Circulation: Cardiovascular Imaging最新文献

{"title":"Coronary Artery Embolism Secondary to Q Fever Endocarditis.","authors":"Minggang Zhou, Li Chen, Yong He","doi":"10.1161/CIRCIMAGING.124.016839","DOIUrl":"10.1161/CIRCIMAGING.124.016839","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e016839"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Right Ventricular Free-Wall Strain in a Multivariable Estimate of Right Ventricular-Arterial Coupling in Pediatric Pulmonary Arterial Hypertension.","authors":"Charles T Simpkin, D Dunbar Ivy, Mark K Friedberg, Dale A Burkett","doi":"10.1161/CIRCIMAGING.124.016882","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.016882","url":null,"abstract":"<p><strong>Background: </strong>Right ventricular-arterial coupling (RVAC) describes the relationship between right ventricular contractility and pulmonary vascular afterload. Noninvasive surrogates for RVAC using echocardiographic estimates of right ventricular function, such as tricuspid annular plane systolic excursion (TAPSE), have been shown to correlate with invasively measured RVAC and predict clinical outcomes in pediatric pulmonary arterial hypertension. However, given the limitations of TAPSE at accurately estimating right ventricular function in children, we hypothesized that a multivariable estimate of RVAC using right ventricular free-wall longitudinal strain (RVFW-LS) may perform better than those utilizing TAPSE at predicting clinical outcomes.</p><p><strong>Methods: </strong>In all, 108 children from 2 institutions with pulmonary arterial hypertension underwent hemodynamic catheterization with simultaneous echocardiography. In a retrospective analysis, hybrid (echo and invasive) RVAC metrics included TAPSE/pulmonary vascular resistance (PVRi) and RVFW-LS/PVRi. Noninvasive echocardiographic metrics were TAPSE/echo-derived pulmonary artery systolic pressure (PASP) and RVFW-LS/PASP.</p><p><strong>Results: </strong>RVFW-LS correlated with PVRi (r=0.315, <i>P</i>=0.01), though TAPSE did not (r=0.058, <i>P</i>=0.64). PVRi, PASP, and RVAC metrics declined in patients with worse World Health Organization Functional Class (n=108), while TAPSE and RVFW-LS did not. PVRi, PASP, RVFW-LS/PVRi, TAPSE/PVRi, and RVFW-LS/PASP predicted the outcome variable of transplant or death (area under the curve, 0.771 [<i>P</i><0.001], 0.729 [<i>P</i>=0.004], 0.748 [<i>P</i>=0.002], 0.732 [<i>P</i>=0.009], and 0.714 [<i>P</i>=0.01], respectively), while TAPSE/PASP, RVFW-LS, and TAPSE did not (area under the curve, 0.671, 0.603, and 0.525, respectively). In patients without a history of repaired congenital heart disease (n=88), only RVFW-LS/PASP, PVRi, PASP, and RVFW-LS/PVRi predicted outcomes (area under the curve, 0.738 [<i>P</i>=0.002], 0.729 [<i>P</i>=0.01], 0.729 [<i>P</i>=0.01], and 0.729 [<i>P</i>=0.015], respectively).</p><p><strong>Conclusions: </strong>In the pediatric population, baseline PVRi and echo-estimated PASP were strongly associated with adverse clinical outcomes, but TAPSE and RVFW-LS were not. Estimates of RVAC utilizing RVFW-LS were superior to those utilizing TAPSE-however, only marginally additive to PASP and PVRi at predicting the adverse clinical outcome in patients without a history of repaired congenital heart disease.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":"17 12","pages":"e016882"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Tissue Alterations in ST-Elevation Myocardial Infarction: Determinants and Prognostic Implications.","authors":"Ivan Lechner, Martin Reindl, Sebastian von der Emde, Alina Desheva, Fritz Oberhollenzer, Christina Tiller, Magdalena Holzknecht, Thomas Kremser, Julian Faccini, Can Gollmann-Tepeköylü, Christian Kremser, Agnes Mayr, Axel Bauer, Bernhard Metzler, Sebastian J Reinstadler","doi":"10.1161/CIRCIMAGING.124.017041","DOIUrl":"10.1161/CIRCIMAGING.124.017041","url":null,"abstract":"<p><strong>Background: </strong>The presence and clinical significance of hepatic tissue alterations as assessed by cardiac magnetic resonance imaging in patients with ST-segment-elevation myocardial infarction (STEMI), are unclear. This study aimed to investigate associations of hepatic T1 patterns with myocardial tissue damage and clinical outcomes in patients suffering from STEMI.</p><p><strong>Methods: </strong>We analyzed 485 patients with STEMI treated with percutaneous coronary intervention who were enrolled in the prospective MARINA STEMI study (Magnetic Resonance Imaging In Acute ST-Elevation Myocardial Infarction). Myocardial function and left and right ventricular (RV) infarct characteristics were assessed by cardiac magnetic resonance within the first week after STEMI. Native hepatic T1 times and extracellular volume were evaluated from standard cardiac T1 maps at baseline and 4 months thereafter.</p><p><strong>Results: </strong>Median hepatic T1 times were 559 ms (interquartile range, 514-605) at baseline and decreased to 542 ms (interquartile range, 507-577) at 4 months (<i>P</i><0.001). Hepatic T1 times at baseline were independently associated with female sex (β 0.116; <i>P</i>=0.008), hyperlipidemia (β -0.116; <i>P</i>=0.008), and myocardial tissue damage (infarct size: β 0.178; <i>P</i><0.001; microvascular obstruction: β 0.193; <i>P</i><0.001; RV infarction: β 0.161; <i>P</i><0.001). Determinants of hepatic T1 times at 4 months were female sex (β 0.123; <i>P</i>=0.002), multivessel disease (β 0.121; <i>P</i>=0.002), N-terminal pro-B-type natriuretic peptide (β 0.101; <i>P</i>=0.010), RV infarction (β 0.501; <i>P</i><0.001), and RV end-systolic volume index (β 0.087; <i>P</i>=0.031). Patients without a decrease exhibited a higher frequency of major adverse cardiovascular events (13% versus 5%; <i>P</i>=0.003). Hepatic T1 times at baseline (hazard ratio, 1.87 [95% CI, 1.40-2.50]; <i>P</i><0.001), 4 months (hazard ratio, 2.69 [95% CI, 2.15-3.36]; <i>P</i><0.001), and hepatic extracellular volume at 4 months (hazard ratio, 1.59 [95% CI, 1.33-1.90]; <i>P</i><0.001) were associated with major adverse cardiovascular events. After adjustment for univariable associates, only hepatic T1 times at 4 months were independently associated with adverse outcomes (hazard ratio, 2.86 [95% CI, 1.99-4.12]; <i>P</i><0.001).</p><p><strong>Conclusions: </strong>Hepatic tissue alterations determined by T1 mapping were associated with female sex, hyperlipidemia, multivessel disease, N-terminal pro-B-type natriuretic peptide, and left and RV myocardial tissue damage. These alterations can persist into the chronic phase after STEMI and indicate a worse clinical outcome.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT04113356.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017041"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement.","authors":"Jonathan Bennett, George D Thornton, Christian Nitsche, Francisco F Gama, Nikoo Aziminia, Uzma Gul, Abhishek Shetye, Peter Kellman, Rhodri H Davies, James C Moon, Thomas A Treibel","doi":"10.1161/CIRCIMAGING.124.017425","DOIUrl":"10.1161/CIRCIMAGING.124.017425","url":null,"abstract":"<p><strong>Background: </strong>In aortic stenosis, the myocardium responds with left ventricular hypertrophy, which is characterized by increased left ventricular mass due to cellular hypertrophy and extracellular matrix expansion. Following aortic valve replacement (AVR), left ventricular hypertrophy regression occurs, but early cellular and extracellular dynamics are unknown.</p><p><strong>Methods: </strong>Patients with severe symptomatic aortic stenosis undergoing surgical or transcatheter AVR were prospectively recruited. Pre- and early post-AVR cardiac magnetic resonance imaging assessed left ventricular remodeling, global longitudinal strain, and T1 mapping to determine extracellular volume fraction and volume of cellular and extracellular compartments.</p><p><strong>Results: </strong>In all, 39 patients (aged 71.4±9.8 years, male 79%, aortic valve peak velocity 4.4±0.5 m/s) underwent cardiac magnetic resonance before and at median 7.7 weeks post-AVR. Left ventricular mass index reduced significantly by 15.4% (<i>P</i><0.001*), primarily driven by cellular compartment regression (18.7%, <i>P</i><0.001*), with a smaller reduction in the extracellular compartment (7.2%, <i>P</i><0.001*). This unbalanced regression led to an apparent increase in extracellular volume fraction (27.4±3.1% to 30.2±2.8%; <i>P</i><0.001*). Although there was no significant change in global longitudinal strain post-AVR, an increase in extracellular volume fraction was associated with worsening of global longitudinal strain (Pearson r=0.41, <i>P</i>=0.01). Mode of intervention (transcatheter versus surgical) did not influence the above myocardial parameters post-AVR (all <i>P</i>>0.05). The asterisk in <i>P</i> values indicates a statistical significance of <0.05.</p><p><strong>Conclusions: </strong>Within 8 weeks of AVR for aortic stenosis, substantial left ventricular hypertrophy regression occurs involving both cellular and extracellular compartments, demonstrating the early myocardial adaptability to afterload relief. Cellular compartment regression is greater than extracellular regression, leading to an apparent increase in extracellular volume fraction. Mode of intervention did not affect degree of reverse remodeling, indicating that both are effective at resulting beneficial changes post-AVR.</p><p><strong>Registration: </strong>URL: https://www.isrctn.com; Unique identifier: NCT04627987.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017425"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boys With Duchenne Muscular Dystrophy Have Diastolic Dysfunction Based on CMR.","authors":"Joseph R Starnes, Jeffrey G Weiner, Kristen George-Durrett, Kimberly Crum, Christopher C Henderson, M Jay Campbell, Katheryn Gambetta, Kan N Hor, Nazia Husain, Jennifer S Li, Frank J Raucci, Brian D Soriano, Christopher F Spurney, Larry W Markham, Jonathan H Soslow","doi":"10.1161/CIRCIMAGING.124.017287","DOIUrl":"10.1161/CIRCIMAGING.124.017287","url":null,"abstract":"<p><strong>Background: </strong>Cardiomyopathy is the leading cause of death in boys with Duchenne muscular dystrophy (DMD). While cardiac magnetic resonance (CMR) is routinely used to assess fibrosis and left ventricular (LV) ejection fraction, CMR measures of LV filling and ejection in DMD have not been reported.</p><p><strong>Methods: </strong>Patients with DMD (n=179) and healthy controls (n=96) were prospectively enrolled and underwent CMR. The DMD cohort was followed clinically at multiple institutions, and clinical data were recorded. Standard volumes and functions were calculated, and LV filling and ejection curves were measured from baseline CMR. Multivariable linear regressions were used to compare ventricular filling and ejection measures between groups, adjusting for baseline differences. Cox regressions were used to evaluate the relationship between diastolic function measures and mortality in the DMD cohort.</p><p><strong>Results: </strong>Patients with DMD had significantly smaller stature and ventricular volumes than healthy control patients (<i>P</i><0.001). They had lower baseline LV ejection fraction (<i>P</i><0.001), though most had normal systolic function. When adjusted for age, sex, heart rate, body surface area, and LV end-diastolic volume, patients with DMD had slower peak filling rates (<i>P</i><0.001) and peak ejection rates (<i>P</i><0.001), as well as slower time to peak ventricular ejection rate (<i>P</i>=0.011). When adjusted for heart rate, a lower peak ventricular ejection rate (<i>P</i>=0.007) and peak filling rate (<i>P</i>=0.033), normalized to LV end-diastolic volume, were associated with mortality in patients with DMD.</p><p><strong>Conclusions: </strong>Patients with DMD have significantly different baseline CMR filling and ejection indices compared with controls. Some filling indices are associated with mortality and may be useful prognostic measures. Further research is needed in larger cohorts to determine the prognostic value of these differences.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017287"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal Compared With Coronary Artery Calcification and Incident Cardiovascular Events and Mortality in Black Adults.","authors":"Temidayo A Abe, Fengxia Yan, Titilope Olanipekun, Michael Blaha, Valery Effoe, Ndausung Udongwo, Robert J Mentz, Adebamike Oshunbade, James G Terry, Jalal K Ghali, Wondwosen K Yimer, Chukwuemezie Kamanu, Ifeoma Onuorah, Michael Hall, Anekwe Onwuanyi, Adolfo Correa, Melvin Echols","doi":"10.1161/CIRCIMAGING.124.016775","DOIUrl":"10.1161/CIRCIMAGING.124.016775","url":null,"abstract":"<p><strong>Background: </strong>Black adults show heightened cardiovascular risk compared with other groups despite comparable or lower coronary artery calcium (CAC) scores, indicating potential cardiovascular risk underestimation by CAC. Abdominal aortic calcification (AAC), preceding CAC, may predict cardiovascular events better in Black adults who are prone to early atherosclerotic cardiovascular disease and excess events at low CAC scores.</p><p><strong>Methods: </strong>We included 2551 participants from the JHS (Jackson Heart Study) visit 2 examination (2005-2008) without cardiovascular disease, followed through 2016. Cox regression estimated hazard ratios for incident cardiovascular events defined as a composite of myocardial infarction, stroke, heart failure, and all-cause mortality. The predictive value of CAC and AAC, when added to the American College of Cardiology/American Heart Association cardiovascular risk algorithm (pool cohort equation), was assessed.</p><p><strong>Results: </strong>Mean age was 57±10 years; 66% were women. Over a follow-up period of 12.6 years, 287 (11.3%) cardiovascular events and 360 (14.1%) mortality cases were observed. Adjusting for demographic and clinical variables, each 2-fold increase in CAC and AAC was associated with cardiovascular events (CAC: hazard ratio, 1.10 [95% CI, 1.06-1.13]; AAC: hazard ratio, 1.10 [95% CI, 1.06-1.13]) and all-cause mortality CAC: hazard ratio, 1.04 [95% CI, 1.01-1.08]; AAC: hazard ratio, 1.05 [95% CI, 1.01-1.08]). The incremental value of CAC (0.17 [95% CI, 0.08-0.23]) and AAC (0.15 [95% CI, 0.07-0.29]) to the pool cohort equation by net reclassification index was comparable. Notably, 45% of participants with 0 CAC showed some degree of AAC. Each 2-fold increase in AAC was associated with an increased risk of cardiovascular events (hazard ratio, 1.07 [95% CI, 1.01-1.19]) but not all-cause mortality among participants with 0 CAC.</p><p><strong>Conclusions: </strong>AAC is comparable to CAC in predicting cardiovascular events and all-cause mortality among Black adults, potentially valuable when CAC is absent.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e016775"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Ventricular Hypertrophy Following Aortic Valve Replacement: Bruce Banner or the Hulk?","authors":"Timothy C Wong","doi":"10.1161/CIRCIMAGING.124.017716","DOIUrl":"10.1161/CIRCIMAGING.124.017716","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017716"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Right Ventricular Strain the New TAPSE to Estimate Right Ventricular Arterial Coupling in Children?","authors":"Matthew Henry, Lisa K Hornberger","doi":"10.1161/CIRCIMAGING.124.017715","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017715","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":"17 12","pages":"e017715"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eclipsed Mitral Regurgitation as an Early Sign of Myocardial Ischemia Due to Coronary Vasospasm.","authors":"Cristina Garcia-Sebastian, Ana García-Martín, Ángel Sánchez-Recalde, Paloma Remior-Pérez, Luisa Salido-Tahoces, Sara Fernandez-Santos, Covadonga Fernández-Golfin, José Luis Zamorano","doi":"10.1161/CIRCIMAGING.124.017521","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017521","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017521"},"PeriodicalIF":6.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormalities in Coronary Microvasculature in Pulmonary Atresia With Intact Ventricular Septum.","authors":"Annabelle Grace Binti Vincent, Kenzo Ichimura, Shoko Ichimura, Aubrey Olive Alden, Elizabeth Price, Darren Salmi, Ankit Kushwaha, Edda Spiekerkoetter, Sushma Reddy","doi":"10.1161/CIRCIMAGING.124.017415","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017415","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017415"},"PeriodicalIF":6.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}