Myocardial Perfusion Imaging With PET: A Head-to-Head Comparison of 82Rubidium Versus 15O-water Tracers Using Invasive Coronary Measurements as Reference.
Simon Winther, Laust Dupont Rasmussen, Salma Raghad Karim, Jelmer Westra, Jonathan Nørtoft Dahl, Jacob Hartmann Søby, Louise Nissen, Fabian Bøgild Lomstein, Morten Würtz, Jens Munch Sundbøll, June Anita Ejlersen, Jesper Mortensen, Lars Poulsen Tolbod, Hanne Maare Søndergaard, Nicolaj Christopher Lyng Hansson, Mette Nyegaard, Rebekka Vibjerg Jensen, Michael Alle Madsen, Evald Høj Christiansen, Lars Christian Gormsen, Morten Böttcher
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引用次数: 0
Abstract
Background: Myocardial perfusion imaging by positron emission tomography (PET) is recommended as a first-line test in stable patients with chest pain symptoms and as a selective second-line test after an abnormal coronary computed tomography angiography (CTA). It is, however, unknown whether the use of Rubidium-82 (82Rb) versus [15O]H2O (15O-water) affects the diagnostic performance in coronary artery disease (CAD). The aim of this study was to compare 82Rb-PET versus 15O-water-PET head-to-head for diagnosing obstructive CAD.
Methods: The study included consecutive patients (n=1000) referred for CTA with symptoms suggestive of obstructive CAD. Patients with suspected stenosis based on CTA were referred for both 82Rb-PET, 15O-water-PET, and subsequently invasive coronary angiography (ICA), including 3-vessel fractional flow reserve and coronary flow reserve measurements.
Results: In total, 196/270 (73%) patients with suspected stenosis on CTA completed 82Rb-PET, 15O-water-PET, and ICA. Myocardial blood flow measurements from 82Rb-PET and 15O-water-PET correlated strongly at rest (ρ, 0.62-0.69) but only moderately during hyperemia (ρ, 0.41-0.59). Only weak correlations were demonstrated between myocardial blood flow reserve by both PET tracers compared with ICA coronary flow reserve (ρ, 0.11-0.38). Hemodynamically obstructive CAD defined as ICA fractional flow reserve ≤0.80, was identified in 86/196 (44%) patients. Using predefined cutoffs, the diagnostic accuracies of 82Rb-PET versus 15O-water-PET were similar (sensitivity 69% [58-78%] versus 71% [60-80%], P=0.59; specificity 85% [76-91%] versus 77% [68-85%], P=0.12). Using ICA diameter stenoses >70% as a reference, only 48/196 (24%) patients had anatomically severe CAD, and 82Rb-PET and 15O-water-PET sensitivities increased to >85%.
Conclusions: For detection of obstructive CAD by PET myocardial perfusion imaging, 82Rb versus 15O-water have similar diagnostic performance.
期刊介绍：
Circulation: Cardiovascular Imaging, an American Heart Association journal, publishes high-quality, patient-centric articles focusing on observational studies, clinical trials, and advances in applied (translational) research. The journal features innovative, multimodality approaches to the diagnosis and risk stratification of cardiovascular disease. Modalities covered include echocardiography, cardiac computed tomography, cardiac magnetic resonance imaging and spectroscopy, magnetic resonance angiography, cardiac positron emission tomography, noninvasive assessment of vascular and endothelial function, radionuclide imaging, molecular imaging, and others.
Article types considered by Circulation: Cardiovascular Imaging include Original Research, Research Letters, Advances in Cardiovascular Imaging, Clinical Implications of Molecular Imaging Research, How to Use Imaging, Translating Novel Imaging Technologies into Clinical Applications, and Cardiovascular Images.
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