Enmanuel A Leiva-Murillo, Erwin Bechtold-Javier, Pol Candela-Parrilla, Ana Matas-García
{"title":"In Reply: Finding the cause of severe hypokalemia.","authors":"Enmanuel A Leiva-Murillo, Erwin Bechtold-Javier, Pol Candela-Parrilla, Ana Matas-García","doi":"10.3949/ccjm.93c.04002","DOIUrl":"https://doi.org/10.3949/ccjm.93c.04002","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"198"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Palatal mass with an overlying white lesion.","authors":"Takuma Watanabe","doi":"10.3949/ccjm.93a.25050","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25050","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"199-200"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Treating perinatal mood and anxiety disorders: A call to action.","authors":"Lulu Zhao","doi":"10.3949/ccjm.93a.26002","DOIUrl":"https://doi.org/10.3949/ccjm.93a.26002","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"207-209"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enmanuel A Leiva-Murillo, Oriol Ventosa-Blázquez, Eduard Solé-González
{"title":"Interpreting the DIGIT-HF trial: Time for a new look at digitalis?","authors":"Enmanuel A Leiva-Murillo, Oriol Ventosa-Blázquez, Eduard Solé-González","doi":"10.3949/ccjm.93a.25098","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25098","url":null,"abstract":"<p><p>The DIGIT-HF (Digitoxin to Improve Outcomes in Patients With Advanced Chronic Heart Failure; N Engl J Med 2025; 393(12):1155-1165) trial compared digitoxin with placebo, added to guideline-directed medical therapy in patients with heart failure with reduced ejection fraction (HFrEF). Compared with placebo, digitoxin reduced the incidence of the composite endpoint of death from any cause or first hospitalization for worsening heart failure by 18% over a median follow-up of 36 months (hazard ratio 0.82, 95% confidence interval 0.69-0.98). There were no statistically significant differences in the rates of all-cause mortality, first hospitalization, or serious adverse events.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"218-226"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical application of the complement system: A historical perspective.","authors":"Adam J Brown","doi":"10.3949/ccjm.93a.26014","DOIUrl":"https://doi.org/10.3949/ccjm.93a.26014","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"237-239"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Finding the cause of severe hypokalemia.","authors":"Philip S Mehler, Dennis Gibson","doi":"10.3949/ccjm.93c.04001","DOIUrl":"https://doi.org/10.3949/ccjm.93c.04001","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"198"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas Salupo, Korey Bartolomeo, Elias Bassil, Corey Cavanaugh, Georges Nakhoul, Jonathan Taliercio, Ali Mehdi
{"title":"Complement inhibition: A whole new world.","authors":"Nicholas Salupo, Korey Bartolomeo, Elias Bassil, Corey Cavanaugh, Georges Nakhoul, Jonathan Taliercio, Ali Mehdi","doi":"10.3949/ccjm.93a.25076","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25076","url":null,"abstract":"<p><p>The complement system is a central component of the innate immune system, and it is a bridge to the adaptive immune system. With this broad functional reach, dysregulation of this system contributes to a wide range of inflammatory and autoimmune conditions. Drugs that inhibit the complement system have dramatically improved outcomes in many previously untreatable diseases, and the number of approved indications is growing rapidly, requiring specialists and generalists alike to be familiar with these drugs.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"227-236"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebeca Ortiz Worthington, Zehra Aftab, Nicole Leong, Jason Alexander
{"title":"Updated guidelines for pharmacologic treatment of perinatal depression: Understanding medication options.","authors":"Rebeca Ortiz Worthington, Zehra Aftab, Nicole Leong, Jason Alexander","doi":"10.3949/ccjm.93a.25052","DOIUrl":"10.3949/ccjm.93a.25052","url":null,"abstract":"<p><p>The 2023 American College of Obstetricians and Gynecologists (ACOG) guideline on perinatal mental health conditions recommends prescribing and titrating pharmacotherapy for perinatal depression, with the selective serotonin reuptake inhibitors sertraline and escitalopram as first-line medications for patients who have not previously taken any medications for mood disorders. A subsequent ACOG Clinical Practice Update addresses zuranolone for postpartum depression. The authors present an overview of the guideline's recommendations on pharmacotherapy for treating perinatal depression and summarize actionable recommendations for nonpsychiatric clinicians.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"201-205"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A 20-year-old woman with a 9-year history of shortness of breath.","authors":"Jack Johnson, Karishma Lukose, Mary C Labanowski","doi":"10.3949/ccjm.93a.25073","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25073","url":null,"abstract":"","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"211-217"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Magnus Chun, Amrit Narwan, Ryan Parto, Andrew John Cruz, Jiayi Ge, Zan Ferrin, Namrita George, Evelyn Kue, Adam Khattak, Vignan Manne, Amber Champion
{"title":"Gastrointestinal disorders in patients with diabetes mellitus: A practical guide for primary care.","authors":"Magnus Chun, Amrit Narwan, Ryan Parto, Andrew John Cruz, Jiayi Ge, Zan Ferrin, Namrita George, Evelyn Kue, Adam Khattak, Vignan Manne, Amber Champion","doi":"10.3949/ccjm.93a.25054","DOIUrl":"https://doi.org/10.3949/ccjm.93a.25054","url":null,"abstract":"<p><p>Gastrointestinal disorders are common in patients with diabetes mellitus and can be linked to diabetes itself, its complications, or medications used to treat it. These disorders include gastroesophageal reflux, gastroparesis, enteropathy manifesting clinically with constipation or diarrhea, and metabolic dysfunction-associated steatotic liver disease. Timely diagnosis and management of these disorders can improve patients' quality of life. The authors provide clinically practical advice on when and how to screen for common diabetes-related gastrointestinal disorders and review the management of these disorders in the primary care setting.</p>","PeriodicalId":10245,"journal":{"name":"Cleveland Clinic Journal of Medicine","volume":"93 4","pages":"241-248"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}