“长期肿瘤坏死因子-α抑制剂治疗银屑病患者的恶性肿瘤风险：一项系统回顾和荟萃分析”-银屑病生物制剂的癌症复发风险。

IF 2.8 4区医学 Q1 DERMATOLOGY

Clinical and Experimental Dermatology Pub Date : 2025-06-25 DOI:10.1093/ced/llaf031

Aparna Potluru, Yasmin Nikookam

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引用次数: 0

摘要

本文回顾了Wu等人关于长期使用肿瘤坏死因子-α抑制剂治疗银屑病患者发生恶性肿瘤风险的研究结果。虽然该研究没有发现大多数癌症的风险显著增加，但它强调了银屑病关节炎患者患非黑色素瘤皮肤癌，特别是鳞状细胞癌的风险更高。本文讨论了有恶性肿瘤病史的银屑病患者的临床意义，提倡个性化治疗方法，警惕监测，并需要进一步研究以更好地了解生物治疗与癌症复发的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comment on 'The risk of malignancy in patients with psoriasis treated with long-term tumour necrosis factor-α inhibitor: a systematic review and meta-analysis': risk of cancer recurrence with biologics in psoriasis.

This article reviews the findings of Wu et al. regarding the risk of malignancy in patients with psoriasis who were treated with long-term tumour necrosis factor-α inhibitors. While the study found no significant increase in the risk of most cancers, it highlighted a higher risk of nonmelanoma skin cancers, particularly squamous cell carcinoma, in patients with psoriatic arthritis. The article discusses the clinical implications for patients with psoriasis who have a history of malignancy, advocating for a personalized treatment approach, vigilant monitoring and the need for further research to better understand the relationship between biologic therapy and cancer recurrence.

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来源期刊

Clinical and Experimental Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

2.40%

发文量

389

审稿时长

3-8 weeks

期刊介绍： Clinical and Experimental Dermatology (CED) is a unique provider of relevant and educational material for practising clinicians and dermatological researchers. We support continuing professional development (CPD) of dermatology specialists to advance the understanding, management and treatment of skin disease in order to improve patient outcomes.