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Laboratory testing for respiratory viruses for the clinician. 为临床医生提供的呼吸道病毒实验室检测。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-04 DOI: 10.3949/ccjm.91.s1.07
Christopher C Attaway, Hannah Wang
{"title":"Laboratory testing for respiratory viruses for the clinician.","authors":"Christopher C Attaway, Hannah Wang","doi":"10.3949/ccjm.91.s1.07","DOIUrl":"https://doi.org/10.3949/ccjm.91.s1.07","url":null,"abstract":"<p><p>Testing for respiratory viruses has changed greatly over the past decade, owing to advances in technology, drug development, vaccine research, and a growing recognition of the importance of improving patient access. Here, we focus on the most common respiratory viruses and review preanalytic variables (eg, collection and storage) that affect test results, testing methods including nucleic acid amplification testing (NAAT), and controversies, challenges, and trends in diagnostic testing relevant to clinicians.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The RSV roadmap in children: Lessons learned, paths forward. 儿童 RSV 路线图：汲取教训，展望未来。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-04 DOI: 10.3949/ccjm.91.s1.04
Ruchita Negi, Jonathan Shabab, Frank Esper
{"title":"The RSV roadmap in children: Lessons learned, paths forward.","authors":"Ruchita Negi, Jonathan Shabab, Frank Esper","doi":"10.3949/ccjm.91.s1.04","DOIUrl":"https://doi.org/10.3949/ccjm.91.s1.04","url":null,"abstract":"<p><p>Respiratory syncytial virus (RSV) is a threat to infants globally causing bronchiolitis and pneumonia. Despite decades of research, RSV outbreaks occur with only modest advancements in prevention or treatment. Vaccine development faced challenges because past attempts caused enhanced disease and treatment options demonstrated limited efficacy. Recent advancements, including maternal vaccines focusing on the prefusion form of the F glycoprotein are now showing significant benefits in preventing severe RSV-related illness in infants. Additionally, monoclonal antibodies offer prevention directly to newborns within 1 week of birth. These innovations have the potential to substantially change the impact of RSV.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meeting the challenge of vaccine hesitancy. 应对疫苗犹豫不决的挑战。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-04 DOI: 10.3949/ccjm.91.s1.08
Oluwatosin Goje, Aanchal Kapoor
{"title":"Meeting the challenge of vaccine hesitancy.","authors":"Oluwatosin Goje, Aanchal Kapoor","doi":"10.3949/ccjm.91.s1.08","DOIUrl":"10.3949/ccjm.91.s1.08","url":null,"abstract":"<p><p>Vaccination is a cornerstone of public health, but vaccine hesitancy poses significant challenges as highlighted during the COVID-19 pandemic. Addressing the challenge requires healthcare professionals to effectively counter misinformation. They have a pivotal role in fostering trust and promoting evidence-based vaccine recommendations, with tailored communication strategies and community engagement initiatives. Legislation, policy interventions, research, innovation, and technology are needed to enhance vaccine uptake and ensure equitable access. Integration of vaccination into routine healthcare is paramount for public health protection against emerging infectious threats.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Having the conversation: Individualizing RSV vaccination in older patients. 对话：为老年患者个性化接种 RSV 疫苗。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-04 DOI: 10.3949/ccjm.91.s1.05
Ronan Factora
{"title":"Having the conversation: Individualizing RSV vaccination in older patients.","authors":"Ronan Factora","doi":"10.3949/ccjm.91.s1.05","DOIUrl":"10.3949/ccjm.91.s1.05","url":null,"abstract":"<p><p>The new vaccines against respiratory syncytial virus (RSV) reduce the risk of RSV illness, which is common in older people and carries the risk of hospitalization with its attendant risks such as delirium and physical decline leading to loss of function and independence. Individualized discussions regarding vaccination should weigh the risks of vaccination, which are minor, against the preventive benefits. Discussions incorporating these elements may lead to greater vaccine uptake, especially by those at high risk.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RSV immunization in adults and children: A practical guide for clinicians. 成人和儿童 RSV 免疫接种：临床医生实用指南。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-04 DOI: 10.3949/ccjm.91.s1.03
Trate DeVolld, Kaitlyn R Rivard
{"title":"RSV immunization in adults and children: A practical guide for clinicians.","authors":"Trate DeVolld, Kaitlyn R Rivard","doi":"10.3949/ccjm.91.s1.03","DOIUrl":"https://doi.org/10.3949/ccjm.91.s1.03","url":null,"abstract":"<p><p>In 2023 and 2024, 3 vaccines were approved by the US Food and Drug Administration (FDA) against respiratory syncytial virus (RSV) in adults. In addition, the first long-acting RSV monoclonal antibody for infants and young children was approved. This review provides clinicians with practical guidance to navigate this new era of RSV prevention.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary adrenal insufficiency in adults: When to suspect, how to diagnose and manage. 成人原发性肾上腺功能不全：何时怀疑、如何诊断和处理。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-03 DOI: 10.3949/ccjm.91a.23072
Michelle D Lundholm, Jayachidambaram Ambalavanan, Pratibha Pr Rao
{"title":"Primary adrenal insufficiency in adults: When to suspect, how to diagnose and manage.","authors":"Michelle D Lundholm, Jayachidambaram Ambalavanan, Pratibha Pr Rao","doi":"10.3949/ccjm.91a.23072","DOIUrl":"https://doi.org/10.3949/ccjm.91a.23072","url":null,"abstract":"<p><p>Primary adrenal insufficiency is rare but serious; it puts patients at risk of acute decompensation and adrenal crisis due to insufficient cortisol and aldosterone production. Further, its diagnosis is often delayed, or it is mistaken for secondary adrenal insufficiency, which can have life-threatening consequences. Early recognition and appropriate treatment can greatly improve patient outcomes and quality of life.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should my patients with hypertension be referred for renal denervation? 我的高血压患者是否应该转诊接受肾脏去神经支配治疗？
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-03 DOI: 10.3949/ccjm.91a.24029
Leen Al-Yacoub, Elias Bassil, George Thomas, Luke Laffin, Aravinda Nanjundappa, Khaled Ziada, Ali Mehdi
{"title":"Should my patients with hypertension be referred for renal denervation?","authors":"Leen Al-Yacoub, Elias Bassil, George Thomas, Luke Laffin, Aravinda Nanjundappa, Khaled Ziada, Ali Mehdi","doi":"10.3949/ccjm.91a.24029","DOIUrl":"https://doi.org/10.3949/ccjm.91a.24029","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenteric ischemia: Recognizing an uncommon disorder and distinguishing among its causes. 肠系膜缺血：认识一种不常见的疾病并区分其病因。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-03 DOI: 10.3949/ccjm.91a.23094
Teresa Wu, Aravinda Nanjundappa
{"title":"Mesenteric ischemia: Recognizing an uncommon disorder and distinguishing among its causes.","authors":"Teresa Wu, Aravinda Nanjundappa","doi":"10.3949/ccjm.91a.23094","DOIUrl":"https://doi.org/10.3949/ccjm.91a.23094","url":null,"abstract":"<p><p>Mesenteric ischemia occurs because of inadequate intestinal blood flow. Its severity depends on the vessels involved and whether collateral blood vessels are available to prevent malperfusion. Mesenteric ischemia is an uncommon cause of abdominal pain, but it is associated with high mortality and often poses a diagnostic challenge to clinicians because its symptoms are nonspecific. Early recognition and treatment are imperative to improve patient outcomes.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abdominal pain without physical findings is not always without physical cause. 没有体检结果的腹痛并不总是没有物理原因。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-03 DOI: 10.3949/ccjm.91b.09024
Brian F Mandell
{"title":"Abdominal pain without physical findings is not always without physical cause.","authors":"Brian F Mandell","doi":"10.3949/ccjm.91b.09024","DOIUrl":"10.3949/ccjm.91b.09024","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should every patient with an unprovoked venous thromboembolism have a hypercoagulable workup? 是否每位无诱因静脉血栓栓塞症患者都应接受高凝检查？
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2024-09-03 DOI: 10.3949/ccjm.91a.24016
Jaime Tan, Neeladri Misra, Sivakumar Reddy
{"title":"Should every patient with an unprovoked venous thromboembolism have a hypercoagulable workup?","authors":"Jaime Tan, Neeladri Misra, Sivakumar Reddy","doi":"10.3949/ccjm.91a.24016","DOIUrl":"https://doi.org/10.3949/ccjm.91a.24016","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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