Clinical and experimental rheumatology最新文献

{"title":"Associations between illness perception, treatment adherence and functional impact in fibromyalgia: a cross-sectional study.","authors":"Tugba Alisik, Yagmur Cagla Reis-Altan, Esra Sahingoz Bakirci, Elif Yaksi, Baris Nacir","doi":"10.55563/clinexprheumatol/9ev4xx","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/9ev4xx","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate treatment adherence in patients with fibromyalgia (FM) and to examine its relationship with illness perception and disease severity.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 84 FM patients. Treatment adherence, illness perception and fibromyalgia-related impact were assessed using the 8-item Morisky Medication Adherence Scale (MMAS), Brief Illness Perception Questionnaire (BIPQ), and Fibromyalgia Impact Questionnaire (FIQ), respectively.</p><p><strong>Results: </strong>The majority of participants were female (79.8%) with a mean age of 43.7±11.2 years. The median MMAS, BIPQ, and FIQ scores were 3 (2-4), 50 (42-60), and 48.0 (36.0-57.8), respectively. Patients with higher disease severity, as classified by FIQ, had significantly lower MMAS scores (p<0.05) and higher BIPQ scores (p<0.05). A negative correlation was found between MMAS and BIPQ scores (rho=-0.445, p<0.001), and a moderate negative correlation was observed between MMAS and FIQ scores (rho=-0.275, p=0.011). Illness perception was positively correlated with FIQ scores (rho=0.615, p<0.001).</p><p><strong>Conclusions: </strong>This study demonstrates that negative illness perceptions are strongly associated with poor treatment adherence and greater disease burden in fibromyalgia. These findings highlight the importance of assessing cognitive and psychosocial factors in routine FM care. Targeted interventions addressing illness beliefs may enhance adherence and improve patient outcomes in this multifaceted condition.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-efficacy is associated with a lower probability of damage accrual in patients with systemic lupus erythematosus: data from the Almenara Lupus Cohort.","authors":"Claudia Elera-Fitzcarrald, Rocío V Gamboa-Cardenas, Victor Pimentel-Quiroz, Cristina Reategui-Sokolova, José Alfaro-Lozano, Zoila Rodriguez-Bellido, Cesar Pastor-Asurza, Risto Perich-Campos, Graciela S Alarcón, Manuel F Ugarte-Gil","doi":"10.55563/clinexprheumatol/fdf5zj","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/fdf5zj","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the association between self-efficacy and damage accrual in SLE patients.</p><p><strong>Methods: </strong>We evaluated SLE patients from the Almenara Lupus Cohort. Self-efficacy was ascertained with the six instruments of the Patient-Reported Outcomes Measurement Information System® (PROMIS®) Self-efficacy for Managing Chronic Conditions. For PROMIS instruments, the higher score, the greater self-efficacy. Damage was assessed with the SLICC/ACR damage index (SDI). Generalised estimating equations were performed, using as the outcome any increase in the SDI and the self-efficacy instrument in the previous visit; multivariable models were adjusted for possible confounders measured at the same visit as the self-efficacy instrument. OR was reported per 5 units increase per self-efficacy instrument component.</p><p><strong>Results: </strong>A total of 209 patients and 563 visits were included. At baseline, mean general self-efficacy was 47.2 (10.4), self-efficacy for managing emotions was 44.6 (8.0), for managing symptoms was 47.7 (8.2), for managing daily activities was 45.5 (7.5), for managing social interactions was 42.9 (7.9) and for managing medications and treatment was 43.9 (7.0). During the follow-up visits, 41 (19.6%) patients accrued damage once and 2 patients (1.0%) accrued it twice. In the multivariable models, a better self-efficacy for managing symptoms and daily activities were predictive of less damage accrual (OR=0.79, 95% CI=0.64-0.98 and OR=0.71, 95% CI=0.54-0.95, respectively).</p><p><strong>Conclusions: </strong>A better self-efficacy mainly in the managing symptoms and daily activities domains is predictive of a lower risk of damage accrual, even after adjusting for possible confounders. Strategies to improve self-efficacy in SLE patients should be encouraged to improve patients' outcomes.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The need to address the risk of osteosarcopenia induced by tirzepatide therapy.","authors":"Giammarco De Mattia, Maurizio Mazzantini","doi":"10.55563/clinexprheumatol/el8zor","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/el8zor","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report on the safety of the influenza vaccine in patients with paediatric inflammatory rheumatic diseases on JAK inhibitors.","authors":"Despoina N Maritsi, Lida Mentesidou, Angeliki Syggelou, Maria N Tsolia","doi":"10.55563/clinexprheumatol/hlidn3","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/hlidn3","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment with upadacitinib in a patient with intractable urticarial vasculitis: a case report.","authors":"Tianhong Xie, Weiye Li, Peicong Li, Ziwei Zhao, Xiang Liu","doi":"10.55563/clinexprheumatol/nmqrck","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/nmqrck","url":null,"abstract":"","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Web search trends on fibromyalgia: development of a machine learning model.","authors":"Matteo Luigi G Leoni, Marco Mercieri, Antonella Paladini, Marco Cascella, Martina Rekatsina, Fabiola Atzeni, Alberto Pasqualucci, Laura Bazzichi, Fausto Salaffi, Piercarlo Sarzi-Puttini, Giustino Varrassi","doi":"10.55563/clinexprheumatol/05r0ib","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/05r0ib","url":null,"abstract":"<p><strong>Objectives: </strong>Fibromyalgia (FM) is a chronic pain condition characterised by widespread musculoskeletal pain, fatigue, and cognitive dysfunction. The growing reliance on the internet for health-related information has transformed how individuals seek medical knowledge, particularly for complex conditions like FM. This study aimed to analyse online search behaviours related to FM across multiple countries, identify temporal trends, and assess machine learning models for predicting search interest.</p><p><strong>Methods: </strong>Google Trends data (2020-2024) were analysed across sixteen countries. Time-series analysis, linear regression, and the Mann-Kendall trend test assessed monotonic trends, while seasonal decomposition identified periodic fluctuations. An Auto-Regressive Integrated Moving Average (ARIMA) model forecasted search volumes for 2025. Machine learning models, including Random Forest (RF) and Extreme Gradient Boosting (XGBoost), were used to predict search trends, with feature importance evaluated using SHAP (Shapley Additive Explanations) values.</p><p><strong>Results: </strong>Search interest in FM varied across countries, with China, the UK, the USA and Canada showing the highest engagement, while Peru, Spain and Turkey had the lowest. Brazil, Italy and the UK exhibited rising search trends, whereas Argentina, Canada, Greece and the USA showed declines. Seasonal analysis revealed mid-year peaks in Brazil and Italy, while Turkey saw late autumn increases. ARIMA forecasting predicted stable or increasing trends in Brazil, Canada and Mexico, while Germany and Venezuela showed slight declines. Machine learning analysis identified short-term search history (search volumes from the previous day, week, and month) as the most influential predictor.</p><p><strong>Conclusions: </strong>Understanding online search behaviour can enhance FM education. Targeted awareness campaigns and improved digital health literacy initiatives could sustain engagement and improve patient knowledge. Future efforts should focus on optimising online health resources and integrating evidence-based decision aids.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated integrin αvβ3 expression activates the NF-κB p65/p100 pathway and promotes inflammatory responses in systemic lupus erythematosus.","authors":"Xiaoli Song, Chong Yang Liu, Tian Qian, Jiacheng Li, Fei Hao","doi":"10.55563/clinexprheumatol/0cfcsp","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/0cfcsp","url":null,"abstract":"<p><strong>Objectives: </strong>Systemic lupus erythematosus (SLE) is a severe autoimmune disease characterised by multi-organ involvement. The onset and progression of SLE are closely associated with the excessive release of various inflammatory factors. Integrin αvβ3, a key member of the integrin protein family, plays an essential role in inflammation. This study aimed to elucidate the molecular mechanism of the NF-κB pathway mediated by integrin αvβ3 in systemic lupus erythematosus (SLE) and further investigate its role in the pathogenesis of SLE.</p><p><strong>Methods: </strong>We collected relevant data from 36 patients with systemic lupus erythematosus and 36 healthy control subjects using. Western blot and immunohistochemistry staining to explore the mechanisms of SE in vivo and in vitro. We used Student's t-test, ANOVA and post-hoc Kruskal-Wallis tests for data analysis.</p><p><strong>Results: </strong>Our results demonstrate that elevated expression of integrin αvβ3 in the serum, skin, and renal tissues of patients with SLE contributes to the activation of NF-κB, a critical initiator of inflammatory responses in SLE. Specifically, the synthesis of NF-κB p65 and NF-κB p100 is enhanced, promoting NF-κB activation, leading to the dysregulation of TLR7 expression. This induces an increase in inflammatory factors such as TNF-α and IL-6, making organs such as the skin and kidneys more susceptible to inflammation. Moreover, our findings indicate that the administration of the integrin αvβ3 antagonist SB273005 in the MRL/lpr lupus mice model significantly reduces the synthesis of NF-κB p65/p100, suppresses NF-κB activation, decreases levels of inflammatory factors in the serum and kidneys, and alleviates organ damage in MRL/lpr lupus mice.</p><p><strong>Conclusions: </strong>This study highlights that the upregulation of integrin αvβ3 expression in SLE activates the NF-κB p65/p100 pathway, which plays a pivotal role in orchestrating inflammatory responses.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased serum soluble interleukin-2 receptor concentrations are linked to high-sensitivity troponin T and disease progression in systemic sclerosis.","authors":"Luise Schumacher, Antje Müller, Andreas Koch, Robert Markewitz, Peter Lamprecht, Gabriela Riemekasten, Sebastian Klapa","doi":"10.55563/clinexprheumatol/re755k","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/re755k","url":null,"abstract":"<p><strong>Objectives: </strong>To determine serum interleukin-2 receptor (sIL-2R) concentrations as biomarker in systemic sclerosis (SSc) and their association with markers for inflammation (high-sensitivity C-reactive protein, hs-CRP), lymphocyte activation and turnover (beta-2 microglobulin, b2M), and cardiac damage (hs-troponin T, hs-TnT).</p><p><strong>Methods: </strong>In this longitudinal cross-sectional observational study, serum sIL-2R concentrations were determined in 315 patients with SSc. Clinical data were assessed at baseline and up to 48 months after. Associations were calculated using logistic regression. Clinical deterioration was estimated using the Kaplan-Meier method.</p><p><strong>Results: </strong>Patients with dcSSc (n=139) displayed increased serum sIL-2R concentrations (p=0.001) compared to lcSSc (n=176). Increase in sIL-2R concentrations was associated with cardiac (p=0.014), pulmonary (p=0.007) and skin involvement (p<0.001) in SSc. Overall, sIL-2R concentrations in SSc correlated with b2M (r=0.6161, p<0.001), hs-CRP (r=0.4091, p<0.001), and hs-TnT (r=0.4548, p<0.001). The serum sIL-2R concentration discriminated normal from pathological range concentrations of hs-TnT (ROC-AUC:0.87; 95%CI, 0.77-0.97; p<0.001; sensitivity 80.0%, specificity 80.1%). In patients with clinical improvement, the concentration of sIL-2R decreased (p=0.004). Using Log-rank test and Mantel-Cox proportional hazard models, we found that a sIL-2R concentration of ≥900 U/ml defined SSc subtypes with increased clinical activity and predicted early disease progression in SSc (HR:2.21, p=0.001).</p><p><strong>Conclusions: </strong>sIL-2R concentrations reflect disease severity, particularly cardiac damage, and early disease progression, and suggest a potential role for disease and therapy monitoring. Thus, sIL-2R should be further evaluated as a biomarker in SSc in prospective studies.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research trends and hotspots on gut microbiota in rheumatoid arthritis: a bibliometric analysis from 2004 to 2024.","authors":"Zesen Zheng, Xiaoyang Liu, Youao Zhang, Huihui Zhang, Shixian Chen, Junqing Zhu","doi":"10.55563/clinexprheumatol/3899sf","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/3899sf","url":null,"abstract":"<p><strong>Objectives: </strong>Rheumatoid arthritis (RA) is an autoimmune condition linked to alterations in the gut microbiota. This study aims to conduct a comprehensive analysis of the literature on gut microbiota and RA over the past 21 years through bibliometric methods, thereby identifying emerging trends and hotspots, and providing insights for the precision treatment of RA.</p><p><strong>Methods: </strong>The authors analysed articles on gut microbiota in RA published from 2004 to 2024 based on the Web of Science Core Collection database. Bibliometric methods employed tools such as CiteSpace, VOSviewer, and COOC to conduct visual analyses of countries, institutions, references, and keywords.</p><p><strong>Results: </strong>1,267 articles from 80 countries led by China and the United States were included. A notable increase in annual publications reflects the growing interest in this field. Simultaneously, contributions and cooperation of institutions in the field are discussed. Furthermore, co-citation and keyword analysis revealed four research hotspots: 1. specific gut microbiota like Prevotella copri modulating immune responses in RA; 2. dietary interventions regulating gut microbiota as therapeutic approaches for RA; 3. high-throughput sequencing technologies enabling microbiome analysis for diagnostic RA; and 4. probiotics and plant-derived bioactive compounds serving as promising adjunctive therapies for RA management.</p><p><strong>Conclusions: </strong>The relationship between RA and gut microbiota has been extensively studied. The hotspot of future research may be to further study the pathological mechanism of gut microbiota in RA and how to improve the symptoms of RA patients through dietary therapy and adjustment of the homeostasis of gut microbiota.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of two years of COVID-19 pandemic on individuals with fibromyalgia.","authors":"Tali Sahar, Amir Minerbi, M Gabrielle Pagé, Sylvie Toupin, Maria Verner, Sabrina Mitrovic, Shir Yoram, Mary-Ann Fitzcharles","doi":"10.55563/clinexprheumatol/ide0x0","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/ide0x0","url":null,"abstract":"<p><strong>Objectives: </strong>The COVID-19 pandemic has caused prolonged stress, potentially exacerbating fibromyalgia (FM) symptoms. This study aimed to compare the health status of FM patients and healthy controls (HC) before and 2.5 years into the pandemic.</p><p><strong>Methods: </strong>A cohort of FM patients and HC with pre-pandemic data completed an online survey in August 2022. The survey collected demographic information, symptom severity, and health perception using the Fibromyalgia Impact Questionnaire (FIQ), Brief Pain Inventory (BPI), Perceived Stress Scale (PSS), and other quality of life and physical activity questionnaires.</p><p><strong>Results: </strong>The study included 32 FM patients and 21 HC, all female and predominantly white, with FM patients having higher BMI. Emotional responses to the pandemic were similar across both groups. Clinical measures in FM showed stability or improvement in 84% for FM severity scores, 66% for FIQ (quality of life), and 50% for pain intensity. Physical activity related to sports decreased in both FM and HC, while leisure activity increased in FM but decreased in HC. In FM insomnia correlated with pain intensity, clinical measures were associated with function and affective status, and changes in leisure activity inversely correlated with pain interference.</p><p><strong>Conclusions: </strong>Contrary to expectations, FM patients' health remained stable or improved during the pandemic. This study is unique due to its pre-pandemic data and comparison to a control group, reducing potential bias. Findings suggest that FM patients may have developed resilience, or benefited from pandemic-related lifestyle changes, such as a slower pace of life. Alternatively, the observed trends could reflect a regression to the mean.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}