青少年特应性皮炎血清维生素D水平及其临床意义

中国基层医药 Pub Date : 2020-03-01 DOI:10.3760/CMA.J.ISSN.1008-6706.2020.05.001

S. Hao

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The serum level of 25(OH)D3 in the AD group was lower than that in the control group[(18.43±3.73)μg/L vs.(19.47±3.27)μg/L, t=2.112, P=0.036]. The mean values of vitamin D deficiency, insufficiency and sufficiency in the AD group were (11.11±1.65)μg/L, (17.49±1.69)μg/L, (21.73±1.17)μg/L, respectively, which in the control group were (12.86±1.47)μg/L, (17.55±1.34)μg/L, (22.05±1.32)μg/L, respectively.The level of vitamin D deficiency in the AD group was significantly lower than that in the control group (t=2.588, P=0.017), but there were no statistically significant differences in vitamin D insufficiency and sufficiency between the AD group and control group.In 102 AD patients, 40 cases were mild, 29 cases were moderate and 33 cases were severe.The levels of 25-(OH)D3, TIgE and peripheral blood EOS% had statistically significant differences among the three groups (F=6.315, 35.813, 31.285, all P 0.05). 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引用次数: 0

摘要

目的探讨血清维生素D水平与青少年特应性皮炎（AD）严重程度的关系。方法选择2016年3月至2017年2月的102名AD青少年（AD组）和100名健康青少年（对照组）。比较两组维生素D的分布和血清水平。根据SCORAD评分将AD患者分为轻度组、中度组和重度组。检测三组患者的25-（OH）D3、总IgE（TIgE）和外周血嗜酸性粒细胞百分比（EOS%）水平。结果AD组与对照组维生素D缺乏、不足和充足的患者比例差异无统计学意义（χ2=2.718，P=0.027）。AD组血清25（OH）D3水平低于对照组[（18.43±3.73）μg/L对（19.47±3.27）μg/L，t=2.112，P=0.036]，AD组的不足和充足分别为（11.11±1.65）μg/L、（17.49±1.69）μg/L和（21.73±1.17）μg/L，对照组分别为（12.86±1.47）μ/L、（17.55±1.34）μg/L及（22.05±1.32）μg/L。AD组维生素D缺乏水平显著低于对照组（t=2.588，P=0.017），但AD组与对照组之间维生素D缺乏和充足程度无统计学显著差异。在102例AD患者中，40例为轻度，29例为中度，33例为重度。三组间25-（OH）D3、TIgE和外周血EOS%水平差异有统计学意义（F=6.315、35.813、31.285，均P＜0.05），重症组>中度组>轻度组（t=8.318，8.788，均P<0.01；t=4.322，4.784，均P<0.01），25-（OH）D3值与AD组的TIgE水平（r=-302，P<0.01）和EOS%（r=-508，P<0.01）呈负相关。结论青少年AD患者存在维生素D缺乏或不足，维生素D水平低与TIgE水平和EOS%高相关，AD的严重程度与血清TlgE水平和EOS%升高以及维生素D水平降低密切相关。关键词：皮炎、特应性；青少年；维生素D；疾病严重程度指数；IgE；嗜酸性粒细胞

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Serum vitamin D levels of atopic dermatitis in adolescents and its clinical significance

Objective To investigate the relationship between the serum level of vitamin D and severity of atopic dermatitis (AD) in adolescents. Methods From March 2016 to February 2017, 102 adolescents with AD(AD group) and 100 healthy adolescents(control group) were selected.The distribution and serum levels of vitamin D in the two groups were compared.According to SCORing atopic dermatitis (SCORAD) score, AD patients were divided into mild group, moderate group and severe group.The levels of 25-(OH)D3, total IgE (TIgE) and peripheral blood eosinophil cells percentage(EOS%) were detected in the three groups. Results There was no statistically significant difference in the proportion of patients with vitamin D deficiency, insufficiency and sufficiency between the AD group and control group(χ2=2.718, P=0.257). The serum level of 25(OH)D3 in the AD group was lower than that in the control group[(18.43±3.73)μg/L vs.(19.47±3.27)μg/L, t=2.112, P=0.036]. The mean values of vitamin D deficiency, insufficiency and sufficiency in the AD group were (11.11±1.65)μg/L, (17.49±1.69)μg/L, (21.73±1.17)μg/L, respectively, which in the control group were (12.86±1.47)μg/L, (17.55±1.34)μg/L, (22.05±1.32)μg/L, respectively.The level of vitamin D deficiency in the AD group was significantly lower than that in the control group (t=2.588, P=0.017), but there were no statistically significant differences in vitamin D insufficiency and sufficiency between the AD group and control group.In 102 AD patients, 40 cases were mild, 29 cases were moderate and 33 cases were severe.The levels of 25-(OH)D3, TIgE and peripheral blood EOS% had statistically significant differences among the three groups (F=6.315, 35.813, 31.285, all P 0.05). Regarding the TIgE level and EOS%, severe group>moderate group>mild group(t=8.318, 8.788, all P<0.01; t=4.322, 4.784, all P<0.01). The value of 25-(OH)D3 was negatively correlated with the TIgE level(r=-302, P<0.01) and EOS%(r=-508, P<0.01) in the AD group. Conclusion Vitamin D deficiency or insufficiency exists in adolescents with AD.Low level of vitamin D is correlated with high TIgE level and EOS%.The severity of AD is closely correlated with increased serum levels of TlgE and EOS%, as well as decreased serum levels of vitamin D. Key words: Dermatitis, atopic; Adolescents; Vitamin D; Severity of illness index; IgE; Eosinophilia cell

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来源期刊

中国基层医药

CiteScore

0.10

自引率

0.00%

发文量

32251

期刊介绍： Since its inception, the journal "Chinese Primary Medicine" has adhered to the development strategy of "based in China, serving the grassroots, and facing the world" as its publishing concept, reporting a large amount of the latest medical information at home and abroad, prospering the academic field of primary medicine, and is praised by readers as a medical encyclopedia that updates knowledge. It is a core journal in China's medical and health field, and its influence index (CI) ranks Q2 in China's academic journals in 2022. It was included in the American Chemical Abstracts in 2008, the World Health Organization Western Pacific Regional Medical Index (WPRIM) in 2009, and the Japan Science and Technology Agency Database (JST) and Scopus Database in 2018, and was included in the Wanfang Data-China Digital Journal Group and the China Academic Journal Comprehensive Evaluation Database.