中国基层医药最新文献

{"title":"Comparison of the effects of laparoscopic catheterization and surgical incision catheterization on catheter-related complications and microinflammation in uremic peritoneal dialysis patients","authors":"Wei Wu, Hong-Fa Zhu, Jiaxi Chen, Guan-zhou Liu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.014","url":null,"abstract":"Objective \u0000To compare the effects of laparoscopic and surgical catheterization on catheter-related complications and microinflammation in uremic peritoneal dialysis (PD) patients. \u0000 \u0000 \u0000Methods \u0000According to different catheterization methods, 98 uremic patients who were scheduled to undergo peritoneal dialysis in the First People's Hospital of Jiande from January 2014 to March 2019 were divided into group A (38 cases), group B (60 cases). Laparoscopic catheterization was used in group A, and incision catheterization was used in group B. Surgical parameters, catheter complications, microinflammation and survival rate of early catheterization were observed in the two groups. \u0000 \u0000 \u0000Results \u0000The operation time of group A was (35.00±3.14)min, which was shorter than that of group B [(50.00±5.17)min], and the operation cost of group A was (5 800.0±318.9)CNY, which was higher than that of group B [(3 400.0±297.4)CNY], and the visual analogue score (VAS) of group A was (2.33±0.31)points, which was lower than that of group B [(3.25±0.49)points], there were statistically significant differences between the two groups (t=11.540, 9.317, 10.328, 36.578, all P 0.05). After catheterization, the levels of hs-CRP, IL-6 and TNF-alpha in group B were (12.52±3.75)mg/L, (12.02±3.76)ng/L, (15.92±5.72)ng/L, respectively, which were higher than those in group A [(9.63±2.36)mg/L, (9.11±3.54)ng/L, (13.41±5.61)ng/L] (t=4.244, 4.081, 4.510, all P<0.05). After 2 months of follow-up, the survival rate of dialysis tube technique was 89.47%(34/38) in group A and 71.67%(43/60) in group B, there was statistically significant difference between the two groups (χ2=4.382, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Application of laparoscopic catheterization in uremic PD patients has satisfactory effect, light pain, fewer complications, mild inflammation and high survival rate of early catheterization technology, which is worthy of clinical promotion. \u0000 \u0000 \u0000Key words: \u0000Uremia; Peritoneal dialysis; Laparoscopy; Catheterization; Postoperative complications; C-reactive protein; Interleukin-6; Tumor necrosis factor-alpha","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"572-576"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47645523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application effect of Zhixinxing health education mode in postoperative pain management of surgical patients","authors":"Sisi Wang, Qingqing Wang, Jianhong Huang, Y. Gu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.023","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.023","url":null,"abstract":"目的 \u0000在手术患者术后疼痛管理中应用知信行健康教育模式，并分析知信行健康教育模式的应用效果。 \u0000 \u0000 \u0000方法 \u0000选择2017年3月至2019年3月舟山市妇幼保健医院接受的手术患者100例，采用随机数字表法分对照组与研究组各50例，分别予以常规教育护理、知信行健康教育模式。比较两组自我管理行为评分、术后疼痛评分、护理总满意率。 \u0000 \u0000 \u0000结果 \u0000研究组的自我管理行为评分[(83.81±5.21)分]高于对照组[(71.35±5.23)分]，且研究组的术后疼痛评分[(2.72±0.16)分]低于对照组[(4.91±0.71)分]，差异均有统计学意义(t＝11.93、21.28，均P<0.05)；研究组的护理总满意率(96.00%)高于对照组(84.00%)，差异有统计学意义(χ2＝4.00，P<0.05)。 \u0000 \u0000 \u0000结论 \u0000在手术患者术后疼痛管理中应用知信行健康教育模式，可以有效提高患者的自我管理水平，能够帮助其减轻机体疼痛感，且增加患者满意度。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"611-613"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46995069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effect of acitretin combined with traditional Chinese Medicine on pustular psoriasis","authors":"L. Qin","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.013","url":null,"abstract":"Objective \u0000To observe the efficacy of acitretin combined with traditional Chinese medicine in the treatment of pustular psoriasis. \u0000 \u0000 \u0000Methods \u0000From July 2011 to October 2017, 91 patients with pustular psoriasis admitted to the Second People's Hospital of Changzhi were randomly divided into treatment group(n=31), control group Ⅰ (n=30) and control group Ⅱ(n=30) according to the digital table.The patients in the three groups were treated with acitretin combined with traditional Chinese medicine, oral acitretin and traditional Chinese medicine, respectively.The therapeutic effects, the time required for hypothermia, the time required for the complete disappearance of pustules and the average length of hospitalization were compared among the three groups. \u0000 \u0000 \u0000Results \u0000The total effective rate was 93.55%(29/31) in the treatment group, 70.00%(21/30) in the control group Ⅰ and 73.33%(22/30) in the control group Ⅱ.The total effective rate in the treatment group was significantly higher than that in the two control groups(χ2=5.720, 4.546, all P 0.05). The fever allaying time, completely disappearance time of pustules, average hospital stay in the treatment group were (4.24±0.86)d, (7.38±0.72)d, (23.46±0.61)d, respectively, which in the control group Ⅰ were (7.45±0.92)d, (10.45±0.52)d, (30.01±0.82)d, respectively, which in the control group Ⅱ were (8.56±0.78)d, (11.56±0.35)d, (31.53±0.68)d, respectively, which in the control group Ⅰ were significantly shorter than those in the control group Ⅱ(t=14.083, 19.037, 35.476, all P<0.05), which in the treatment group were significantly lower than those in the control group Ⅰ and the control group Ⅱ(t=20.529, 28.682, 48.826, 5.041, 9.699, 7.816, all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Acitretin capsule combined with traditional Chinese medicine is effective in the treatment of pustular psoriasis, which can control body temperature in a short time, shorten the time of disappearance of pustule, relieve the pain of patients, and shorten the time of hospitalization at the same time. \u0000 \u0000 \u0000Key words: \u0000Psoriasis; Skin diseases; Avera; Drugs, chinese herbal; Drug therapy, combination; Treatment outcome; Comparative study","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"568-571"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43350761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of failure mode and effect analysis in radiotherapy and chemotherapy for breast cancer patients","authors":"S. Xu, Yan-ju Xiao","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.026","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.026","url":null,"abstract":"目的 \u0000探讨失效模式与效应分析(FMEA)在乳腺癌放化疗过程中的应用效果。 \u0000 \u0000 \u0000方法 \u0000回顾性分析温州医科大学附属第一医院2017年3月至2019年3月行放化疗的乳腺癌患者120例的临床资料，根据护理方法不同分为两组，观察组60例采用FMEA护理管理干预，对照组60例采用常规护理干预。评价两组患者干预后乳腺癌患者生命质量测定量表(FACT－B)、抑郁自评量表(SDS)及焦虑自评量表(SAS)评分情况，比较两组患者满意度、病情知晓情况，观察并发症发生情况。 \u0000 \u0000 \u0000结果 \u0000干预后，观察组各项生活质量评分均显著优于对照组(均P<0.05)。观察组病情知晓率、满意度分别为98.33%、95.83%，均显著高于对照组的83.33%、81.67%(χ2＝8.107、5.175，均P<0.05)。观察组FACT－B、SDS、SAS评分分别为(130.26±14.42)分、(42.35±4.32)分、(38.35±4.66)分，均显著优于对照组的(112.25±8.93)分、(59.24±6.95)分、(51.42±6.23)分(t＝5.236、3.236、11.865，均P<0.05)。观察组并发症发生率为11.67%，显著低于对照组的28.33%(χ2＝5.208，P＝0.022)。 \u0000 \u0000 \u0000结论 \u0000实施FMEA护理管理能有效提高乳腺癌患者放化疗过程中的生活质量，缓解患者心理和生理上的各种不适，提高患者的满意度，降低并发症发生率。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"621-624"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41385505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of plasma BNP combined with Tei index in evaluating left ventricular function in children with congenital heart disease before interventional therapy","authors":"Tugui Li, J. Chen","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.003","url":null,"abstract":"Objective \u0000To explore the clinical value of combined detection of plasma BNP and Tei index in evaluating left ventricular function in children with congenital heart disease before interventional therapy. \u0000 \u0000 \u0000Methods \u0000From April 2017 to April 2019, a total of 60 children with congenital heart disease who were going to receive interventional therapy in Dachong Hospital of Zhongshan and Boai Hospital of Zhongshan were selected as observation subjects, and the patients were divided into cardiac function class Ⅰ group and cardiac function class Ⅱ group according to NYHA cardiac function classification, with 30 cases in each group.At the same time, 30 normal children were selected as healthy control group.The differences of plasma BNP concentration, left ventricular ejection fraction(LVEF) and left ventricular Tei index in different group were compared.The correlation between the plasma concentration and the cardiac function was investigated, and the correlation between the plasma BNP concentration and the Tei index was analyzed. \u0000 \u0000 \u0000Results \u0000The concentration of serum BNP[(6.8±1.2)ng/L] and the Tei index of left ventricle (0.63±0.08) in the cardiac function class Ⅱ group were significantly higher than those in the cardiac function class Ⅰ group[(5.4±1.3)ng/L, (0.48±0.11)], and the differences were statistically significant (t=1.92, 3.01, all P<0.05). These two indicators of the two groups were higher than those of the healthy control group[(3.7±1.5)ng/L, (0.33±0.09)], the differences were statistically significant(t=2.14, 2.28, 4.19, 6.14, all P<0.05). In addition, the LVEF of the cardiac function class Ⅱ group was significantly lower than that of the cardiac function class Ⅰ group(t=5.00, P<0.05), and the LVEF of the two groups were significantly lower those that of the healthy control group(t=10.32, 4.51, all P<0.05). With the increase of severity of cardiac insufficiency, the BNP and Tei index gradually increased(F=3.054, 3.491, all P<0.05), and the LVEF value decreased gradually (F=12.50, P<0.05). At the same time, the linear correlation analysis showed that the plasma BNP concentration had a positive correlation with the left ventricular Tei index(r=0.69, P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Plasma BNP combined with Tei index can quickly and accurately assess the left ventricular function in children with congenital heart disease before intervention.As a sensitive index for clinical detection, it has clinical application value. \u0000 \u0000 \u0000Key words: \u0000Heart defects, congenital; Angioplasty, balloon, coronary; Preoperative period; Natriuretic peptide, brain; Ventricular function, left; Child","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"522-525"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41676674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effect of extended lumpectomy in the treatment of patients with single benign thyroid disease","authors":"Jian Xu, Yuanjiang Zhang, K. Jin","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.019","url":null,"abstract":"Objective \u0000To investigate the clinical effect of extended lumpectomy in the treatment of patients with single benign thyroid disease of different sizes. \u0000 \u0000 \u0000Methods \u0000From June 2008 to June 2011, 132 patients with single benign thyroid lesion in the Second People′s Hospital of Changshu were selected as observation group.According to the size of the lump, 132 patients with single benign thyroid disease were divided into two groups: ≤2cm group(64 patients) and >2cm group(68 patients). In addition, 62 patients with single benign thyroid lesion underwent subtotal thyroidectomy at the same time were randomly selected as control group.The incision size, operating time, intraoperative blood loss, postoperative drainage volume, hospital day, hospital cost and postoperative complications (hoarseness, water bucking, low calcium, hypothyroidism, tumor recurrence) of the two groups were recorded and compared with the control group. \u0000 \u0000 \u0000Results \u0000The incision size, operating time, intraoperative blood loss, postoperative drainage volume, hospital day, hospital cost of ≤2cm group were less or shorter than those of the control group[(3.6±0.4)cm vs.(4.5±0.6)cm, (40.1±9.6)min vs.(76.2±15.3)min, (52.2±17.8)mL vs.(82.1±16.8)mL, (49.8±15.7)mL vs.(78.1±12.4)mL, (4.9±0.9)d vs.(6.1±1.2)d, (7125.2±219.4)CNY vs.(8321.2±308.1)CNY, t=9.935, 15.917, 9.690, 11.205, 6.363, 25.161, all P 0.05). The operating time, hospital cost of >2cm group were less than those of the control group[(49.6±12.7)min vs.(76.2±15.3)min, (7 641.6±382.4)CNY vs.(8 321.2±308.1)CNY, t=10.820, 11.090, all P 0.05). The incidences of postoperative hoarseness, water bucking, low calcium and hypothyroidism of ≤2cm group had no statistically significant differences compared with those of the control group (χ2=2.175, 0.443, 1.105, 1.670, all P>0.05). The patients were followed-up for 7-10 years, the postoperative recurrence rate in >2cm group was higher than that in the control group[10.3%(7/68) vs.1.6%(1/62), χ2=4.232, P<0.05]. \u0000 \u0000 \u0000Conclusion \u0000Compared with conventional subtotal thyroidectomy, extended lumpectomy in the treatment of patients with small single benign thyroid disease(≤2cm) has good effect.The incision size, operating time, intraoperative blood loss, postoperative drainage volume, hospital day, hospital cost, postoperative hoarseness and postoperative hypothyroidism are less than subtotal thyroidectomy.And it don't increase tumor recurrence rate of ipsilateral thyroid gland.So it is worthy of clinical application.But it is not suitable for larger single benign thyroid disease (>2cm) because of higher recurrence rate. \u0000 \u0000 \u0000Key words: \u0000Thyroid diseases; Neoplasms; Thyroidectomy; Hypothyroidism; Postoperative complications","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"596-600"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49397075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the diagnostic value of multimodal ultrasound in thyroid microcarcinoma","authors":"Yanhua Zhao, Qinglan Zhang, Xiao-Qiang Zhou","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.016","url":null,"abstract":"Objective \u0000To study the diagnostic value of multimodal ultrasound in thyroid microcarcinoma(TMC). \u0000 \u0000 \u0000Methods \u0000The clinical data of 203 TMC patients in the Sixth Hospital of Shanxi Medical University from March 2015 to January 2019 were retrospectively analyzed.The preoperative multimodal ultrasound results [high frequency ultrasonography(HFU), color Doppler (DU), ultrasonic elastography (UE)] were collected, the postoperative pathological results were seen as the gold standard, and the consistency of multimodal ultrasound diagnosis and the pathological results was analyzed, the diagnosis effect index of multimodal ultrasound was calculated, ROC curve was used to analyze the diagnostic value of multimodal ultrasound for TMC. \u0000 \u0000 \u0000Results \u0000The diagnostic results of HFU, UE were highly consistent with the postoperative pathological results (0.8 0.9). DU had medium diagnostic value for TMC (0.7≤AUC≤0.9). \u0000 \u0000 \u0000Conclusion \u0000Multimodal ultrasonography has high diagnostic value for TMC, and it can be used in many fields such as clinical diagnosis, efficacy evaluation and reexamination due to its good repeatability and non-invasive. \u0000 \u0000 \u0000Key words: \u0000Thyroid neoplasms; Ultrasonography; Ultrasonography, doppler, color; Elasticity imaging techniques; ROC curve; Area under curve; Diagnosis; Case-control studies","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"581-585"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43689598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation of recombinant human growth hormone in the treatment of growth hormone deficiency","authors":"Chun-ya Ni","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.008","url":null,"abstract":"Objective \u0000To investigate the clinical effect of recombinant human growth hormone (rhGH) in the treatment of children with growth hormone deficiency and its effect on thyroid function. \u0000 \u0000 \u0000Methods \u0000From June 2016 to June 2018, 81 children with growth hormone deficiency in Da Jiangdong Hospital of Hangzhou were selected.The rhGH was given 1 time before bedtime, and the treatment course was 6 months.The growth and development, bone metabolism and thyroid function were compared before treatment, 3 months and 6 months after treatment. \u0000 \u0000 \u0000Results \u0000The height and growth rate at 3 months after treatment [(131.76±2.28)cm, (10.40±0.87)cm/year] and at 6 months after treatment [(134.83)cm, (11.74±0.72)cm/year] were higher than those before treatment [(127.32±3.49)cm, (4.32±1.08)cm/year] (F=7.973, P=0.000, F=12.314, P=0.000), which at 6 months after treatment were higher than those 3 months after treatment (height: t=9.586, 16.405, growth rate: t=39.457, 51.448, P=0.000). There was no statistically significant difference in BMI among before treatment [(17.21±4.28)kg/m2], 3 months after treatment [(17.86±5.14)kg/m2] and 6 months after treatment [(18.01±4.35)kg/m2] (F=0.762, P=0.391). The serum levels of BGP and ALP at 3 months after treatment [(7.19±0.38)ng/mL, (129.34±8.97)U/L] and at 6 months after treatment [(7.94±0.63)ng/mL, (154.67±10.42)U/L] were higher than those before treatment [(6.38±0.57)ng/mL, (108.49±6.51)U/L] (F=8.971, P=0.000, F=15.427, P=0.000), and the levels of BGP and ALP at 6 months after treatment were higher than those 3 months after treatment (t=9.175, P=0.000, t=16.581, P=0.000). There were no statistically significant differences in serum FT3, TSH and FT4 levels before treatment, 3 months after treatment and 6 months after treatment (F=0.893, P=0.287, F=0.472, P=0.517, F=1.084, P=0213). \u0000 \u0000 \u0000Conclusion \u0000rhGH has significant clinical effects on children with growth hormone deficiency, and has no significant effect on thyroid function, which is worthy of clinical reference. \u0000 \u0000 \u0000Key words: \u0000Growth disorders; Human growth hormone; Thyroid function tests","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"546-549"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47457361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of T-SPOT test for pediatric tuberculosis","authors":"Pin-Hui Wang, Yong-qiang Deng","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.005","url":null,"abstract":"Objective \u0000To investigate the diagnostic performance of T-SPOT test for pediatric tuberculosis (TB). \u0000 \u0000 \u0000Methods \u0000The results of T-SPOT and PPD in 67 TB children and 71 TB-excluded children that diagnosed and treated in the People's Hospital of Jianyang from June 2014 to May 2017 were retrospectively analyzed.The diagnostic efficacy and consistency of the two tests, and the diagnostic efficacy of combined examination were evaluated. \u0000 \u0000 \u0000Results \u0000The sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, Youden′s index of T-SPOT were 88.1%, 94.4%, 93.7%, 89.3%, 15.6, 0.13, 0.83, respectively.While the above parameters of PPD were 68.7%, 74.6%, 71.9%, 71.6%, 2.71, 0.42, 0.43, respectively.T-SPOT had higher sensitivity, specificity, positive predictive value, negative predictive value compared with PPD, and the differences were statistically significant(χ2=7.44, 10.54, 10.51, 7.45, all P 0.05). The positive rate of T-SPOT was higher in 5-18 years old group than that in 0-4 years old group(95.1% vs.76.2 %, χ2=5.01, P 0.05). \u0000 \u0000 \u0000Conclusion \u0000T-SPOT outperformed PPD in diagnostic assistance of pediatric TB overall.The diagnostic superiority is noticeable in the>4-18 years old other than the 0-4 years old.Compared with T-SPOT alone, combined tests should not be regarded to have increased sensitivity. \u0000 \u0000 \u0000Key words: \u0000T-lymphocytes; Enzyme-linked immunospot assay; Tuberculosis, pulmonary; Mycobacterium tuberculosis; Tuberculin test; Diagnosis; Child","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"532-536"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42464787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effect of directional soft-channel puncture and suction drainage in the treatment of spontaneous cerebral hemorrhage in basal ganglia and its influence on neurological function","authors":"J. Xiong","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.05.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.05.018","url":null,"abstract":"Objective \u0000To investigate the clinical effect of directional soft-channel puncture and suction drainage in the treatment of spontaneous cerebral hemorrhage in basal ganglia and its influence on neurological function. \u0000 \u0000 \u0000Methods \u0000From January 2017 to December 2018, 61 patients with spontaneous cerebral hemorrhage in basal ganglia were selected in the First People's Hospital of Jiande.According to the random table method, they were divided into control group (30 cases) and observation group (31 cases). The control group was treated conservatively, while the observation group was treated with directional soft-channel puncture and suction drainage combined with conventional therapy.The therapeutic effects, NIHSS score, ADL score, brain edema volume change and complications were compared before treatment, 1 week after treatment and 2 weeks after treatment. \u0000 \u0000 \u0000Results \u0000The total effective rate of the observation group (96.77%) was higher than that of the control group (76.67%) (χ2=3.989, P<0.05). The NIHSS score of the observation group was (16.54±2.19)points at one week after treatment and (9.12±1.24)points at two weeks after treatment, which were lower than those of the control group [(19.98±1.65)points and (13.25±2, 37)points] (t=6.911, 8.568, all P<0.05). The ADL score of the observation group was (43.42±5.67)points at one week after treatment and (63.98±3.46)points at two weeks after treatment, which were higher than those of the control group [(37.89±2.86)points and (52.37±4.10)points] (t=4.785, 11.967, all P<0.05). The volume of brain edema of the observation group was (12.08±2.14)mL at 1 week after treatment and (4.37±0.89)mL at 2 weeks after treatment, which were lower than those of the control group [(16.89±3.20)mL and (9.74±1.07)mL] (t=6.922, 21.339, all P<0.05). The incidence of complications in the observation group (6.45%) was lower than that in the control group (30.00%) (χ2=5.720, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Directional soft-channel puncture and suction drainage is effective in the treatment of spontaneous cerebral hemorrhage in basal ganglia, which can reduce the degree of neurological deficit and with fewer complications, and it is worthy of clinical study. \u0000 \u0000 \u0000Key words: \u0000Cerebral hemorrhage; Paracentesis; Neurological deficit; Activity of daily living; Brain edema volume; Complications","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"591-595"},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48391877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}