Circulation: Cardiovascular Imaging最新文献

{"title":"Unfolding Evidence on Risk Stratification in Women Using Quantitative Atherosclerotic Plaque Measurements.","authors":"Leslee J Shaw, Fay Y Lin","doi":"10.1161/CIRCIMAGING.125.018438","DOIUrl":"10.1161/CIRCIMAGING.125.018438","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018438"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Quantitative CT Coronary Plaque Features Associate With a Higher Relative Risk in Women: CONFIRM2 Registry.","authors":"Gudrun M Feuchtner, Pietro G Lacaita, Jeroen J Bax, Fatima Rodriguez, Rine Nakanishi, Gianluca Pontone, Saima Mushtaq, Ronny R Buechel, Christoph Gräni, Amit R Patel, Cristiane C Singulane, Andrew D Choi, Mouaz Al-Mallah, Daniele Andreini, Ronald P Karlsberg, Geoffrey Cho, Carlos E Rochitte, Mirvat Alasnag, Ashraf Hamdan, Filippo Cademartiri, Erica Maffei, Hugo Marques, Pedro M Gonçalves Pereira, Himanshu Gupta, Martin Hadamitzky, Omar Khalique, Dinesh Kalra, James D Mills, Nick S Nurmohamed, Paul Knaapen, Matthew Budoff, Kashif Shaikh, Enrico Martin, David M German, Maros Ferencik, Andrew C Oehler, Roderick Deaño, Prashant Nagpal, Marly Van Assen, Carlo Nicola De Cecco, Borek Foldyna, Jan Michael Brendel, Victor Y Cheng, Kelley Branch, Marcio Bittencourt, Sabha Bhatti, Venkateshwar Polsani, George Wesbey, Rhanderson Cardoso, Ron Blankstein, Augustin Delago, Amit Pursnani, Amro Alsaid, Stephen Bloom, Vasileios Kamperidis, Fabian Barbieri, Melissa Aquino, Ibrahim Danad, Alexander van Rosendael","doi":"10.1161/CIRCIMAGING.125.018235","DOIUrl":"10.1161/CIRCIMAGING.125.018235","url":null,"abstract":"<p><strong>Background: </strong>Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic value. This study aimed to define sex differences in the coronary atherosclerotic phenotypes assessed by artificial intelligence-based quantitative computed tomography (AI-QCT) and the associated risk of major adverse cardiovascular events (MACEs).</p><p><strong>Methods: </strong>Global multicenter registry including symptomatic patients with suspicion of coronary artery disease referred for coronary computed tomography angiography. AI-QCT analyzed 16 coronary artery disease features. The primary end point was MACE defined as death, myocardial infarction, late revascularization, cerebrovascular events, unstable angina, and congestive heart failure.</p><p><strong>Results: </strong>Among 3551 patients (mean age, 59±12 years; 49.5% women), MACE occurred in 3.2% of women and 6.1% of men during an average follow-up of 4.8±2.2 years. The AI-QCT features total plaque volume, noncalcified plaque, calcified plaque, and percentage atheroma volume were significantly higher in men (<i>P</i><0.001), and high-risk plaques were more prevalent (9.2% versus 2.5%; <i>P</i><0.0001). Independent of age and cardiovascular risk factors, the AI-QCT-derived features of total plaque volume, noncalcified plaque, calcified plaque, and percentage atheroma volume conferred a higher relative risk of MACE in women than men. For every 50-mm³ increase in total plaque volume, relative risk increased by 17.7% (95% CI, 1.12-1.24) in women versus 5.3% (95% CI, 1.03-1.07) in men (<i>P</i>_interaction<0.001); for noncalcified plaque, relative risk increased by 27.1% (95% CI, 1.17-1.38) versus 11.6% (95% CI, 1.08-1.15; <i>P</i>_interaction=0.0015); and for calcified plaque, relative risk increased by 22.9% (95% CI, 1.14-1.33) versus 5.4% (95% CI, 1.01-1.10; <i>P</i>_interaction=0.0012), respectively. Similarly, for percentage atheroma volume, the risk was higher in women. The findings remained unchanged when restricted to a secondary composite end point (death and myocardial infarction).</p><p><strong>Conclusions: </strong>The AI-QCT plaque features, total plaque volume, noncalcified plaque, calcified plaque, and percentage atheroma volume, conferred a higher relative MACE risk in women and may prompt more aggressive antiatherosclerotic therapy and reinforced preventive interventions.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT04279496.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018235"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Barbieri et al Regarding Article, \"Abnormal Exercise Electrocardiography With Normal Stress Echocardiography Is Associated With Subclinical Coronary Atherosclerosis\".","authors":"Andrea Barbieri, Francesca Bursi, Francesca Mantovani","doi":"10.1161/CIRCIMAGING.125.018294","DOIUrl":"10.1161/CIRCIMAGING.125.018294","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018294"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹²⁴I-Evuzamitide PET/CT Diagnosis of Wild-Type Transthyretin Amyloid Cardiomyopathy in a Woman With Negative Diagnostic Evaluation.","authors":"Annu Kurian, Alyssa de Moraes, Olivier F Clerc, Ardel J Romero Pabon, Robert F Padera, Sarah A M Cuddy, Sharmila Dorbala","doi":"10.1161/CIRCIMAGING.124.017807","DOIUrl":"10.1161/CIRCIMAGING.124.017807","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017807"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Left Ventricular Remodeling in Fabry Cardiomyopathy: The Key Diagnostic Role of T1 Mapping.","authors":"Stefano Censi, Giada De Angeli, Federico Pieruzzi, Lara Tondi, Gianluigi Guida, Giandomenico Disabato, Andrea Attanasio, Pietro Spagnolo, Gianpaolo Carrafiello, Massimo Lombardi, Antonia Camporeale","doi":"10.1161/CIRCIMAGING.124.017640","DOIUrl":"10.1161/CIRCIMAGING.124.017640","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017640"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absolute Myocardial Blood Flow Quantification With PET: Should Diagnostic Cutoffs Be Tracer Specific?","authors":"Prem Soman, Robert J Gropler, Robert A deKemp","doi":"10.1161/CIRCIMAGING.125.018354","DOIUrl":"10.1161/CIRCIMAGING.125.018354","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018354"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic Stenosis Grading With CT: Do We Still Need Noncontrast Scans?","authors":"Matthias Eberhard, Hatem Alkadhi","doi":"10.1161/CIRCIMAGING.125.018437","DOIUrl":"10.1161/CIRCIMAGING.125.018437","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018437"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Perfusion Imaging With PET: A Head-to-Head Comparison of ⁸²Rubidium Versus ¹⁵O-water Tracers Using Invasive Coronary Measurements as Reference.","authors":"Simon Winther, Laust Dupont Rasmussen, Salma Raghad Karim, Jelmer Westra, Jonathan Nørtoft Dahl, Jacob Hartmann Søby, Louise Nissen, Fabian Bøgild Lomstein, Morten Würtz, Jens Munch Sundbøll, June Anita Ejlersen, Jesper Mortensen, Lars Poulsen Tolbod, Hanne Maare Søndergaard, Nicolaj Christopher Lyng Hansson, Mette Nyegaard, Rebekka Vibjerg Jensen, Michael Alle Madsen, Evald Høj Christiansen, Lars Christian Gormsen, Morten Böttcher","doi":"10.1161/CIRCIMAGING.124.017479","DOIUrl":"10.1161/CIRCIMAGING.124.017479","url":null,"abstract":"<p><strong>Background: </strong>Myocardial perfusion imaging by positron emission tomography (PET) is recommended as a first-line test in stable patients with chest pain symptoms and as a selective second-line test after an abnormal coronary computed tomography angiography (CTA). It is, however, unknown whether the use of Rubidium-82 (⁸²Rb) versus [¹⁵O]H₂O (¹⁵O-water) affects the diagnostic performance in coronary artery disease (CAD). The aim of this study was to compare ⁸²Rb-PET versus ¹⁵O-water-PET head-to-head for diagnosing obstructive CAD.</p><p><strong>Methods: </strong>The study included consecutive patients (n=1000) referred for CTA with symptoms suggestive of obstructive CAD. Patients with suspected stenosis based on CTA were referred for both ⁸²Rb-PET, ¹⁵O-water-PET, and subsequently invasive coronary angiography (ICA), including 3-vessel fractional flow reserve and coronary flow reserve measurements.</p><p><strong>Results: </strong>In total, 196/270 (73%) patients with suspected stenosis on CTA completed ⁸²Rb-PET, ¹⁵O-water-PET, and ICA. Myocardial blood flow measurements from ⁸²Rb-PET and ¹⁵O-water-PET correlated strongly at rest (ρ, 0.62-0.69) but only moderately during hyperemia (ρ, 0.41-0.59). Only weak correlations were demonstrated between myocardial blood flow reserve by both PET tracers compared with ICA coronary flow reserve (ρ, 0.11-0.38). Hemodynamically obstructive CAD defined as ICA fractional flow reserve ≤0.80, was identified in 86/196 (44%) patients. Using predefined cutoffs, the diagnostic accuracies of ⁸²Rb-PET versus ¹⁵O-water-PET were similar (sensitivity 69% [58-78%] versus 71% [60-80%], <i>P</i>=0.59; specificity 85% [76-91%] versus 77% [68-85%], <i>P</i>=0.12). Using ICA diameter stenoses >70% as a reference, only 48/196 (24%) patients had anatomically severe CAD, and ⁸²Rb-PET and ¹⁵O-water-PET sensitivities increased to >85%.</p><p><strong>Conclusions: </strong>For detection of obstructive CAD by PET myocardial perfusion imaging, ⁸²Rb versus ¹⁵O-water have similar diagnostic performance.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT04707859.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017479"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cave Under the Aortic Valve: The Rare Left Ventricular Outflow Tract Pseudoaneurysm With Thrombosis.","authors":"Shuang Wang, Wanwan Song, Wenjun Yu, Jinping Liu, Bin Wang","doi":"10.1161/CIRCIMAGING.124.017574","DOIUrl":"10.1161/CIRCIMAGING.124.017574","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017574"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Post-PCI Lipid Core Burden Index on Angiographic and Clinical Outcomes: Insights From NIRS-IVUS.","authors":"Woohyeun Kim, Hyungdon Kook, Soojung Park, Ran Heo, Jin-Kyu Park, Jinho Shin, Yonggu Lee, Young-Hyo Lim","doi":"10.1161/CIRCIMAGING.124.017740","DOIUrl":"10.1161/CIRCIMAGING.124.017740","url":null,"abstract":"<p><strong>Background: </strong>The impact of lipid core burden index (LCBI) after percutaneous coronary intervention (PCI) in the stented segment assessed by intracoronary near-infrared spectroscopy on the outcomes remains unclear.</p><p><strong>Methods: </strong>In this prospective observational study, we aimed to assess the impact of post-PCI LCBI on late lumen loss and clinical outcomes. Post-PCI intracoronary near-infrared spectroscopy imaging was performed in the stented segment after PCI. Patients were categorized into 2 groups based on the post-PCI _maxLCBI_4mm with a cut-off value of 200. Angiographic and clinical outcomes were compared at 12 months. The primary end point was angiographic late lumen loss. The secondary end point was target lesion failure (composite of cardiovascular death, target vessel myocardial infarction, and clinically driven target lesion revascularization) and major adverse cardiac and cerebrovascular events (composite of cardiac death, myocardial infarction, any repeat revascularization, and stroke).</p><p><strong>Results: </strong>A total of 228 patients with 278 target lesions were followed up for 1 year. One-year follow-up angiography was performed on 198 lesions in 163 patients. Follow-up quantitative coronary angiography revealed that stented segments with post-PCI _maxLCBI_4mm ≥200 had higher late lumen loss compared with those with a post-PCI _maxLCBI_4mm <200 (mean, 0.503±0.683 mm versus 0.115±0.326 mm; <i>P</i><0.001; median, 0.250 mm versus 0.050 mm; <i>P</i><0.001). Patients with post-PCI _maxLCBI_4mm ≥200 had a significantly higher 1-year cumulative incidence of both target lesion failure (6.9% versus 0.6%; <i>P</i>=0.002) and major adverse cardiac and cerebrovascular events (15.1% versus 2.2%; <i>P</i><0.001).</p><p><strong>Conclusions: </strong>Post-PCI LCBI assessed by intracoronary near-infrared spectroscopy-intravascular ultrasound was associated with late lumen loss as well as subsequent target lesion failure and major adverse cardiac and cerebrovascular events.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017740"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}