{"title":"The Case Against Race-Based Coronary Artery Calcium Screening.","authors":"Shoa L Clarke","doi":"10.1161/CIRCIMAGING.124.017875","DOIUrl":"10.1161/CIRCIMAGING.124.017875","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017875"},"PeriodicalIF":6.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can We Make the Next Step in Precision Risk Stratification of Dilated Cardiomyopathy?","authors":"Viren Ahluwalia, Brian P Halliday","doi":"10.1161/CIRCIMAGING.125.018057","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.125.018057","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":"18 3","pages":"e018057"},"PeriodicalIF":6.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jie Wang, Jinquan Zhang, Wei Liu, Lutong Pu, Weitang Qi, Yuanwei Xu, Ke Wan, Georgios V Gkoutos, Yuchi Han, Yucheng Chen
{"title":"Prognostic Value of Myocardial T1 Mapping for Predicting Adverse Events in Hypertrophic Cardiomyopathy.","authors":"Jie Wang, Jinquan Zhang, Wei Liu, Lutong Pu, Weitang Qi, Yuanwei Xu, Ke Wan, Georgios V Gkoutos, Yuchi Han, Yucheng Chen","doi":"10.1161/CIRCIMAGING.124.017174","DOIUrl":"10.1161/CIRCIMAGING.124.017174","url":null,"abstract":"<p><strong>Background: </strong>In patients with hypertrophic cardiomyopathy, the prognostic value of myocardial T1 and extracellular volume fraction for adverse cardiovascular events has not been well defined.</p><p><strong>Methods: </strong>A total of 663 consecutive participants with hypertrophic cardiomyopathy who underwent 3T cardiovascular magnetic resonance were recruited. The follow-up end points included heart failure (HF)-related death, HF hospitalization, and sudden cardiac death or aborted sudden cardiac death.</p><p><strong>Results: </strong>On Cox proportional hazards regression multivariable analyses, global native T1 excluding late gadolinium enhancement areas (hazard ratio [HR], 1.04 [95% CI, 0.99-1.09]; <i>P</i>=0.094) and global extracellular volume fraction excluding late gadolinium enhancement (HR, 1.02 [95% CI, 0.95-1.10]; <i>P</i>=0.565) were not associated with sudden cardiac death. Conversely, global native T1 (HR, 1.08 per 10 ms increase [95% CI, 1.02-1.16], <i>P</i>=0.014; HR, 1.05 per 10 ms increase [95% CI, 1.01-1.09]; <i>P</i>=0.009) and global extracellular volume fraction (HR, 1.23 per 1% increase [95% CI, 1.11-1.36], <i>P</i><0.001; HR, 1.10 per 1% increase [95% CI, 1.04-1.16]; <i>P</i><0.001) were independently associated with HF-related death and the composite end point of HF-related death or HF hospitalization in multivariable Cox models, respectively.</p><p><strong>Conclusions: </strong>In this study of patients with hypertrophic cardiomyopathy, we found global native T1 and global extracellular volume fraction (excluding late gadolinium enhancement) to be both independently associated with HF-related events, but not sudden cardiac death in multivariable analysis. These findings are hypothesis-generating and will require external validation in larger cohorts.</p><p><strong>Registration: </strong>URL: https://www.chictr.org.cn; Unique identifier: ChiCTR1900024094.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017174"},"PeriodicalIF":6.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie-Julie D K Lemmens, Samuel Heuts, Elham Bidar, Joachim E Wildberger, Casper Mihl, Martijn W Smulders
{"title":"Integrating Coronary Artery Assessment and Myocardial Late Enhancement Imaging With Photon-Counting Detector CT: Visualizing the Invisible.","authors":"Marie-Julie D K Lemmens, Samuel Heuts, Elham Bidar, Joachim E Wildberger, Casper Mihl, Martijn W Smulders","doi":"10.1161/CIRCIMAGING.124.017238","DOIUrl":"10.1161/CIRCIMAGING.124.017238","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017238"},"PeriodicalIF":6.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James Wilson, Chong Jun Hua, Nikoo Aziminia, Charlotte Manisty
{"title":"Imaging of the Acute and Chronic Cardiovascular Complications of Radiation Therapy.","authors":"James Wilson, Chong Jun Hua, Nikoo Aziminia, Charlotte Manisty","doi":"10.1161/CIRCIMAGING.124.017454","DOIUrl":"10.1161/CIRCIMAGING.124.017454","url":null,"abstract":"<p><p>Chest radiotherapy (XRT) plays a crucial role in the treatment of a multitude of cancers including breast, lung, esophageal, and lymphoma. Although XRT enhances cancer survival rates, it may also expose healthy bystander tissues to radiation, potentially leading to severe complications. Initially considered relatively resistant to radiation damage, the heart has been shown over the past 4 decades to be susceptible to radiation-induced cardiovascular toxicity and despite advances in XRT which can minimize radiation exposure to heart tissue, no cardiac radiation dose is entirely safe. The clinical spectrum of radiation-induced cardiovascular toxicity is broad, encompassing coronary artery disease, myocardial dysfunction, valvular abnormalities, and pericardial disorders. Radiation-induced cardiovascular toxicity may manifest acutely or many years after XRT, with each condition more likely to present at certain time points post-XRT. Cardiac imaging is a crucial tool in both the screening and diagnosis of radiation-induced cardiovascular toxicity with an understanding of its pathophysiology, incidence, and progression required to implement a comprehensive, multimodality imaging approach to detect and manage these complications effectively.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017454"},"PeriodicalIF":6.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zainab Albar, Pedro R V O Salerno, Nour Tashtish, Santosh K Sirasapalli, Shuo Li, Khurram Nasir, Salil Deo, Sanjay Rajagopalan, Sadeer Al-Kindi
{"title":"Interplay Between Social Vulnerability Index and Coronary Artery Calcium Scores With Major Adverse Cardiovascular Events.","authors":"Zainab Albar, Pedro R V O Salerno, Nour Tashtish, Santosh K Sirasapalli, Shuo Li, Khurram Nasir, Salil Deo, Sanjay Rajagopalan, Sadeer Al-Kindi","doi":"10.1161/CIRCIMAGING.124.016658","DOIUrl":"10.1161/CIRCIMAGING.124.016658","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery calcium (CAC) scoring predicts cardiovascular risk, but social determinants of health may play a role in its prognostic ability. We examined whether the Social Vulnerability Index (SVI) modifies the association between CAC and major adverse cardiovascular events (MACE) in a community-based screening cohort.</p><p><strong>Methods: </strong>We studied 49 224 participants without known cardiovascular disease referred for CAC scanning from 2014 to 2022 based on cardiovascular risk factors. SVI was determined for each participant based on the census tract. We examined 8-year incidence of MACE (myocardial infarction, stroke, heart failure, revascularization, death) by SVI quartile across CAC score strata (0, 1-99, 100-399, ≥400). Cox proportional hazard models estimated hazard ratios for MACE, associated with demographics, metabolic factors, and CAC.</p><p><strong>Results: </strong>Higher SVI was associated with female sex, non-White race, greater comorbidities, and higher CAC scores. The 8-year MACE rate increased monotonically by SVI quartile, with a hazard ratio of 1.54 (95% CI, 1.24-1.90, <i>P</i><0.001) for the highest versus lowest SVI quartile after adjustment. The association between CAC score and MACE was modified by SVI, with a stronger gradient in risk across CAC strata apparent among vulnerable subgroups.</p><p><strong>Conclusions: </strong>In this no-cost community-based CAC cohort, SVI independently predicted adverse cardiovascular outcomes across all CAC strata. Focused efforts to mitigate the incremental risk associated with social vulnerability are needed.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e016658"},"PeriodicalIF":6.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Di Zhou, Leyi Zhu, Shuang Li, Weichun Wu, Baiyan Zhuang, Jing Xu, Wenjing Yang, Jian He, Yining Wang, Yuhui Zhang, Guanshu Liu, Xiaoxin Sun, Qiang Zhang, Zhongzhao Teng, Arlene Sirajuddin, Andrew E Arai, Shihua Zhao, Minjie Lu
{"title":"Prognosis and Risk Stratification in Dilated Cardiomyopathy With LVEF≤35%: Cardiac MRI Insights for Better Outcomes.","authors":"Di Zhou, Leyi Zhu, Shuang Li, Weichun Wu, Baiyan Zhuang, Jing Xu, Wenjing Yang, Jian He, Yining Wang, Yuhui Zhang, Guanshu Liu, Xiaoxin Sun, Qiang Zhang, Zhongzhao Teng, Arlene Sirajuddin, Andrew E Arai, Shihua Zhao, Minjie Lu","doi":"10.1161/CIRCIMAGING.124.017246","DOIUrl":"10.1161/CIRCIMAGING.124.017246","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines recommend implantable cardioverter defibrillators for the primary prevention of sudden cardiac death (SCD) in patients with dilated cardiomyopathy with left ventricular ejection fraction (LVEF)≤35%. However, its effectiveness is hindered by the inability to reliably discriminate between the risk of SCD and competing death of heart failure deterioration, thereby limiting its clinical utility. We aimed to refine the SCD risk stratification model based on cardiac magnetic resonance imaging for patients with dilated cardiomyopathy with LVEF≤35%.</p><p><strong>Methods: </strong>A total of 1272 patients with dilated cardiomyopathy with LVEF≤35% who underwent cardiac magnetic resonance imaging were consecutively enrolled in this study. The primary end point is a composite of SCD or aborted SCD and the second end point is a composite of heart failure death and heart transplantation.</p><p><strong>Results: </strong>Over a median follow-up of 86.3 months, 101 patients reached the primary end point. In the adjusted analysis, age (hazard ratio [HR], 1.02 [95% CI, 1.01-1.04]; <i>P</i>=0.006) years, a family history of SCD (HR, 2.00 [95% CI, 1.01-3.98]; <i>P</i>=0.05), NT-proBNP (N-terminal pro-B-type natriuretic peptide) (HR, 2.02 [95% CI, 1.18-3.44]; <i>P</i>=0.01), LVEF (per 5% HR, 0.79 [95% CI, 0.66-0.95]; <i>P</i>=0.01), and late gadolinium enhancement≥7.5% (HR, 4.11[95% CI, 2.72-6.21]; <i>P</i><0.001) were associated with SCD or aborted SCD. Left atrial volume index≥68.3 mL/m<sup>2</sup> was an independent predictor of the secondary end point (adjusted HR, 1.65 [95% CI, 1.13-2.40]; <i>P</i>=0.009). Compared with late gadolinium enhancement<7.5%, patients with late gadolinium enhancement≥7.5% and LVEF≤20% had a 7.12-fold higher risk of experiencing SCD events in competing Cox analysis (annual event rate, 4.8%).</p><p><strong>Conclusions: </strong>Patients with dilated cardiomyopathy with late gadolinium enhancement≥7.5% were at heightened risk of SCD events, which can be used for risk assessment. Risk stratifications for SCD, combining clinical and cardiac magnetic resonance imaging may potentially guide decision-making for implantable cardioverter defibrillator therapy.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":"18 3","pages":"e017246"},"PeriodicalIF":6.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annu Kurian, Alyssa de Moraes, Olivier F Clerc, Ardel J Romero Pabon, Robert F Padera, Sarah A M Cuddy, Sharmila Dorbala
{"title":"<sup>124</sup>I-Evuzamitide PET/CT Diagnosis of Wild-Type Transthyretin Amyloid Cardiomyopathy in a Woman With Negative Diagnostic Evaluation.","authors":"Annu Kurian, Alyssa de Moraes, Olivier F Clerc, Ardel J Romero Pabon, Robert F Padera, Sarah A M Cuddy, Sharmila Dorbala","doi":"10.1161/CIRCIMAGING.124.017807","DOIUrl":"10.1161/CIRCIMAGING.124.017807","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017807"},"PeriodicalIF":6.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}