DYNAMIC OBSERVATION OF PERIPHERAL T CELL SUBGROUP IN PATIENTS WITH RECTAL CANCER PREOPERATIVELY AND POSTOPERATIVELY

Abstract

Objective\ The changes of peripheral T cell subgroup in patients with rectal cancer preoperatively and postoperatively were studied dynamicly.Method\ Peripheral T cell subgroup of 46 patients with rectal cancer was measured dynamicly by the monoclonar antibody enzyme labelling techniques during the preoperative and postoperative period.Result\ (1)CD 3 cell and CD 4 cell decreased markedly,the CD 4/CD 8 rate increased apparently in patients with rectal cancer.(2)Depressed immunity was related to the term of cancer.(3)The immunity of patients treated by radical rectal resection may recover gradually,the immunity of patients treated by palliative rectal resection,colostomy and laparotomy was depressed constantly.Conclusion\ The depressed immunity of patient with rectal cancer was related to the tumour preponderance.T cell subgroup dynamic surveillance was important to juide the possibility of recurrence and prognosis in patient with rectal cancer.