Circulation: Cardiovascular Imaging最新文献

{"title":"Periaortic Adipose Tissue Density as a Marker of Vascular Inflammation From Ungated, Noncontrast CT.","authors":"Jacob Abdaem, Robert J H Miller","doi":"10.1161/CIRCIMAGING.125.018487","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.125.018487","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018487"},"PeriodicalIF":6.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Manuel to Letter Regarding Article, \"Progressive LV Dysfunction and Adverse Outcomes After Aortic Valve Replacement With Bioprosthetic Valves in Young Patients\".","authors":"Alexander C Egbe","doi":"10.1161/CIRCIMAGING.125.018560","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.125.018560","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018560"},"PeriodicalIF":6.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dark Side of Pericardial Effusions: What Shall We Keep in Mind.","authors":"Alexander Suchodolski, Rafał Skowronek, Jan Głowacki, Jerzy Nożyński, Paweł Ziora, Bogna Drozdzowska, Dariusz Lange, Mariola Szulik","doi":"10.1161/CIRCIMAGING.124.017747","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017747","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017747"},"PeriodicalIF":6.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Echocardiographic Probability of Pulmonary Hypertension on Prognosis and Outcomes Among Patients With Myeloproliferative Neoplasms.","authors":"Orly Leiva, Steven Soo, Nathaniel R Smilowitz, Harmony Reynolds, Binita Shah, Samuel Bernard, Joan How, Michelle Hyunju Lee, Gabriela Hobbs","doi":"10.1161/CIRCIMAGING.124.017986","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017986","url":null,"abstract":"<p><strong>Background: </strong>Myeloproliferative neoplasms (MPN) are a group of chronic leukemias that are associated with pulmonary hypertension (PH), which has been associated with increased risk adverse outcomes. The echocardiographic characterization of PH in MPN has not been reported, and the prognostic significance of PH among patients with MPN remains unclear.</p><p><strong>Methods: </strong>Multicenter, retrospective cohort study of patients with MPN with ≥1 echocardiogram from 2010 to 2023. The echocardiographic probability of PH was determined according to the guidelines. The outcomes were hematologic progression and major adverse cardiovascular events. Exploratory analysis included outcomes among patients with right heart catheterization after the first echocardiogram, with PH defined as mean pulmonary artery pressure of >20 mm Hg. Multivariable Fine-Gray competing risk regression was used to estimate the subhazard ratio of hematologic progression and major adverse cardiovascular events.</p><p><strong>Results: </strong>Five hundred fifty-five patients were included and 237 (42.7%) had an intermediate or high probability of PH on echocardiography. Over a median follow-up period of 51.2 months (interquartile range, 29.5-79.8), it was observed that echocardiographic probability of PH was associated with increased risk of hematologic progression (adjusted subhazard ratio, 1.92 [95% CI, 1.09-3.39]) and major adverse cardiovascular events (adjusted subhazard ratio, 1.66 [95% CI, 1.04-2.66]) but not all-cause death (adjusted hazard ratio, 1.51 [95% CI, 0.98-2.32]). Among patients with right heart catheterization (n=61), PH was present in 51 (83.6%) of patients and was associated with a higher risk of hematologic progression (29.4% versus 0%; <i>P</i>=0.048).</p><p><strong>Conclusions: </strong>Among patients with MPN, echocardiographic probability of PH was associated with an increased risk of hematologic progression. Prospective studies are needed to assess the optimal use of echocardiography on MPN-specific prognostication.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017986"},"PeriodicalIF":6.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Murai et al Regarding Article, \"Impact of Post-PCI Lipid Core Burden Index on Angiographic and Clinical Outcomes: Insights From NIRS-IVUS\".","authors":"Kota Murai, Yu Kataoka, Teruo Noguchi","doi":"10.1161/CIRCIMAGING.125.018568","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.125.018568","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018568"},"PeriodicalIF":6.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning to Automatically Differentiate Hypertrophic Cardiomyopathy, Cardiac Light Chain, and Cardiac Transthyretin Amyloidosis: A Multicenter CMR Study.","authors":"Lukas Damian Weberling, Andreas Ochs, Mitchel Benovoy, Fabian Aus dem Siepen, Janek Salatzki, Evangelos Giannitsis, Chong Duan, Kevin Maresca, Yao Zhang, Jan Möller, Silke Friedrich, Stefan Schönland, Benjamin Meder, Matthias G Friedrich, Norbert Frey, Florian André","doi":"10.1161/CIRCIMAGING.124.017761","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017761","url":null,"abstract":"<p><strong>Background: </strong>Cardiac amyloidosis is associated with poor outcomes and is caused by the interstitial deposition of misfolded proteins, typically ATTR (transthyretin) or AL (light chains). Although specific therapies during early disease stages exist, the diagnosis is often only established at an advanced stage. Cardiovascular magnetic resonance (CMR) is the gold standard for imaging suspected myocardial disease. However, differentiating cardiac amyloidosis from hypertrophic cardiomyopathy may be challenging, and a reliable method for an image-based classification of amyloidosis subtypes is lacking. This study sought to investigate a CMR machine learning (ML) algorithm to identify and distinguish cardiac amyloidosis.</p><p><strong>Methods: </strong>This retrospective, multicenter, multivendor feasibility study included consecutive patients diagnosed with hypertrophic cardiomyopathy or AL/ATTR amyloidosis and healthy volunteers. Standard clinical information, semiautomated CMR imaging data, and qualitative CMR features were integrated into a trained ML algorithm.</p><p><strong>Results: </strong>Four hundred participants (95 healthy, 94 hypertrophic cardiomyopathy, 95 AL, and 116 ATTR) from 56 institutions were included (269 men aged 58.5 [48.4-69.4] years). A 3-stage ML screening cascade sequentially differentiated healthy volunteers from patients, then hypertrophic cardiomyopathy from amyloidosis, and then AL from ATTR. The ML algorithm resulted in an accurate differentiation at each step (area under the curve, 1.0, 0.99, and 0.92, respectively). After reducing included data to demographics and imaging data alone, the performance remained excellent (area under the curve, 0.99, 0.98, and 0.88, respectively), even after removing late gadolinium enhancement imaging data from the model (area under the curve, 1.0, 0.95, 0.86, respectively).</p><p><strong>Conclusions: </strong>A trained ML model using semiautomated CMR imaging data and patient demographics can accurately identify cardiac amyloidosis and differentiate subtypes.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017761"},"PeriodicalIF":6.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Atrial to Left Ventricular Volume Ratio in Patients With Severe Functional Mitral Regurgitation.","authors":"Sophia Koschatko, Gregor Heitzinger, Noemi Pavo, Georg Spinka, Suriya Prausmüller, Katharina Mascherbauer, Varius Dannenberg, Christoph Torrefranca, Matthias Koschutnik, Carolina Donà, Raphael Rosenhek, Charlotte Jantsch, Kseniya Halavina, Laurenz Hauptmann, Rayyan Hemetsberger, Christian Nitsche, Caglayan Demirel, Christian Hengstenberg, Martin Hülsmann, Georg Goliasch, Philipp E Bartko","doi":"10.1161/CIRCIMAGING.124.017872","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017872","url":null,"abstract":"<p><strong>Background: </strong>Severe functional mitral regurgitation (fMR) is a heterogenous disease that exhibits different underlying pathophysiological mechanisms and represents independent entities. The aim of this study was to characterize remodeling patterns defined by the left atrial (LA) to left ventricular (LV) volume ratio in patients with severe fMR and heart failure, and to examine its prognostic implications.</p><p><strong>Methods: </strong>A total of 13 052 patients with fMR were included. Based on the LA/LV volume ratio, patients with severe fMR were divided into 2 distinct groups: predominant LV remodeling (PLVR [ratio ≤0.56, n=581]) and predominant LA remodeling (PLAR [ratio >0.56, n=582]).</p><p><strong>Results: </strong>Patients with PLAR were more often female, with the peak age a decade later. PLAR was associated with lower leaflet tethering indices, as indicated by the leaflet tenting area (PLVR versus PLAR: 227 mm² versus 181 mm², <i>P</i><0.001) and angles (PLVR versus PLAR: posterior leaflet: 42° versus 36°, <i>P</i><0.001; anterior leaflet: 28° versus 23°, <i>P</i><0.001). PLAR was the predominant subtype in heart failure with preserved (76%) and heart failure with mildly reduced ejection fraction (61%), but a significant proportion could be observed in heart failure with reduced ejection fraction (32%). The median follow-up time for severe fMR was 66 months (interquartile range, 60-85) months. After 4 years, 42.1% with PLAR and 34.1% with PLVR had died. At 8 years, 57.3% of patients with PLAR, and 49.6% of patients with PLVR had died. Compared with PLVR, PLAR showed excess mortality, with a hazard ratio of 1.37 ([95% CI, 1.13-1.65]; <i>P</i>=0.001) in the univariate analysis. This effect remained after multivariable adjustment.</p><p><strong>Conclusions: </strong>The LA/LV volume ratio indicates the prevailing remodeling pattern in severe fMR. It is associated with morphological features of valve apparatus distortion resulting from differential remodeling. A strong correlation is observed between the LA/LV volume ratio and mortality.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017872"},"PeriodicalIF":6.5,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unfolding Evidence on Risk Stratification in Women Using Quantitative Atherosclerotic Plaque Measurements.","authors":"Leslee J Shaw, Fay Y Lin","doi":"10.1161/CIRCIMAGING.125.018438","DOIUrl":"10.1161/CIRCIMAGING.125.018438","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018438"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Quantitative CT Coronary Plaque Features Associate With a Higher Relative Risk in Women: CONFIRM2 Registry.","authors":"Gudrun M Feuchtner, Pietro G Lacaita, Jeroen J Bax, Fatima Rodriguez, Rine Nakanishi, Gianluca Pontone, Saima Mushtaq, Ronny R Buechel, Christoph Gräni, Amit R Patel, Cristiane C Singulane, Andrew D Choi, Mouaz Al-Mallah, Daniele Andreini, Ronald P Karlsberg, Geoffrey Cho, Carlos E Rochitte, Mirvat Alasnag, Ashraf Hamdan, Filippo Cademartiri, Erica Maffei, Hugo Marques, Pedro M Gonçalves Pereira, Himanshu Gupta, Martin Hadamitzky, Omar Khalique, Dinesh Kalra, James D Mills, Nick S Nurmohamed, Paul Knaapen, Matthew Budoff, Kashif Shaikh, Enrico Martin, David M German, Maros Ferencik, Andrew C Oehler, Roderick Deaño, Prashant Nagpal, Marly Van Assen, Carlo Nicola De Cecco, Borek Foldyna, Jan Michael Brendel, Victor Y Cheng, Kelley Branch, Marcio Bittencourt, Sabha Bhatti, Venkateshwar Polsani, George Wesbey, Rhanderson Cardoso, Ron Blankstein, Augustin Delago, Amit Pursnani, Amro Alsaid, Stephen Bloom, Vasileios Kamperidis, Fabian Barbieri, Melissa Aquino, Ibrahim Danad, Alexander van Rosendael","doi":"10.1161/CIRCIMAGING.125.018235","DOIUrl":"10.1161/CIRCIMAGING.125.018235","url":null,"abstract":"<p><strong>Background: </strong>Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic value. This study aimed to define sex differences in the coronary atherosclerotic phenotypes assessed by artificial intelligence-based quantitative computed tomography (AI-QCT) and the associated risk of major adverse cardiovascular events (MACEs).</p><p><strong>Methods: </strong>Global multicenter registry including symptomatic patients with suspicion of coronary artery disease referred for coronary computed tomography angiography. AI-QCT analyzed 16 coronary artery disease features. The primary end point was MACE defined as death, myocardial infarction, late revascularization, cerebrovascular events, unstable angina, and congestive heart failure.</p><p><strong>Results: </strong>Among 3551 patients (mean age, 59±12 years; 49.5% women), MACE occurred in 3.2% of women and 6.1% of men during an average follow-up of 4.8±2.2 years. The AI-QCT features total plaque volume, noncalcified plaque, calcified plaque, and percentage atheroma volume were significantly higher in men (<i>P</i><0.001), and high-risk plaques were more prevalent (9.2% versus 2.5%; <i>P</i><0.0001). Independent of age and cardiovascular risk factors, the AI-QCT-derived features of total plaque volume, noncalcified plaque, calcified plaque, and percentage atheroma volume conferred a higher relative risk of MACE in women than men. For every 50-mm³ increase in total plaque volume, relative risk increased by 17.7% (95% CI, 1.12-1.24) in women versus 5.3% (95% CI, 1.03-1.07) in men (<i>P</i>_interaction<0.001); for noncalcified plaque, relative risk increased by 27.1% (95% CI, 1.17-1.38) versus 11.6% (95% CI, 1.08-1.15; <i>P</i>_interaction=0.0015); and for calcified plaque, relative risk increased by 22.9% (95% CI, 1.14-1.33) versus 5.4% (95% CI, 1.01-1.10; <i>P</i>_interaction=0.0012), respectively. Similarly, for percentage atheroma volume, the risk was higher in women. The findings remained unchanged when restricted to a secondary composite end point (death and myocardial infarction).</p><p><strong>Conclusions: </strong>The AI-QCT plaque features, total plaque volume, noncalcified plaque, calcified plaque, and percentage atheroma volume, conferred a higher relative MACE risk in women and may prompt more aggressive antiatherosclerotic therapy and reinforced preventive interventions.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT04279496.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018235"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹²⁴I-Evuzamitide PET/CT Diagnosis of Wild-Type Transthyretin Amyloid Cardiomyopathy in a Woman With Negative Diagnostic Evaluation.","authors":"Annu Kurian, Alyssa de Moraes, Olivier F Clerc, Ardel J Romero Pabon, Robert F Padera, Sarah A M Cuddy, Sharmila Dorbala","doi":"10.1161/CIRCIMAGING.124.017807","DOIUrl":"10.1161/CIRCIMAGING.124.017807","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017807"},"PeriodicalIF":6.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}