals with SS experience diminished quality of life, anxiety and depression. Nonetheless, the impact of SS on mental health remains unclear.</p><p><strong>Objectives: </strong>To assess whether SS affects mental health and the relationship between symptom severity and its impact.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea, between June 2022 and March 2023. The Sensitive Scale 10 (SS-10) was used for SS diagnosis and severity scoring, and the Dermatology Life Quality Index (DLQI) and Hospital Anxiety and Depression Scale (HADS) anxiety (HADS-A) and depression (HADS-D) subscales were used to assess mental health. On the basis of their SS-10 scores, participants were categorized as 'nonsensitive' (score < 20), 'sensitive' (score 20-49) and 'extremely sensitive' (score ≥ 50). Objective measurements included transepidermal water loss (TEWL), stratum corneum hydration, erythema and Demodex mite density.</p><p><strong>Results: </strong>Of the 200 participants, 146 completed the study. Participants were predominantly women [n = 116/146 (79.5%)] with a mean (SD) age of 36.86 (12.25) years. DLQI scores were higher in more sensitive groups (nonsensitive 6.25; sensitive 14.46; extremely sensitive 18.86; P < 0.001). HADS-A and HADS-D scores also increased with severity. HADS-A scores ranged from 4.94 in nonsensitive participants to 7.80 in extremely sensitive participants (P < 0.05), while HADS-D scores ranged from 3.88 in nonsensitive participants to 8.54 in extremely sensitive participants (P < 0.001). DLQI was significantly influenced by discomfort and redness, HADS-A by TEWL (negatively) and flushes, and HADS-D by flushes.</p><p><strong>Conclusions: </strong>SS is associated with lower quality of life and increased anxiety and depression. Symptoms of SS substantially impact patients' psychological wellbeing.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1163-1170"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Global Register of Alopecia areata disease Severity and treatment Safety - United Kingdom (GRASS-UK): importance of real-world data in alopecia areata.","authors":"Matthew Harries, Yusur Al-Nuaimi, Dmitri Wall, Anne Chandidzura, Shehnaz Ahmed, Nekma Meah","doi":"10.1093/ced/llaf055","DOIUrl":"10.1093/ced/llaf055","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1250-1252"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of interleukin-17A inhibitors in 306 patients with psoriasis with or without latent tuberculosis: a dual-centre retrospective study in China.","authors":"Kun Hu, Yizhang Liu, Yang Sha, Mi Zhang, Lu Jian, Yongfang Duan, Chengzhi Lv, Yehong Kuang","doi":"10.1093/ced/llae549","DOIUrl":"10.1093/ced/llae549","url":null,"abstract":"<p><strong>Background: </strong>New interleukin (IL)-17A inhibitors seem to demonstrate smaller effects on tuberculosis (TB) reactivation than expected.</p><p><strong>Objectives: </strong>To evaluate the risk of TB reactivation, to assess serial interferon (IFN)-γ levels, and to weigh up the risks and benefits of TB chemoprophylaxis in patients with psoriasis treated with IL-17A inhibitors.</p><p><strong>Methods: </strong>This dual-centre study included patients with psoriasis who were treated with IL-17A inhibitors. The incidence of active TB, serial IFN-γ levels tested by IFN-γ release assays (IGRAs), adverse events (AEs) and effectiveness were evaluated through 1 year in patients with psoriasis treated with IL-17A inhibitors. According to the chemoprophylaxis treatment regimen, patients with latent TB infection (LTBI) were classified into three groups: a complete chemoprophylaxis dose regimen (CCP), an incomplete chemoprophylaxis (ICCP) or no chemoprophylaxis (NCP).</p><p><strong>Results: </strong>In 220 IGRA-negative patients, 17 of 220 (7.3%) became IGRA positive after receiving a mean of 69.1 weeks of IL-17A inhibitor treatment. Only one case of new-onset TB was observed after 52 weeks of ixekizumab therapy. Significant changes in IFN-γ levels were observed in IGRA-negative patients. Similarly, IFN-γ levels [listed as the mean (SD)] significantly increased at 1 year compared with baseline among IGRA-positive patients in the NCP [105 (68.7) vs. 236 (80.8) pg mL-1, P < 0.01] and ICCP [75.3 (48.3) vs. 608 (249) pg mL-1, P < 0.001] groups, whereas the changes were not significant [125 (26.6) vs. 131 (21.7) pg mL-1, P = 0.70] in the CCP group.</p><p><strong>Conclusions: </strong>During IL-17A inhibitor therapy, there is a need for increased awareness of annual screening and assessment of individual risk for early detection of TB infection. LTBI treatment is generally well tolerated and is effective in preventing increased IFN-γ responses in patients with psoriasis treated with IL-17A inhibitors.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1107-1115"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General dermatology.","authors":"Emily Orr, Nicholas Stefanovic, Richard Watchorn","doi":"10.1093/ced/llaf091","DOIUrl":"10.1093/ced/llaf091","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1268-1269"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory eosinophilic pustular folliculitis treated with tofacitinib: a case series and literature review.","authors":"Qin-Xiao Wang, Hai-Yang He, Ying-Luo Niu, Sheng Fang","doi":"10.1093/ced/llaf053","DOIUrl":"10.1093/ced/llaf053","url":null,"abstract":"<p><p>Eosinophilic pustular folliculitis (EPF) is an uncommon skin condition that presents as follicular papules or pustules. The treatment of EPF is challenging because of the high relapse rates. This study aims to evaluate the efficacy and safety of tofacitinib as a treatment for EPF. We present three patients with refractory EPF who were successfully treated with tofacitinib at our clinic. We also conducted a literature review using the PubMed database to gain further insight into this promising therapy. Our patients were effectively treated with tofacitinib. To the best of our knowledge, only three other patients with EPF treated with Janus kinase inhibitors have been reported and reviewed: one treated with tofacitinib and two with abrocitinib. Complete remission was observed in all patients - both our patients and the patients in the other studies - with no adverse events or relapses reported during an average follow-up period of 4.3 months. Tofacitinib may be an emerging alternative treatment option for patients with EPF. Larger randomized controlled studies are needed to confirm these findings.</p>","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1196-1200"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Widespread imiquimod-induced psoriasis-like eruption: case report and analysis of mast cell infiltration.","authors":"Tatsuya Katsumi, Ryota Hayashi, Shingo Takei, Manon Okamura, Yuka Tsutsui, Osamu Ansai, Akito Hasegawa, Yu Matsui, Tatsuya Takenouchi, Riichiro Abe","doi":"10.1093/ced/llae527","DOIUrl":"10.1093/ced/llae527","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1221-1224"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of nonscarring alopecia with follicular accentuation on the limbs of a paediatric patient.","authors":"Nicola Kearney, Nicholas Stefanovic, Gregg Murray, Catherine Stacey, Clive Kilgallen, Kevin Molloy, Richard Watchorn","doi":"10.1093/ced/llaf033","DOIUrl":"10.1093/ced/llaf033","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1291-1293"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teen smoking and chronic skin disease: an ethical crossroad in hidradenitis suppurativa care.","authors":"Fiona Sexton, Stephanie Bowe, David Sheridan, Michelle Murphy","doi":"10.1093/ced/llaf030","DOIUrl":"10.1093/ced/llaf030","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1272-1273"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year clinical outcomes of atypical Spitz tumours: a prospective, single-centre observational cohort study.","authors":"Katie Weir, Donna Torley, Sarah Digby","doi":"10.1093/ced/llaf024","DOIUrl":"10.1093/ced/llaf024","url":null,"abstract":"","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"1249-1250"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}