Philip Haaf, Daniel Tobler, Simon M Frey, Stefan Gherca, Christian Gernhardt, Michael J Zellweger, Jens Bremerich, Maurice Pradella
{"title":"Four-Dimensional Flow MRI in Adult Type Christmas Tree ALCAPA With High Cardiac Output.","authors":"Philip Haaf, Daniel Tobler, Simon M Frey, Stefan Gherca, Christian Gernhardt, Michael J Zellweger, Jens Bremerich, Maurice Pradella","doi":"10.1161/CIRCIMAGING.123.016476","DOIUrl":"10.1161/CIRCIMAGING.123.016476","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Power of Zero Resilience in Genetic Dyslipidemia: Kuhn Model Crisis Moment for the Lipid Hypothesis?","authors":"Khurram Nasir, Sadeer Al-Kindi","doi":"10.1161/CIRCIMAGING.124.016972","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.016972","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter by Tomaselli et al Regarding Article, \"Left Atrial Strain Predicts Subclinical Atrial Fibrillation Detected by Long-Term Continuous Monitoring in Elderly High-Risk Individuals\".","authors":"Michele Tomaselli, Luigi P Badano, Denisa Muraru","doi":"10.1161/CIRCIMAGING.124.016864","DOIUrl":"10.1161/CIRCIMAGING.124.016864","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stressing the Importance of Autonomic Nervous System Dysfunction.","authors":"Jamie W Bellinge, Ahmed Tawakol","doi":"10.1161/CIRCIMAGING.124.017028","DOIUrl":"10.1161/CIRCIMAGING.124.017028","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Pisu, Brady J Williamson, Valentina Nardi, Kosmas I Paraskevas, Josep Puig, Achala Vagal, Gianluca de Rubeis, Michele Porcu, Riccardo Cau, John C Benson, Antonella Balestrieri, Giuseppe Lanzino, Jasjit S Suri, Abdelkader Mahammedi, Luca Saba
{"title":"Machine Learning Detects Symptomatic Plaques in Patients With Carotid Atherosclerosis on CT Angiography.","authors":"Francesco Pisu, Brady J Williamson, Valentina Nardi, Kosmas I Paraskevas, Josep Puig, Achala Vagal, Gianluca de Rubeis, Michele Porcu, Riccardo Cau, John C Benson, Antonella Balestrieri, Giuseppe Lanzino, Jasjit S Suri, Abdelkader Mahammedi, Luca Saba","doi":"10.1161/CIRCIMAGING.123.016274","DOIUrl":"10.1161/CIRCIMAGING.123.016274","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to develop and validate a computed tomography angiography based machine learning model that uses plaque composition data and degree of carotid stenosis to detect symptomatic carotid plaques in patients with carotid atherosclerosis.</p><p><strong>Methods: </strong>The machine learning based model was trained using degree of stenosis and the volumes of 13 computed tomography angiography derived intracarotid plaque subcomponents (eg, lipid, intraplaque hemorrhage, calcium) to identify plaques associated with cerebrovascular events. The model was internally validated through repeated 10-fold cross-validation and tested on a dedicated testing cohort according to discrimination and calibration.</p><p><strong>Results: </strong>This retrospective, single-center study evaluated computed tomography angiography scans of 268 patients with both symptomatic and asymptomatic carotid atherosclerosis (163 for the derivation set and 106 for the testing set) performed between March 2013 and October 2019. The area-under-receiver-operating characteristics curve by machine learning on the testing cohort (0.89) was significantly higher than the areas under the curve of traditional logit analysis based on the degree of stenosis (0.51, <i>P</i><0.001), presence of intraplaque hemorrhage (0.69, <i>P</i><0.001), and plaque composition (0.78, <i>P</i><0.001), respectively. Comparable performance was obtained on internal validation. The identified plaque components and associated cutoff values that were significantly associated with a higher likelihood of symptomatic status after adjustment were the ratio of intraplaque hemorrhage to lipid volume (≥50%, 38.5 [10.1-205.1]; odds ratio, 95% CI) and percentage of intraplaque hemorrhage volume (≥10%, 18.5 [5.7-69.4]; odds ratio, 95% CI).</p><p><strong>Conclusions: </strong>This study presented an interpretable machine learning model that accurately identifies symptomatic carotid plaques using computed tomography angiography derived plaque composition features, aiding clinical decision-making.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11186714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeffery Osei, Viola Vaccarino, Maggie Wang, Anish S Shah, Rachel Lampert, Louis Y Li, Yi-An Ko, Brad D Pearce, Michael Kutner, Ernest V Garcia, Marina Piccinelli, Paolo Raggi, J Douglas Bremner, Arshed A Quyyumi, Yan V Sun, Hashir Ahmed, George Haddad, Obada Daaboul, Tatum Roberts, Lewam Stefanos, Luis Correia, Amit J Shah
{"title":"Stress-Induced Autonomic Dysfunction is Associated With Mental Stress-Induced Myocardial Ischemia in Patients With Coronary Artery Disease.","authors":"Jeffery Osei, Viola Vaccarino, Maggie Wang, Anish S Shah, Rachel Lampert, Louis Y Li, Yi-An Ko, Brad D Pearce, Michael Kutner, Ernest V Garcia, Marina Piccinelli, Paolo Raggi, J Douglas Bremner, Arshed A Quyyumi, Yan V Sun, Hashir Ahmed, George Haddad, Obada Daaboul, Tatum Roberts, Lewam Stefanos, Luis Correia, Amit J Shah","doi":"10.1161/CIRCIMAGING.124.016596","DOIUrl":"10.1161/CIRCIMAGING.124.016596","url":null,"abstract":"<p><strong>Background: </strong>Mental stress-induced myocardial ischemia (MSIMI) is associated with adverse cardiovascular outcomes in individuals with coronary artery disease, but the mechanisms underlying this phenomenon are unknown. We examined the relationship between stress-induced autonomic dysfunction, measured by low heart rate variability (HRV) in response to stress, and MSIMI in patients with stable coronary artery disease. We hypothesized that stress-induced autonomic dysfunction is associated with higher odds of MSIMI.</p><p><strong>Methods: </strong>In 735 participants with stable coronary artery disease, we measured high- and low-frequency HRV in 5-minute intervals before and during a standardized laboratory-based speech stressor using Holter monitoring. HRV at rest and stress were categorized into low HRV (first quartile) versus high HRV (second to fourth quartiles); the low category was used as an indicator of autonomic dysfunction. Multivariable logistic regression models were used to examine the association of autonomic dysfunction with MSIMI.</p><p><strong>Results: </strong>The mean age was 58 (SD, ±10) years, 35% were women, 44% were Black participants, and 16% developed MSIMI. Compared with high HRV during stress, low HRV during stress (both high and low frequencies) was associated with higher odds of MSIMI after adjusting for demographic and clinical factors (odds ratio for high-frequency HRV, 2.1 [95% CI, 1.3-3.3]; odds ratio for low-frequency HRV, 2.1 [95% CI, 1.3-3.3]). Low-frequency HRV at rest was also associated with MSIMI but with slightly reduced effect estimates.</p><p><strong>Conclusions: </strong>In individuals with coronary artery disease, mental stress-induced autonomic dysfunction may be a mechanism implicated in the causal pathway of MSIMI.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":6.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11187646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Santiago Luna-Alcala, Mauricio Garcia-Cardenas, Pavel Martinez-Dominguez, Enrique C Guerra, Nilda Espinola-Zavaleta
{"title":"Circumflex Retroesophageal Left Aortic Arch With Aortic Coarctation: A Multimodality Approach.","authors":"Santiago Luna-Alcala, Mauricio Garcia-Cardenas, Pavel Martinez-Dominguez, Enrique C Guerra, Nilda Espinola-Zavaleta","doi":"10.1161/CIRCIMAGING.123.016264","DOIUrl":"10.1161/CIRCIMAGING.123.016264","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Germán Alegre-García, Jorge Segovia-Reyes, Jorge Rodríguez-Capitán, Luis García-Rodríguez, Luis Morcillo-Hidalgo, Juan José Gómez-Doblas, Manuel F Jiménez-Navarro
{"title":"Massive Mitral Valve Prosthetic Thrombosis in a Patient Undergoing Nintedanib Treatment: A Challenging Case Highlighting the Role of Echocardiography.","authors":"Germán Alegre-García, Jorge Segovia-Reyes, Jorge Rodríguez-Capitán, Luis García-Rodríguez, Luis Morcillo-Hidalgo, Juan José Gómez-Doblas, Manuel F Jiménez-Navarro","doi":"10.1161/CIRCIMAGING.123.016212","DOIUrl":"10.1161/CIRCIMAGING.123.016212","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":null,"pages":null},"PeriodicalIF":7.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}