Beyond the hCG test: Microbiome-based diagnosis of pregnancy

Abstract

The complex but definitive relationship between pregnancy and the body microbiota offers a significant opportunity for novel diagnostic techniques. This work proposes a new diagnostic method that correlates the significant changes in the gut, vaginal, and oral microbiota composition that occur in the early stages of pregnancy. The main premise is identification of those microbial indicators that are strongly linked to early pregnancy by describing the periodic shifts in these microbial ecosystems. Early and precise pregnancy identification may be made possible by these biomarkers' potential as highly sensitive and precise indicators. More importantly, an understanding of the fundamental processes by which the microbiota in various organs affects pregnancy outcomes, tailored therapies to enhance the health of both the mother and the fetus may be considered as a long-term goal. Analysis of vaginal swabs or saliva is proposed as a non-invasive method that might transform prenatal care. Healthcare professionals might monitor pregnancy progress, understand and mitigate the expected problems, and initiate prompt measures by identifying early pregnancy indicators. Finding microbiome-based indicators of pregnancy complications may also make it possible to identify at-risk patients early and implement individualized treatment plans. We may get fresh understanding of the intricacies of pregnancy and create creative methods to enhance the health of both mothers and children by utilizing the potential of the human microbiome.