中国医师进修杂志最新文献_第2页

Relationship between platelet activating factor acetylhydrolase genetic polymorphism and platelet activation and prognosis in patients with ischemic stroke 缺血性脑卒中患者血小板活化因子乙酰水解酶基因多态性与血小板活化及预后的关系

Chinese Journal of Postgraduates of Medicine Pub Date : 2009-04-05 DOI: 10.3760/CMA.J.ISSN.1673-4904.2009.10.010

Jian-ping Zhou, Yuqing Shen, Y. Kui, Wang Chen, Yuqi Qiu, Wan-xiang Wang, Jiangrong Deng

{"title":"Relationship between platelet activating factor acetylhydrolase genetic polymorphism and platelet activation and prognosis in patients with ischemic stroke","authors":"Jian-ping Zhou, Yuqing Shen, Y. Kui, Wang Chen, Yuqi Qiu, Wan-xiang Wang, Jiangrong Deng","doi":"10.3760/CMA.J.ISSN.1673-4904.2009.10.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2009.10.010","url":null,"abstract":"Objective To investigate the corelation between platelet activating factor acetylhydrolase (PAF-AH) genetic polymorphism and ischemic stroke. Methods The plasma PAF-AH genotype was determined in 205 patients with iachemic stroke and 114 normal subjects by the polymerase chain reaction. The levels of plasma platelet activating factor (PAF), platelet α-granule membrane glycoprotein-140(GMP-140), β-thromboglobulin (β-TG) and the levels of platelet factor 4 (PF4) were analyzed. Results The prevalence of the mutation genotype and plasma PAF, GMP-140, β-TG and PF4 in the patients with isehemic stroke [42.44%,(91.08 ± 39.10) ng/L, (36.46 ± 13.10) μg/L, (41.75 ± 11.18) μg/L, (29.05 ± 9.16) g/L, respectively] were significantly higher than those in the controls[21.05%,(64.30 ± 18.81) ng/L, (18.27 ± 7.68) μg/L, (30.94 ± 8.47) μg/L, (18.75 ± 6.06) μg/L](P< 0.01). The levels of plasma PAF, GMP-140 were significantly higher in mutation genotype patients than those in the normal genotype patients (P < 0.01). Conclusions The activation function of platelet in the acute phase of patients with ischemic stroke increases, and it is associated with genetic polymorphism of PAF-AH. The PAF-AH gene mutation may be a novel genetic marker for high risk of ischemic stroke. \u0000 \u0000Key words: \u0000Cerebrovascular anident; Platelet activation; 1-Alkyl-2-acetylglycerophospho-choline esterase; Gene polymorphism","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":"32 1","pages":"27-29"},"PeriodicalIF":0.0,"publicationDate":"2009-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69928887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical treatment of ruptured aneurysm of the sinus of Valsalva combined with infective endocarditis 静脉窦破裂动脉瘤合并感染性心内膜炎的手术治疗

Chinese Journal of Postgraduates of Medicine Pub Date : 2008-09-15 DOI: 10.3760/CMA.J.ISSN.1673-4904.2008.26.002

Chun-sheng Li, Zhongya Yan, Lu Zhong, Wang Yijun, Lei Hong, Zhengyan Zhu, Sun Yun, Zheng Li, Guangcun Cheng

{"title":"Surgical treatment of ruptured aneurysm of the sinus of Valsalva combined with infective endocarditis","authors":"Chun-sheng Li, Zhongya Yan, Lu Zhong, Wang Yijun, Lei Hong, Zhengyan Zhu, Sun Yun, Zheng Li, Guangcun Cheng","doi":"10.3760/CMA.J.ISSN.1673-4904.2008.26.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2008.26.002","url":null,"abstract":"Objective To summarize the susceptible factors and the experience of the surgical treatment of ruptured aneurysm of the sinus of Valsalva combined with infective endecarditis.Methods From January 2000 to March 2008,30 cases with raptured aneurysm of the sinus of Valsalva were admitted, clinical data of 10 cases combined with infective endocarditis were retrospectively reviewed.Nine cases underwent the surgical treatment,including 6 cases accepted aortic valve replacement (AVR).Results Nine eases underwent the surgical treatment followed up for 2 months to 8 years,cardiac function of the survivors recovered to Class Ⅰ-Ⅱ in NYHA,7 cases were Ⅰ grade,2 cases were Ⅱ grade.One case was dead for MSOF not underwent the surgical treatment.Conclusions Associated with ventricular septal defect is one of the susceptible factors.Following diagnosis of ruptured aneurysm of sinus of Valsalva combined with infective endocarditis,sufficiently and validly antibiotic and surgical treatment should be pedormed as quickly as possible,and AVR to the moderate and severe aortic insufficiency. \u0000 \u0000Key words: \u0000Sinus of Valsalva; Aneurysm,ruptured; Surgical procedures,operative; Endocarditis,bacterial","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":"95 1","pages":"4-6"},"PeriodicalIF":0.0,"publicationDate":"2008-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91394271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of extracorporeal membrane oxygenation in patients with acute respiratory distress syndrome 体外膜氧合在急性呼吸窘迫综合征中的应用

Chinese Journal of Postgraduates of Medicine Pub Date : 2006-05-05 DOI: 10.3760/CMA.J.ISSN.1673-4904.2006.13.010

qian-xia xiao, Zhi-gang Zhang, bin-fei li, Zhanyuan Zhao, kai-hong mao, Zhou Ce

引用次数: 0

Clinical analysis of early gastric carcinoma in 101 patients 早期胃癌101例临床分析

Chinese Journal of Postgraduates of Medicine Pub Date : 2006-03-05 DOI: 10.3760/CMA.J.ISSN.1673-4904.2006.18.001

田大宇, 胡祥, 袁波

{"title":"Clinical analysis of early gastric carcinoma in 101 patients","authors":"田大宇, 胡祥, 袁波","doi":"10.3760/CMA.J.ISSN.1673-4904.2006.18.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2006.18.001","url":null,"abstract":"Objective To investigate the principle of lymph nodes metastasis (LNM) in early gastric carcinoma (EGC),and try to provide theoretical basis for individualized treatment. Methods One hundredand one patients were operated upon due to EGC, all clinicopathologic data were analyzed retrospectively. Results LNM was detected in 16 cases with lesion in lower stomach, the incidence of LNM was 15.8%. LNM correlated with depth of infiltration, tumor size and pathological type. The rate of LNM was 27.9% in SM2 ,significantly higher than that in M(2.8%) and SM(13.6%),P0.05.The incidence increased along with the increment of tumor size, no LNM was found in minute gastric cancer (MGC),5.0% in small gastric cancer(SGC),14.8% in patients with 1.1-2.0 cm lesion in diameter and 27.5% in greater than 2.0 cm (P0.05).Well-differentiated EGC without LNM, while the risk was 17.2%,19.6% for moderate- and poor- differentiated respectively. The research showed that, in levelⅠ tier lymph nodes (LN),the risk of No.3 LN involvement reached up to 50.0%, followed by No.6(37.5%), No.4(31.3%) and No.5(12.5%).In levelⅡ, the risk decreased gradually by 25.0%,12.5%,6.3% for No.7,8 a,9 LN respectively. In our series, M and SM1 involved level I tier LN, but levelⅡ tier LN involvement obviously increased in SM2.MGC without LNM, SGC involved level I tier LN only. Nevertheless the rate of levelⅡ tier LN involvement rose in patients with lesion greater than 1.1 cm in diameter. As the same that, no LNM in well-differentiated cancer, the risk of levelⅡ increased accompanying the worsening of differentiation. Conclusions The cognition to principle of LNM, especially the EGC in lower stomach, contribute to individualized surgery therapy and offer theoretical support for microinvasive operation.","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":"12 1","pages":"489"},"PeriodicalIF":0.0,"publicationDate":"2006-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69928844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE ASSESSMENT OF LOCALITIVE METHODS IN INSULINOMAS 胰岛素瘤局部治疗方法的评价

Chinese Journal of Postgraduates of Medicine Pub Date : 2001-07-15 DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.07.007

Li Huabin, Liu Junlai, L. Yuyou, W. Dong, Gui Xiaoyan, H. Jun

引用次数: 0

MULTIPLE ENDOCRME NEOPLASIA-AN ANALYSIS OF 68 CASES 多发性内分泌肿瘤68例分析

Chinese Journal of Postgraduates of Medicine Pub Date : 2001-07-15 DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.07.009

Zhang Wenjuan, Fu Xiaoying, L. Ping, Wen Shilin

引用次数: 0

DYNAMIC OBSERVATION OF PERIPHERAL T CELL SUBGROUP IN PATIENTS WITH RECTAL CANCER PREOPERATIVELY AND POSTOPERATIVELY 直肠癌患者术前、术后外周血t细胞亚群动态观察

Chinese Journal of Postgraduates of Medicine Pub Date : 2001-06-15 DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.06.009

Yuan Dongfeng, Wan Guangsheng

引用次数: 0

INVESTIGATION ON ASSOCIATION OF SERUM BILIRUBIN CONCENTRATION WITH RISK OF CORONARY HEART DISEASE 血清胆红素浓度与冠心病危险关系的研究

Chinese Journal of Postgraduates of Medicine Pub Date : 2001-05-15 DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.05.008

Zhang Shu-ya, Chen Hong-tao

引用次数: 0

OBSERVATION OF NONINVASIVE BI-LEVEL POSITIVE PRESSURE VENTILATION FOR THE TREATMENT OF SEVERE ACUTE LEFT HEART FAILURE 无创双水平正压通气治疗严重急性左心衰的疗效观察

Chinese Journal of Postgraduates of Medicine Pub Date : 2001-05-15 DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.05.011

Mao Yao-sheng, You Rong-kai

引用次数: 0

THE USE OF 6-AMINOCAPROIC ACID (EACA) TO REDUCE POSTOPERATIVE BLEEDING FOLLOWING IN MITRAL VALVE REPLACEMENT 应用6-氨基己酸(eaca)减少二尖瓣置换术后出血

Chinese Journal of Postgraduates of Medicine Pub Date : 2001-05-15 DOI: 10.3760/CMA.J.ISSN.1673-4904.2001.05.009

Du Zheng-long, Kuang Zhu-sheng, Xiong Rong-sheng, W. Zhi-gang, Liu Yi-bo, Xiao Hong-tao, B. Tao, Deng Sheng, Z. Fu

{"title":"THE USE OF 6-AMINOCAPROIC ACID (EACA) TO REDUCE POSTOPERATIVE BLEEDING FOLLOWING IN MITRAL VALVE REPLACEMENT","authors":"Du Zheng-long, Kuang Zhu-sheng, Xiong Rong-sheng, W. Zhi-gang, Liu Yi-bo, Xiao Hong-tao, B. Tao, Deng Sheng, Z. Fu","doi":"10.3760/CMA.J.ISSN.1673-4904.2001.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-4904.2001.05.009","url":null,"abstract":"Objective To determine the effect of 6-aminocaproic acid (EACA) to reduce postoperation bleeding following in mitral valve replacement.Method 50 adult patients uddergoing mitral valve replacement was adopted a double-bisind randomized trial to be divided into two groups.Each group is 25 patients.The patients in control groups received NS,the ones in study groups received NS as same as control groups but added EACE 10 g by intravation.The bleeding amount in cavitas thoracis were recorded on the sixth,twenty-fourth postoperative hours and ACT was recorded as well.Results The bleeding amount in study groups on the sixth postoperative hours were (290.0±41.3) ml.On twenty-fourth postoperative hours were (336.3±81.3) ml.The bleeding amount in control groups on the sixth postoperative hours were (393.4±73.6) ml.On twenty-fourth postoperative hours were (450.0±79.6) ml.The bleeding amount in study groups were decreased significantly as compared with in control groups (P0.05).Conclusion:6-aminocaproic acid can reduce postoperation bleeding following in mitral valve replacement.","PeriodicalId":10229,"journal":{"name":"Chinese Journal of Postgraduates of Medicine","volume":"5 1","pages":"20-21"},"PeriodicalIF":0.0,"publicationDate":"2001-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82921982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0