Erica Rocco, Marco Ciacciarelli, Salvino Bilancini, Sonia Ferri, Alessandro Polidoro, Marco Rengo, Beatrice Simeone, Valentina Valenti, Sebastiano Sciarretta, Luigi Iuliano
{"title":"Recurrent Cryptogenic Ischemic Strokes in a Young Female Patient: A Case of a Bilateral Carotid Web.","authors":"Erica Rocco, Marco Ciacciarelli, Salvino Bilancini, Sonia Ferri, Alessandro Polidoro, Marco Rengo, Beatrice Simeone, Valentina Valenti, Sebastiano Sciarretta, Luigi Iuliano","doi":"10.1161/CIRCIMAGING.124.017819","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017819","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017819"},"PeriodicalIF":6.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesca Sperotto, Pakaparn Kittichokechai, Andrew J Powell, Tal Geva, Naomi Gauthier, Joyce C Chang, Brian D Soriano, Nikhil Thatte
{"title":"Endomyocardial Fibrosis Mimicking a Heart Tumor and Dysplastic Tricuspid Valve in a Teenager: A Rare Cardiac Manifestation of Behçet Disease.","authors":"Francesca Sperotto, Pakaparn Kittichokechai, Andrew J Powell, Tal Geva, Naomi Gauthier, Joyce C Chang, Brian D Soriano, Nikhil Thatte","doi":"10.1161/CIRCIMAGING.124.017064","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017064","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017064"},"PeriodicalIF":6.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dominik C Benz, Ali Sadeghi, Pat G Rafter, Olivier F Clerc, Jocelyn Canseco Neri, Alexandra Taylor, Shilpa Vijayakumar, Carolyn Y Ho, Sarah A M Cuddy, Rodney H Falk, Sharmila Dorbala
{"title":"Echocardiographic Characterization of Myocardial Stiffness in Healthy Volunteers, Cardiac Amyloidosis, and Hypertrophic Cardiomyopathy: A Case-Control Study Using Multimodality Imaging.","authors":"Dominik C Benz, Ali Sadeghi, Pat G Rafter, Olivier F Clerc, Jocelyn Canseco Neri, Alexandra Taylor, Shilpa Vijayakumar, Carolyn Y Ho, Sarah A M Cuddy, Rodney H Falk, Sharmila Dorbala","doi":"10.1161/CIRCIMAGING.124.017475","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017475","url":null,"abstract":"<p><strong>Background: </strong>Noninvasive tools to measure myocardial stiffness are limited. Intrinsic cardiac elastography in echocardiography relates to myocardial stiffness by measuring the propagation of the myocardial stretch generated by atrial contraction. The aims of the present study were (1) to evaluate myocardial stiffness using intrinsic cardiac elastography in healthy volunteers versus those with myocardial diseases (ie, cardiac amyloidosis [CA] and hypertrophic cardiomyopathy) and (2) to identify key factors that affect myocardial stiffness.</p><p><strong>Methods: </strong>In this prospective study, myocardial stiffness was estimated in 54 participants, including 10 hypertrophic cardiomyopathy, 28 CA, and 16 healthy volunteers. Myocardial stiffness was assessed as intrinsic velocity propagation of myocardial stretch (iVP, m/s) measured by high frame rate echocardiography (ie, above 250 frames per second). Extracellular volume was quantified by cardiac magnetic resonance in 22 participants. Amyloid burden was quantified by cardiac amyloid activity in <sup>99m</sup>Tc-labeled pyrophosphate single-photon emission computed tomography in 10 participants.</p><p><strong>Results: </strong>Myocardial stiffness was significantly higher in the CA cohort (median iVP, 2.6 m/s; interquartile range, 1.7-3.9 m/s) than in the hypertrophic cardiomyopathy cohort (median iVP, 1.4 m/s; interquartile range, 1.0-1.8 m/s; <i>P</i>=0.011). In patients with CA or hypertrophic cardiomyopathy, iVP was correlated with NT-proBNP (N-terminal pro-B-type natriuretic peptide) (ρ=0.498, <i>P</i>=0.003), extracellular volume (ρ=0.646, <i>P</i>=0.004), and cardiac amyloid activity (ρ=0.891, <i>P</i><0.001). In multivariate linear regression analysis, extracellular volume was independently associated with myocardial stiffness even after accounting for indexed left ventricular mass, global longitudinal strain, and E/e'. In healthy volunteers, normal myocardial stiffness was defined by the upper limit of normal of iVP at 1.7 m/s. Patients with CA and normal myocardial stiffness (iVP <1.7 m/s) were characterized by a low risk profile including lower NT-proBNP (<i>P</i>=0.034), lower troponin T (<i>P</i>=0.041), lower National Amyloidosis Center stage (<i>P</i>=0.031), smaller interstitial expansion (<i>P</i>=0.014), and smaller amyloid burden (<i>P</i>=0.056).</p><p><strong>Conclusions: </strong>Intrinsic cardiac elastography is a reliable noninvasive tool to measure myocardial stiffness. In this pilot study, it is related to imaging markers of interstitial expansion and amyloid burden.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017475"},"PeriodicalIF":6.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yvette A Yeboah-Kordieh, Ellen Boakye, Albert D Osei, Omar Dzaye, Zeina A Dardari, Joao A C Lima, Alan Rozanski, Daniel S Berman, Matthew J Budoff, Michael D Miedema, Khurram Nasir, John A Rumberger, Leslee J Shaw, David R Jacobs, Michael J Blaha
{"title":"Race- and Sex-Specific Age at Which Coronary Artery Calcium Becomes Detectable Among Young Adults.","authors":"Yvette A Yeboah-Kordieh, Ellen Boakye, Albert D Osei, Omar Dzaye, Zeina A Dardari, Joao A C Lima, Alan Rozanski, Daniel S Berman, Matthew J Budoff, Michael D Miedema, Khurram Nasir, John A Rumberger, Leslee J Shaw, David R Jacobs, Michael J Blaha","doi":"10.1161/CIRCIMAGING.124.016599","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.016599","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery calcium (CAC) is an excellent predictor of atherosclerotic cardiovascular disease (ASCVD) risk. Limited data exist on the age at which CAC transitions to nonzero among young adults. We aimed to assess the prevalence of CAC by the number of ASCVD risk factors and use this data to model the race- and sex-specific ages at which young adults transition to a CAC >0.</p><p><strong>Methods: </strong>We included 17 285 participants aged 30 to 50 years from the CAC Consortium and the CARDIA (Coronary Artery Risk Development in Young Adults) study in this cross-sectional study. We estimated the burden of CAC by the number of ASCVD risk factors and used sex- and race-specific multivariable logistic regression models to predict the probability of CAC >0. From these, we estimated the age at CAC conversion from zero, using a minimum testing yield of 25%.</p><p><strong>Results: </strong>Of the 17 285 participants included in this study (mean age, 43.3±4.7years, 66.9% men, and 87.5% White), 30.1% had CAC >0. The probability of CAC >0 at each specified age and risk factor profile was higher among men than women and White compared with Black individuals. With 2 ASCVD risk factors, the estimated age at which CAC became detectable was 36.1 (35.1-36.9) years for White men, 41.9 (40.6-43.2) years for Black men, 47.6 (46.3-48.9) years for White women, and 51.6 (48.2-54.5) years for Black women.</p><p><strong>Conclusions: </strong>The age at which CAC becomes detectable in young adults varies substantially by race, sex, and the number of ASCVD risk factors. Earlier initiation of CAC scans may be indicated in select subgroups at greater risk of premature atherosclerosis.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e016599"},"PeriodicalIF":6.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keyan Wang, Haiyu Li, Yong Zhang, Jie Zheng, Jingliang Cheng
{"title":"Heterogeneity of Myocardial Fibrosis Found in Twins With the MYBPC3 Variant Manifesting as Hypertrophic Cardiomyopathy.","authors":"Keyan Wang, Haiyu Li, Yong Zhang, Jie Zheng, Jingliang Cheng","doi":"10.1161/CIRCIMAGING.124.017837","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017837","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017837"},"PeriodicalIF":6.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Case Against Race-Based Coronary Artery Calcium Screening.","authors":"Shoa L Clarke","doi":"10.1161/CIRCIMAGING.124.017875","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017875","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017875"},"PeriodicalIF":6.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annu Kurian, Alyssa de Moraes, Olivier F Clerc, Ardel J Romero Pabon, Robert F Padera, Sarah A M Cuddy, Sharmila Dorbala
{"title":"<sup>124</sup>I-Evuzamitide PET/CT Diagnosis of Wild-Type Transthyretin Amyloid Cardiomyopathy in a Woman With Negative Diagnostic Evaluation.","authors":"Annu Kurian, Alyssa de Moraes, Olivier F Clerc, Ardel J Romero Pabon, Robert F Padera, Sarah A M Cuddy, Sharmila Dorbala","doi":"10.1161/CIRCIMAGING.124.017807","DOIUrl":"10.1161/CIRCIMAGING.124.017807","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017807"},"PeriodicalIF":6.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryota Kakizaki, Lorenz Räber, Christian Gerges, Peter Dorfmüller, Irene M Lang
{"title":"3D Reconstruction of Pulmonary Vascular Lesions in Chronic Thromboembolic Pulmonary Hypertension.","authors":"Ryota Kakizaki, Lorenz Räber, Christian Gerges, Peter Dorfmüller, Irene M Lang","doi":"10.1161/CIRCIMAGING.124.017935","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017935","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017935"},"PeriodicalIF":6.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}