Matthew B Saunders, Matthew S Michaleski, Jeffrey Yim, Miles Marchand, John Jue, David A Wood, Christina L Luong, Michael Y C Tsang, Teresa S M Tsang, Darwin F Yeung
{"title":"Platypnea-Orthodeoxia Syndrome After Esophageal Dilation in a Patient With a Dilated Ascending Aorta.","authors":"Matthew B Saunders, Matthew S Michaleski, Jeffrey Yim, Miles Marchand, John Jue, David A Wood, Christina L Luong, Michael Y C Tsang, Teresa S M Tsang, Darwin F Yeung","doi":"10.1161/CIRCIMAGING.124.016887","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.016887","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Nørtoft Dahl, Marie B Nielsen, Laust D Rasmussen, Per Ivarsen, Michelle C Williams, My Hanna Sofia Svensson, Henrik Birn, Morten Bøttcher, Simon Winther
{"title":"Coronary Plaque Characteristics in Patients With Chronic Kidney Failure: Impact on Cardiovascular Events and Mortality.","authors":"Jonathan Nørtoft Dahl, Marie B Nielsen, Laust D Rasmussen, Per Ivarsen, Michelle C Williams, My Hanna Sofia Svensson, Henrik Birn, Morten Bøttcher, Simon Winther","doi":"10.1161/CIRCIMAGING.124.017066","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017066","url":null,"abstract":"<p><strong>Background: </strong>In patients with coronary artery disease, coronary plaques with high-risk features and low-attenuation plaque burden are independent measures associated with major adverse cardiovascular events (MACEs). Patients with chronic kidney failure may have different coronary artery disease characteristics. The aim was to assess the association of coronary plaque characteristics and coronary artery disease extent with MACE and all-cause mortality in patients with chronic kidney failure.</p><p><strong>Methods: </strong>Potential kidney transplant candidates who underwent coronary computed tomography angiography as part of the cardiac screening program before kidney transplantation were included. We evaluated high-risk plaques and diameter stenosis semiqualitatively and quantified coronary artery calcium score and plaque burden (percentage atheroma volume).</p><p><strong>Results: </strong>In 484 patients with chronic kidney failure and few or no symptoms of coronary artery disease (mean age, 53±12 years; 62% men; 32% on dialysis), 56 (12%) patients suffered MACE and 69 (14%) patients died during a median follow-up of 4.9 years. High-risk plaques were present in 39 (70%) patients with MACE. Median calcified plaque burden was 3.7% in patients with MACE versus 0.2% in patients without MACE. The median low-attenuation plaque burden was 0.3% versus 0.03%, respectively. In semiqualitative analyses, the presence of high-risk plaque and a higher coronary artery calcium score were associated with increased risk of MACE (hazard ratio (HR), 2.0 [95% CI, 1.0-3.7]; <i>P</i>=0.040; HR, 1.2 [95% CI, 1.0-1.3]; <i>P</i>=0.014), respectively. Neither were associated with all-cause mortality. In quantified analysis, increasing levels of both calcified and low-attenuation plaque burdens were associated with risk of MACE (HR, 2.6 [95% CI, 1.8-3.7]; <i>P</i><0.001; HR, 2.6 [95% CI, 1.5-4.5]; <i>P</i>=0.001 [per variable doubling, respectively]) and all-cause mortality (HR, 1.6 [95% CI, 1.2-2.1]; <i>P</i>=0.002; HR, 1.8 [95% CI, 1.1-3.0]; <i>P</i>=0.028, respectively).</p><p><strong>Conclusions: </strong>In patients with chronic kidney failure, calcified and low-attenuation plaque burdens were independently associated with MACE and all-cause mortality, while high-risk plaques and coronary artery calcium score were only associated with MACE.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT01344434.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milán Vecsey-Nagy, Giuseppe Tremamunno, U Joseph Schoepf, Chiara Gnasso, Emese Zsarnóczay, Nicola Fink, Dmitrij Kravchenko, Moritz C Halfmann, Gerald S Laux, Jim O'Doherty, Bálint Szilveszter, Pál Maurovich-Horvat, Ismail Mikdat Kabakus, Pal Spruill Suranyi, Akos Varga-Szemes, Tilman Emrich
{"title":"Intraindividual Comparison of Ultrahigh-Spatial-Resolution Photon-Counting Detector CT and Energy-Integrating Detector CT for Coronary Stenosis Measurement.","authors":"Milán Vecsey-Nagy, Giuseppe Tremamunno, U Joseph Schoepf, Chiara Gnasso, Emese Zsarnóczay, Nicola Fink, Dmitrij Kravchenko, Moritz C Halfmann, Gerald S Laux, Jim O'Doherty, Bálint Szilveszter, Pál Maurovich-Horvat, Ismail Mikdat Kabakus, Pal Spruill Suranyi, Akos Varga-Szemes, Tilman Emrich","doi":"10.1161/CIRCIMAGING.124.017112","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017112","url":null,"abstract":"<p><strong>Background: </strong>A recent simulation study proposed that stenosis measurements on coronary computed tomography (CT) angiography are influenced by the improved spatial resolution of photon-counting detector (PCD)-CT. The aim of the current study was to evaluate the impact of ultrahigh-spatial-resolution (UHR) on coronary stenosis measurements and Coronary Artery Disease Reporting and Data System (CAD-RADS) reclassification rates in patients undergoing coronary CT angiography on both PCD-CT and energy-integrating detector (EID)-CT and to compare measurements against quantitative coronary angiography.</p><p><strong>Methods: </strong>Patients with coronary calcification on EID-CT (collimation, 192×0.6 mm) were prospectively enrolled for a research coronary CT angiography with UHR PCD-CT (collimation, 120×0.2 mm) within 30 days (between April 1, 2023 and January 31, 2024). PCD-CT was acquired with the same or lower CT dose index and equivalent contrast media volume as EID-CT. Percentage diameter stenosis (PDS) for calcified, partially calcified, and noncalcified lesions were compared between scanners. Patient-level reclassification rates for CAD-RADS were evaluated. The accuracy of PDS measurements was validated against quantitative coronary angiography in patients who underwent invasive coronary angiography.</p><p><strong>Results: </strong>In total, PDS of 278 plaques were quantified in 49 patients (calcified, 202; partially calcified, 51; noncalcified, 25). PCD-CT-based PDS values were lower than EID-CT measurements for calcified (45.1±20.7 versus 54.6±19.2%; <i>P</i><0.001) and partially calcified plaques (44.3±19.6 versus 54.9±20.0%; <i>P</i><0.001), without significant differences for noncalcified lesions (39.1±15.2 versus 39.0±16.0%; <i>P</i>=0.98). The reduction in stenosis degrees led to a 49.0% (24/49) reclassification rate to a lower CAD-RADS with PCD-CT. In a subset of 12 patients with 56 lesions, UHR-based PDS values showed higher agreement with quantitative coronary angiography (mean difference, 7.3%; limits of agreement, -10.7%/25.2%) than EID-CT measurements (mean difference, 17.4%; limits of agreement, -6.9%/41.7%).</p><p><strong>Conclusions: </strong>Compared with conventional EID-CT, UHR PCD-CT results in lower PDS values and more accurate stenosis measurements in coronary plaques with calcified components and leads to a substantial Coronary Artery Disease Reporting and Data System reclassification rate in 49.0% of patients.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Jose Santa Ana-Bayona, Pavel Martinez-Dominguez, Oscar Perez-Orpinel, Enrique C Guerra, Nilda Espinola-Zavaleta
{"title":"Beyond the Usual Suspects: Myocardial Infarction Triggered by Coronary Vasculitis in a Young Patient With Systemic Lupus Erythematosus.","authors":"Maria Jose Santa Ana-Bayona, Pavel Martinez-Dominguez, Oscar Perez-Orpinel, Enrique C Guerra, Nilda Espinola-Zavaleta","doi":"10.1161/CIRCIMAGING.124.017009","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017009","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Accelerated Pace of Atherosclerosis in Steatotic Liver Disease: Implications for Risk Stratification.","authors":"Andrei C Sposito","doi":"10.1161/circimaging.124.017376","DOIUrl":"https://doi.org/10.1161/circimaging.124.017376","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: Paolisso et al, \"Cardiac Magnetic Resonance to Predict Cardiac Mass Malignancy: The CMR Mass Score\".","authors":"","doi":"10.1161/hci.0000000000000084","DOIUrl":"https://doi.org/10.1161/hci.0000000000000084","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keishi Ichikawa,Jaewon Lim,Robyn L McClelland,Shriraj Susarla,Srikanth Krishnan,Travis Benzing,Sina Kianoush,Jairo Aldana-Bitar,Venkat S Manubolu,Matthew J Budoff
{"title":"Impact of Nonalcoholic Hepatic Steatosis on the Warranty Period of a Coronary Artery Calcium Score of 0: Results From the Multi-Ethnic Study of Atherosclerosis.","authors":"Keishi Ichikawa,Jaewon Lim,Robyn L McClelland,Shriraj Susarla,Srikanth Krishnan,Travis Benzing,Sina Kianoush,Jairo Aldana-Bitar,Venkat S Manubolu,Matthew J Budoff","doi":"10.1161/circimaging.123.016465","DOIUrl":"https://doi.org/10.1161/circimaging.123.016465","url":null,"abstract":"BACKGROUNDFor individuals with a coronary artery calcium (CAC) score of 0, CAC rescans at appropriate timings are recommended, depending on individual risk profiles. Although nonalcoholic fatty liver disease, recently redefined as metabolic-associated fatty liver disease, is a risk factor for atherosclerotic cardiovascular disease events, its relationship with the warranty period of a CAC score of 0 has not been elucidated.METHODSA total of 1944 subjects from the MESA (Multi-Ethnic Study of Atherosclerosis) with a baseline CAC score of 0, presence or absence of nonalcoholic hepatic steatosis, and at least 1 follow-up computed tomography scan were included. Nonalcoholic hepatic steatosis was defined using nonenhanced computed tomography and liver/spleen attenuation ratio <1. The association between nonalcoholic hepatic steatosis and new CAC incidence (CAC score >0) was evaluated using a Weibull survival model.RESULTSNonalcoholic hepatic steatosis was identified in 268 (14%) participants. Participants with nonalcoholic hepatic steatosis had higher CAC incidence than those without nonalcoholic hepatic steatosis. Nonalcoholic hepatic steatosis was independently associated with new CAC incidence after adjustment for atherosclerotic cardiovascular disease risk factors (hazard ratio, 1.28 [95% CI, 1.05-1.57]; P=0.015). Using a 25% testing yield (25% of participants with zero CAC at baseline would be expected to have developed a CAC score >0), the warranty period of a CAC score of 0 in participants with nonalcoholic hepatic steatosis was shorter than in those without nonalcoholic hepatic steatosis (4.7 and 6.3 years). This association was consistent regardless of sex, race/ethnicity, age, and 10-year atherosclerotic cardiovascular disease risk.CONCLUSIONSNonalcoholic hepatic steatosis had an impact on the warranty period of a CAC score of 0. The study suggests that the time period until a CAC rescan should be shorter in those with nonalcoholic hepatic steatosis and a CAC score of 0.","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Between the Extremes: The Impact of Lipid Variability on Cardiovascular Risk.","authors":"Michael D Shapiro","doi":"10.1161/circimaging.124.017375","DOIUrl":"https://doi.org/10.1161/circimaging.124.017375","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}