RSC Advances最新文献

{"title":"Genome mining of albocandins A–E from Streptomyces sp. YINM00030†","authors":"Zhou-Tian-Le Zhang, Zhen Ren, Xiaoyu Su, Tian-Peng Xie, Mengzhuo Yi, Hao Zhou, Min Yin and Zhong-Tao Ding","doi":"10.1039/D4RA08447K","DOIUrl":"https://doi.org/10.1039/D4RA08447K","url":null,"abstract":"<p >The natural products of 2,5-diketopiperazines have attracted considerable attention due to their potent pharmacological activities. Guided by genome mining techniques, five albonoursin analogues, designated as albocandins A–E (<strong>1–5</strong>), were isolated from <em>Streptomyces</em> sp. YINM00030, an actinomycete sourced from the rhizosphere soil of medicinal plants. The structures and absolute configurations of these compounds were elucidated through comprehensive spectroscopic analyses, HRESIMS, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analyses. The biosynthetic pathway of these compounds were proposed. The investigation of biological activity showed that albocandins C and D exhibited cytotoxic activity against five human cancer cell lines (HL-60, A549, SMMC-7721, MDA-MB-231, SW480) <em>in vitro</em> with IC<small>₅₀</small> values ranging from 3.50 to 32.66 μM.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1805-1812"},"PeriodicalIF":3.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra08447k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase stability, electronic, mechanical, lattice distortion, and thermal properties of complex refractory-based high entropy alloys TiVCrZrNbMoHfTaW with varying elemental ratios†","authors":"Sahib Hasan, Puja Adhikari, Saro San and Wai-Yim Ching","doi":"10.1039/D4RA07460B","DOIUrl":"https://doi.org/10.1039/D4RA07460B","url":null,"abstract":"<p >This study examines the intricate area of refractory-based high entropy alloys (RHEAs), focusing on a series of complex compositions involving nine diverse refractory elements: Ti, V, Cr, Zr, Nb, Mo, Hf, Ta, and W. We investigate the phase stability, bonding interactions, electronic structures, lattice distortions, mechanical, and thermal properties of six RHEAs with varying elemental ratios using VASP and OLCAO DFT calculations. Through comprehensive analysis, we investigate the impact of elemental variations on the electronic structure, interacting bond dynamics, lattice distortion, thermodynamic, mechanical, and thermal properties within these RHEAs, providing an insight into how these specific elemental variations in composition give rise to changes in the calculated properties in ways that would guide future experimental and computational efforts. The correlation between the lattice distortion, mechanical, and thermal properties is explored in detail in this work. Our findings reveal significant insights into how these factors contribute to the unique properties of RHEAs, such as enhanced strength, ductility, and resistance to corrosion and wear. This research not only advances our understanding of the fundamental aspects of RHEAs but also opens new avenues for the design and application of these materials in various industrial sectors.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1878-1895"},"PeriodicalIF":3.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra07460b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel LC-TQ-MS/MS method for quantifying mefenamic acid-NDSRI (N-nitroso drug substance-related impurity) in mefenamic acid tablet and pediatric suspension dosage forms: a comparative study with a cost-effective white, green, and blue UPLC method†","authors":"Srinivas Nakka, Naresh Kumar Katari, Siva Krishna Muchakayala, Sreekantha Babu Jonnalagadda and Surendra Babu Manabolu Surya","doi":"10.1039/D4RA08425J","DOIUrl":"https://doi.org/10.1039/D4RA08425J","url":null,"abstract":"<p >The current research presents novel LC-TQ-MS/MS and cost-effective UPLC methods intended for the accurate quantification of mefenamic acid-N-nitroso drug substance-related impurity-NDSRI (N-MFA) in mefenamic acid (MFA) tablet and pediatric suspension dosage forms. The acceptable intake of N-MFA is derived from the TD50 (Median Toxic Dose-50%) value of N-nitroso diphenylamine. The analytical separation was achieved for the UPLC method using an XBridge BEH Shield RP18 Column (150 × 3.0 mm, 3.5 μm), employing 0.1% formic acid and acetonitrile as mobile phases in a gradient mode. A flow rate of 0.7 mL min<small>⁻¹</small> was set for the pump, and the detection wavelength was 230 nm. LC-TQ-MS-MS analysis was accomplished utilizing a Xevo TQ-XS mass spectrometer with electrospray ionization in the positive mode. N-MFA quantification was carried out using multiple reaction monitoring (MRM) as the mass transition: <em>m</em>/<em>z</em> 271.13 → 241.14. The proposed methods were successfully validated following ICH guidelines and are capable of quantifying at 0.01 ng mL<small>⁻¹</small> at an MFA concentration of 1 mg mL<small>⁻¹</small> for the LC-MS/MS method and at 0.036 μg mL<small>⁻¹</small> at an MFA concentration of 10 mg mL<small>⁻¹</small> for UPLC. The validated methods exhibited excellent linearity over the concentration ranges of 0.01 to 125 ppm for LC-MS/MS and 0.036 μg mL<small>⁻¹</small> to 1.250 μg mL<small>⁻¹</small> (3.6 to 125 ppm) for UPLC, with a Pearson correlation coefficient of 0.999. The method's trueness, in terms of accuracy recoveries, ranged from 90.43% to 101.34% for LC-MS/MS and 92.12% to 101.21% for UPLC. The applicability of these methods was successfully verified through the analysis of commercial samples of MFA formulations. Additionally, the sustainability and eco-friendliness of the method were assessed using whiteness and greenness metrics, including RGB12 (Red-Gree-Blue) tools, GAPI (Green Analytical Procedure Index), analytical eco-scale, AGREE (Analytical GREEnness), AGREEprep (Analytical GREEnnesspreparation), and BAGI (Blue Applicability Grade Index). Both methods can be used to determine N-MFA content in mefenamic acid formulation dosage based on the availability of instruments LC-TQ-MS/MS and UPLC in R&amp;D (Research and Development) and quality control laboratories.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1957-1969"},"PeriodicalIF":3.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra08425j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fiber ring laser biosensor based on no-core fibers for label-free DNA biomolecule measurements","authors":"Lina Wang and Chong Li","doi":"10.1039/D4RA08156K","DOIUrl":"https://doi.org/10.1039/D4RA08156K","url":null,"abstract":"<p >An erbium-doped fiber ring laser based on a single-mode fiber–no-core fiber–single-mode fiber (SMF-NCF-SMF) structure was constructed and experimentally demonstrated for label-free DNA hybridization measurement. The SMF-NCF-SMF structure acts as a sensing element and a filter to select the laser wavelength. The proposed fiber ring laser sensor exhibits a high optical signal-to-noise ratio (SNR, &gt;50 dB) and narrow full width at half maximum (FWHM, &lt;0.05 nm). Its refractive index sensitivity is 116.8 nm per RIU in the range of 1.3406–1.3705, and its detection limit is 1.79 × 10<small>⁻⁴</small> RIU. By continuously monitoring the laser wavelength, we successfully achieved label-free measurement of complementary DNA (cDNA) at concentrations as low as 1 μM. Subsequently, the specificity of the sensor was detected by non-complementary DNA (N-cDNA). Experimental results show that the fiber ring laser biosensor has the advantages of simple operation, label-free measurement, and high specificity. Furthermore, it shows a broad application prospect in several fields, especially in key areas such as medical diagnosis and cancer screening.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1831-1837"},"PeriodicalIF":3.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra08156k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially-resolved characterization of the metabolic and N-glycan alterations in colorectal cancer using matrix-assisted laser desorption/ionization mass spectrometry imaging†","authors":"Yaqi Zhang, Qiangjun Chen, Lei Wang, Haoyuan Geng, Zihan Zhu, Cancan Lv, Yisheng Zhao, Xiao Wang, Chenglong Sun, Panpan Chen and Chao Zhang","doi":"10.1039/D4RA08100E","DOIUrl":"https://doi.org/10.1039/D4RA08100E","url":null,"abstract":"<p >Colorectal cancer is the second leading cause of cancer-related deaths worldwide, and its development typically involves complex metabolic reprogramming. By mapping the spatial distributions of metabolites and <em>N</em>-glycans in heterogeneous colorectal cancer tissues, we can elucidate cancer-associated metabolic and <em>N</em>-glycan changes. Herein, we combine mass spectrometry imaging-based metabolomics and <em>N</em>-glycomics to characterize the spatially resolved reprogramming of metabolites and <em>N</em>-glycans in colorectal cancer tissues. The metabolic characteristics of different regions of colorectal cancer were evaluated through the utilization of orthogonal partial least squares discriminant analysis. In combination with metabolic pathway enrichment analysis, significant alterations were identified in the fatty acid metabolism, arginine and proline metabolism of colorectal cancer. Cancer cell regions exhibited a marked upregulation of saturated fatty acids, monounsaturated fatty acids, polyamines, and histidine. Additionally, we discovered that the high-mannose <em>N</em>-glycans were predominantly distributed in tumor tissue regions, whereas complex <em>N</em>-glycans were more commonly found in the normal tissue regions adjacent to the tumor. Such findings provide new insights into the spatial signatures of metabolites and <em>N</em>-glycans in colorectal cancer, thereby offering a crucial basis for the diagnosis of colorectal cancer and potential vulnerabilities that might be targeted for cancer therapy.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1838-1845"},"PeriodicalIF":3.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra08100e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro and in silico hybrid approach to unveil triterpenoids from Helicteres hirsuta leaves as potential compounds for inhibiting Nrf2†","authors":"Minh Hien Nguyen, Nguyen Thien Han Le, Bui Quoc Huy Nguyen, Mai Thanh Thi Nguyen, Truong Nhat Van Do, Tho Huu Le, Vu Thanh Nguyen and Chia-Hung Yen","doi":"10.1039/D4RA07646J","DOIUrl":"https://doi.org/10.1039/D4RA07646J","url":null,"abstract":"<p >Cancer is a leading global health concern, with over 20 million new cases and 9.7 million deaths reported in 2022. Chemotherapy remains a widely used treatment, but drug resistance, which affects up to 90% of treatment outcomes, significantly hampers its effectiveness. The transcription factor Nrf2, which is crucial for cellular defense against oxidative stress, plays a dual role in cancer treatment. Although Nrf2 activation can suppress early carcinogenesis, its overexpression in cancer cells contributes to drug resistance, resulting in poor patient outcomes. Thus, inhibiting Nrf2 has emerged as a promising strategy for overcoming cancer drug resistance. Natural compounds such as luteolin and brusatol have shown potential in inhibiting Nrf2, although with limitations. This study isolates and characterizes seven triterpenoids from the <em>n</em>-hexane sub-fraction of <em>Helicteres hirsuta</em>, a plant traditionally used for medicinal purposes, to evaluate their ability to modulate Nrf2 activity in Huh7 cancer and HaCaT normal cells. Additionally, molecular docking and dynamic simulations were utilized to assess the binding potential of these compounds to the PI3Kα receptor, which regulates downstream signaling pathways, thereby suppressing Nrf2 activity in cancer cells. Our findings provide insights into new strategies seeking triterpenoids as promising structures to reverse chemoresistance by regulating Nrf2. The results also reveal the potential of 3β-<em>O-trans</em>-caffeoylbetulinic acid from <em>H. hirsuta</em> leaves as the unprecedented compound inhibiting Nrf2 activity, with an IC<small>₅₀</small> of 74.5 μg mL<small>⁻¹</small> in Huh7 cancer cells.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1915-1923"},"PeriodicalIF":3.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra07646j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of the mechanism of action of antibacterial silver N-heterocyclic carbene complexes by variation of the halide ligand†","authors":"Igor V. Esarev and Ingo Ott","doi":"10.1039/D4RA08093A","DOIUrl":"https://doi.org/10.1039/D4RA08093A","url":null,"abstract":"<p >The antimicrobial properties of silver and silver complexes have been known in medicine since ancient times. However, limitations in stability and solubility have impaired medicinal chemistry and drug development research. With the advent of N-heterocyclic carbenes (NHC) as ligands, the development of synthesis methods for organometallic silver species of the type (NHC)AgX (where X = halide) has brought significant improvements, and the class of antimicrobial silver NHC complexes has emerged. However, reports studying structure–activity relationships and the mechanism of action of this compound type are still rare. This paper explores the activity of silver NHC complexes with halide (chloride, iodide) ligands and attempts to elucidate their mechanism of antibacterial action in Gram-negative <em>E. coli</em> bacteria in comparison to non-organometallic silver nitrate. In particular, the complexes with an iodide ligand were confirmed to cause stronger antibacterial effects in <em>E. coli</em> than silver nitrate. Moreover, iodide complexes exhibit an enhanced cellular uptake, show signs of DNA condensation, strongly inhibit TrxR in <em>E. coli</em> and cause a strong depolarization of the membrane potential and permeability of the inner cell membrane. In contrast, chloride silver NHC complexes and silver nitrate caused permeability of the outer membranes and also showed a different activity pattern in most of the studied mechanisms. In conclusion, by variation of the halide ligand of silver NHC complexes the mechanism of action and strength of antibacterial activity can be fine-tuned.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1782-1791"},"PeriodicalIF":3.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra08093a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2D V2C MXene/2D g-C3N4 nanosheet heterojunctions constructed via a one-pot method for remedying water pollution through high-efficient adsorption together with in situ photocatalytic degradation†","authors":"Shishan Xue, Dengliang He, Herong Zhang, Yuning Zhang, Yu Wang, Yurong Zeng, Shuxin Liu and Ning Chen","doi":"10.1039/D4RA07222G","DOIUrl":"https://doi.org/10.1039/D4RA07222G","url":null,"abstract":"<p >With the development of modern industry, the problems of water pollution have become increasingly serious. There is a strong need to develop highly efficient and environmentally friendly technologies to address water pollution. In this work, a novel 2D V<small>₂</small>C MXene/2D g-C<small>₃</small>N<small>₄</small> nanosheet heterojunction was constructed <em>via</em> a one-pot method. The obtained composite materials displayed excellent purifying capacity for dye pollutants, with removal ratios for crystal violet (CV), Rhodamine B (RhB) and methylene blue (MB) of 99.5%, 99.5%, and 95% within 80 min (including an adsorption process for 50 min and photodegradation process for 27 min), respectively. The extraordinary purifying capacity was accomplished through high-efficient adsorption together with <em>in situ</em> photocatalytic degradation within the unique 2D/2D heterojunction structure. The successful exploitation of 2D V<small>₂</small>C MXene/2D g-C<small>₃</small>N<small>₄</small> nanosheet heterojunctions provided a simple method to efficiently remedy water pollution.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1792-1804"},"PeriodicalIF":3.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra07222g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the properties of In–N dual-doped SnO2 films: incorporation of nitrogen into the SnO2 lattice at the optimal content via direct current sputtering","authors":"Tran Le","doi":"10.1039/D4RA08468C","DOIUrl":"https://doi.org/10.1039/D4RA08468C","url":null,"abstract":"<p >Direct current magnetron sputtering was employed to fabricate In–N dual-doped SnO<small>₂</small> films, with varying concentrations of N<small>₂</small> in a mixed sputtering gas of N<small>₂</small> and argon (Ar). The quantity of <em>N</em>-substituted O elements in the SnO<small>₂</small> lattice was confirmed through energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS). A comprehensive investigation of properties of the In–N dual-doped SnO<small>₂</small> films was conducted using various techniques, including X-ray diffraction analysis, field-emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), ultraviolet absorption spectroscopy, Hall effect measurements, and current–voltage (<em>I</em>–<em>V</em>) characteristic assessments. The results indicated that when the ratio of N<small>₂</small> to the mixed gas (Ar + N<small>₂</small>) exceeded 15%, the films exhibited p-type conductivity. The films demonstrated optimal electrical and structural properties at an N<small>₂</small> content of 45%, with a resistivity of 5.1 × 10<small>⁻³</small> Ω cm, hole mobility of 12.75 cm<small>²</small> V<small>⁻¹</small> s<small>⁻¹</small>, crystal grain size of 25.74 nm, and a root mean square (RMS) roughness of 0.61 nm, resulting in the highest photocurrent at the INTO-45/Si interface.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1766-1775"},"PeriodicalIF":3.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra08468c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmonic Cu-supported amorphous RuP for efficient photothermal CO2 hydrogenation to CO†","authors":"Xiuping Li, Jiaqi Wang, Bolin Yin, Kaihong Liu, Jingjing Zhao, Bo Jiang and Hexing Li","doi":"10.1039/D4RA07361D","DOIUrl":"https://doi.org/10.1039/D4RA07361D","url":null,"abstract":"<p >The hydrogenation of carbon dioxide into profitable chemicals is a viable path toward achieving the objective of carbon neutrality. However, the typical approach for hydrogenation of CO<small>₂</small> heavily relies on thermally driven catalysis at high temperatures, which is not aligned with the goals of carbon neutrality. Thus, there is a critical need to explore new catalytic methods for the high-efficiency conversion of CO<small>₂</small>. Herein, we present a new class of catalysts, featuring phosphorus-doped amorphous ruthenium nanoparticles supported on copper nanoparticles, which capitalizes on the plasmonic effects of copper to achieve the photothermal transformation of CO<small>₂</small> to CO within a gas–solid flow system. Our findings indicated that the reaction efficiency in the presence of photothermal energy was over eight times greater than that with thermal energy alone. The catalyst system exhibited nearly 100% selectivity towards CO under mild conditions, with an impressive CO yield of 123.16 mmol g<small>⁻¹</small> h<small>⁻¹</small>. This study highlights the significant potential of amorphous metal phosphides in photocatalytic CO<small>₂</small> hydrogenation under mild conditions and offers a fresh avenue for the robust catalysis of amorphous materials.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" 3","pages":" 1658-1664"},"PeriodicalIF":3.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/ra/d4ra07361d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142994170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}