Effect of triple therapy with omeprazole in the treatment of children with peptic ulcer

中国基层医药 Pub Date : 2020-03-01 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.05.002

Mei-qian Wu, Zhengjin Hu, L. Lan, F. Wu, Rubo Lan

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Abstract

Objective To observe the clinical effect of omeprazole based triple therapy in the treatment of children with peptic ulcer. Methods From September 2016 to September 2018, 86 children with peptic ulcer in the People's Hospital of Qingyuan County were selected in this study.By using the random number table method, they were divided into two groups, with 43 cases in each group.The control group received ranitidine based triple therapy treatment, the observation group was given omeprazole based triple therapy treatment.The treatment course of the two groups was 30 d. The eradication rate, clinical effect, gastrointestinal hormone level and adverse reactions of helicobacter pylori were compared between the two groups. Results The eradication rate and total effective rate of helicobacter pylori in the observation group were 97.67%(42/43) and 95.35%(41/43), respectively, which were higher than those in the control group[81.40%(34/43) and 79.07%(34/43)], the differences were statistically significant (χ2=6.081, 5.108, all P 0.05). Conclusion Omeprazole based triple therapy is safe and effective in the treatment of children with peptic ulcer, which is helpful to eradicate helicobacter pylori, reduce gastrin, motilin levels and improve the level of somatostatin. Key words: Peptic ulcer; Polypharmacy; Omeprazole; Ranitidine; Helicobacter pylori; Gastrins; Motilin; Somatostatin; Child; Comparative study

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奥美拉唑三联疗法治疗儿童消化性溃疡的疗效观察

目的观察奥美拉唑三联疗法治疗儿童消化性溃疡的临床疗效。方法选择清远县人民医院2016年9月至2018年9月收治的消化性溃疡患儿86例。采用随机数表法将患者分为两组，每组43例。对照组给予雷尼替丁为主的三联治疗，观察组给予奥美拉唑为主的三联疗法。两组疗程30d，比较两组幽门螺杆菌根除率、临床疗效、胃肠激素水平及不良反应。结果观察组幽门螺杆菌根除率和总有效率分别为97.67%（42/43）和95.35%（41/43），高于对照组的81.40%（34/43）和79.07%（34/43，结论奥美拉唑三联疗法治疗儿童消化性溃疡安全有效，有助于根除幽门螺杆菌，降低胃泌素、胃动素水平，提高生长抑素水平。关键词：消化性溃疡；多药治疗；奥美拉唑；雷尼替丁；幽门螺杆菌；胃泌素；Motilin；生长抑素；儿童；比较研究

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来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.