Thymic stromal lymphopoietin in systemic sclerosis interstitial lung disease: a pilot study.

IF 3.4 4区医学 Q2 RHEUMATOLOGY

Clinical and experimental rheumatology Pub Date : 2025-08-01 Epub Date: 2025-03-20 DOI:10.55563/clinexprheumatol/s4m3ax

Chiara Pellicano, Giuseppina Cusano, Amalia Colalillo, Francesca Villani, Valeria Carnazzo, Umberto Basile, Francesca De Filippis, Antonietta Gigante, Gregorino Paone, Edoardo Rosato

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引用次数: 0

Abstract

Objectives: Systemic sclerosis (SSc) is an autoimmune disease, characterised by microvascular alterations, dysregulation of immune system and fibrosis. The most important complication is interstitial lung disease (ILD). The aim of this study was to evaluate serum levels of thymic stromal lymphopoietin (TSLP) in SSc patients and healthy controls (HC). The secondary aim was to correlate TSLP with skin fibrosis and extension of ILD.

Methods: 75 SSc patients and 20 HC were enrolled and serum TSLP levels were measured in both cohorts. Pulmonary function tests (PFTs), high-resolution computed tomography (HRCT) and exhaled fraction of nitric oxide (FeNO) were assessed in SSc patients. A visual semi-quantitative staging system, tomographic fibrosis score (TFS), was used to assess SSc-ILD.

Results: Serum levels of TSLP were higher in SSc patients than HC. A positive correlation between TSLP and mRSS was observed (r=0.409, p<0.001) and a negative correlation was found between TSLP and FVC (r=-0.356, p<0.01). Serum TSLP was significantly higher in SSc patients with Type 2 inflammation than patients without Type 2 inflammation [172 pg/ml (IQR 154.67;224.67) vs. 150 pg/ml (IQR 110;210.33), p<0.05]. The median value of serum TSLP was significantly higher in SSc patients with TFS ≥ 5% than SSc patients with TFS <5% [216.67 pg/ml (IQR 172;298.67) vs 140.67 pg/ml (IQR 122;166.67), p<0.001).

Conclusions: In conclusion, TSLP might have a key role in ILD and skin fibrosis.

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胸腺基质淋巴生成素在系统性硬化症间质性肺病中的作用：一项初步研究。

目的：系统性硬化症（SSc）是一种自身免疫性疾病，以微血管改变、免疫系统失调和纤维化为特征。最重要的并发症是间质性肺疾病（ILD）。本研究的目的是评估血清胸腺基质淋巴生成素（TSLP）水平在SSc患者和健康对照（HC）。次要目的是将TSLP与皮肤纤维化和ILD扩展联系起来。方法：入选75例SSc患者和20例HC患者，测定两组患者血清TSLP水平。评估SSc患者的肺功能测试（PFTs）、高分辨率计算机断层扫描（HRCT）和呼出一氧化氮（FeNO）分数。ct纤维化评分（TFS）是一种视觉半定量分期系统，用于评估SSc-ILD。结果：SSc患者血清TSLP水平高于HC。TSLP与mRSS呈正相关（r=0.409）。结论：TSLP可能在ILD和皮肤纤维化中起关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and experimental rheumatology 医学-风湿病学

CiteScore

6.10

自引率

18.90%

发文量

377

审稿时长

3-6 weeks

期刊介绍： Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.