Circulation: Cardiovascular Imaging最新文献

{"title":"Response to Letter Regarding Article, \"Association of Lipoprotein(a) With Changes in Coronary Atherosclerosis in Patients Treated With Alirocumab\".","authors":"Konstantinos C Koskinas, Lorenz Räber","doi":"10.1161/CIRCIMAGING.125.017965","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.125.017965","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017965"},"PeriodicalIF":6.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Cardiac Duo: Double Orifice Mitral Valve and Bicuspid Aortic Valve.","authors":"Chieh-Mei Tsai, Hector I Michelena, Ratnasari Padang, Sorin V Pislaru, Talha Niaz, Vuyisile T Nkomo","doi":"10.1161/CIRCIMAGING.124.017602","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017602","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017602"},"PeriodicalIF":6.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Natale et al Regarding Article, \"Association of Lipoprotein(a) With Changes in Coronary Atherosclerosis in Patients Treated With Alirocumab\".","authors":"Francesco Natale, Paolo Golino, Giovanni Cimmino","doi":"10.1161/CIRCIMAGING.124.017942","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017942","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017942"},"PeriodicalIF":6.5,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Assessment of Subclinical Arterial Inflammation in Patients Receiving Immune Checkpoint Inhibitors by Sequential [¹⁸F]FDG PET Scans.","authors":"Lucas Bacmeister, Niklas Hempfling, Alexander Maier, Susanne Weber, Annette Buellesbach, Adrian Heidenreich, Istvan Bojti, Mark Colin Gissler, Ingo Hilgendorf, Constantin von Zur Muehlen, Dirk Westermann, Philipp Tobias Meyer, Christian Goetz, Dennis Wolf","doi":"10.1161/CIRCIMAGING.124.016851","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.016851","url":null,"abstract":"<p><strong>Background: </strong>Immune checkpoint inhibitors (ICIs), though revolutionary in cancer treatment, may accelerate atherosclerosis by inducing arterial inflammation. Due to a lack of controlled studies, the capacity of arterial 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) uptake in patients with cancer to detect this arterial inflammation remains unclear.</p><p><strong>Methods: </strong>Arterial [¹⁸F]FDG uptake at 6 anatomic landmarks was assessed on serial positron emission tomography scans in patients with cancer treated at a German University Hospital between January 2010 and May 2023. Patients aged ≥65 years with at least 4 sequential scans within 30 months were included. Linear mixed regression analyses were used to evaluate the change in arterial tracer uptake in patients who received ICI or not.</p><p><strong>Results: </strong>Of the 156 patients included, 50 (30.1%) received ICIs after the baseline scan. Baseline arterial [¹⁸F]FDG uptake correlated with traditional cardiovascular risk factors, such as body mass index and male sex. Cross-sectional analyses suggested a negative effect of cholesterol-lowering medication on arterial [¹⁸F]FDG uptake at follow-up. In a time-dependent interaction analysis, arterial [¹⁸F]FDG uptake increased by 0.8% annually in patients without ICIs (95% CI, 0.2%-1.4%), potentially reflecting the background progression of arterial inflammation in patients with cancer. In ICI users, [¹⁸F]FDG uptake increased by 2.5% annually (95% CI, 1.7%-3.3%; <i>P</i>=0.001 for interaction with no ICI). Higher annual increase rates in ICI users were consistent across several anatomic landmarks, preexisting cardiovascular disease status, arterial calcification status, and concomitant chemotherapy or steroid use. However, this effect did not reach statistical significance in patients with melanoma and those with prior irradiation therapy.</p><p><strong>Conclusions: </strong>This is the first controlled clinical study supporting the role of ICIs in accelerating atherosclerosis through low-grade arterial inflammation. However, although detectable by repeated [¹⁸F]FDG scans, the increase in tracer uptake associated with ICI use was modest compared with individual variability, questioning whether [¹⁸F]FDG captures the full pathophysiological process of ICI-induced, lymphocyte-driven inflammation.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e016851"},"PeriodicalIF":6.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Myocarditis: Exploring the Vascular Impact of Immune Checkpoint Inhibitors.","authors":"Brett W Sperry, Patrick J Miller","doi":"10.1161/CIRCIMAGING.125.017937","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.125.017937","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017937"},"PeriodicalIF":6.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-In-Human Study of [⁶⁴Cu]Cu-DOTATATE PET/CT in Infective Endocarditis: A Prospective Head-to-Head Comparison With [¹⁸F]FDG.","authors":"Katra Hadji-Turdeghal, Marie Øbro Fosbøl, Philip Hasbak, Johan Löfgren, Ida Bull Rasmussen, Henning Bundgaard, Kasper Iversen, Niels Eske Bruun, Christian H Møller, Christian Tuxen, Helle Hjorth Johannesen, Lars Køber, Andreas Kjær, Rasmus Sejersten Ripa, Emil Loldrup Fosbøl","doi":"10.1161/CIRCIMAGING.124.017156","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017156","url":null,"abstract":"<p><strong>Background: </strong>Infective endocarditis (IE) can be challenging to diagnose. Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[¹⁸F]-fluoro-d-glucose ([¹⁸F]FDG) is recommended as a diagnostic tool in the guidelines, but holds limitations. The aim of this study was to compare the tracer uptake between the novel [⁶⁴Cu]Cu-DOTATATE, which has low cardiac uptake and does not require fasting or dietary restrictions, and [¹⁸F]FDG in patients with IE and examine the sensitivity and specificity.</p><p><strong>Methods: </strong>The CuDOS study (Cu-Dotatate Positron Emissions Tomography in Infective Endocarditis) was a prospective study including 20 patients with IE (10 with prosthetic valve endocarditis and 10 with native valve endocarditis) and 20 controls. All participants underwent [⁶⁴Cu]Cu-DOTATATE and [¹⁸F]FDG PET/CT. Scans were read blinded to clinical data. Tracer uptakes were measured as maximum standardized uptake values in each heart valve. Differences were tested with Wilcoxon rank tests.</p><p><strong>Results: </strong>The median age of the cases and controls was 68 years (interquartile range [IQR], 55.0-75.5) and 61 years (IQR, 57.0-69.5), respectively. [⁶⁴Cu]Cu-DOTATATE uptake (median maximum standardized uptake value [IQR]) in patients with IE was higher than in controls (2.34 [1.40-3.23] versus 1.44 [1.21-1.60]; <i>P</i> =0.008), although this difference was mainly driven by prosthetic valve endocarditis cases (3.23 [2.02-3.86]; <i>P</i> <0.001) and not between native valve endocarditis cases and controls (1.51 [1.23-2.58]; <i>P</i>=0.428). The sensitivity of [⁶⁴Cu]Cu-DOTATATE and [¹⁸F]FDG PET/CT in 20 cases versus 20 controls were equal, and the specificity was 90% and 75%, respectively. The analysis of prosthetic valve endocarditis versus the 20 controls showed equal sensitivity (80%), and a specificity of 90% and 75%, respectively (<i>P</i> =0.38). In addition, a greater proportion of scans achieved diagnostic certainty with [⁶⁴Cu]Cu-DOTATATE PET/CT compared with [¹⁸F]FDG PET/CT for native valve endocarditis, prosthetic valve endocarditis, and controls.</p><p><strong>Conclusions: </strong>[⁶⁴Cu]Cu-DOTATATE PET/CT showed uptake in the infected valve in patients with IE, and has major advantage as it does not require any preparation compared with [¹⁸F]FDG. [⁶⁴Cu]Cu-DOTATATE had a numerically higher specificity than [¹⁸F]FDG, although the difference was not statistically significant. Both tracers were limited in the detection of native valve endocarditis.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT05432427. www.clinicaltrialsregister.eu; Unique identifier: 2021-005501-27.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017156"},"PeriodicalIF":6.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Left Ventricular Remodeling in Fabry Cardiomyopathy: The Key Diagnostic Role of T1 Mapping.","authors":"Stefano Censi, Giada De Angeli, Federico Pieruzzi, Lara Tondi, Gianluigi Guida, Giandomenico Disabato, Andrea Attanasio, Pietro Spagnolo, Gianpaolo Carrafiello, Massimo Lombardi, Antonia Camporeale","doi":"10.1161/CIRCIMAGING.124.017640","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017640","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017640"},"PeriodicalIF":6.5,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Changes in Myocardial Deformation in Hutchinson-Gilford Progeria Syndrome.","authors":"Flemming J Olsen, Tor Biering-Sørensen, Fatima I Lunze, Sheila M Hegde, Rachel Ehrbar, Joseph Massaro, Alessandra M Ferraro, David M Harrild, Monica E Kleinman, Leslie B Gordon, Ashwin Prakash","doi":"10.1161/CIRCIMAGING.124.017544","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017544","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017544"},"PeriodicalIF":6.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cave Under the Aortic Valve: The Rare Left Ventricular Outflow Tract Pseudoaneurysm With Thrombosis.","authors":"Shuang Wang, Wanwan Song, Wenjun Yu, Jinping Liu, Bin Wang","doi":"10.1161/CIRCIMAGING.124.017574","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017574","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017574"},"PeriodicalIF":6.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal Exercise Electrocardiography With Normal Stress Echocardiography Is Associated With Subclinical Coronary Atherosclerosis.","authors":"Jessica M Duran, Peter Shrader, Chuan Hong, Francois Haddad, Everton J Santana, Nicholas Cauwenberghs, Tatiana Kouznetsova, Michael Salerno, Gerald Bloomfield, Lynne Koweek, Adrian Hernandez, Kenneth W Mahaffey, Svati H Shah, Pamela S Douglas, Melissa A Daubert","doi":"10.1161/CIRCIMAGING.124.017380","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017380","url":null,"abstract":"<p><strong>Background: </strong>Patients with abnormal (positive) exercise electrocardiography, but normal stress echocardiography (+ECG/-Echo), have an increased risk of adverse cardiovascular events compared with patients with a normal (negative) ECG and a normal stress Echo (-ECG/-Echo). However, it is unclear if +ECG/-Echo discordance is associated with a greater burden of subclinical coronary atherosclerosis.</p><p><strong>Methods: </strong>Project Baseline Health Study participants who underwent a stress Echo and coronary artery calcium (CAC) scan were stratified by stress Echo result: -ECG/-Echo or +ECG/-Echo. Multivariable regression investigated the association between stress Echo results and CAC burden. Event-free survival from a composite of adverse cardiovascular events was compared between groups.</p><p><strong>Results: </strong>Among 1630 asymptomatic participants in this observational cohort study, 1503 (92.2%) had a -ECG/-Echo, 105 (6.4%) had a +ECG/-Echo, and 22 (1.3%) had a +Echo. The +ECG/-Echo group had a significantly greater burden of coronary atherosclerosis than the -ECG/-Echo group (mean CAC score, 198±470 versus 53±186; <i>P</i><0.001; CAC_log, 2.2±2.7 versus 1.2±2.0; <i>P</i><0.001). The -ECG/-Echo group was more likely to have CAC=0 compared with the +ECG/-Echo group (65.9% versus 53.3%; <i>P</i>=0.01), whereas the +ECG/-Echo group more commonly had CAC ≥100 (28.6% versus 11.4%; <i>P</i><0.001). After adjustment, CAC_log scores were 52% higher in the +ECG/-Echo group than in the -ECG/-Echo group (<i>P</i>=0.002). Compared with the -ECG/-Echo group, the +ECG/-Echo group was 4.5× more likely to have a CAC score ≥400 (adjusted odds ratio, 4.54 [95% CI, 1.95-10.05]; <i>P</i><0.001). After a median follow-up of 4.3 years, a trend toward increased adverse cardiovascular events was observed among participants with +ECG/-Echo.</p><p><strong>Conclusions: </strong>Individuals with a +ECG/-Echo have a higher burden of subclinical coronary atherosclerosis than those with a -ECG/-Echo, which may explain, at least in part, the increased risk for adverse cardiac events in this population. Further study is needed to determine the optimal strategy for mitigating cardiovascular risk in these patients.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT03154346.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017380"},"PeriodicalIF":6.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}