直肠癌患者术前、术后外周血t细胞亚群动态观察

中国医师进修杂志 Pub Date : 2001-06-15 DOI:10.3760/CMA.J.ISSN.1673-4904.2001.06.009

Yuan Dongfeng, Wan Guangsheng

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引用次数: 0

摘要

目的动态观察直肠癌患者术前、术后外周血T细胞亚群的变化。方法采用单克隆抗体酶标记技术对46例直肠癌患者术前和术后外周血T细胞亚群进行动态检测。结果:(1)直肠癌患者cd3细胞和cd4细胞明显下降，cd4 / cd8细胞率明显升高。(2)免疫功能低下与癌期有关。(3)根治性直肠切除术患者免疫功能可逐渐恢复，姑息性直肠切除术、结肠造口术和剖腹手术患者免疫功能持续下降。结论直肠癌患者免疫功能低下与肿瘤发病率有关。T细胞亚群动态监测对判断直肠癌患者复发的可能性和预后具有重要意义。

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DYNAMIC OBSERVATION OF PERIPHERAL T CELL SUBGROUP IN PATIENTS WITH RECTAL CANCER PREOPERATIVELY AND POSTOPERATIVELY

Objective\ The changes of peripheral T cell subgroup in patients with rectal cancer preoperatively and postoperatively were studied dynamicly.Method\ Peripheral T cell subgroup of 46 patients with rectal cancer was measured dynamicly by the monoclonar antibody enzyme labelling techniques during the preoperative and postoperative period.Result\ (1)CD 3 cell and CD 4 cell decreased markedly,the CD 4/CD 8 rate increased apparently in patients with rectal cancer.(2)Depressed immunity was related to the term of cancer.(3)The immunity of patients treated by radical rectal resection may recover gradually,the immunity of patients treated by palliative rectal resection,colostomy and laparotomy was depressed constantly.Conclusion\ The depressed immunity of patient with rectal cancer was related to the tumour preponderance.T cell subgroup dynamic surveillance was important to juide the possibility of recurrence and prognosis in patient with rectal cancer.

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来源期刊

中国医师进修杂志

自引率

0.00%

发文量

26239

期刊介绍： Chinese Journal of Postgraduates of Medicine (founded in 1978, monthly) is one of the series of journals of the Chinese Medical Association (CMA) under the supervision of the National Health Commission of the People's Republic of China, sponsored by the Chinese Medical Association (CMA) and Dalian Institute of Theoretical Medicine (DITM). It is a core journal of Chinese science and technology, a statistical source journal of Chinese scientific and technical papers, and a statistical source journal of China Academic Journal Impact Factor Annual Report. The journal adheres to the purpose of using continuing medical education and post training, highlights new theories, new knowledge, new methods and new technologies, and focuses on the combination of theory and practice, and the combination of popularisation and improvement. Main columns: Special tutorials, expert forums, clinical treatises, clinical experience, reviews and lectures, continuing medical education, teaching and research, advanced training forum, drugs and clinics, overview of progress, introduction of new technologies, imaging and clinics, lessons learnt, discussions and evaluations, case reports, discussions of clinical cases, conference proceedings, and domestic and international academic developments. The main target readers are clinical medical personnel in internal medicine, surgery, gynaecology, paediatrics and ophthalmology.