RSC Advances最新文献

{"title":"Green-synthesized iron-zinc oxide nanomaterials immobilized on <i>Morus alba</i> sawdust for highly sensitive optical glucose sensing.","authors":"Akhtar Hayat, Murtaza, Essam R I Mahmoud, Muhammad Asad, Noaman Khan, Mohibullah Shah, Khaled Fahmi Fawy, Amir Badshah, Umar Nishan","doi":"10.1039/d6ra05736e","DOIUrl":"https://doi.org/10.1039/d6ra05736e","url":null,"abstract":"<p><p>Glucose is a prime source of energy for the human body, and its concentration is a vital biomarker for various pathological conditions. Despite the availability of multiple platforms for glucose sensing, significant efforts are still needed to develop a complete package that is inexpensive, easy to operate, rapid, environmentally friendly, and sensitive. The current work capitalizes on the presence of reductants in <i>Citrus sinensis</i> and the porous surface morphology of <i>Morus alba</i> sawdust. We deposited iron and zinc oxide on sawdust as an ingenious approach to enhance electron mobility in the fabricated system. The synthesized material, <i>i.e.</i>, iron and zinc oxide deposited on sawdust (Fe-ZnO@SD), was characterized through UV-Vis spectroscopy, FTIR spectroscopy, XRD, SEM, and elemental mapping. The proposed method was successfully applied to detect glucose using the chromogenic substrate tetramethylbenzidine (TMB). We optimized various parameters that play a vital role in the sensor's performance. Under the optimized conditions, the fabricated sensor detected glucose over a wide linear range of 9-81 µM, with an <i>R</i> ² of 0.996 and LOQ and LOD of 0.57 and 0.17 µM, respectively. The selectivity of the fabricated sensor was confirmed in physiological solutions and urine samples, exhibiting high linearity within the tested concentration ranges.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a triazine-pyrone Schiff base methacrylate adsorbent for the selective recovery of beryllium ions from hazardous industrial sludge.","authors":"Asma Ghazzy, Ali Marashdeh, Ala'a Al-Akhras, Eshraq Aljamal, Mohamed E Eissa, Mohamed F Cheira, Mohamed A Gado, Taha F Hassanein, Amal H Tilp","doi":"10.1039/d6ra06027g","DOIUrl":"https://doi.org/10.1039/d6ra06027g","url":null,"abstract":"<p><p>The extreme hydration, small ionic size, and high charge density of Be²⁺ ions make their recovery from hazardous industrial sludge a challenge, raising environmental concerns. Using a newly developed method, we synthesized triazine-pyrone Schiff base methacrylate (TP-SB-MA), a new chelating adsorbent, and evaluated its effectiveness for Be²⁺ separation. A two-step process was employed to synthesize TP-SB-MA. The first step involved changing the Schiff base from 1,3,5-tris(4-aminophenyl)triazine to 3-acetyl-4-hydroxy-6-methyl-2<i>H</i>-pyran-2-one. Then, a urethane link was used to functionalize the methacrylate. The material primarily displays nitrogen and oxygen donor sites, and its pore size ranges from 0.8 to 1.3 nm. The network of persistent micropores is another feature. The data fitted the Langmuir isotherm model (<i>q</i> _m = 169.56 mg g^-1) with the highest <i>R</i> ² value and the lowest SSE and <i>χ</i> ² values among the isotherm models studied, consistent with the monolayer surface coverage; together with the pseudo-second-order kinetics and Dubinin-Radushkevich adsorption energy, this supports a chemisorption-dominated uptake mechanism. Batch adsorption experiments demonstrated an experimental maximum capacity of 165.7 mg g^-1 at pH 3.5, with a theoretical monolayer capacity of up to 175.19 mg g^-1 predicted by Dubinin-Radushkevich isotherm modeling, and the equilibrium period was approximately 30 minutes. The spontaneous endothermic reaction (Δ<i>H</i>° = +9.0 kJ mol^-1; Δ<i>G</i>° < 0) was demonstrated by the thermodynamic results. FTIR spectroscopic and XPS analyses provided converging evidence that the imine, carbonyl, and urethane groups were directly involved in Be²⁺ binding. Under optimal elution conditions (0.4 M H₂SO₄), TP-SB-MA achieved a desorption efficiency of 87.15% and retained approximately 80% of its adsorption capacity after 9 cycles, demonstrating its high reusability, as confirmed by post-cycling XPS, which revealed the retention of both its Schiff-base structure and Be²⁺-coordinating sites. The acid leaching of real sludge, followed by TP-SB-MA adsorption, selective acid stripping, and pH-controlled precipitation-calcination, successfully recovered wurtzite-phase BeO with an experimentally verified chemical purity of 98.48 ± 0.33 wt% (confirmed by PXRD and ICP elemental assay). This study is the first to show that methacrylate-tuned Schiff base chelating ligands may be used for beryllium remediation and sustainable high-scopic recovery as a part of a circular resource management strategy.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, microwave-assisted domino synthesis, and biological evaluation of novel naphtho[2,3-<i>b</i>]furan-4,9-diones as rigidified combretastatin A-4 analogs inducing G0/G1 cell cycle arrest and apoptosis.","authors":"Tuan Anh Nguyen, Ha Thanh Nguyen, Nga Nguyen Thi, Giang Le-Nhat-Thuy, Quynh Giang Nguyen Thi, Phuong Hoang Thi, Mai Dang Thi, Julien Braire, Tu Anh Le Thi, Van Anh Pham Thi, Xuan Nhiem Nguyen, Tuyen Van Nguyen","doi":"10.1039/d6ra08348j","DOIUrl":"https://doi.org/10.1039/d6ra08348j","url":null,"abstract":"<p><p>A novel series of fourteen fluorinated naphtho[2,3-<i>b</i>]furan-4,9-dione derivatives (5a-n) was designed, synthesized, and structurally mapped as conformational equivalents of the microtubule-disrupting agent combretastatin A-4 (CA-4). The core medicinal chemistry strategy relied on replacing the highly flexible exo-ethylene linker of native CA-4 with a rigid carbonyl lock at the C-2 position of the furan ring, thereby restricting rotatable bonds and freezing the peripheral aromatic rings into a stable <i>cis</i>-like bioactive orientation. One aryl domain was substituted with an electron-deficient naphthoquinone core to maximize target pocket engagement. These target compounds were efficiently synthesized in good yields (69-81%) <i>via</i> a microwave-assisted three-component reaction utilizing 2-hydroxy-1,4-naphthoquinone, fluorinated aromatic aldehydes, pyridinium bromides, and 1,4-diazabicyclo[2.2.2]octane as a base catalyst. Cytotoxicity screening demonstrated that this structural rigidification maintained antiproliferative profiles across human cancer cells (KB, HepG2, A549, and MCF7), with compound 5c emerging as the most potent compound exhibiting IC₅₀ values ranging from 1.90 to 11.48 µM. Flow cytometric analysis showed that compound 5c induced concentration-dependent cell cycle arest at G0/G1 phase and apoptosis in A549 cells. Molecular docking and density functional theory simulations predicted that 5c establishes a highly stable interaction network within the colchicine binding site of the α,β tubulin interface. Collectively, these findings highlight compound 5c as a highly promising preliminary cytotoxic lead for the development of novel anticancer agents.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An effective fluoroquinolone-based fluorescent probe for ultrasensitive Zn²⁺ detection exhibiting \"turn-on\" fluorescence.","authors":"Daniel Arulraj Abraham, Ravikumar Ayyanu, Ellairaja Sundaram, Balasubramani Govindasamy, A Anand Babu Christus","doi":"10.1039/d6ra00838k","DOIUrl":"https://doi.org/10.1039/d6ra00838k","url":null,"abstract":"<p><p>Contamination of water and soil by heavy metal ions is a major global concern because these ions are toxic and persist in the environment for long periods. A new, effective fluorescent sensor based on a fluoroquinolone was developed for detecting zinc ions (Zn²⁺) with a turn-on signal. When Zn²⁺ ions are gradually added to the fluoroquinolone solution, the fluorescence intensity increases due to an internal charge transfer mechanism. We evaluated the detection of Zn²⁺ ions using the fluorescence probe in various solvents and across different pH conditions. The key results showed that the fluorescent probe demonstrated a strong preference for detecting Zn²⁺ ions in ethanol, maintaining accuracy despite the presence of other metal ions, and exhibited enhanced sensitivity. The developed sensor achieved a remarkably low detection limit of 1 nM for Zn²⁺ ions, outperforming earlier reported sensors. Fluorescence measurements exhibited a consistent linear correlation for Zn²⁺ concentrations between 1 nM and 15 µM. Furthermore, spectrophotometric data showed increased absorbance peaks upon addition of Zn²⁺ to the fluoroquinolone solution, confirming the creation of a fluoroquinolone-Zn²⁺ complex. The suggested probe was successfully applied to detect Zn²⁺ ions in wastewater and drinking water samples, achieving recovery rates ranging from 97.0% to 102.75%. More interestingly, binding to Zn²⁺ leads to significant changes in the fluorescence lifetime of the proposed probe, which can be used to visualize Zn²⁺ ions in A549 cells <i>via</i> Confocal fluorescence microscopy. The reported chemosensor with fluoroquinolone is an effective and economical system for real-time monitoring of Zn²⁺ ions.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Composite microneedle-mediated co-delivery of magnesium hydride-magnolol for androgenetic alopecia.","authors":"Wenting Wang, Xiaoxia Wang, Xiaojiang Hou, Tao Liu, Da Zhai, Tianyu Cao, Ling Liu","doi":"10.1039/d6ra06529e","DOIUrl":"https://doi.org/10.1039/d6ra06529e","url":null,"abstract":"<p><p>Androgenetic alopecia (AGA) impairs quality of life, yet current pharmacotherapies are hampered by limited efficacy and adverse effects. Microneedle-assisted transdermal co-delivery of bioactive natural products and gaseous agents offers a promising alternative. Herein, we report composite polymer microneedles (MNs) for controlled co-delivery of magnesium hydride (MgH₂, which generates cytoprotective H₂ and Mg²⁺ <i>in vivo</i>) and magnolol (Mag, a polyphenol with anti-inflammatory and antioxidant activities). Drug-loaded particles were fabricated <i>via</i> mechanical ball milling and ethanol solvent methods, characterized by XRD, FTIR and SEM, and then incorporated into dissolving PVA:PVP MNs by micromolding with two-step centrifugation. Ball milling yielded superior phase purity and a denser microstructure compared with ethanol, evidenced by distinct XRD peaks and intact FTIR signatures for both Mag and MgH₂. Optimized MNs exhibited markedly enhanced mechanical strength after drug loading (14.524 N <i>vs.</i> 10.729 N). <i>In vitro</i> release best followed first-order kinetics (<i>R</i> ² = 0.99879), reaching 96% at 40 °C or under UV irradiation <i>versus</i> 80.7% at ambient conditions. This MgH₂-Mag MN system combines robust mechanical resilience with thermoresponsive and photoresponsive release, providing a tunable transdermal platform for AGA intervention.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide-AuNP-drug conjugate-integrated photocrosslinkable hydrogel with pH/glutathione dual-responsive drug delivery and NIR-triggered heating for combined chemo-photothermal treatment.","authors":"Ranran Wang, Xinyue Wang, Junyu Yi, Yunyan Shi, Gang Wei, Qie Guo","doi":"10.1039/d6ra08612h","DOIUrl":"https://doi.org/10.1039/d6ra08612h","url":null,"abstract":"<p><p>Doxorubicin (DOX)-based chemotherapy for breast cancer is frequently compromised by systemic toxicity, poor tumor selectivity, and multidrug resistance, underscoring the need for localized and multimodal therapeutic strategies. Here, we developed an injectable peptide-gold-drug (PAD) conjugate-integrated photocrosslinked methacry-loyl hyaluronic acid (HAMA/PAD) hydrogel that couples stimuli-responsive chemotherapy with NIR-triggered photothermal therapy in a single platform. Two-dimensional peptide nanosheets (PNSs) self-assembled from Fmoc-FKKGSHC served as multifunctional molecular scaffolds for the spatial organization of gold nanoparticles (AuNPs) and thiolated DOX (DOX-SH) through Au-S coordination, generating PAD conjugates. This hierarchical nano-to-macro integration enables the HAMA/PAD hydrogel to function simultaneously as an injectable depot and a localized tumor microenvironment. The resulting HAMA/PAD hydrogel exhibited an interconnected porous architecture, shear-thinning behaviour, compatible with syringe-based delivery prior to photocrosslinking, and a storage modulus of approximately 100 Pa. Importantly, PAD exhibited efficient DOX incorporation, while the hydrogel provided pH- and glutathione (GSH)-responsive drug release, offering stimuli-dependent control over DOX availability. Under 808 nm NIR irradiation, HAMA/PAD rapidly generated localized hyperthermia, reaching approximately 55 °C, and maintained stable photothermal performance over repeated irradiation cycles. Additionally, the hydrogel exhibited good cytocompatibility toward L929 fibroblasts, whereas combined HAMA/PAD and NIR treatment reduced 4T1 breast cancer cell viability to approximately 10%, demonstrating a pronounced chemo-photothermal effect. Overall, this study establishes a PNS-enabled strategy for integrating nanoscale drug/photothermal components within an injectable hydrogel depot, providing a versatile platform for localized, stimulus-responsive, and combined chemo-photothermal treatment.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waste-to-resource: utilizing soot as a performing adsorbent for rhodamine B. structural characterization and process optimization.","authors":"Soufiane Youcef, Fadoua Nihad Chergui, Leila Youcef, Beatriz Merillas, Amane Sahli","doi":"10.1039/d6ra04770j","DOIUrl":"https://doi.org/10.1039/d6ra04770j","url":null,"abstract":"<p><p>This study investigates the potential of soot, a low-cost byproduct of incomplete combustion, as an effective adsorbent for the removal of rhodamine B (RhB) from aqueous solutions. The adsorbent was prepared from poultry heating furnace soot and characterized using SEM-EDX, particle size distribution, pH point zero charge, BET surface area, FTIR and XRD analysis. Results revealed a mesoporous structure (BET surface area: 249.19 m² g^-1, average pore diameter: 3.89 nm), and functional groups favorable to RhB adsorption. A Central Composite Design (CCD) under Response Surface Methodology (RSM) was applied to optimize process parameters (contact time, pH, initial concentration of RhB, and soot dosage). The model achieved high predictive accuracy (<i>R</i> ² = 98.87%), with adsorbent dosage and dye concentration identified as the most influential factors. Under optimized conditions, complete RhB removal (100%) was achieved under both neutral (95 min, pH 7, 147 mg L^-1, 2 g L^-1 adsorbent) and acidic environments (95 min, pH 3, 5 mg L^-1, 2 g L^-1 adsorbent). Compared to conventional activated carbons and other modified adsorbents reported in the published studies, soot achieved a maximum adsorption capacity of 226.57 mg g^-1, comparable to several higher-cost materials, without requiring chemical activation or synthesis, highlighting its potential as a low-cost alternative for sustainable wastewater treatment applications.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MnO₂-Co₃O₄@RGO hybrid nanocomposite-modified carbon paste electrode for sensitive electrochemical detection of hydrogen peroxide in food and edible-oil matrices.","authors":"Asmaa H Ragab, Hend S Mager, Rasha M El-Nashar, Rabeay Y A Hassan","doi":"10.1039/d6ra05902c","DOIUrl":"https://doi.org/10.1039/d6ra05902c","url":null,"abstract":"<p><p>Repeated heating of cooking oils promotes lipid oxidation and the formation of reactive oxygen species (ROS) and other oxidation products, including hydrogen peroxide (H₂O₂). Excessive ROS generation can disrupt cellular redox homeostasis and contribute to oxidative stress, which is associated with cellular damage and biological processes implicated in carcinogenesis. Consequently, reliable methods for monitoring H₂O₂ in food and cooking oils are of interest for assessing oxidative changes in these matrices. In this work, a non-enzymatic electrochemical sensor was developed for the rapid and sensitive direct determination of H₂O₂ in food and oil samples. A carbon paste electrode was modified with a hybrid nanocomposite comprising MnO₂ and Co₃O₄ nanostructures supported on reduced graphene oxide (RGO) nanosheets to construct an efficient electrochemical sensing interface. The structural, morphological, and electrochemical characteristics of the synthesized materials and modified electrodes were investigated using transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV). Following optimization, the MnO₂-Co₃O₄@RGO-modified electrode exhibited enhanced electrocatalytic activity toward the H₂O₂ oxidation and was evaluated by chronoamperometry (CA), achieving a detection limit of 0.03 µM and a wide dynamic linear range of 0.1-1800 µM. Furthermore, the sensor exhibited good selectivity toward H₂O₂ in the presence of common interfering species and high sensor surface stability. Thus, its practical applicability was evaluated using H₂O₂-spiked burger, salami, and cheese samples and repeatedly heated palm-oil samples, with satisfactory recoveries obtained. Accordingly, the newly developed MnO₂-Co₃O₄@RGO-modified electrode provides a simple, cost-effective, and efficient platform for non-enzymatic H₂O₂ determination, with potential applications in monitoring oxidative changes in cooking oils and selected food matrices.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanochemical generation of chlorine dioxide radical for solvent-free oxygenation of dibenzothiophenes.","authors":"Kensho Sekiguchi, Yuki Itabashi, Tsuyoshi Inoue, Kei Ohkubo, Haruyasu Asahara","doi":"10.1039/d6ra07225a","DOIUrl":"https://doi.org/10.1039/d6ra07225a","url":null,"abstract":"<p><p>Herein, we present a method for generating chlorine dioxide radical under solvent-free conditions by ball milling sodium chlorite with silica gel. The mechanochemical formation of was supported by UV-vis absorption spectroscopy and ESR measurements. The <i>in situ</i>-generated was directly used for the selective monooxygenation of dibenzothiophenes, including a poorly soluble π-extended benzothiophene derivative. This method provides a practical solvent-free platform for -mediated oxygenation of poorly soluble organosulfur compounds.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends towards multidrug-resistant bacteria: heterocyclic compounds containing antimicrobial agents: review.","authors":"Fatma A M Mohamed, Amira A E Satti, Hemat S Khalaf, Ahmed A Fayed","doi":"10.1039/d6ra06419a","DOIUrl":"https://doi.org/10.1039/d6ra06419a","url":null,"abstract":"<p><p>The rapid emergence of multidrug-resistant (MDR) pathogens poses a severe global health threat, as current antibiotics become increasingly ineffective due to antimicrobial resistance (AMR), irrational drug use across human, veterinary, and agricultural sectors, and aggressive pharmaceutical marketing. This crisis is further aggravated by a shortage of novel antibacterial agents entering clinical practice, highlighting the urgent need for new treatment modalities and drug repurposing strategies. In response, heterocyclic compounds have emerged as a highly versatile and promising class of organic molecules with unique broad-spectrum antibacterial activity against both Gram-positive and Gram-negative strains. To successfully translate these bench discoveries into clinical solutions against superbugs, a combined approach integrating rigorous antibiotic stewardship principles with streamlined regulatory pathways is essential.</p>","PeriodicalId":102,"journal":{"name":"RSC Advances","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}