Clinical and Experimental Dermatology最新文献_第7页

Effectiveness of deucravacitinib for genital, nail and scalp lesions in patients with psoriasis: a 24-week real-world study. deucravacitinib对生殖器、指甲和头皮银屑病皮损的疗效：一项为期24周的真实世界研究。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-23 DOI: 10.1093/ced/llae312

Teppei Hagino, Marina Onda, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda

{"title":"Effectiveness of deucravacitinib for genital, nail and scalp lesions in patients with psoriasis: a 24-week real-world study.","authors":"Teppei Hagino, Marina Onda, Hidehisa Saeki, Eita Fujimoto, Naoko Kanda","doi":"10.1093/ced/llae312","DOIUrl":"10.1093/ced/llae312","url":null,"abstract":"Psoriasis is a chronic, complicated inflammatory skin disease. Genital, nail and scalp lesions with psoriasis are difficult to treat and can considerably impair patients' quality of life (QoL). Deucravacitinib, an oral selective tyrosine kinase 2 inhibitor, may represent a novel therapeutic option that could improve these challenging manifestations. To investigate this, we conducted a retrospective study between January 2023 and February 2024, involving 70 patients with psoriasis treated with deucravacitinib 6 mg orally once daily for 24 weeks. We evaluated how many patients achieved a static Physician's Global Assessment (PGA) of Genitalia (sPGA-GTM) score of clear/almost clear (0/1), PGA of Fingernail Psoriasis (PGA-F) 0/1, scalp-specific PGA (ss-PGA) 0/1, static PGA (sPGA) 0/1 and Dermatology Life Quality Index 0/1 at weeks 4, 16 and 24. We also assessed the Psoriasis Area and Severity Index scores. Deucravacitinib improved genital, nail and scalp lesions, as well as systemic eruption and QoL in patients with psoriasis. Deucravacitinib may be a promising treatment option for lesions in difficult-to-treat areas in patients with psoriasis.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"130-133"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient and caregiver experience of accessing information on hidradenitis suppurativa through social media. 患者和护理人员通过社交媒体获取扁平苔藓信息的体验。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-23 DOI: 10.1093/ced/llae330

Anna Wolinska, Barry M McGrath, Anne-Marie Tobin

引用次数: 0

Assessment of hidradenitis suppurativa specialty care in dermatology residency programmes across the USA. 评估全美皮肤科住院医师培训项目中的化脓性扁平湿疹专科护理。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-23 DOI: 10.1093/ced/llae353

Hailey Jenkins, Linnea Westerkam, Christopher Sayed

引用次数: 0

Breslow density ability to predict melanoma survival: should it be used in clinical practice? 布瑞斯洛密度预测黑色素瘤存活率的能力：是否应在临床实践中使用？

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-23 DOI: 10.1093/ced/llae292

Pedro Gil-Pallares, Olalla Figueroa-Silva, Laura Taboada-Paz, María Eugenia Gil-Pallares, María Dolores Sánchez-Aguilar Rojas, Vanesa Balboa-Barreiro, Alba Navarro-Bielsa, José Manuel Suárez-Peñaranda

{"title":"Breslow density ability to predict melanoma survival: should it be used in clinical practice?","authors":"Pedro Gil-Pallares, Olalla Figueroa-Silva, Laura Taboada-Paz, María Eugenia Gil-Pallares, María Dolores Sánchez-Aguilar Rojas, Vanesa Balboa-Barreiro, Alba Navarro-Bielsa, José Manuel Suárez-Peñaranda","doi":"10.1093/ced/llae292","DOIUrl":"10.1093/ced/llae292","url":null,"abstract":"Background: Breslow density (BD) is an estimation of melanoma volume, which has emerged as a novel histopathological prognostic biomarker.Objectives: To evaluate the role of BD as a predictor of patients' survival and assess its prognostic value in relation to overall survival (OS), disease-free survival (DFS), melanoma-specific survival (MSS) and metastasis-free survival (MFS).Methods: A retrospective observational study in a cohort of 107 patients with invasive melanoma was conducted. Kaplan-Meier and Log-rank tests were used for 10-year survival analysis. The ability of BD and Breslow thickness (BT) to predict survival was assessed using receiver operating characteristic curves.Results: The average follow-up was 115 months, excluding deaths. People with BD ≥ 65% showed lower survival rates compared with the BD < 65% group (log-rank test P < 0.001). Area under the curve (AUC) of BD ≥ 65% was higher than BTs for all studied survival rates except for MSS, in which absolute BD showed the highest value.Conclusions: BD is proposed as a simple, valuable and inexpensive histopathological feature that could provide additional valuable information to that available from melanoma staging, as it has proved to have a statistically significant prognostic value in relation to survival in patients with melanoma and comparable 10-year survival prediction ability with that of BT.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"56-61"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient topical treatments of cutaneous lupus erythematosus: a systematic review and network -meta-analysis. 皮肤红斑狼疮的高效局部治疗：系统综述和网络荟萃分析。

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-23 DOI: 10.1093/ced/llae236

Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Atsushi Enomoto, Kiyoshi Miyagawa, Shinichi Sato, Ayumi Yoshizaki

{"title":"Efficient topical treatments of cutaneous lupus erythematosus: a systematic review and network -meta-analysis.","authors":"Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Atsushi Enomoto, Kiyoshi Miyagawa, Shinichi Sato, Ayumi Yoshizaki","doi":"10.1093/ced/llae236","DOIUrl":"10.1093/ced/llae236","url":null,"abstract":"Although topical agents have been used to treat cutaneous lupus erythematosus (CLE), there was previously no high-quality evidence of which agents were most effective and which clinical scores were most suitable. On 22 December 2023, a search was conducted across five databases to identify randomized controlled trials (RCTs) for CLE. Two authors independently screened the titles and abstracts of articles based on predetermined criteria. Selected articles were then assessed for inclusion in a blinded manner, with any disagreements resolved through consensus. Data were abstracted in duplicate, and a random-effects model was utilized for network meta-analysis. The certainty of the evidence was evaluated according to the PRISMA guidelines, using the GRADE approach. The analysis was finalized in January 2024, with the primary outcome focused on the change in Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) from baseline. Seven RCTs involving 231 participants were analysed. The network meta-analysis revealed that nicotinamide 4% demonstrated the highest probability of achieving the intended outcomes, with a mean difference (MD) of 3.10 and a 95% confidence interval (CI) of 1.99-4.21. Additionally, clobetasol 0.05%, nicotinamide 2% and tacrolimus 0.1% also exhibited statistically significant differences, with MDs of 2.30 (95% CI of 0.73-3.88), 2.30 (95% CI 0.97-3.63) and 1.30 (95% CI 0.03-2.57), respectively. This NMA demonstrates with a high level of evidence that nicotinamide 4%, clobetasol 0.05%, nicotinamide 2% and tacrolimus 0.1% are statistically significant topical agents for CLE. CLASI may be an appropriate outcome to evaluate drug efficacy in CLE.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":"21-28"},"PeriodicalIF":3.7,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Switching from Baricitinib to Ritlecitinib in Severe Alopecia Areata.

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-21 DOI: 10.1093/ced/llae548

Ying Chen, Qiuyun Xu, Xiaoqing Lv, Zeyu Zhuang, Siyi Bao, Jing Mao, Ting Gong, Chao Ji

引用次数: 0

Low-Dose Ionizing Radiation Exposure and Its Impact on Skin Aging Among Healthcare Workers.

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-21 DOI: 10.1093/ced/llae547

Huriye Aybüke Koç, Cansu Altınöz Güney

{"title":"Low-Dose Ionizing Radiation Exposure and Its Impact on Skin Aging Among Healthcare Workers.","authors":"Huriye Aybüke Koç, Cansu Altınöz Güney","doi":"10.1093/ced/llae547","DOIUrl":"https://doi.org/10.1093/ced/llae547","url":null,"abstract":"Background: Ionizing radiation (IR) is a occupational risk for healthcare professionals, which can result in a range of health issues.Objectives: This study aims to assess the relationship between low-dose IR exposure and the development of early aging-related skin wrinkles in healthcare workers.Methods: In the current cross-sectional study, 70 health workers exposed to low-dose ionizing radiation for at least five years were compared with 70 non-exposed health workers. Skin wrinkles of the participants were assessed by Lemperle Wrinkle Assessment Scale and statistical analysis comparing wrinkle score between the exposed to control was done.Results: There were no significant differences in sociodemographic factors and Fitzpatrick skin types between the radiation-exposed healthcare workers and the control group. The Lemperle Wrinkle Assessment Scale scores revealed significant differences, with radiation workers showing higher scores in all wrinkle categories, including horizontal forehead lines, glabellar frown lines, periorbital lines, preauricular lines, cheek folds, nasolabial folds, upper and lower lip lines, corner of the mouth lines, marionette lines, and labiomental creases (all p < 0.00001), and for horizontal neck folds (p = 0.00152).Conclusion: This is the first study to investigate health care workers with long-term low-dose IR exposure for skin wrinkles, a visible consequence of skin aging. Chronic low-dose IR exposure can lead to increased skin wrinkles, representative of advanced skin aging in health workers. These findings underscore the need for enhanced protective measures and regular monitoring for individuals exposed to occupational radiation.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lichen sclerosus and me - the male perspective.

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-19 DOI: 10.1093/ced/llae545

Chris Stanton, Rosalind C Simpson

引用次数: 0

Global prevalence of mental health comorbidity in patients with acne: An analysis of trends from 1961 to 2023.

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-18 DOI: 10.1093/ced/llae531

Yiran Chen, Suting Sun, Han Yang, Xiaoya Fei, Ying Zhang, Jiankun Song, Yi Ru, Hang Zhao, Ying Luo, Le Kuai, Yue Luo, Bin Li, Mengji Xie, Bin Fan, Xiaojie Ding

{"title":"Global prevalence of mental health comorbidity in patients with acne: An analysis of trends from 1961 to 2023.","authors":"Yiran Chen, Suting Sun, Han Yang, Xiaoya Fei, Ying Zhang, Jiankun Song, Yi Ru, Hang Zhao, Ying Luo, Le Kuai, Yue Luo, Bin Li, Mengji Xie, Bin Fan, Xiaojie Ding","doi":"10.1093/ced/llae531","DOIUrl":"https://doi.org/10.1093/ced/llae531","url":null,"abstract":"Background: Acne patients increasingly face mental health challenges such as anxiety, depression, and suicidal thoughts. However, no global systematic analysis exists on this topic.Objective: To examine the prevalence of mental disorders-specifically, anxiety, depression, and suicidal thoughts-among acne patients.Methods: An exhaustive search of six databases was conducted up to May 2023. Data analysis was performed using Python and STATA MP 17, including subgroup evaluations, meta-regression, and sensitivity analyses.Results: Forty-three studies were analyzed. Findings indicate depression, anxiety, and suicidal thoughts in acne patients are prevalent at 22%, 30%, and 12% respectively. Depression rates peaked in Asia at 42%, led by India (53%) and Saudi Arabia (51%). Anxiety was also most common in Asia, at 45%, notably in Singapore (60%) and Iran (58%). Suicidal thoughts were highest in Oceania, specifically New Zealand, at 24%.Limitations: The study is limited by the inclusion of only Chinese and English-language research, potentially introducing selection bias.Conclusion: The results of this study highlight the incidence of mental health disorders coexisting with acne, which may help to foster greater understanding and awareness among both medical professionals and patients regarding the psychological complexities tied to acne.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of ChatGPT in the dermatological field: a narrative review.

IF 3.7 4区医学

Clinical and Experimental Dermatology Pub Date : 2024-12-18 DOI: 10.1093/ced/llae546

Luca Potestio, Federica Feo, Fabrizio Martora, Matteo Megna, Maddalena Napolitano, Michela D'Agostino

{"title":"The use of ChatGPT in the dermatological field: a narrative review.","authors":"Luca Potestio, Federica Feo, Fabrizio Martora, Matteo Megna, Maddalena Napolitano, Michela D'Agostino","doi":"10.1093/ced/llae546","DOIUrl":"https://doi.org/10.1093/ced/llae546","url":null,"abstract":"Artificial Intelligence (AI) encompasses the development of computer systems capable of tasks typically requiring human intelligence, such as visual perception, speech recognition, decision-making, and language translation. Over time, numerous applications have emerged, with AI's integration into medicine marking a significant leap forward in healthcare delivery, diagnosis, and treatment. Among medical specialties, dermatology stands at the forefront of AI advancements, leveraging machine learning and deep learning to enhance dermatologists' abilities and improve patient care. ChatGPT is an advanced language model by OpenAI, originally designed for conversations, which has expanded its utility into diverse fields, including healthcare and dermatology. In this context, the aim of this review article was exploring the synergistic relationship between ChatGPT and dermatology, examining how this innovative AI model is reshaping skin health management, its potential applications, preliminary data on its efficiency and accuracy, as well as ethical and legal concerns related to the use of its tool.","PeriodicalId":10324,"journal":{"name":"Clinical and Experimental Dermatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0