Woohyeun Kim, Hyungdon Kook, Soojung Park, Ran Heo, Jinkyu Park, Jinho Shin, Yonggu Lee, Young-Hyo Lim
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The secondary end point was target lesion failure (composite of cardiovascular death, target vessel myocardial infarction, and clinically driven target lesion revascularization) and major adverse cardiac and cerebrovascular events (composite of cardiac death, myocardial infarction, any repeat revascularization, and stroke).</p><p><strong>Results: </strong>A total of 228 patients with 278 target lesions were followed up for 1 year. One-year follow-up angiography was performed on 198 lesions in 163 patients. Follow-up quantitative coronary angiography revealed that stented segments with post-PCI <sub>max</sub>LCBI<sub>4mm</sub> ≥200 had higher late luminal loss compared with those with a post-PCI <sub>max</sub>LCBI<sub>4mm</sub> <200 (mean, 0.503±0.683 mm versus 0.115±0.326 mm; <i>P</i><0.001; median, 0.250 mm versus 0.050 mm; <i>P</i><0.001). Patients with post-PCI <sub>max</sub>LCBI<sub>4mm</sub> ≥200 had a significantly higher 1-year cumulative incidence of both target lesion failure (6.9% versus 0.6%; <i>P</i>=0.002) and major adverse cardiac and cerebrovascular events (15.1% versus 2.2%; <i>P</i><0.001).</p><p><strong>Conclusions: </strong>Post-PCI LCBI assessed by intracoronary near-infrared spectroscopy-intravascular ultrasound was associated with late luminal loss as well as subsequent target lesion failure and major adverse cardiac and cerebrovascular events.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017740"},"PeriodicalIF":6.5000,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of Post-PCI Lipid Core Burden Index on Angiographic and Clinical Outcomes: Insights From NIRS-IVUS.\",\"authors\":\"Woohyeun Kim, Hyungdon Kook, Soojung Park, Ran Heo, Jinkyu Park, Jinho Shin, Yonggu Lee, Young-Hyo Lim\",\"doi\":\"10.1161/CIRCIMAGING.124.017740\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The impact of lipid core burden index (LCBI) after percutaneous coronary intervention (PCI) in the stented segment assessed by intracoronary near-infrared spectroscopy on the outcomes remains unclear.</p><p><strong>Methods: </strong>In this prospective observational study, we aimed to assess the impact of post-PCI LCBI on late luminal loss and clinical outcomes. Post-PCI intracoronary near-infrared spectroscopy imaging was performed in the stented segment after PCI. Patients were categorized into 2 groups based on the post-PCI <sub>max</sub>LCBI<sub>4mm</sub> with a cut-off value of 200. Angiographic and clinical outcomes were compared at 12 months. The primary end point was angiographic late luminal loss. The secondary end point was target lesion failure (composite of cardiovascular death, target vessel myocardial infarction, and clinically driven target lesion revascularization) and major adverse cardiac and cerebrovascular events (composite of cardiac death, myocardial infarction, any repeat revascularization, and stroke).</p><p><strong>Results: </strong>A total of 228 patients with 278 target lesions were followed up for 1 year. One-year follow-up angiography was performed on 198 lesions in 163 patients. 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引用次数: 0
摘要
背景：冠状动脉内近红外光谱评估支架段经皮冠状动脉介入治疗（PCI）后脂质核心负荷指数（LCBI）对预后的影响尚不清楚。方法：在这项前瞻性观察性研究中，我们旨在评估pci后LCBI对晚期管腔损失和临床结果的影响。在PCI后支架段进行冠状动脉内近红外光谱成像。根据pci术后maxLCBI4mm分为两组，截断值为200。12个月时比较血管造影和临床结果。主要终点为血管造影晚期管腔丧失。次要终点是靶病变失败（心血管死亡、靶血管心肌梗死和临床驱动的靶病变血运重建的复合）和主要的心脑血管不良事件（心源性死亡、心肌梗死、任何重复血运重建和卒中的复合）。结果：共随访228例患者，靶病灶278个，随访1年。对163例患者的198个病变进行1年随访血管造影。随访定量冠状动脉造影显示，pci后支架段maxLCBI4mm≥200的晚期管腔损失高于pci后支架段maxLCBI4mm的晚期管腔损失，PPmaxLCBI4mm≥200的1年累积目标病变失败发生率显著高于pci后支架段(6.9% vs 0.6%；P=0.002)和主要的心脑血管不良事件(15.1% vs 2.2%；结论：经冠状动脉内近红外光谱-血管内超声评估的pci后LCBI与晚期管腔丧失、随后的靶病变失败和主要的心脑血管不良事件相关。
Impact of Post-PCI Lipid Core Burden Index on Angiographic and Clinical Outcomes: Insights From NIRS-IVUS.
Background: The impact of lipid core burden index (LCBI) after percutaneous coronary intervention (PCI) in the stented segment assessed by intracoronary near-infrared spectroscopy on the outcomes remains unclear.
Methods: In this prospective observational study, we aimed to assess the impact of post-PCI LCBI on late luminal loss and clinical outcomes. Post-PCI intracoronary near-infrared spectroscopy imaging was performed in the stented segment after PCI. Patients were categorized into 2 groups based on the post-PCI maxLCBI4mm with a cut-off value of 200. Angiographic and clinical outcomes were compared at 12 months. The primary end point was angiographic late luminal loss. The secondary end point was target lesion failure (composite of cardiovascular death, target vessel myocardial infarction, and clinically driven target lesion revascularization) and major adverse cardiac and cerebrovascular events (composite of cardiac death, myocardial infarction, any repeat revascularization, and stroke).
Results: A total of 228 patients with 278 target lesions were followed up for 1 year. One-year follow-up angiography was performed on 198 lesions in 163 patients. Follow-up quantitative coronary angiography revealed that stented segments with post-PCI maxLCBI4mm ≥200 had higher late luminal loss compared with those with a post-PCI maxLCBI4mm <200 (mean, 0.503±0.683 mm versus 0.115±0.326 mm; P<0.001; median, 0.250 mm versus 0.050 mm; P<0.001). Patients with post-PCI maxLCBI4mm ≥200 had a significantly higher 1-year cumulative incidence of both target lesion failure (6.9% versus 0.6%; P=0.002) and major adverse cardiac and cerebrovascular events (15.1% versus 2.2%; P<0.001).
Conclusions: Post-PCI LCBI assessed by intracoronary near-infrared spectroscopy-intravascular ultrasound was associated with late luminal loss as well as subsequent target lesion failure and major adverse cardiac and cerebrovascular events.
期刊介绍：
Circulation: Cardiovascular Imaging, an American Heart Association journal, publishes high-quality, patient-centric articles focusing on observational studies, clinical trials, and advances in applied (translational) research. The journal features innovative, multimodality approaches to the diagnosis and risk stratification of cardiovascular disease. Modalities covered include echocardiography, cardiac computed tomography, cardiac magnetic resonance imaging and spectroscopy, magnetic resonance angiography, cardiac positron emission tomography, noninvasive assessment of vascular and endothelial function, radionuclide imaging, molecular imaging, and others.
Article types considered by Circulation: Cardiovascular Imaging include Original Research, Research Letters, Advances in Cardiovascular Imaging, Clinical Implications of Molecular Imaging Research, How to Use Imaging, Translating Novel Imaging Technologies into Clinical Applications, and Cardiovascular Images.
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