中国基层医药最新文献

{"title":"A prospective study on the incidence and risk factors of central venous catheter-related thrombosis after gastrointestinal surgery","authors":"Zhenjiang Guo, N. Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.012","url":null,"abstract":"Objective \u0000To investigate the incidence and risk factors of central venous catheter-related thrombosis after gastrointestinal surgery. \u0000 \u0000 \u0000Methods \u0000From May 2018 to May 2019, 124 patients who received surgical treatment with central venous catheter placement in gastrointestinal surgery department at Harrsion International Peace Hospital were prospectively analyzed, and the factors that may be related to catheter-related thrombosis were collected.And performed ultrasound screening before the removal of central venous catheter, According to whether there was thrombosis or not, they were divided into thrombosis group(n=66) and non-thrombosis group(n=58). Multivariate logistic regression analysis was performed for the factors with statistical differences between the two groups. \u0000 \u0000 \u0000Results \u0000A total of 66 patients were diagnosed with catheter-related thrombus by ultrasonography, with an incidence of 53.2%(66/124), 63 cases with no clinical symptoms(50.8%), only 3 cases with clinical symptoms, and the incidence of catheter-related thrombus with symptoms was 2.4%(3/124). The operation type, central venous catheter indwelling time, fibrinogen on the 3rd day after surgery and D-dimer on the 3rd day after surgery between the two groups had statistically significant differences (χ2=21.415, 7.651, t=5.7181, 0.418, all P<0.05). Multivariable logistic regression analysis showed that operation type(OR=0.157, 95%CI: 0.040-0.612, P=0.008), fibrinogen on the 3rd day after surgery(OR=7.371, 95%CI: 2.318-23.442, P=0.001), D-dimer on the 3rd day after surgery(OR=6.920, 95%CI: 2.854-16.783, P=0.000) were independent risk factors of catheter-related thrombosis. \u0000 \u0000 \u0000Conclusion \u0000The incidence of central venous catheter-related thrombosis is higher after gastrointestinal surgery, and most patients have no obvious clinical symptoms.The patients who undergoing tumor surgery or with abnormal levels of fibrinogen and D-dimer on the 3rd day after surgery should aware of catheter-related thrombosis. \u0000 \u0000 \u0000Key words: \u0000Gastrointestinal diseases; Surgery; Central venous catheters; Venous thrombosis; Risk factor; Neoplasms; Fibrinogen; Fibrin fragment D","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"694-698"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44841328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the expression of microRNA-16, microRNA-124 and microRNA-195 in peripheral blood of schizophrenic patients and their cognitive and social functions","authors":"Qiao Xu, Weihua Zhang, Zhenyuan Luo","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.019","url":null,"abstract":"Objective \u0000To investigate the correlation between the expression of microRNA-16, mircoRNA-124 and mircoRNA-195 in peripheral blood of schizophrenic patients and their cognitive and social functions. \u0000 \u0000 \u0000Methods \u0000From January 2016 to December 2018, 112 schizophrenic patients admitted to the Second People's Hospital of Taizhou were selected as observation group, and 93 healthy examinees from the Second People's Hospital of Taizhou were selected as control group.The expression of mircoRNA-16, mircoRNA 124 and mircoRNA 195 in peripheral blood was detected by real-time quantitative fluorescent PCR.The cognitive function of patients was evaluated by Chinese version of Montreal Cognitive Assessment Scale (MoCA), and the social function of inpatients with mental illness was evaluated by SSPI. \u0000 \u0000 \u0000Results \u0000The expression of mircoRNA-16 (0.03±0.01) and mircoRNA 195(0.08±0.03) in peripheral blood of the observation group was lower than that of the control group[(0.12±0.02) and (0.27±0.06)], while the expression of mircoRNA 124 (14.63±3.24) of the observation group was higher than that of the control group (7.45±1.39), the differences were statistically significant(t=41.763, 19.898, 29.389, all P<0.05). The score of MoCA scale in the observation group[(22.17±3.45)points]was lower than that in the control group[(28.39±1.28)points](t=16.465, P<0.05). The SSPI score of the observation group[(26.58±5.16)points]was lower than that of the control group[(45.37±3.27)points](t=30.405, P<0.05). MicroRNA-16 and microRNA-195 were positively correlated with MoCA scale score and SSPI scale score (r=0.641, 0.724, SSPI scale score: r=0.801, 0.657, all P<0.05), while microRNA-124 was negatively correlated with MoCA scale score and SSPI scale score (r=-0.738, -0.769, all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The expression of mircoRNA-16 and mircoRNA-195 in peripheral blood of schizophrenic patients decreased, while the expression of mircoRNA-124 increased.The expressions of mircoRNA-16 and mircoRNA-195 were positively correlated with cognitive and social functions, while mircoRNA-124 was negatively correlated with cognitive and social functions. \u0000 \u0000 \u0000Key words: \u0000Schizophrenia; Healthy examinees; Peripheral blood; MicroRNA-16; MicroRNA-124; MicroRNA-195; Cognitive function; Social function; Relevance","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"729-732"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49327320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of high-risk human papillomavirus A9 infection in cervical cancer screening","authors":"Su-Hsun Liu, Qingling Gong, Xiaoqing Lu, Jun Zhou","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.009","url":null,"abstract":"Objective \u0000To investigate the infection incidence of women with high-risk human papillomavirus(HPV) A9 in Quzhou, and to analyze its clinical significance in cervical cancer screening by combining with liquid-based cytology(TCT). \u0000 \u0000 \u0000Methods \u0000A total of 9 010 patients were collected from January 2017 to May 2018 in the Maternal and Child Health Hospital of Quzhou.HPV detection was performed by Cervista method.In combination with TCT, cervical biopsy was carried out under vaginal microscopy. \u0000 \u0000 \u0000Results \u0000Among 9 010 patients, 1 401 patients were HPV positive, and the A9 group had the highest rate for inspection(6.98%). The experiment data of the A9 group indicated that the portions of cervical intraepithelial lesions in liquid-based cytology NILM, ASC-US, LSIL, ASC-H, HSIL, SCC were 5.96%, 80.10%, 100.00%, 100.00%, 100.00%, respectively.Its coincidence rate with histology increased as liquid-based cytology increased, associated with high-grade lesions. \u0000 \u0000 \u0000Conclusion \u0000A9 group infection is the most important cause of cervical intraepithelial lesions in Quzhou.High-risk HPV test, especially A9 group infection combined with TCT, can effectively improve the accuracy of cervical cancer screening. \u0000 \u0000 \u0000Key words: \u0000Human papillomavirus; Infection; Cytological techniques; Uterine cervical neoplasms; Multiphasic screening; Precancerous conditions; Neoplasms, squamous cell; Colposcopy; Pathology, clinical","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"681-684"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41820667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation on the clinical effect of laparoscopic surgery in the treatment of ectopic pregnancy","authors":"Hui-ying Wang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.011","url":null,"abstract":"Objective \u0000To investigate the effect of laparoscopic surgery in the treatment of ectopic pregnancy and its influence on pregnancy and complications. \u0000 \u0000 \u0000Methods \u0000From January 2014 to January 2018, 130 cases of ectopic pregnancy patients admitted to the Fourth People's Hospital of Tongxiang were selected.Among them, 93 cases with fertility requirements were selected as the study subjects.According to different surgical method, they were divided into observation group (46 cases) and control group (47 cases). The observation group was treated by laparoscopic surgery, while the control group was treated by open surgery.The operative indicators and complications were compared between the two groups.The pregnancy was followed up at 12 months after operation. \u0000 \u0000 \u0000Results \u0000The bleeding volume in the observation group was (43.24±8.98)mL, which was less than that in the control group[(87.94±15.46)mL], the anal exhaust time[(14.96±3.24)h] and the time of getting out of bed activity[(10.13±2.41)h]in the observation group were shorter than that in the control group[(26.53±2.89)h and (18.65±2.76)h], the hospitalization time[(5.41±1.23)d] and the operation time[(65.89±13.21)min] in the observation group were shorter than that in the control group[(7.87±1.54)d and (81.32±14.25)min], the differences between the two groups were statistically significant(t=17.002, 18.183, 15.844, 8.501, 5.405, all P<0.05). The incidence of postoperative complications in the observation group (6.52%) was lower than that in the control group (25.53%) (χ2=6.211, P<0.05). The intrauterine pregnancy rate in the observation group (78.26%) was higher than that in the control group (51.06%) (χ2=7.482, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Laparoscopic surgery is effective in the treatment of ectopic pregnancy.It can improve the rate of intrauterine pregnancy, reduce postoperative complications and shorten hospitalization time. \u0000 \u0000 \u0000Key words: \u0000Pregnancy, ectopic; Laparoscopic; Effect; Pregnancy; Complications","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"690-693"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48458379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of cognitive behavioral intervention on the burden of care and quality of life of primary caregivers in lung cancer patients with chemotherapy","authors":"Yifan Wu, Jianjuan Dai, Boshi Liu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.024","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.024","url":null,"abstract":"目的 \u0000分析认知行为干预用于肺癌化疗患者照顾者中对照顾者负担和生活质量的影响及临床应用价值。 \u0000 \u0000 \u0000方法 \u0000选取浙江大学舟山医院2017年4月至2018年4月化疗的肺癌患者主要照顾者150例，采用随机数字表法分为对照组75例、观察组75例。对照组采取健康宣教，观察组联合认知行为干预措施。比较两组照顾者照顾负担和生活质量。 \u0000 \u0000 \u0000结果 \u0000观察组干预后个人负担评分(24.86±1.02)分、责任负担担评(7.02±1.12)分、照顾者负担量表评分(ZBI)总分(38.98±2.03)分，对照组分别为(28.99±1.98)分、(8.87±1.86)分、(45.22±3.47)分，两组差异均有统计学意义(t＝6.198、5.329、6.103，均P<0.05)。观察组干预后焦虑自评量表评分(44.23±2.54)分、抑郁自评量表评分(47.04±3.26)分，对照组分别为(52.98±4.93)分、(58.97±4.96)分，两组差异均有统计学意义(t＝6.198、7.810，均P<0.05)。观察组身体健康、心理健康、社会适应、精神健康、生活质量评分总分分别为(42.97±3.21)分、(24.12±2.23)分、(45.76±2.76)分、(51.54±2.88)分、(171.67±9.76)分，对照组分别为(32.54±1.65)分、(12.51±1.13)分、(32.31±1.46)分、(40.24±1.25)分、(134.65±4.08)分，两组差异均有统计学意义(t＝11.329、12.818、13.027、12.387、14.028，均P<0.05)。 \u0000 \u0000 \u0000结论 \u0000认知行为干预应用在肺癌化疗患者主要照顾者中能够减轻负性情绪，提升照顾者生活质量，减轻照顾负担。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"748-751"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46751670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of autologous fat particles combined with silicone gel prosthesis in augmentation mammoplasty","authors":"Y. Zeng, Qi Hong","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.022","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.022","url":null,"abstract":"目的 \u0000分析自体脂肪颗粒联合硅凝胶假体在隆乳术中的应用效果。 \u0000 \u0000 \u0000方法 \u0000选择2015年3月至2018年3月在东阳市红十字会医院接受隆乳术治疗的哺乳后乳腺萎缩患者125例，按照随机数字表法分为观察组68例、对照组57例，对照组采取硅凝胶假体隆乳术，观察组采取自体脂肪颗粒联合硅凝胶假体隆乳术。比较两组术后并发症发生情况，术后6个月乳房美观程度以及患者手术前后生活质量改善情况。 \u0000 \u0000 \u0000结果 \u0000术前两组患者乳房美观程度比较差异无统计学意义(10.53%比13.24%，χ2＝0.216，P>0.05)；术后6个月，两组患者乳房美观程度均较术前显著提升(56.14%比10.53%、79.41%比13.24%，χ2＝26.684、59.883，均P 0.05)；术前两组患者心理状态、情感状态以及日常社交评分差异均无统计学意义[(65.24±6.33)分比(64.85±5.93)分，(62.12±7.84)分比(61.03±6.49)分，(65.92±9.24)分比(67.52±7.21)分，t＝0.355、0.851、1.087，均P>0.05]；术后6个月两组患者心理状态、情感状态以及日常社交评分均较术前显著升高[(65.24±6.33)分比(80.11±7.95)分，(62.12±7.84)分比(79.69±6.95)分，(65.92±9.24)分比(82.31±6.90)分，(65.92±9.24)分比(82.31±6.90)分，(64.85±5.93)分比(87.53±8.34)分，(61.03±6.49)分比(84.52±7.82)分，(67.52±7.21)分比(88.50±8.04)分，t＝11.047、12.661、10.730、18.276、19.061、16.020，均P<0.05]，且术后6个月观察组患者心理状态、情感状态以及日常社交评分显著高于对照组[(80.11±7.95)分比(87.53±8.34)分，(79.69±6.95)分比(84.52±7.82)分，(82.31±6.90)分比(88.50±8.04)，t＝5.061、3.617、4.570，均P<0.05]。 \u0000 \u0000 \u0000结论 \u0000自体脂肪颗粒联合硅凝胶假体隆乳术具有着较好的安全性，且更有助于患者乳房外观形态的改善以及生活质量的提高。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"741-744"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44016906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical efficacy of dydrogesterone and progesterone in the treatment of threatened abortion","authors":"Shasha Ying, Man-man Zhang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.008","url":null,"abstract":"Objective \u0000To compare the clinical effect of dydrogesterone and progesterone in the treatment of threatened abortion. \u0000 \u0000 \u0000Methods \u0000From March 2015 to May 2017, 50 patients with threatened abortion admitted in the Maternal and Child Health Hospital of Ninghai County were selected and randomly divided into two groups according to the digital table, with 25 cases in each group.The control group was treated with progesterone.The observation group was treated with dydrogesterone.The hormone levels, symptom disappearance time, fetal retention and adverse drug reactions were compared between the two groups. \u0000 \u0000 \u0000Results \u0000One week after treatment, the levels of progesterone, estradiol and human chorionic gonadotropin in the observation group were (1 12.65±6.35)nmol/L, (2 137.99±371.22)pmol/L, (4 261.54±245.55)IU/L, respectively, which in the control group were (101.56±5.32)nmol/L, (1 782.12±350.71)pmol/L, (3 642.26±210.20)IU/L, respectively, the differences between the two groups were statistically significant (t=6.694, 3.484, 9.581, all P 0.05). \u0000 \u0000 \u0000Conclusion \u0000The effect of dydrogesterone in the treatment of threatened abortion is better than progesterone. \u0000 \u0000 \u0000Key words: \u0000Abortion, threatened; Progesterone; Dydrogesterone; Receptors, progesterone; Estradiol; Chorionic gonadotropin; Drug therapy; Comparative study","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"676-680"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42971623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problems and countermeasures in the operation of medical complex of secondary general hospitals","authors":"Li Xu","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.025","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.025","url":null,"abstract":"通过对二级综合性医院医疗联合体运行中存在问题进行分析，构建起行之有效的管理机制，实现更为高效地运行。申请加大政策支持，医联体内医保联动；利用现代信息技术提高医联体的资源共享；增强共享机制，充分发挥出分工协作作用；加强医联体内部建设。通过科学管理，提高医联体运行质量。","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"752-754"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48845316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early diagnosis of intermuscular venous thrombosis of lower extremity after gynecological operation","authors":"Qingjiang Liu, Chaojie Zhou, Yingzi Zhang","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.029","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.029","url":null,"abstract":"Due to the particularity of pelvic anatomical structure, intermuscular venous thrombosis of lower extremity is very easy to form after gynecologic surgery.After thrombosis, it can migrate and diffuse, leading to fatal pulmonary embolism or sequelae of thrombosis after organization.Seriously, it will threaten patients' health and quality of life.How to evaluate and diagnose early is especially vital.In this article, the early diagnosis of intermuscular venous thrombosis of lower extremity after gynecologic surgery was summarized.Mainly from the aspects of high risk factors, application of risk assessment scale, clinical manifestations, auxiliary examination and so on., it was briefly analyzed. \u0000 \u0000Key words: \u0000Venous thrombosis; Lower extremity; Gynecologic surgical procedures; Diagnosis","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"766-768"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48184401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study of Naoxintong capsule combined with levamlodipine tablets in the treatment of essential hypertension","authors":"Zhiyong Li","doi":"10.3760/CMA.J.ISSN.1008-6706.2020.06.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6706.2020.06.017","url":null,"abstract":"Objective \u0000To investigate the clinical effect of Naoxintong capsule combined with levamlodipine tablets in the treatment of essential hypertension. \u0000 \u0000 \u0000Methods \u0000From February 2018 to February 2019, 182 cases of essential hypertension were selected in Jiangshan Hospital of Traditional Chinese Medicine and divided into treatment group (91 cases) and control group (91 cases) according to the random digital table.The treatment group was treated with Naoxintong capsule combined with levamlodipine tablets, while the control group was treated with levamlodipine tablets.Both two groups were treated for 12 weeks.The therapeutic effects, blood pressure, urinary microalbumin (MAU), vascular endothelial function and inflammatory mediators before and after treatment were compared between the two groups. \u0000 \u0000 \u0000Results \u0000The total effective rate of the treatment group[91.21%(83/91)]was higher than that of the control group[79.12%(72/91)](χ2=5.262, P<0.05). After treatment, SBP[(132.36±8.27)mmHg], DBP[(84.35±5.32)mmHg]and MAU[(26.47±5.47)mg/L] in the treatment group were lower than those in the control group[(139.62±6.58)mmHg, (89.74±4.12)mmHg and (33.82±3.76)mg/L](t=6.553, 7.641, 10.563, all P<0.05). The NO[(52.17±5.36)μmol/L]and FMD[(7.98±0.42)%] in the treatment group were higher than those in the control group[(41.09±7.28)μmol/L and (6.79±0.37)%], while ADMA[(0.23±0.06)μmol/L]in the treatment group was lower than that in the control group[(0.34±0.07)μmol/L], the differences were statistically significant(t=11.692, 20.281, 11.382, all P<0.05). The serum levels of IL-1[(128.32±13.25)ng/L] and IL-4[(24.35±5.71)ng/L] in the treatment group were lower than those in the control group[(173.79±23.19)ng/L and (32.19±6.57)ng/L], while the serum IL-10 level[(23.54±3.25)ng/L] in the treatment group was higher than that in the control group[(18.09±4.86)ng/L], the differences were statistically significant(t=16.240, 8.592, 8.892, all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Naoxintong capsule combined with levamlodipine tablets is effective in the treatment of essential hypertension, which can reduce MAU, improve vascular endothelial dysfunction and alleviate inflammation. \u0000 \u0000 \u0000Key words: \u0000Hypertension; Therapeutic effect; Urinary microalbumin; Vascular endothelial function; Inflammatory mediator; Naoxintong capsule; Levamlodipine tablet","PeriodicalId":10226,"journal":{"name":"Chinese Journal of Primary Medicine and Pharmacy","volume":"27 1","pages":"719-723"},"PeriodicalIF":0.0,"publicationDate":"2020-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44686406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}