中国基层医药最新文献

{"title":"Application of hospital-community-patient ternary continuous nursing model in the management of hypertensive patients","authors":"Lili Guo, F. Xu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.028","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.028","url":null,"abstract":"目的 \u0000探讨医院－社区－患者三元联动延续护理模式在高血压患者管理中的应用效果。 \u0000 \u0000 \u0000方法 \u0000选择2018年2月至2019年1月临海市中医院收治的高血压患者136例，采用随机数字表法分为对照组和研究组，每组68例。对照组出院时给予常规出院指导与健康宣教，出院后定期进行门诊随访；研究组在此基础上给予医院－社区－患者三元联动延续护理模式进行干预。比较两组干预前与干预6个月后健康的依从性、血压指标与生活质量的变化。 \u0000 \u0000 \u0000结果 \u0000干预后研究组收缩压、舒张压分别为(103.2±10.5)mmHg、(75.0±4.8)mmHg，均低于对照组的(114.5±8.6)mmHg、(82.6±4.2)mmHg，差异均有统计学意义(t＝6.856、5.985，均P<0.05)。干预后研究组社会功能、生活状态、躯体功能及心理功能评分分别为(60.2±2.3)分、(45.3±3.2)分、(45.2±2.6)分、(49.5±2.6)分，均高于对照组的(54.5±3.0)分、(40.2±3.0)分、(40.3±2.5)分、(45.2±2.0)分(t＝5.056、5.266、6.053、4.985，均P<0.05)。 \u0000 \u0000 \u0000结论 \u0000医院－社区－患者三元联动延续护理模式在高血压患者中具有显著的管理效果，能够有效提高患者对健康的依从性，改善血压指标与生活质量，值得应用。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"629-632"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45900755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of OEC management mode in the clinical nursing management of elderly patients","authors":"H. Shi, Yang Su, Zhipingzhai Huang, L. Bian","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.024","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.024","url":null,"abstract":"目的 \u0000分析OEC管理模式在老年病临床护理管理中的应用及效果。 \u0000 \u0000 \u0000方法 \u0000选择2015年6月至2017年5月海南省老年病医院49名护理人员为研究对象，按OEC管理模式设立考核目标、考核单元、考核内容，确立考核指标体系、护理日清体系和奖励机制。比较OEC管理实施前后患者对护理工作的满意度和护理质量，评估OEC管理模式的实施效果。 \u0000 \u0000 \u0000结果 \u0000OEC管理模式实施后，医院整体护理能力[(97.2±3.2)分]、病区护理管理能力[(96.1±5.4)分]、医疗文书管理水平[(97.8±2.8)分]、基础护理能力[(98.3±5.1)分]等护理工作质量以及患者满意度(97.2%)均明显高于实施前(t＝3.86、3.61、3.26、3.38，χ2＝5.42，均P<0.05)。 \u0000 \u0000 \u0000结论 \u0000OEC管理模式对提高老年病临床护理工作质量，实现护理的目标化和精细化管理有较明显的作用。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"614-616"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48267061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the clinical effects of early enteral and parenteral nutrition support in patients with severe stroke","authors":"W. Shi","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.015","url":null,"abstract":"Objective \u0000To compare the clinical effects of early enteral and parenteral nutrition support in patients with severe stroke. \u0000 \u0000 \u0000Methods \u0000From June 2017 to July 2018, 65 patients with severe stroke admitted in the First People's Hospital of Yongkang were selected in the study, and the patients were randomly divided into control group(32 cases) and observation group(33 cases) according to the digital table.The control group received early parenteral nutrition support, while the observation group received early enteral nutrition support.The nutritional index, biochemical index, NIHSS score, CPIS score of clinical pulmonary infection and the incidence of complications were compared between the two groups. \u0000 \u0000 \u0000Results \u0000After nutritional support, the serum levels of total protein(TP), albumin(Alb), hemoglobin(Hb) in the observation group were (57.01±2.59)g/L, (39.98±2.64)g/L, (126.86±10.75)g/L, respectively, which were significantly higher than those in the control group [(54.28±0.76)g/L, (37.31±2.35)g/L, (120.75±13.46)g/L](t=5.727, 4.302, 2.025, all P<0.05). The serum levels of glucose(GLU), creatinine (SCr), alanine aminotransferase (ALT) in the observation group were (12.35±2.38)mmol/L, (84.37±13.62)μmol/L, (47.84±4.03)U/L, respectively, which were lower than those in the control group [(14.18±2.37)mmol/L, (91.84±13.21)μmol/L, (66.28±3.76)U/L] (t=3.106, 2.244, 19.060, all P<0.05). The levels of triglyceride(TG), serum urea nitrogen(BUN) in the observation group were (1.95±0.45)mmol/L, (5.80±0.61)mmol/L, respectively, which were higher than those in the control group [(1.66±0.30)mmol/L, (5.32±0.43)mmol/L] (t=0.341, 3.656, all P<0.05). The scores of NIHSS and CPIS in the observation group were (10.31±2.10)points and (3.00±0.76)points, respectively, which were lower than those in the control group [(14.68±2.75)points, (3.79±1.45)points](t=5.279, 2.763, P=0.001, 0.008). The incidence of complications in the observation group [9.38%(3/33)] was lower than that in the control group [31.25%(10/32)], and the difference was statistically significant(χ2=4.986, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Compared with early parenteral nutrition support, early enteral nutrition support can improve the nutritional status of patients with severe stroke and is safe and effective. \u0000 \u0000 \u0000Key words: \u0000Stroke; Enteral nutrition; Parenteral nutrition; Nutritional support; Albumins; Serum albumin; Hemoglobins; Comparative effectiveness research","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"577-580"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45432500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the homogenization training path of emergency nursing skills in medical community mode","authors":"Li Yan, Hua-sheng Yang, Tianquan Wu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.029","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.029","url":null,"abstract":"目的 \u0000探讨在医联体模式下急救技能同质化培训路径的应用效果。 \u0000 \u0000 \u0000方法 \u0000选择绍兴市柯桥区中医医院湖塘、柯岩、夏履三家医联体分院护士39名为观察对象，成立急救技能培训管理小组，设计急救技能同质化培训路径，根据路径严格落实培训，运用PDCA工具进行质量监控，不断完善，实施后评价效果，比较同质化培训路径前后的效果。 \u0000 \u0000 \u0000结果 \u0000湖塘、柯岩、夏履三家医联体分院护士经过同质化培训，急救药物知识知晓评分[(92.6±5.3)分、(94.5±5.2)分、(92.0±3.4)分]、急救流程知晓评分[(94.6±4.2)分、(89.5±4.8)分、(94.0±3.8)分]、应急流程知晓评分[(95.4±3.9)分、(89.1±4.1)分、(93.0±3.5)分]、团队配合评分[(90.3±1.2)分、(90.5±3.1)分、(86.4±2.5)分]均显著提高，与培训前差异均有统计学意义(t＝－8.583、－8.583、－10.914，－8.744、－12.091、－6.260、－6.188、－7.366、－16.645，－13.856、－11.916、－12.112，均P<0.05)；急救技术操作合格率、急救药品耗材完好率、急救设备完好率均为100.0%，与培训前差异均有统计学意义(均P<0.05)。 \u0000 \u0000 \u0000结论 \u0000急救技能同质化培训路径能有效提升医联体各分院急救水平和应急能力，值得在医联体内应用和推广。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"633-636"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46646738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamin D levels of atopic dermatitis in adolescents and its clinical significance","authors":"S. Hao","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.001","url":null,"abstract":"Objective \u0000To investigate the relationship between the serum level of vitamin D and severity of atopic dermatitis (AD) in adolescents. \u0000 \u0000 \u0000Methods \u0000From March 2016 to February 2017, 102 adolescents with AD(AD group) and 100 healthy adolescents(control group) were selected.The distribution and serum levels of vitamin D in the two groups were compared.According to SCORing atopic dermatitis (SCORAD) score, AD patients were divided into mild group, moderate group and severe group.The levels of 25-(OH)D3, total IgE (TIgE) and peripheral blood eosinophil cells percentage(EOS%) were detected in the three groups. \u0000 \u0000 \u0000Results \u0000There was no statistically significant difference in the proportion of patients with vitamin D deficiency, insufficiency and sufficiency between the AD group and control group(χ2=2.718, P=0.257). The serum level of 25(OH)D3 in the AD group was lower than that in the control group[(18.43±3.73)μg/L vs.(19.47±3.27)μg/L, t=2.112, P=0.036]. The mean values of vitamin D deficiency, insufficiency and sufficiency in the AD group were (11.11±1.65)μg/L, (17.49±1.69)μg/L, (21.73±1.17)μg/L, respectively, which in the control group were (12.86±1.47)μg/L, (17.55±1.34)μg/L, (22.05±1.32)μg/L, respectively.The level of vitamin D deficiency in the AD group was significantly lower than that in the control group (t=2.588, P=0.017), but there were no statistically significant differences in vitamin D insufficiency and sufficiency between the AD group and control group.In 102 AD patients, 40 cases were mild, 29 cases were moderate and 33 cases were severe.The levels of 25-(OH)D3, TIgE and peripheral blood EOS% had statistically significant differences among the three groups (F=6.315, 35.813, 31.285, all P 0.05). Regarding the TIgE level and EOS%, severe group>moderate group>mild group(t=8.318, 8.788, all P<0.01; t=4.322, 4.784, all P<0.01). The value of 25-(OH)D3 was negatively correlated with the TIgE level(r=-302, P<0.01) and EOS%(r=-508, P<0.01) in the AD group. \u0000 \u0000 \u0000Conclusion \u0000Vitamin D deficiency or insufficiency exists in adolescents with AD.Low level of vitamin D is correlated with high TIgE level and EOS%.The severity of AD is closely correlated with increased serum levels of TlgE and EOS%, as well as decreased serum levels of vitamin D. \u0000 \u0000 \u0000Key words: \u0000Dermatitis, atopic; Adolescents; Vitamin D; Severity of illness index; IgE; Eosinophilia cell","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"513-517"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47733277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Zhibitai capsule combined with atorvastatin calcium in the treatment of coronary heart disease","authors":"Chang-xian Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.022","url":null,"abstract":"目的 \u0000探讨脂必泰胶囊联合阿托伐他汀钙治疗冠心病的临床疗效。 \u0000 \u0000 \u0000方法 \u0000选取德惠市中医院2017年3月至2019年3月收治的冠心病患者89例为研究对象，采用随机数字表法分为观察组45例和对照组44例。两组患者均予以硝酸酯类、钙离子拮抗剂、血管紧张素转换酶抑制剂等常规对症治疗，对照组在此基础上采用阿托伐他汀钙片治疗，观察组采用脂必泰胶囊联合阿托伐他汀钙片治疗。比较两组患者的临床疗效，观察患者治疗前后血脂指标的变化。 \u0000 \u0000 \u0000结果 \u0000观察组总有效率为91.1%(41/45)，高于对照组的75.0%(33/44)，两组差异有统计学意义(χ2＝6.937，P<0.05)。治疗后，观察组血清总胆固醇(TC)为(1.69±0.31)mmol/L、甘油三酯(TG)为(3.54±0.41)mmol/L，对照组分别为(2.04±0.35)mmol/L、(4.11±0.49)mmol/L，两组均低于治疗前(对照组：t＝6.671、5.681，观察组：t＝12.495、10.456，均P<0.05)，观察组均低于对照组，差异均有统计学意义(t＝6.357、6.120，均P<0.05)。 \u0000 \u0000 \u0000结论 \u0000在常规治疗基础上，脂必泰胶囊联合阿托伐他汀钙片治疗冠心病，能提高临床疗效，有效调节血脂水平。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 6","pages":"608-610"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41245968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of focus resolution technique in improving positive emotion of nurses in obstetrics and gynecology","authors":"Xiao-ling Xie, Jingjing Yu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.027","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.027","url":null,"abstract":"目的 \u0000分析焦点解决技术应用在妇产科护士中对情绪影响及临床应用价值。 \u0000 \u0000 \u0000方法 \u0000选取2018年6－12月杭州市西溪医院妇产科护理人员21名作为研究对象，通过给予焦点解决技术开展护理人员干预，观察焦点解决技术对改善护理人员心理状态和睡眠状况的影响。 \u0000 \u0000 \u0000结果 \u0000干预后护理人员心理弹性评分各维度中坚韧评分[(35.56±3.88)分]，自强评分[(26.01±3.22)分]，乐观评分[(12.24±2.88)分]，均高于干预前(t＝11.302、9.328、10.091，均P<0.05)。干预后护理人员汉密尔顿焦虑量表评分[(8.11±1.42)分]，汉密尔顿抑郁量表评分[(9.06±1.23)分]，干预后焦虑发生率[10.71%(6/21)]，抑郁发生率[5.36%(3/21)]，均低于干预前(t＝10.991、11.378，χ2＝4.771、4.017，均P<0.05)。干预后护理人员主观睡眠评分[(1.41±0.23)分]，入睡时间评分[(2.04±0.35)分]，睡眠时间评分[(1.37±0.21)分]，睡眠效率评分[(1.43±0.26)分]，睡眠障碍评分[(1.31±0.11)分]，睡眠质量总分[(10.16±1.01)分]，均低于干预前(t＝6.943、8.327、9.161、8.378、10.007、9.661，均P<0.05)。 \u0000 \u0000 \u0000结论 \u0000焦点解决技术应用在妇产科护士中可以可以提高护理人员心理弹性水平，改善睡眠质量，降低护理人员负性情绪，值得在临床推广应用。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"625-628"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44810154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracoscopic repair with simplified mattress sutures in the treatment of diaphragmatic hernia in neonates without posterolateral rim of diaphragm","authors":"Bing Li, Wei-bing Chen, Shunlin Xia, Mengxu Liu, Shou-qing Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.009","url":null,"abstract":"Objective \u0000To explore the initial experience of thoracoscopic repair with simplified mattress sutures in the treatment of diaphragmatic hernia in neonates without posterolateral rim of diaphragm. \u0000 \u0000 \u0000Methods \u0000A retrospective review of the new simplified technique in 10 cases from March 2015 to October 2017 was performed.Of the patients, 6 cases were male, 4 cases were female.The age was 10min-1d, 7 cases were term newborns, and 3 cases were premature.The mean weight was 2.88 kg(ranged 2.3-3.5kg). All the 4 cases were left-sided.Two to three primary suture sites were taken from the relative intercostal region of the body surface projection of the defect.A snip incision about 1 mm of the skin was done.Two 2-0 non-absorbable sutures round the rib were inserted between the front edged of the defect and the diaphragm muscle through a syringe needle.The first thread was brought out of the body by the ring of the second thread and knot tying was made extracorporally.The posterolateral defect was closed; the knot was under the skin of intercostals space. \u0000 \u0000 \u0000Results \u0000Ten neonates with CDH were repaired successfully using this new simplified technique.The mean operative time was 37.5min(ranged 25-60min) for each CDH repair.No cases required conversion to open surgery, blood loss was minimal.The 10 cases were followed up for 16.5 months(ranged 5-24 months), with no death and no recurrence.One neonate complicated with subcutaneous emphysema postoperatively and healed in one week. \u0000 \u0000 \u0000Conclusion \u0000The new technique of thoracoscopic repairing with simplified mattress sutures when no posterolateral rim of diaphragm exists has all the advantages of thoracoscopy in neonates combined with the advantages of reduced operative time, simplicity, feasibility and definite curative effect and has the value of clinical popularization. \u0000 \u0000 \u0000Key words: \u0000Hernia, diaphragmatic; Thoracoscopy; Reconstructive surgical procedures; Infant, newborn","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"550-554"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48448134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of traditional Chinese medicine nursing on mental state, quality of life and satisfaction of patients with cerebral infarction in recovery period","authors":"Jin Yu, Ling Li","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.025","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.025","url":null,"abstract":"目的 \u0000探讨中医护理对脑梗死患者恢复期心理状态、生活质量及护理满意度影响。 \u0000 \u0000 \u0000方法 \u0000选取2016年8月至2018年8月浙江省人民医院收治的脑梗死恢复期患者136例为研究对象，采用随机数字表法将其分为对照组和研究组，每组68例。对照组予以常规护理，研究组予以常规护理联合中医护理。比较两组患者的心理状态、生活质量以及护理满意度。 \u0000 \u0000 \u0000结果 \u0000研究组护理后焦虑自评量表和抑郁自评量表评分均明显低于对照组(t＝6.158、7.013，均P<0.001)。研究组护理后SF－36各维度评分均明显高于对照组(t＝9.642、10.057、11.570、8.671、11.975、10.643，均P<0.05)。研究组护理满意度为98.53%(67/68)，明显高于对照组的83.82%(57/68)(χ2＝18.016，P<0.001)。 \u0000 \u0000 \u0000结论 \u0000中医护理对于脑梗死恢复期患者心理状态的调节、生活质量的提高以及和谐护患关系的构建具有非常重要的临床意义。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"617-620"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45528629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of triple therapy with omeprazole in the treatment of children with peptic ulcer","authors":"Mei-qian Wu, Zhengjin Hu, L. Lan, F. Wu, Rubo Lan","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.002","url":null,"abstract":"Objective \u0000To observe the clinical effect of omeprazole based triple therapy in the treatment of children with peptic ulcer. \u0000 \u0000 \u0000Methods \u0000From September 2016 to September 2018, 86 children with peptic ulcer in the People's Hospital of Qingyuan County were selected in this study.By using the random number table method, they were divided into two groups, with 43 cases in each group.The control group received ranitidine based triple therapy treatment, the observation group was given omeprazole based triple therapy treatment.The treatment course of the two groups was 30 d. The eradication rate, clinical effect, gastrointestinal hormone level and adverse reactions of helicobacter pylori were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The eradication rate and total effective rate of helicobacter pylori in the observation group were 97.67%(42/43) and 95.35%(41/43), respectively, which were higher than those in the control group[81.40%(34/43) and 79.07%(34/43)], the differences were statistically significant (χ2=6.081, 5.108, all P 0.05). \u0000 \u0000 \u0000Conclusion \u0000Omeprazole based triple therapy is safe and effective in the treatment of children with peptic ulcer, which is helpful to eradicate helicobacter pylori, reduce gastrin, motilin levels and improve the level of somatostatin. \u0000 \u0000 \u0000Key words: \u0000Peptic ulcer; Polypharmacy; Omeprazole; Ranitidine; Helicobacter pylori; Gastrins; Motilin; Somatostatin; Child; Comparative study","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"518-521"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45843954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}