Clinical and experimental rheumatology最新文献_第10页

A rare case of curative colectomy for Takayasu's arteritis. 一例罕见的高安动脉炎治愈性结肠切除术。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-17 DOI: 10.55563/clinexprheumatol/a1okxy

Laura Kek, Griffin J Reed, Matthew J Koster

引用次数: 0

Allogeneic stem cell transplantation in difficult-to-treat rheumatoid arthritis. 异体干细胞移植治疗难以治愈的类风湿性关节炎。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-17 DOI: 10.55563/clinexprheumatol/qonstg

Kevin Van Compernolle, Dominik Selleslag, Glen S Hazlewood, Jan Storek, Jacob M van Laar, Yves Piette

引用次数: 0

Assessing IgG4-related autoimmune pancreatitis with contrast-enhanced ultrasonography based on time-intensity curve: a single-centre prospective study. 基于时间-强度曲线的造影剂增强超声造影评估 IgG4 相关自身免疫性胰腺炎：一项单中心前瞻性研究。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-15 DOI: 10.55563/clinexprheumatol/evg4tn

Minhui Lu, Hui Wang, Yiwen Wang, Yanfeng Zhang, Xi Zheng, Yufei Guo, Huiqiong Zhou, Lichun An, Jian Zhu

{"title":"Assessing IgG4-related autoimmune pancreatitis with contrast-enhanced ultrasonography based on time-intensity curve: a single-centre prospective study.","authors":"Minhui Lu, Hui Wang, Yiwen Wang, Yanfeng Zhang, Xi Zheng, Yufei Guo, Huiqiong Zhou, Lichun An, Jian Zhu","doi":"10.55563/clinexprheumatol/evg4tn","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/evg4tn","url":null,"abstract":"Objectives: The aim of this study was to investigate the changes in various parameters of contrast-enhanced ultrasound (CEUS) before and after treatment in patients with IgG4-related autoimmune pancreatitis (IgG4-AIP), and to identify potential indicators that can assist in evaluating disease activity.Methods: In this prospective study, we enrolled patients diagnosed with IgG4-AIP from June 2021 to November 2022. Demographic characteristics, clinical features, laboratory tests were recorded. Baseline and follow-up, conventional ultrasound and CEUS were conducted. Additionally, a region of interest (ROI) within lesions, pancreatic head, pancreatic body, and pancreatic tail was taken to draw time-intensity curves (TIC) and parameters of TIC were recorded and analysed.Results: Seventy-three active IgG4-AIP patients were enrolled. Follow-up, a notable decrease in the size of the pancreatic lesion was observed with a reduction in the maximum diameter from 4.3 ± 2.0 cm to 1.7 ± 1.6 cm (p=0.01). The results revealed a statistically significant increase in peak intensity (PI) in the head, body, and tail regions of the pancreas (p<0.001), along with a significant rise in the area under the curve (AUC) in the tail region of the pancreas (p=0.029) after treatment compared to baseline. In contrast, no statistically significant differences were observed in other parameters of TIC. A significant increase of PI was observed in 12 patients with diffuse IgG4-AIP following treatment. Following treatment, there was a significant increase in PI in the focal area among the 12 patients with focal lesions.Conclusions: CEUS based on TIC holds great potential for assessing response to treatment in patients with IgG4 AIP.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ankylosing spondylitis and atrial fibrillation: a contemporary overview. 强直性脊柱炎与心房颤动：当代综述。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-14 DOI: 10.55563/clinexprheumatol/ue8sp5

Christos S Konstantinou, Maria Karakosta, Aliki I Venetsanopoulou, Panagiotis Korantzopoulos, Paraskevi V Voulgari

{"title":"Ankylosing spondylitis and atrial fibrillation: a contemporary overview.","authors":"Christos S Konstantinou, Maria Karakosta, Aliki I Venetsanopoulou, Panagiotis Korantzopoulos, Paraskevi V Voulgari","doi":"10.55563/clinexprheumatol/ue8sp5","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/ue8sp5","url":null,"abstract":"Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and it is associated with increased morbidity and mortality. AF is linked with inflammatory signalling while inflammation and oxidative stress promote atrial remodelling, favouring the development and perpetuation of the arrhythmia. On the other hand, ankylosing spondylitis (AS) is considered a chronic inflammatory rheumatic condition with flares and remissions that affects the axial skeleton and mainly young people. AS has been associated with an increased risk of valvular and aorta disease but its relationship with AF has not been studied well. Recent epidemiological evidence indicates an association between AS and AF. This brief review provides a concise overview of all available data regarding the association between AS and AF including the predictive role of electrocardiographic and echocardiographic markers. Several unresolved issues including the thromboembolic risk in this setting and the potential role of anti-inflammatory interventions are also discussed.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IgA vasculitis with nephritis: an overview of the pathogenesis and clinical characteristic. IgA 血管炎伴肾炎：发病机制和临床特征概述。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-08 DOI: 10.55563/clinexprheumatol/mjhyff

Yuxin Zhang, Gaosi Xu

{"title":"IgA vasculitis with nephritis: an overview of the pathogenesis and clinical characteristic.","authors":"Yuxin Zhang, Gaosi Xu","doi":"10.55563/clinexprheumatol/mjhyff","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/mjhyff","url":null,"abstract":"IgA vasculitis with nephritis (IgAVN) is closely related to IgA nephritis (IgAN) and IgA vasculitis (IgAV), but the clinical characteristics and exact pathogenesis of IgAVN remain unclear. In the present study, we have reviewed 8 clinical trials with different treatments and found that most IgAVN patients had partial recovery after treatments while few patients (26.5%) recovered completely within 6 months. Adding cyclophosphamide to mycophenolate mofetil was beneficial in children with severe kidney damage but was not effective in adults with serious organ damage (p=0.847). Tonsillectomy reduced the recurrence rate (p=0.03). In 18 reported cases we summarised, intravenous methylprednisolone pulse (MEP) combined with immunosuppressants (66.7%) and MEP combined with oral prednisolone (27.8%) were the two most commonly utilised treatments, and rituximab (40%) was the most frequently used monoclonal antibody. Mechanistically, activated cytotoxic T lymphocytes, natural killer cells, macrophage and completements contributed to the inflammation and endothelial cell apoptosis in IgAVN patients. Galactose-deficient IgA1 may be a threshold for IgAVN. The bulk formation of immune complexes and the decreased clearance rate led to the deposition of immune complexes. In severe cases, coagulation cascade would be triggered and thus caused renal fibrosis.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-utility of tofacitinib in the treatment of moderate-to-severe rheumatoid arthritis in France: a multi-state Markov model analysis. 托法替尼治疗法国中重度类风湿关节炎的成本效益：多状态马尔可夫模型分析。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-03

Joey Fournier, Bastien Boussat, Benoit Dervaux, Philippe Gaudin, Xavier Romand

{"title":"Cost-utility of tofacitinib in the treatment of moderate-to-severe rheumatoid arthritis in France: a multi-state Markov model analysis.","authors":"Joey Fournier, Bastien Boussat, Benoit Dervaux, Philippe Gaudin, Xavier Romand","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: This study aimed to evaluate the cost-effectiveness of introducing tofacitinib in second-line therapies after methotrexate failure for rheumatoid arthritis in France.Methods: Using a Markov model, we simulated a cohort of 10,000 patients based on literature data to compare various treatment strategies. The reference strategy included the four classes of biologics commonly used in France (TNFi, tocilizumab, abatacept, rituximab). The trial strategies additionally included tofacitinib at different introduction positions. The cycle duration was set at 6 months, and the time horizon was a lifetime. The data for severe adverse effects were sourced from the ORAL Surveillance study.Results: Compared to the reference strategy, introducing tofacitinib is a dominant strategy, regardless of its introduction position. Introducing it as the first-line treatment results in the greatest cost savings (€1,679 per patient) while increasing quality-adjusted life years (QALYs) by 0.29. According to the one-way sensitivity analysis, the discount rate and the cost of TNFi were the two variables that most influenced costs, while the change in HAQ score and the discount rate were the two variables that most influenced QALYs.Conclusions: Our study represents the first assessment of the cost-effectiveness of tofacitinib in France and incorporates the latest adverse effects reported in the literature. It reinforces previously obtained results from other countries. Our study has some limitations, mainly related to the use of data from clinical trials. Our analysis is limited to severe adverse effects, and their cost is extrapolated from the average hospitalisation cost. The estimated costs are therefore underestimated for chronic diseases such as cancer.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroidal vascularity analysis in patients with juvenile idiopathic arthritis without acute uveitis. 无急性葡萄膜炎的幼年特发性关节炎患者脉络膜血管分析。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-03

Barbara Iaccheri, Nicola De Santi, Alessio Cerquaglia, Francesco Della Lena, Eduardo Bianchi, Veronica Gerli, Daniela Fruttini, Jay Chhablani, Carlo Cagini, Tito Fiore

{"title":"Choroidal vascularity analysis in patients with juvenile idiopathic arthritis without acute uveitis.","authors":"Barbara Iaccheri, Nicola De Santi, Alessio Cerquaglia, Francesco Della Lena, Eduardo Bianchi, Veronica Gerli, Daniela Fruttini, Jay Chhablani, Carlo Cagini, Tito Fiore","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: We aimed to investigate choroidal involvement and the degree of anterior chamber inflammation in a cohort of patients with juvenile idiopathic arthritis (JIA) without clinical signs of active uveitis and to compare it with healthy controls (HC).Methods: Enhanced-depth imaging optical coherence tomography (EDI-OCT) scans of 21 patients diagnosed with JIA and 22 HC of equal age were acquired. Images were binarised to measure subfoveal choroidal thickness (SCT), nasal choroidal thickness (NCT), temporal choroidal thickness (TCT), total choroidal area (TCA), luminal area (LA), stromal area (SA) and choroidal vascular index (CVI). Patients also underwent a measurement of the degree of inflammation in the anterior chamber by laser flare meter (LFM).Results: No significant differences were found in the choroidal thickness in the subfoveal region (p=0.274), nasally to the fovea (p=0.568) and temporally to the fovea (p=0.430) between JIA patients and HC. No statistically significant difference in the choroidal area (TCA, LA and SA) between the JIA patients and HC were found. Moreover, CVI was not significantly different between the two groups (p=0.166), while the LFM of the JIA patients and HC (p=0.002) revealed a statistically significant difference.Conclusions: In the absence of active uveitis, choroidal thickness and vascularity are not significantly different in JIA patients and HC.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk prediction modelling in idiopathic inflammatory myositis-associated interstitial lung disease based on seven factors including serum KL-6 and lung ultrasound B-lines. 基于血清 KL-6 和肺部超声 B 线等七个因素的特发性炎症性肌炎相关性间质性肺病风险预测模型

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-02 DOI: 10.55563/clinexprheumatol/ylf0oe

Weijin Zhang, Guohai Huang, Shaoyu Zheng, Jianqun Lin, Shijian Hu, Jinghua Zhuang, Zexuan Zhou, Guangzhou Du, Kedi Zheng, Shaoqi Chen, Qichuan Zhang, Angelina Mikish, Anna-Maria Hoffmann-Vold, Masataka Kuwana, Marco Matucci-Cerinic, Daniel E Furst, Yukai Wang

{"title":"Risk prediction modelling in idiopathic inflammatory myositis-associated interstitial lung disease based on seven factors including serum KL-6 and lung ultrasound B-lines.","authors":"Weijin Zhang, Guohai Huang, Shaoyu Zheng, Jianqun Lin, Shijian Hu, Jinghua Zhuang, Zexuan Zhou, Guangzhou Du, Kedi Zheng, Shaoqi Chen, Qichuan Zhang, Angelina Mikish, Anna-Maria Hoffmann-Vold, Masataka Kuwana, Marco Matucci-Cerinic, Daniel E Furst, Yukai Wang","doi":"10.55563/clinexprheumatol/ylf0oe","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/ylf0oe","url":null,"abstract":"Objectives: To develop a user-friendly nomogram-based predictive model for interstitial lung disease (ILD) in patients with idiopathic inflammatory myositis (IIM).Methods: A retrospective study was conducted at Shantou Central Hospital, encompassing 205 IIM patients diagnosed between January 2013 and December 2022. We used the LASSO regression method in the discovery set to select features for model construction, followed by efficacy verification through AUC of ROC. Afterwards, KL-6 values and LUS B-lines number were added into this model to evaluate whether these 2 factors added to the model efficiency. Finally, a web version was constructed to make it more available.Results: Among the 205 IIM patients, 115 (56.1%) patients were diagnosed with ILD, and 90 (43.9%) did not. The predictive model, derived from the training set, comprised four independent risk factors, including age, presence of respiratory symptoms, anti-melanoma differentiation-associated gene 5 (MDA-5) antibody positivity, and anti-aminoacyl transfer RNA synthetase (anti-ARS) antibodies positivity. Notably, anti-TIF1-γ antibody positivity emerged as a protective factor. The AUC of the ROC based on these 5 factors was 0.876 in the training set and 0.861 in the validation set. The AUC of the ROC based on the 5 factors plus KL-6 was 0.922, 5 factors plus B-line number was 0.949 and 5 factors plus both KL-6 and B-line number was 0.951. Accordingly, a nomogram and a web version were developed.Conclusions: This predictive model demonstrates robust capability to assess ILD risk in IIM patients, particularly when augmented with serum KL-6 level or/and LUS B-line number.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of canakinumab in familial Mediterranean fever in Japan: a single-centre retrospective study. 卡那单抗在日本家族性地中海热中的疗效和安全性：一项单中心回顾性研究。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-01 Epub Date: 2024-10-15 DOI: 10.55563/clinexprheumatol/0grby5

Yoshika Tsuji, Tomohiro Koga, Takuya Tomokawa, Masataka Umeda, Naoki Iwamoto, Atsushi Kawakami

引用次数: 0

Identification of hub genes and gene modules associated with Behçet's disease by weighted gene co-expression network analysis of neutrophil transcriptome. 通过对中性粒细胞转录组进行加权基因共表达网络分析，确定与白塞氏病相关的枢纽基因和基因模块。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2024-10-01 Epub Date: 2024-07-15 DOI: 10.55563/clinexprheumatol/05pc5q

Jun Zou, Yi-Rong Zhu, Jian-Long Guan

{"title":"Identification of hub genes and gene modules associated with Behçet's disease by weighted gene co-expression network analysis of neutrophil transcriptome.","authors":"Jun Zou, Yi-Rong Zhu, Jian-Long Guan","doi":"10.55563/clinexprheumatol/05pc5q","DOIUrl":"10.55563/clinexprheumatol/05pc5q","url":null,"abstract":"Objectives: Behçet's disease (BD) is a chronic inflammatory condition with recurrent skin lesions, uveitis, and oral and genital ulcers. Neutrophils are important in the pathogenesis of BD, but their molecular mechanisms are unclear.Methods: We performed weighted gene co-expression network analysis on the transcriptome of neutrophils from 10 BD patients and 10 healthy controls to identify hub genes and gene modules associated with BD.Results: We found eight co-expression modules with different biological functions. The turquoise module was involved in response to hydrogen peroxide and reactive oxygen species, the blue module was involved in response to external stimulus and inflammatory response, and the brown module was involved in the type I interferon signalling pathway. We further identified hub genes and transcription factors in each module by using module membership and gene significance.Conclusions: Our results reveal novel gene modules and hub genes that are associated with neutrophil activation and dysfunction in BD, which could serve as potential biomarkers and therapeutic targets for this disease.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":"2049-2056"},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0