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Immunotherapy meets William Shakespeare. 免疫疗法与莎士比亚的结合。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92b.07025
Brian F Mandell
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引用次数: 0
Most elderly patients with subclinical hypothyroidism do not need to be treated. 大多数老年亚临床甲状腺功能减退患者不需要治疗。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92c.07001
Scott Selinger
{"title":"Most elderly patients with subclinical hypothyroidism do not need to be treated.","authors":"Scott Selinger","doi":"10.3949/ccjm.92c.07001","DOIUrl":"https://doi.org/10.3949/ccjm.92c.07001","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 7","pages":"395"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fecal microbiota transplantation: Current evidence and future directions. 粪便微生物群移植：目前的证据和未来的方向。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92a.24107
Michael Cymbal, Arjun Chatterjee, Brian Baggott
{"title":"Fecal microbiota transplantation: Current evidence and future directions.","authors":"Michael Cymbal, Arjun Chatterjee, Brian Baggott","doi":"10.3949/ccjm.92a.24107","DOIUrl":"https://doi.org/10.3949/ccjm.92a.24107","url":null,"abstract":"<p><p>As we advance our understanding of the gut microbiota, the implications of dysbiosis are becoming increasingly apparent. Fecal microbiota transplantation (FMT), a well-established procedure, is recognized for effectively treating recurrent <i>Clostridioides difficile</i> infection, prompting further investigation into its other possible clinical applications. Donor selection and screening are essential to ensure safety and efficacy. Product development and standardization, such as the US Food and Drug Administration-approved live biotherapeutic products Rebyota and Vowst, are helping efforts to evaluate FMT for other gastrointestinal and extraintestinal diseases. However, additional clinical trials are needed to support its use beyond recurrent <i>C difficile</i> infection.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 7","pages":"421-428"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast cancer risk and screening for transgender and gender-diverse individuals. 跨性别和性别多样化个体的乳腺癌风险和筛查。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92a.24088
Dzhuliyan V Vasilev, Juliana M Kling, Evelyn F Carroll
{"title":"Breast cancer risk and screening for transgender and gender-diverse individuals.","authors":"Dzhuliyan V Vasilev, Juliana M Kling, Evelyn F Carroll","doi":"10.3949/ccjm.92a.24088","DOIUrl":"https://doi.org/10.3949/ccjm.92a.24088","url":null,"abstract":"<p><p>Evidence from well-established studies of breast cancer risk in transgender and gender-diverse (TGD) people is lacking. As a result, current screening guidelines are based on extrapolation from cisgender populations, expert consensus, and retrospective cohort studies. Guideline recommendations focus on knowing patient baseline breast cancer risk and the risks associated with chosen gender-affirming hormone therapy and gender-affirming chest surgery. While existing guidelines are helpful, tailored protocols and research on effective breast cancer screening specific to TGD people are needed.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 7","pages":"439-447"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How should I manage my patient with cancer who is experiencing diarrhea while on immunotherapy? 如果我的癌症患者在接受免疫治疗时出现腹泻，我应该如何处理？
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92a.24090
Rupayan Kundu, Arjun Chatterjee, Jessica Philpott, Lucy Boyce Kennedy
{"title":"How should I manage my patient with cancer who is experiencing diarrhea while on immunotherapy?","authors":"Rupayan Kundu, Arjun Chatterjee, Jessica Philpott, Lucy Boyce Kennedy","doi":"10.3949/ccjm.92a.24090","DOIUrl":"https://doi.org/10.3949/ccjm.92a.24090","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 7","pages":"401-405"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights from the LAAOS III trial of left atrial appendage occlusion to prevent stroke in atrial fibrillation. 左心房附件阻断预防房颤卒中LAAOS III试验的启示
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92a.25001
Anže Djordjević, Edward Soltesz
{"title":"Insights from the LAAOS III trial of left atrial appendage occlusion to prevent stroke in atrial fibrillation.","authors":"Anže Djordjević, Edward Soltesz","doi":"10.3949/ccjm.92a.25001","DOIUrl":"https://doi.org/10.3949/ccjm.92a.25001","url":null,"abstract":"<p><p>Occluding the left atrial appendage during cardiac surgery for other indications reduced the risk of ischemic stroke or systemic embolism in patients with atrial fibrillation in LAAOS III (the third Left Atrial Appendage Occlusion Study) (N Engl J Med 2021; 384(22):2081-2091). But questions remain.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 7","pages":"415-419"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Odontogenic cutaneous fistula. 牙源性皮瘘。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92a.24096
Sagar Khanna
{"title":"Odontogenic cutaneous fistula.","authors":"Sagar Khanna","doi":"10.3949/ccjm.92a.24096","DOIUrl":"https://doi.org/10.3949/ccjm.92a.24096","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 7","pages":"399-400"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recreational cannabis legalization: Potential implications for individual and community health. 娱乐性大麻合法化：对个人和社区健康的潜在影响。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92a.24086
Taseen Alam, Connor Riegal, Natalie Saadeh, Fernanda Gushken, Hannah Snyder, Brenden Jenks, Akhil Anand
{"title":"Recreational cannabis legalization: Potential implications for individual and community health.","authors":"Taseen Alam, Connor Riegal, Natalie Saadeh, Fernanda Gushken, Hannah Snyder, Brenden Jenks, Akhil Anand","doi":"10.3949/ccjm.92a.24086","DOIUrl":"https://doi.org/10.3949/ccjm.92a.24086","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 7","pages":"407-413"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Reply: Managing right ventricular failure in the setting of pulmonary embolism. 回复：肺栓塞后右心室衰竭的处理。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92c.07004
Sharmeen Sorathia, Anibelky Almanzar, Abhishek Bhandiwad, Phoo Pwint Nandar
{"title":"In Reply: Managing right ventricular failure in the setting of pulmonary embolism.","authors":"Sharmeen Sorathia, Anibelky Almanzar, Abhishek Bhandiwad, Phoo Pwint Nandar","doi":"10.3949/ccjm.92c.07004","DOIUrl":"https://doi.org/10.3949/ccjm.92c.07004","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 7","pages":"396-397"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Managing noninsulin glucose-lowering medications before surgery: A comparison of clinical practice guidelines. 术前管理非胰岛素降糖药物：临床实践指南的比较。
IF 3.4 4区 医学
Cleveland Clinic Journal of Medicine Pub Date : 2025-07-01 DOI: 10.3949/ccjm.92a.24118
Oscar L Morey-Vargas, Mona Gossmann, Jeffrey M Ketz, Basem B Abdelmalak
{"title":"Managing noninsulin glucose-lowering medications before surgery: A comparison of clinical practice guidelines.","authors":"Oscar L Morey-Vargas, Mona Gossmann, Jeffrey M Ketz, Basem B Abdelmalak","doi":"10.3949/ccjm.92a.24118","DOIUrl":"https://doi.org/10.3949/ccjm.92a.24118","url":null,"abstract":"<p><p>Preoperative management of noninsulin glucose-lowering medications can be challenging as clinicians navigate adjustment amid decreased oral intake while maintaining euglycemia and avoiding hyper- or hypoglycemia. The authors review current published guidelines, along with the local protocol currently in place at Cleveland Clinic, to help clinicians determine which noninsulin glucose-lowering drugs may need to be held preoperatively and for how long.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 7","pages":"429-437"},"PeriodicalIF":3.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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