Clinical and experimental rheumatology最新文献

{"title":"Phenotype-based risk stratification for deep vein thrombosis in Behçet's disease: a global 10-year longitudinal study.","authors":"Hiroko Nagafuchi, Takayasu Ando, Kimito Kawahata","doi":"10.55563/clinexprheumatol/ir8mqc","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/ir8mqc","url":null,"abstract":"<p><strong>Objectives: </strong>Vascular involvement, particularly deep vein thrombosis (DVT), is a major cause of morbidity and mortality in Behçet's disease (BD). This study aimed to identify independent risk factors for DVT and establish a robust framework for phenotype-based risk stratification.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the TriNetX global health research network and identified 19,739 patients with BD. Three independent propensity score-matched cohorts were established to evaluate the impact of intestinal involvement, thrombophlebitis, and antiphospholipid syndrome (APS). A multivariable Cox proportional hazards model was used to identify independent predictors of DVT over a 10-year follow-up. To ensure the robustness of our findings and minimise peri-diagnostic detection bias, a 90-day landmark analysis was performed as a sensitivity analysis.</p><p><strong>Results: </strong>Multivariable analysis identified APS (adjusted hazard ratio [aHR] 6.28, 95% confidence interval [CI] 4.56-8.64) and a history of thrombophlebitis (aHR 5.92, 95% CI 4.72-7.41) as the strongest independent predictors of DVT. In the 90-day landmark analysis, these associations remained significant, with persistent risk observed for APS (aHR 5.10) and thrombophlebitis (aHR 2.50), confirming their long-term predictive value. Additional independent predictors included intestinal involvement (defined as non-infective inflammatory colitis; aHR 1.51), obesity (aHR 1.98), glucocorticoid use (aHR 1.78), and male sex (aHR 1.77).</p><p><strong>Conclusions: </strong>APS and thrombophlebitis, markers of heightened inflammatory and thrombotic activity at diagnosis, also appear to be persistent indicators of elevated DVT risk in BD. These findings support phenotype-based risk stratification and highlight the need for intensive monitoring and individualised preventive strategies to improve long-term outcomes.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstitial lung disease as the initial manifestation of systemic autoimmune disease: a narrative review of autoantibodies, biomarkers, prognosis, and management.","authors":"Haralampos M Moutsopoulos","doi":"10.55563/clinexprheumatol/objsua","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/objsua","url":null,"abstract":"<p><p>Interstitial lung disease (ILD) may be the first or only clinically apparent manifestation of systemic autoimmune rheumatic disease (SARD), preceding extrapulmonary features by months or years. The European Respiratory Society/American Thoracic Society research classification of interstitial pneumonia with autoimmune features (IPAF) provides a framework for patients with interstitial pneumonia and autoimmune features who do not meet criteria for a defined SARD. Importantly, IPAF requires features from at least two of three domains - clinical, serologic, and morphologic - and cannot be assigned on autoantibody positivity alone. Extended, phenotype-directed autoantibody testing can reveal lung-dominant anti-synthetase syndrome, clinically amyopathic dermatomyositis, early systemic sclerosis, rheumatoid arthritis, or Sjögren's syndrome (Autoimmune epithelitis). Prognosis is heterogeneous and is driven more consistently by the fibrotic burden, usual interstitial pneumonia pattern, baseline and longitudinal pulmonary physiology, and comorbidities than by the IPAF label itself. KL-6, surfactant protein D, CCL18, MMP-7, and multiplex proteomic signatures are promising biomarkers, but none is sufficiently validated to replace serial high-resolution computed tomography and pulmonary function testing. Management should be individualised through multidisciplinary discussion. Immunomodulation is most defensible for inflammatory or SARD-like phenotypes, whereas antifibrotic therapy should be considered when progressive pulmonary fibrosis is established despite appropriate management. IPAF should therefore be viewed as a dynamic research phenotype within a continuum of lung-dominant autoimmunity, requiring longitudinal reassessment for evolution to a defined SARD.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition characteristics in patients with inflammatory myopathy based on bioelectrical impedance analysis.","authors":"Zheng Wei, Guo Yanlin, Luo Jing, Awang Shazhen, Zhang Zhihan, Zhang Zhuo, Yang Jiajia, Guo Xia, Li Xue, Yang Shiyi, Xiao Fei","doi":"10.55563/clinexprheumatol/fhq0ug","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/fhq0ug","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate body composition features in idiopathic inflammatory myopathy (IIM) using bioelectrical impedance analysis (BIA) and evaluate their clinical, diagnostic and follow-up value.</p><p><strong>Methods: </strong>This study included 103 patients with inflammatory myopathy over a 6-year period, excluding 15 cases, resulting in a final cohort of 88 IIM patients. Clinical assessments and BIA were performed. Healthy controls and patients with amyotrophic lateral sclerosis (ALS) were independently recruited as separate comparison groups.</p><p><strong>Results: </strong>IIM patients showed reduced muscle mass (SMM: 20.9±4.4 vs. 23.4±4.8, p=0.001), elevated ECW/TBW ratio (ECW/TBW total (ETT): 0.398±0.015 vs. 0.381±0.007, p<0.001), and decreased phase angle (PhARA: 3.50 [2.92, 4.50]° vs. 5.15 [4.50, 5.62]°, p<0.001; PhALA: 3.55 [2.84, 4.43]° vs. 5.03 [4.48, 5.42]°, p<0.001). These features correlated with disease severity, inflammation, and nutritional status. Compared to ALS, IIM patients had more marked ECW retention (ETT: 0.397±0.0145 vs. 0.389±0.0110, p=0.001) and impaired membrane integrity (PhARA: 3.450±0.99° vs. 4.295±1.44°, p=0.014; PhALA: 3.500 [2.850, 4.400]° vs. 4.400 [3.875, 4.925]°, p=0.003). Body composition demonstrated substantial potential for diagnostic application (XGBoost model: specificity 85.00%, sensitivity 88.46%), and more importantly, may serve as a valuable tool for disease management.</p><p><strong>Conclusions: </strong>BIA technology provides important novel disease characteristics for IIM patients, which are closely related to traditional clinical features and demonstrate significant diagnostic and management potential.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AA amyloidosis as a rare presentation leading to the diagnosis of mevalonate kinase deficiency in a male adult: a diagnostic challenge mimicking familial Mediterranean fever.","authors":"Alba Chiara Pozzi, Giulia Voltarel, Paolo Airo', Micol Frassi, Ilaria Cavazzana, Francesca Crisafulli","doi":"10.55563/clinexprheumatol/0rs4nj","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/0rs4nj","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum advanced glycation end products and glyoxalase-1 levels in Behçet's disease: a cross-sectional study.","authors":"Taylan Kaplan, Zeynep Serra Tüzün, Tülin Ergun, Fatma Alibaz-Öner, Dilek Gogas Yavuz, Haner Direskeneli","doi":"10.55563/clinexprheumatol/fhrzy8","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/fhrzy8","url":null,"abstract":"<p><strong>Objectives: </strong>Behçet's disease (BD) is a chronic, systemic inflammatory disorder. Despite the presence of chronic inflammation in BD, a clear increase in atherosclerotic cardiovascular mortality has not been documented. However, chronic inflammation may contribute to atherogenesis through various pathways, including accelerated generation of advanced glycation end products (AGEs). The objective of this study was to assess serum AGEs, Nε-carboxymethyllysine (CML), and glyoxalase-1 (GLO1) levels in a cohort of individuals with BD.</p><p><strong>Methods: </strong>This cross-sectional study comprised 81 patients with BD (mean age: 43±11 years; 51 men/30 women) and 56 control subjects (mean age: 52±11 years; 45 women/11 men). Serum concentrations of AGEs, CML, and GLO1 were assessed using enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>AGE levels in patients with BD were significantly higher than those in the control group (BD: median 555 [453-864] ng/L vs. controls: median 512 [430-557] ng/L; p=0.008). CML levels in patients with BD were also higher than those in controls (median 532 [443-694] ng/mL vs. median 360 [308-442] ng/mL; p<0.001). Moreover, GLO1 levels in patients with BD were significantly lower than those in controls (median 15 [13-22] ng/mL vs. median 21 [18-27] ng/mL; p<0.001). No significant differences were observed in AGEs, CML, or GLO1 levels in individuals with BD according to smoking status, BMI, colchicine, glucocorticoids, immunosuppressive therapies, or major organ involvement.</p><p><strong>Conclusions: </strong>Elevated levels of advanced glycation end products and decreased glyoxalase-1 levels were observed in BD. This pattern suggests that the inflammatory process in BD may be associated with AGE accumulation and attenuation of protective antioxidant/dicarbonyl-detoxification pathways. Elevated AGEs may contribute to the pathogenesis of atherosclerosis in individuals with BD.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinically overt aortic aneurysm in giant cell arteritis: a nationwide hospital-based study.","authors":"Mario Martín-Portugués, Victor Bello-Rico, Jorge Esteban-Sampedro, Rafael Muñoz-Viana, Román Fernández-Guitián, Victor Moreno-Torres","doi":"10.55563/clinexprheumatol/ctftt6","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/ctftt6","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the incidence, time to aortic aneurysm (AA) diagnosis, and factors associated with AA development in patients admitted with giant cell arteritis (GCA).</p><p><strong>Methods: </strong>We conducted a nationwide, registry-based study using the Spanish National Hospital Discharge Database. The study included all hospitalised patients aged ≥50 years with a diagnosis of GCA between 2016 and 2024.</p><p><strong>Results: </strong>Among 5,120 patients hospitalised because of GCA without prior AA, 54 (1.1%) were diagnosed with AA during current admission (AAo group) and 41 (0.8%) developed AA during follow-up (AAf group). Median time from first GCA admission and AA diagnosis was 2.7 years. Incidence rate was 1.8 per 100 patient-years. Established heart disease was markedly more frequent in the AAo compared with the other groups (50.0% at onset vs. 19.5% during follow-up and 32.3% in patients without aneurysm; p=0.006). After adjustment, male sex was independently associated with a higher risk of AA at baseline (RRR 2.42, 95% CI 1.40-4.20), whereas smoking at GCA diagnosis was the only factor independently associated with AA development during follow-up (RRR 3.23, 95% CI 1.47-7.08).</p><p><strong>Conclusions: </strong>Clinically recognised AA was uncommon among hospitalised patients with GCA and was associated mainly with traditional cardiovascular risk factors, particularly male sex and smoking. Because estimates were based on hospital discharge diagnoses, they reflect clinically overt, hospital-recorded AA rather than the overall aneurysm burden in GCA. Follow-up should prioritise individualised vascular surveillance, particularly in smokers.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with chronic kidney disease in patients with gout: a two-centre study incorporating ultrasonographic features.","authors":"Beilei Lu, Peishan Guan, Qun Wang, Ying Wang, Zitong Chen, Cuixian Li, Fan Zhuang, Qing Lu, Jinwang Huang, Xiyuan Lin, Beijian Huang, Wenping Wang, Huixiong Xu","doi":"10.55563/clinexprheumatol/rzqs4p","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/rzqs4p","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic kidney disease (CKD) is a significant comorbidity in patients with gout, yet the specific phenotypes associated with its prevalence remain insufficiently characterised. This study aimed to evaluate the association between clinical indicators and ultrasonographic features with CKD using a transparent, interpretable machine learning approach.</p><p><strong>Methods: </strong>This cross-sectional bicentric study analysed a cohort of 666 patients with gout, who were partitioned into a derivation cohort (n=500) for model development and internal validation, and an independent validation cohort (n=166). Three architectures (GLM, Random Forest, SVM) modelled associations between biomarkers and CKD status. SHapley Additive exPlanations (SHAP) analysis quantified individual variable contributions, and a dynamic nomogram visualised cumulative relevance.</p><p><strong>Results: </strong>Six key correlates were identified, comprising two clinical indicators (age and hypertension) and four ultrasonographic findings (bone erosion, high-burden (≥3 joints) tophi, synovial hyperplasia, and double contour sign). The GLM demonstrated the strongest associative performance, with an AUC of 0.842 (internal) and 0.835 (independent cohort), indicating high discriminative power. SHAP analysis identified advanced age and ultrasound-detected tophi as the most influential contributors to the observed associations. DCA and calibration plots confirmed that the framework accurately reflected the underlying probability distribution.</p><p><strong>Conclusions: </strong>We established an interpretable analytical framework that characterises the clinical and ultrasonographic profile associated with CKD in gout. By integrating imaging markers with clinical indicators, this approach identifies associated phenotypes, providing a transparent reference for individualised assessment and enhanced clinical vigilance regarding renal status.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune responses targeting homocitrullinated peptides drive rheumatoid arthritis-like pathology in HLA-DR4 transgenic mice.","authors":"Gabrielle Buckley, Sheri Saunders, Ewa Cairns, Lillian Barra","doi":"10.55563/clinexprheumatol/4v6z8a","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/4v6z8a","url":null,"abstract":"<p><strong>Objectives: </strong>Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by persistent synovial inflammation and progressive joint destruction. A hallmark feature of RA is the presence of anti-citrullinated protein autoantibodies (ACPAs), which have been extensively studied in disease pathogenesis. The development of these autoantibodies is strongly associated with the expression of HLA-DR4, containing the shared epitope. More recently, anti-homocitrullinated protein autoantibodies (AHCPAs) have also been implicated in RA and demonstrate a similar genetic association. Therefore, this study aimed to evaluate the role of homocitrulline immune responses in RA pathogenesis.</p><p><strong>Methods: </strong>HLA-DR4 transgenic (DR4tg) and C57Bl/6 (B6) mice were immunised with a synthetic homocitrullinated peptide (HomoCitJED) or PBS followed by a booster 21 days later. Beginning on day 75 post-primary immunisation mice received knee intra-articular (i.a.) injections of HomoCitJED once a week for three consecutive weeks. Swelling post i.a. injection was measured using digital calipers. IgG antibodies against citrullinated/homocitrullinated peptides/proteins were measured using enzyme-linked immunosorbent assay (ELISA). Knees were sectioned and analysed for histopathological damage and citrullinated/homocitrullinated protein levels.</p><p><strong>Results: </strong>HomoCitJED immunised DR4tg mice exhibited significantly greater swelling and incidence of anti-HomoCitJED and anti-homocitrullinated fibrinogen IgG autoantibodies. Additionally, 30% had responses against CitJED, a synthetic citrullinated peptide. HomoCitJED immunised DR4tg mice also experienced greater total histopathological damage; however, the immunisations/injections did not affect citrullinated/homocitrullinated protein levels in the joint.</p><p><strong>Conclusions: </strong>Homocitrulline-specific immune responses can induce RA-like disease in DR4tg mice, supporting the pathogenic role of AHCPAs in RA.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of pulmonary amyloidosis with lymphocytic interstitial pneumonia in a patient with systemic lupus erythematosus.","authors":"Osman Erhan Akcan, Sema Yılmaz, Hatice Dökmeci Yıldız, Ismail Harmankaya, Burcu Yormaz","doi":"10.55563/clinexprheumatol/g3t8q2","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/g3t8q2","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prokineticin 2 promotes endoplasmic reticulum stress in rheumatoid arthritis by potentiating IL-1β-induced inflammation.","authors":"Rong Zhu, Haiyang Liao, Juan Zhang, Haili Shen","doi":"10.55563/clinexprheumatol/p8oudj","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/p8oudj","url":null,"abstract":"<p><strong>Objectives: </strong>Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by persistent synovial inflammation and progressive joint destruction. Although current therapies have greatly improved disease management, many patients show an inadequate response or develop resistance to existing therapies. Therefore, identifying novel molecular targets remains essential to improve therapeutic outcomes, particularly in refractory cases.</p><p><strong>Methods: </strong>Commercially available rheumatoid arthritis-derived fibroblast-like synoviocytes (RA-FLS) were stimulated with pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α), to evaluate cytokine-induced gene expression changes. Gene set enrichment analysis (GSEA) and functional assays were used to explore signalling pathways regulated by the candidate gene prokineticin 2 (PK2). Expression of pathway-related markers was validated by qRT-PCR and Western blotting. The in vivo role of PK2 was further assessed in a collagen-induced arthritis (CIA) mouse model.</p><p><strong>Results: </strong>PK2 expression was significantly increased in synovial tissue from RA patients. In vitro, IL-1β and TNF-α upregulated PK2 expression in RA-FLS. Transcriptomic analysis showed that co-stimulation with PK2 and IL-1β significantly enriched pathways involved in protein processing in the endoplasmic reticulum. Further experiments demonstrated that combined PK2 and IL-1β stimulation increased the expression of XBP1, GRP78, CHOP, and HSPA6. In vivo, PK2 aggravated joint inflammation and tissue damage in CIA mice, whereas the PK2 antagonist PKRA7 significantly alleviated disease severity.</p><p><strong>Conclusions: </strong>PK2 is a key RA-associated gene that is closely involved in endoplasmic reticulum protein-processing pathways. Targeting PK2-mediated ER stress may represent a promising therapeutic strategy for RA.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}