Managing the side effects of sodium-glucose cotransporter-2 inhibitors.

IF 4.1 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Cleveland Clinic Journal of Medicine Pub Date : 2025-08-01 DOI:10.3949/ccjm.92a.24071

Nandan Kodur, Betemariam Sharew, M Cecilia Lansang, W H Wilson Tang

引用次数: 0

Abstract

Although sodium-glucose cotransporter-2 (SGLT2) inhibitors are widely used because of their exceptional cardiovascular and renal benefits, their side effects and corresponding management strategies have not been well characterized to date. The latest evidence suggests that class effects of SGLT2 inhibitors include volume depletion, genital fungal infections, and euglycemic diabetic ketoacidosis, while medication-specific side effects include urinary tract infections with dapagliflozin and potential increased risk of amputations with canagliflozin. Management strategies include close monitoring, adjusting medication dosages, and temporarily holding SGLT2 inhibitors when appropriate.

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处理钠-葡萄糖共转运蛋白-2抑制剂的副作用。

尽管钠-葡萄糖共转运蛋白-2 （SGLT2）抑制剂因其特殊的心血管和肾脏益处而被广泛使用，但其副作用和相应的管理策略迄今尚未得到很好的描述。最新证据表明，SGLT2抑制剂的类效应包括体积耗损、生殖器真菌感染和血糖型糖尿病酮症酸中毒，而药物特异性副作用包括达格列净的尿路感染和卡格列净可能增加的截肢风险。管理策略包括密切监测，调整药物剂量，适当时暂时持有SGLT2抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cleveland Clinic Journal of Medicine 医学-医学：内科

CiteScore

3.80

自引率

0.00%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The mission of Cleveland Clinic Journal of Medicine (CCJM) is to provide its readers with up-to-date, practical, clinical information relevant to internal medicine, cardiology, and related fields. Consistent with this mission, CCJM focuses on timely review articles and other content that has a continuing-education orientation rather than on original research or case reports. CCJM authors, drawn from Cleveland Clinic and other top medical institutions throughout the world, are asked to identify new findings that are changing the practice of medicine and to advise readers how to apply them in daily patient care. Authors are chosen for their experience, acquired through caring for patients, teaching other physicians, and researching clinical questions.