Clinical and experimental rheumatology最新文献

{"title":"Should multisystem inflammatory syndrome in children be considered occult macrophage activation syndrome?","authors":"Jung Woo Rhim, Soo-Young Lee","doi":"10.55563/clinexprheumatol/hc0ukd","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/hc0ukd","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the comments on: Increased serum soluble interleukin-2 receptor concentrations are linked to high-sensitivity troponin T and disease progression in systemic sclerosis.","authors":"Sebastiann Klapa, Luise Schumacher, Peter Lamprecht","doi":"10.55563/clinexprheumatol/eaaqk8","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/eaaqk8","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of upadacitinib in giant cell arteritis.","authors":"Hande Ogun, Yesim Ozguler","doi":"10.55563/clinexprheumatol/5ozvlt","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/5ozvlt","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on: Increased serum soluble interleukin-2 receptor concentrations are linked to high-sensitivity troponin T and disease progression in systemic sclerosis.","authors":"Gang Chen, Lu Mei Zhang, Yu Zhang","doi":"10.55563/clinexprheumatol/5ynhsh","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/5ynhsh","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Evaluation of the nocebo effect after switching from etanercept or adalimumab originator to a biosimilar: a retrospective study of patients with inflammatory rheumatism.","authors":"Vicenç Torrente-Segarra, Cynthia Rojas, Maria Bonet","doi":"10.55563/clinexprheumatol/v0g0cd","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/v0g0cd","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the ratios: what influences neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in paediatric systemic lupus erythematosus?","authors":"Fatih Demircioğlu","doi":"10.55563/clinexprheumatol/k79lo4","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/k79lo4","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world outcomes of rituximab- and cyclophosphamide-based induction therapy regimens alone and in combination over 24 months in ANCA-associated vasculitis.","authors":"Katja von Allwörden, Sebastian Klapa, Stephan Christian Werth, Anja Leheis, Hanna Graßhoff, Antje Müller, Gabriela Riemekasten, Martin Nitschke, Diamant Thaçi, Peter Lamprecht","doi":"10.55563/clinexprheumatol/cfyh9p","DOIUrl":"10.55563/clinexprheumatol/cfyh9p","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective cohort study aimed to evaluate real-world data on the efficacy of rituximab (RTX) alone versus combined rituximab/cyclophosphamide (RTX/CYC) induction therapy, followed by RTX maintenance, compared with cyclophosphamide-azathioprine (CYC-AZA) therapy in ANCA-associated vasculitis (AAV).</p><p><strong>Methods: </strong>Patients with new-onset or relapsing organ- or life-threatening AAV (granulomatosis with polyangiitis [GPA] n=97; microscopic polyangiitis [MPA], n=69) were followed over 24-months. Patients with previous RTX and/or CYC therapy were excluded. Treatment comprised combination of GC with either RTX alone or RTX/CYC combination for remission induction, each followed by RTX maintenance therapy, or CYC-AZA therapy. The primary outcome measure was complete remission defined as absence of vasculitis activity with no concomitant GC therapy after 12 and 24 months.</p><p><strong>Results: </strong>20% and 35% of the patients in the RTX group and 22% and 33% in the RTX/CYC group achieved complete remission at 12 and 24 months, contrasting with 3% and 9% in the CYC-AZA group (p=0.008 and p=0.003, respectively). The majority of patients achieved remission with concomitant GC therapy at any time during the 24-months observation period (RTX, 88%; RTX/CYC, 87%; CYC-AZA, 81%; p=0.097). RTX alone was associated with a lower relapse rate compared with RTX/CYC in the subgroup of GPA patients (p=0.041). Moreover, RTX alone was comparably effective to RTX/CYC and CYC-AZA in terms of relapse in patients with severe renal disease (p=0.091).</p><p><strong>Conclusions: </strong>RTX alone was similarly effective to RTX/CYC combination and CYC-AZA therapy in AAV patients, including those with severe renal involvement.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovial biopsy in a case of nivolumab-induced arthritis.","authors":"Roberto Pereira da Costa, Mafalda Pinho, João Patrocínio, Sofia Torres, Cristina Ferreira, João Eurico Fonseca, Nikita Khmelinskii","doi":"10.55563/clinexprheumatol/2z7vho","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/2z7vho","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictions of rheumatoid arthritis burden in 204 countries and territories by 2044: based on the Global Burden of Disease Study 2021.","authors":"Wenhao Zhang, Dongmei Zhuang, Huan Lu, Ziyan Lv, Limin Huang, He Du, Jin Chang, Mengmeng Xiao, Mingyu Chen, Wenjie Ying, Haoyang Lei, Xiaoming Li","doi":"10.55563/clinexprheumatol/7dijpb","DOIUrl":"10.55563/clinexprheumatol/7dijpb","url":null,"abstract":"<p><strong>Objectives: </strong>We conducted a comprehensive analysis of the spatiotemporal dynamics of rheumatoid arthritis (RA), including age‑standardised prevalence (ASPR), incidence (ASIR), and disability‑adjusted life years (DALYs, ASDR), from 1990 to 2021, and projected trends through 2044 using data from the Global Burden of Disease (GBD) 2021 to inform and strengthen global prevention, control strategies, and public health policy for RA.</p><p><strong>Methods: </strong>ASPR, ASIR, and ASDR estimates for 204 countries and territories (1990-2021) were retrieved from GBD 2021. We quantified temporal trends by the estimated annual percentage change (EAPC) and average annual percentage change (AAPC). We examined gender‑age‑specific differences in ASPR, ASIR, and ASDR and the relationships between RA‑related DALYs and risk factors across strata. What's more, we employed AutoRegressive Integrated Moving Average (ARIMA) and the Nordpred age‑period‑cohort model to forecast prevalence and incidence through 2044. All statistical analyses were performed in R 4.4.1 and Joinpoint Trend Analysis Software.</p><p><strong>Results: </strong>Between 1990 and 2021, global ASPR and ASIR rose (AAPC: 0.44 and 0.40, respectively), while ASDR declined modestly (AAPC: -0.03). In 2021, Ireland exhibited the highest ASPR (529.08) and ASIR (35.08), whereas Mexico recorded the highest ASDR (87.45). Although higher sociodemographic index (SDI) regions bore a greater RA burden overall, lower SDI regions experienced more rapid increases. Across all metrics, women - particularly those aged ≥60 years - demonstrated higher rates than men. 'Smoking' emerged as a vital risk of DALYs across age groups, genders, and regions. Projections from Nordpred and ARIMA model indicate continued rapid growth in prevalence and incidence cases through 2044, with more gradual increases in ASPR and ASIR.</p><p><strong>Conclusions: </strong>Global prevalence and incidence of RA are projected to rise further. Detailed knowledge of these trends and their drivers is essential to inform targeted interventions and mitigate the worldwide impact of RA.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent myocarditis revealing a desmoplakin cardiomyopathy successfully treated with anakinra.","authors":"Thomas Barba, Marie Robert, Arnaud Hot","doi":"10.55563/clinexprheumatol/vxe3tj","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/vxe3tj","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}