{"title":"Managing right ventricular failure in the setting of pulmonary embolism.","authors":"Sharmeen Sorathia, Anibelky Almanzar, Abhishek Bhandiwad, Phoo Pwint Nandar","doi":"10.3949/ccjm.92a.24069","DOIUrl":"https://doi.org/10.3949/ccjm.92a.24069","url":null,"abstract":"<p><p>Pulmonary embolism (PE) has a significant impact on right-sided heart function. Clinical presentation can range from no involvement of the right ventricle to right ventricular dysfunction, cardiogenic shock, and even cardiac arrest. The authors explore the pathophysiology of PE-induced right ventricular failure, emphasizing the mechanisms by which PE contributes to dysfunction, current diagnostic tools for risk stratification, and the importance of timely diagnosis. The primary focus is on strategies for managing right ventricular failure secondary to PE, including medical, percutaneous interventional, and surgical options. Recent advances in the field are also noted, including emerging therapies and evolving treatment algorithms.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 5","pages":"301-309"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karthik Meiyappan Udayappan, Christopher V Anstine
{"title":"What diagnostic tests should be done after discovering clubbing in a patient without cardiopulmonary symptoms?","authors":"Karthik Meiyappan Udayappan, Christopher V Anstine","doi":"10.3949/ccjm.92a.24052","DOIUrl":"https://doi.org/10.3949/ccjm.92a.24052","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 5","pages":"273-276"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zehra Naseem, Aun Muhammad, Arjun Chatterjee, Alberto Rubio-Tapia
{"title":"Alpha-gal syndrome: Recognizing and managing a tick-bite-related meat allergy.","authors":"Zehra Naseem, Aun Muhammad, Arjun Chatterjee, Alberto Rubio-Tapia","doi":"10.3949/ccjm.92a.24072","DOIUrl":"10.3949/ccjm.92a.24072","url":null,"abstract":"<p><p>Alpha-gal syndrome is an emerging condition characterized by an immunoglobulin (Ig) E-mediated reaction to galactose-alpha-1,3-galactose (alpha-gal) after consumption of mammalian-derived food products. Identified in the early 2000s, the syndrome is linked to sensitization through tick bites; in the United States, the lone star tick (<i>Amblyomma americanum</i>) is the main vector. Symptoms range from pruritus and hives to severe systemic reactions like anaphylaxis, and typically occur 3 to 8 hours after eating meat. Diagnosis involves a history of consistent symptoms, positive alpha-gal IgE serology, and dietary exclusion trials. Management focuses on avoiding foods and products that contain alpha-gal and preventing tick bites.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 5","pages":"311-319"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paloma Rodriguez Alvarez, Vicente T San Martin, Oscar L Morey-Vargas
{"title":"In Reply: In defense of the anion gap.","authors":"Paloma Rodriguez Alvarez, Vicente T San Martin, Oscar L Morey-Vargas","doi":"10.3949/ccjm.92c.05002","DOIUrl":"https://doi.org/10.3949/ccjm.92c.05002","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 5","pages":"269-270"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In defense of the anion gap.","authors":"Michael Emmett","doi":"10.3949/ccjm.92c.05001","DOIUrl":"https://doi.org/10.3949/ccjm.92c.05001","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 5","pages":"269"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The gift of lasting immunity.","authors":"Brian F Mandell","doi":"10.3949/ccjm.92b.05025","DOIUrl":"https://doi.org/10.3949/ccjm.92b.05025","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 5","pages":"263-264"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sandra Howell, Alphonsus Liew, Christopher Aldo Rinaldi
{"title":"The beat goes on: Highlights from the new American and European A-fib guidelines.","authors":"Sandra Howell, Alphonsus Liew, Christopher Aldo Rinaldi","doi":"10.3949/ccjm.92a.25030","DOIUrl":"https://doi.org/10.3949/ccjm.92a.25030","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 5","pages":"297-300"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does my adult patient need a measles vaccine?","authors":"Kaitlyn R Rivard","doi":"10.3949/ccjm.92a.25038","DOIUrl":"https://doi.org/10.3949/ccjm.92a.25038","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 5","pages":"279-282"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura A Campbell, Jessica P Ammon, Rachana Kombathula, Naa'irah Muhammad, Christopher D Jackson
{"title":"New atrial fibrillation guideline: Modify risk, control rhythm, prevent progression.","authors":"Laura A Campbell, Jessica P Ammon, Rachana Kombathula, Naa'irah Muhammad, Christopher D Jackson","doi":"10.3949/ccjm.92a.24067","DOIUrl":"10.3949/ccjm.92a.24067","url":null,"abstract":"<p><p>The latest (2023) guideline on atrial fibrillation from the American College of Cardiology, American Heart Association, American College of Chest Physicians, and Heart Rhythm Society introduces a new staging system for the disease, emphasizes risk-factor modification, prioritizes rhythm control over rate control, and clarifies which patients should be considered for catheter ablation. It also delves deeper than earlier guidelines into calculations of risk of thrombosis when deciding whether to start anticoagulant therapy.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"92 5","pages":"291-296"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}