Clinica Chimica Acta最新文献

{"title":"Non-nucleic acid biomarkers in early detection of lung cancer","authors":"Suresh Saravanan ,&nbsp;Ravikumar Baskar ,&nbsp;Vishwar Devendiran ,&nbsp;Natarajan Alangudi Palaniappan ,&nbsp;Mugip Rahaman Abdul Wahab ,&nbsp;S. Manivannan ,&nbsp;Safia Obaidur Rab ,&nbsp;Mohd Saeed ,&nbsp;Thirunavukkarasu Palaniyandi","doi":"10.1016/j.cca.2025.120642","DOIUrl":"10.1016/j.cca.2025.120642","url":null,"abstract":"<div><div>Lung cancer remains a leading cause of cancer mortality worldwide, largely due to its asymptomatic onset, histological heterogeneity, and frequent late-stage diagnosis. Conventional diagnostic approaches such as imaging and biopsies, although essential, are invasive, costly, and limited in detecting early-stage disease. These challenges have accelerated research into non-invasive biomarkers derived from body fluids. A structured literature search was performed in PubMed, Scopus, Web of Science, and ScienceDirect for studies published between 2010 and 2025. Peer-reviewed original research and review articles evaluating the clinical or translational role of non-nucleic acid biomarkers in early lung cancer detection were included, while non-English publications, case reports, and non-cancer studies were excluded. Among these, non-nucleic acid biomarkers including proteins, extracellular vesicles (EVs), circulating tumour cells (CTCs), and metabolic signatures are emerging as promising diagnostic tools. Protein markers such as CEA, CYFRA 21-1, and NSE demonstrate clinically relevant sensitivity and specificity. EVs provide a stable reservoir of tumour-derived molecules that reflect the tumour microenvironment. CTCs offer real-time insights into tumour progression and metastasis, while metabolomic profiling using LC-MS and NMR identifies distinct metabolic fingerprints linked to lung cancer pathogenesis. This review critically assesses recent advances, applicability, and technological platforms for detecting non-nucleic acid biomarkers, and compares them not only with nucleic acid-based biomarkers but also with conventional diagnostic methods such as imaging and tissue biopsies. Integrating these biomarkers into clinical workflows may complement existing tools, enhance early diagnostic accuracy, and ultimately improve survival outcomes in lung cancer patients.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"579 ","pages":"Article 120642"},"PeriodicalIF":2.9,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the hCG test: Microbiome-based diagnosis of pregnancy","authors":"Prince Kumar ,&nbsp;Monica Gulati ,&nbsp;Bhupinder Kapoor ,&nbsp;Ankit Kumar Yadav ,&nbsp;Md Sadique Hussain ,&nbsp;Rajesh Kumar","doi":"10.1016/j.cca.2025.120639","DOIUrl":"10.1016/j.cca.2025.120639","url":null,"abstract":"<div><div>The complex but definitive relationship between pregnancy and the body microbiota offers a significant opportunity for novel diagnostic techniques. This work proposes a new diagnostic method that correlates the significant changes in the gut, vaginal, and oral microbiota composition that occur in the early stages of pregnancy. The main premise is identification of those microbial indicators that are strongly linked to early pregnancy by describing the periodic shifts in these microbial ecosystems. Early and precise pregnancy identification may be made possible by these biomarkers' potential as highly sensitive and precise indicators. More importantly, an understanding of the fundamental processes by which the microbiota in various organs affects pregnancy outcomes, tailored therapies to enhance the health of both the mother and the fetus may be considered as a long-term goal. Analysis of vaginal swabs or saliva is proposed as a non-invasive method that might transform prenatal care. Healthcare professionals might monitor pregnancy progress, understand and mitigate the expected problems, and initiate prompt measures by identifying early pregnancy indicators. Finding microbiome-based indicators of pregnancy complications may also make it possible to identify at-risk patients early and implement individualized treatment plans. We may get fresh understanding of the intricacies of pregnancy and create creative methods to enhance the health of both mothers and children by utilizing the potential of the human microbiome.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"579 ","pages":"Article 120639"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First automated immunoassay for symmetric dimethylarginine (SDMA) with reference interval establishment","authors":"Jillian Kodger ,&nbsp;Marilyn Strong-Townsend ,&nbsp;Giosi Farace ,&nbsp;Sarah Peterson ,&nbsp;Murthy Yerramilli ,&nbsp;Joe M. El-Khoury","doi":"10.1016/j.cca.2025.120638","DOIUrl":"10.1016/j.cca.2025.120638","url":null,"abstract":"<div><div>The measurement of kidney function is critical for early detection and management of acute kidney injury and chronic kidney disease. Traditional biomarkers such as creatinine and cystatin C are commonly used but have significant limitations due to factors such as muscle mass, diet, hydration, and extrarenal conditions. Creatinine-based equations have raised concerns over health equity regarding racial differences in estimates of kidney function. In response, symmetric dimethylarginine (SDMA) has emerged as a promising biomarker due to its reduced sensitivity to muscle mass and other extrarenal variables. However, the clinical adoption of SDMA has been limited by the need for more efficient, automated testing methods. This study aimed to evaluate the first fully automated immunoassay for SDMA and compare its performance to the gold-standard liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. We also established reference intervals using over five hundred samples from the Association for Diagnostics and Laboratory Medicine (formerly AACC) sample bank. Our results demonstrate that the automated IDEXX SDMA® immunoassay provides rapid, accurate, and reliable measurements, offering significant potential to introduce this biomarker to the clinical space to aid in diagnosing and treating kidney dysfunction.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"579 ","pages":"Article 120638"},"PeriodicalIF":2.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurofilament light chain - matrix comparison and long-term stability in frozen serum","authors":"Lea Tybirk ,&nbsp;Cindy Søndersø Knudsen ,&nbsp;Tina Parkner","doi":"10.1016/j.cca.2025.120637","DOIUrl":"10.1016/j.cca.2025.120637","url":null,"abstract":"<div><h3>Objective</h3><div>Neurofilament light chain (NfL) is a sensitive biomarker of neuronal damage and degeneration increasingly used both in research and clinical practice. We aimed to investigate the relationship between NfL concentration in cerebrospinal fluid (CSF), serum, and lithium-heparin plasma samples, and the storage stability of NfL in serum at −20 °C.</div></div><div><h3>Methods</h3><div>Serum and lithium-heparin plasma were compared by adding an extra lithium-heparin tube to routine serum NfL requisitions in our hospital until 50 samples were collected. Serum and CSF NfL were compared by extracting results of 955 paired samples from Danish hospitals taken within four hours of each other and analysed in our hospital laboratory. The stability of serum NfL during storage at −20 °C was assessed in 10 samples from the department of neurology, with repeated measurements performed over 12 months.</div></div><div><h3>Results</h3><div>Very strong correlations were observed between serum and lithium-heparin plasma (Spearman's rho = 0.98) and between serum and CSF (Spearman's rho = 0.80). A small positive bias of 3.7 % was found for lithium-heparin plasma versus serum, while the median CSF/serum ratio was 54.5 (range: 1.6–385.6). In both comparisons, considerable variability across individual sample pairs was observed, independent of NfL concentration. In the stability study, the mean change from baseline was −7.1 % (95 %CI: −1.7 %; −12.6 %) after 12 months at −20 <strong>°</strong>C.</div></div><div><h3>Conclusions</h3><div>NfL concentrations in different matrices were highly correlated, but due to variability across pairs, we recommend using the same matrix to monitor individual patients. Serum NfL concentrations remained stable during 12 months at −20 °C.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"579 ","pages":"Article 120637"},"PeriodicalIF":2.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycated albumin is a useful marker for early screening of undiagnosed prediabetes and diabetes in patients presenting to a metropolitan emergency department","authors":"Julie Sherfan ,&nbsp;Gail Del Olmo ,&nbsp;Myron Lee ,&nbsp;Andrew Ah-Loo ,&nbsp;David R. Sullivan ,&nbsp;Ian D. Caterson","doi":"10.1016/j.cca.2025.120624","DOIUrl":"10.1016/j.cca.2025.120624","url":null,"abstract":"<div><h3>Background</h3><div>Glycated albumin (GA) is formed from the non-enzymatic reaction of glucose with lysine residues of the albumin molecule. Its concentration reflects glycaemia in the preceding 3 weeks and has been proposed as an alternative marker in conditions when HbA1c is not accurate.</div></div><div><h3>Methods</h3><div>Patients presenting to the emergency department of a small metropolitan hospital were screened for diabetes and prediabetes using HbA1c, glycated albumin and fructosamine.</div></div><div><h3>Results</h3><div>Our in-house derived reference interval in adults &gt;18 years old was 163 to 280 mmol/mol (9.2–15.8 %). GA levels in chronic kidney disease and hypoalbuminaemia patients were not different from non-diabetic, apparently healthy group.</div><div>GA and fructosamine were found to be equally good at identifying patients at risk of prediabetes and diabetes. A GA level of ≥274 mmol/mol (16 %) had a diagnostic sensitivity and specificity of 65 % and 77 % in identifying prediabetes risk (AUC = 0.709) and GA ≥ 308 mmol/mol (17 %) had a sensitivity of 76 % and specificity of 92 % in identifying those at risk of diabetes (AUC = 0.863).</div><div>GA has a poor correlation with HbA1c (<em>R</em> = 0.410) and a GA of 458 mmol/mol (26 %) equated to an HbA1c of 48 mmol/mol (7 %).</div></div><div><h3>Conclusion</h3><div>Our study provides further evidence that GA can be used as an effective mid-term glycaemic marker in screening for prediabetes and diabetes in patients presenting to the emergency department.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"579 ","pages":"Article 120624"},"PeriodicalIF":2.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA biomarkers in psoriasis","authors":"Shikha Singh,&nbsp;Medha Rajappa","doi":"10.1016/j.cca.2025.120633","DOIUrl":"10.1016/j.cca.2025.120633","url":null,"abstract":"<div><div>Psoriasis, a T-helper mediated chronic inflammatory autoimmune skin disease, has significant socioeconomic burden worldwide. Unfortunately, its etiology and underlying pathophysiology remains unclear. Although several biologics have substantially improved therapy, recurrence is common. The identification of reliable biomarkers for early diagnosis, prognosis, and therapeutic response remains as a significant challenge. Advances in omics technologies have enabled newer approaches in biomarker discovery including microRNAs. These small non-coding RNA molecules have emerged as promising biomarkers due to their regulatory roles in immune filtration, keratinocyte proliferation, apoptosis and inflammatory pathways in psoriasis. This review unites evidence on the prognostic and diagnostic potential of miRNAs in psoriasis. Role of specific miRNAs, such as miR-21, miR-31, miR-99a, miR-146a, miR-125b, and miR-203, miR-138, miR-155 in psoriasis pathogenesis and their association with disease severity, treatment response, and co-morbidities are explored. Furthermore, the integration of miRNA profiling with advanced omics technologies and machine learning provides a framework for developing predictive algorithms. The review consolidates the potential of miRNAs to guide personalized treatment strategies and their utility in monitoring therapeutic efficacy. Future research focusing on standardizing miRNA-based assays, integrating miRNA signatures with other omics approaches to enhance therapeutic outcomes and exploring their mechanistic roles may pave the way for their clinical translation as reliable biomarkers in management of the disease.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"579 ","pages":"Article 120633"},"PeriodicalIF":2.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter clinical validation of a novel rapid single-integrated TAT immunoassay and combined thrombosis biomarker panel for venous thromboembolism risk stratification in colorectal cancer","authors":"Meng Liu ,&nbsp;Chaolin Guo ,&nbsp;Hongsheng Zhou ,&nbsp;Ziyan Xie ,&nbsp;Yankun Yang ,&nbsp;Kuiqi Jin ,&nbsp;Jianqi Nie ,&nbsp;Jinhua Xiao ,&nbsp;Yang Sun ,&nbsp;Zhonghu Bai","doi":"10.1016/j.cca.2025.120631","DOIUrl":"10.1016/j.cca.2025.120631","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to validate the reliability of a novel point-of-care testing technology for measuring the thrombin–antithrombin III complex (TAT) and to evaluate its utility in evaluating venous thromboembolism (VTE) risk and enabling dynamic monitoring in patients with colorectal cancer (CRC).</div></div><div><h3>Design and methods</h3><div>The novel immunoassay for TAT measurement was assessed against a reference system. Biomarker levels-including TAT, plasmin–α2-antiplasmin complex (PIC), thrombomodulin (TM), and tissue plasminogen activator-inhibitor complex (tPAIC)-were quantified in patients with CRC and healthy controls. Statistical analyses were conducted to assess differences among various groups. Receiver operating characteristic (ROC) curve analysis was employed to evaluate the predictive performance of biomarkers for VTE risk stratification.</div></div><div><h3>Results</h3><div>The novel TAT assay showed excellent correlation with the reference method (<em>r</em> &gt; 0.99). All biomarkers were significantly elevated in CRC patients compared to healthy controls (<em>p</em> &lt; 0.001), with TAT and PIC levels increasing by 3.5-fold and 2.4-fold, respectively. Significant differences in the levels of TAT, PIC, and tPAIC were also observed between CRC patients with VTE and those without VTE (<em>p</em> &lt; 0.001). Advanced-stage patients showed a median TAT concentration 1.8-fold higher than early-stage patients (p &lt; 0.001). ROC analysis revealed strong predictive performance for TAT and the combined biomarker model, with an area under the curve (AUC) of 0.9544, sensitivity of 90.5 %, and specificity of 93.5 %.</div></div><div><h3>Conclusions</h3><div>The novel TAT immunoassay represents a reliable system for clinical application. Furthermore, a combined biomarker model enhances VTE risk stratification in CRC patients, providing a valuable strategy for personalized anticoagulant therapy and dynamic monitoring.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"579 ","pages":"Article 120631"},"PeriodicalIF":2.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICBCCR: A new path for harmonization and clinical verification on a multi-center real-world cohort of 278703","authors":"Penghui Zhang ,&nbsp;Zhiwu Dong ,&nbsp;Yingting Wu ,&nbsp;Lufei Jiang ,&nbsp;Huiling Fang ,&nbsp;Xue Yuan ,&nbsp;Houqun Ying ,&nbsp;Chong Chen ,&nbsp;Xin Chang ,&nbsp;Xinxin Ren ,&nbsp;Manman Zhang ,&nbsp;Wenqing Chu ,&nbsp;Lianxiang Xing ,&nbsp;Keliang Huang ,&nbsp;Weiyi Wu ,&nbsp;Yuqing Zhu","doi":"10.1016/j.cca.2025.120632","DOIUrl":"10.1016/j.cca.2025.120632","url":null,"abstract":"<div><h3>Background</h3><div>In this study, we aimed to develop a novel harmonization algorithm to achieve the conversion from current results to harmonized results directly and perform a clinical verification on a multi-center real-world cohort of 278,703.</div></div><div><h3>Methods</h3><div>Sixty patient samples were collected as harmonization reference materials to develop and internally validate the harmonization algorithm. We assessed the harmonization effectiveness through multiple dimensions such as method comparison and evaluation. Then, the harmonization algorithm was performed on 278,703 sample results. We compared the distributions of the harmonized results from different in vitro diagnostic measurement devices through the Bhattacharyya distance.</div></div><div><h3>Results</h3><div>After harmonized by the novel algorithm, equivalent results were obtained among 5 in vitro diagnostic measurement devices for MYO with mean percent differences from −1.5 % to −0.1 % and the 95 % limits of agreement from 14.1 % to 20.3 % and for CK-MB with mean percent differences from −0.2 % to 1.1 % and the 95 % limits of agreement from 14.5 % to 36.6 %. The coefficients of variation of the results for the same sample presented a significant decrease from 20.6 % to 4.6 % for MYO and from 38.6 % to 5.3 % for CK-MB. Furthermore, after the harmonization algorithm was performed on 278,703 sample results from the real world, the Bhattacharyya distance decreased from 0.0046 to 0.0019 for MYO and from 0.0949 to 0.0049 for CK-MB after harmonization, respectively.</div></div><div><h3>Conclusions</h3><div>The novel algorithm is a new path for harmonization only based on current results and its clinical applicability has been fully verified in the real world.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"579 ","pages":"Article 120632"},"PeriodicalIF":2.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"The predictive value of serum mRNA-RGS10 for the severity and prognosis of acute pancreatitis\" [Clin. Chim. Acta 578 (2026) 120531].","authors":"Jie Li, Hanhui Li, Xiaoping Tan, Jun Zhang, Shengqi Du, Yueyue Lu, Qing Zhang","doi":"10.1016/j.cca.2025.120622","DOIUrl":"https://doi.org/10.1016/j.cca.2025.120622","url":null,"abstract":"","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":" ","pages":"120622"},"PeriodicalIF":2.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clot waveform analysis potentially provides predictive information on the sensitivity of activated partial thromboplastin time reagents to lupus anticoagulants","authors":"Shusaku Oka ,&nbsp;Masatoshi Wakui ,&nbsp;Yuta Fujimori ,&nbsp;Terumichi Nakagawa ,&nbsp;Maria Ziparo ,&nbsp;Hisao Haniu ,&nbsp;Hiromichi Matsushita","doi":"10.1016/j.cca.2025.120628","DOIUrl":"10.1016/j.cca.2025.120628","url":null,"abstract":"<div><h3>Background</h3><div>While previous studies have assessed the clinical values of clot waveform analysis (CWA) for detecting lupus anticoagulants (LA), there are no reports focusing on whether CWA predicts the LA sensitivity of activated partial thromboplastin time (APTT) reagents. The present study aimed to assess the usefulness of CWA in evaluating the LA sensitivity of APTT reagents.</div></div><div><h3>Methods</h3><div>Commercially available pooled normal plasma (PNP) and LA-positive plasma control (LPC) were used. CWA findings were compared among nine APTT reagents.</div></div><div><h3>Results</h3><div>Waveform abnormality appeared in assays with six APTT reagents for LPC but not for PNP. No waveform abnormality was evident in assays with three reagents for LPC or for PNP. In assays using reagents exhibiting waveform abnormality, APTT for LPC was longer and ratios of APTT for LPC/APTT for PNP were higher. Waveform abnormality was associated with indexes for evaluating mixing tests. Quantitative evaluation regarding the reduction of CWA parameters adjusted to compensate the influence of fibrinogen was likely applicable for predicting the LA sensitivity of APTT reagents.</div></div><div><h3>Conclusion</h3><div>The present study suggested the usefulness of CWA for evaluating the LA sensitivity of APTT reagents. The results provide insights into use of APTT reagents for LA screening.</div></div>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":"579 ","pages":"Article 120628"},"PeriodicalIF":2.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}