Clinical significance of high-risk human papillomavirus A9 infection in cervical cancer screening

中国基层医药 Pub Date : 2020-03-15 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.06.009

Su-Hsun Liu, Qingling Gong, Xiaoqing Lu, Jun Zhou

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Abstract

Objective To investigate the infection incidence of women with high-risk human papillomavirus(HPV) A9 in Quzhou, and to analyze its clinical significance in cervical cancer screening by combining with liquid-based cytology(TCT). Methods A total of 9 010 patients were collected from January 2017 to May 2018 in the Maternal and Child Health Hospital of Quzhou.HPV detection was performed by Cervista method.In combination with TCT, cervical biopsy was carried out under vaginal microscopy. Results Among 9 010 patients, 1 401 patients were HPV positive, and the A9 group had the highest rate for inspection(6.98%). The experiment data of the A9 group indicated that the portions of cervical intraepithelial lesions in liquid-based cytology NILM, ASC-US, LSIL, ASC-H, HSIL, SCC were 5.96%, 80.10%, 100.00%, 100.00%, 100.00%, respectively.Its coincidence rate with histology increased as liquid-based cytology increased, associated with high-grade lesions. Conclusion A9 group infection is the most important cause of cervical intraepithelial lesions in Quzhou.High-risk HPV test, especially A9 group infection combined with TCT, can effectively improve the accuracy of cervical cancer screening. Key words: Human papillomavirus; Infection; Cytological techniques; Uterine cervical neoplasms; Multiphasic screening; Precancerous conditions; Neoplasms, squamous cell; Colposcopy; Pathology, clinical

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高危型人乳头瘤病毒A9感染在宫颈癌症筛查中的临床意义

目的了解衢州市高危女性人乳头瘤病毒(HPV) A9感染情况，并结合液基细胞学(TCT)分析其在宫颈癌筛查中的临床意义。方法选取衢州市妇幼保健院2017年1月~ 2018年5月收治的9 010例患者。采用Cervista法检测HPV。结合TCT，在阴道显微镜下进行宫颈活检。结果9 010例患者中HPV阳性1 401例，其中A9组检出率最高(6.98%)。A9组实验数据显示，宫颈液基细胞学NILM、ASC-US、LSIL、ASC-H、HSIL、SCC病变占宫颈上皮内病变的比例分别为5.96%、80.10%、100.00%、100.00%、100.00%。其与组织学的符合率随着液基细胞学的增加而增加，与高级别病变相关。结论A9群感染是衢州地区宫颈上皮内病变的主要原因。高危HPV检测，特别是A9组感染联合TCT，可有效提高宫颈癌筛查的准确性。关键词:人乳头瘤病毒;感染;细胞学技术;子宫颈肿瘤;多相筛选;癌前条件;肿瘤，鳞状细胞;阴道镜;病理、临床

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来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.