土耳其家族性地中海热的流行、发病率和地理分布:一项国家队列研究。

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Hasan Satiş, Ahmet Gül, Gizem Ayan, Hakan Babaoğlu, Berkan Armağan, Abdulsamet Erden, Emre Bilgin, Erdem Karabulut, Levent Kiliç, Duygu Tecer, Alper Sari, Orhan Küçükşahin, Serdal Uğurlu, Özgür Kasapçopur, Seza Özen, Mustafa Okan Ayvali, Ali Aykut Fidanci, Mustafa Mahir Ülgü, Naim Ata, Şuayip Birinci, Umut Kalyoncu
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引用次数: 0

摘要

目的:本研究旨在利用卫生部电子病历数据库(e-Pulse)分析土耳其家族性地中海热(FMF)的发病率和地理分布。方法:该研究利用了自2016年开始运行的e-Pulse的全国健康数据。患者选择基于FMF的ICD-10代码,至少间隔30天输入两个记录代码。年龄≥50岁的患者和具有痛风相关ICD-10编码的患者被排除在外。考虑到性别、年龄人口统计和地区分布,计算了2018年FMF的患病率和发病率。结果:在82,003,882名人群中,共发现了160,897名FMF患者,患病率为139 / 10,000人。发病率为2.78 / 10000。在15-19岁的人群中发现了最多的记录。从地理上看,土耳其东北部的阿尔达汉、Bayburt和Sivas地区的患病率最高。家庭记录显示,11.7%的18岁以下FMF患儿的父母中至少有一方被诊断为FMF。结论:在土耳其,FMF超出了罕见病的定义,是一个重大的健康问题,其分布不均匀,受遗传和历史因素的影响。本研究结果强调了e-Pulse等国家电子健康记录在开展大规模流行病学研究方面的效用,这可以指导未来FMF患者的公共卫生策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence, incidence and geographic distribution of familial Mediterranean fever in Turkey: a national cohort study.

Objectives: This study aimed to analyse the incidence and geographical distribution of Familial Mediterranean Fever (FMF) in Turkey using the electronic medical records database (e-Pulse) of the Ministry of Health.

Methods: The study utilised nationwide health data from the e-Pulse, which has been operational since 2016. Patient selection was based on ICD-10 codes for FMF, with a minimum of two recorded codes entered at least 30 days apart. Patients aged ≥50 and those with gout-related ICD-10 codes were excluded. The prevalence and incidence of FMF in 2018 were calculated, taking into account gender, age demographics, and regional distribution.

Results: A total of 160,897 FMF patients were identified from a population of 82,003,882, yielding a prevalence of 139 per 10,000 individuals. The incidence was 2.78 per 10,000. The highest number of records was found among individuals aged 15-19. Geographically, the highest rate of prevalence was found in Ardahan, Bayburt, and Sivas, regions in the North-Eastern part of Turkey. Family records revealed that 11.7% of children under 18 with FMF had at least one parent diagnosed with FMF.

Conclusions: FMF is beyond the definition of a rare disease and a significant health issue in Turkey, with a non-uniform distribution influenced by both genetic and historical factors. The findings of this study highlight the utility of national electronic health records like e-Pulse in conducting large-scale epidemiological research, which could guide future public health strategies for FMF patients.

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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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