Roel Hoek, Yvemarie B O Somsen, Ruben W de Winter, Ruurt A Jukema, Jos W Twisk, Pieter G Raijmakers, Ibrahim Danad, Juhani Knuuti, Paul Knaapen, Pepijn A van Diemen, Roel S Driessen
{"title":"相对血流储备对既往冠状动脉疾病患者的诊断价值：PACIFIC-2试验的事后分析","authors":"Roel Hoek, Yvemarie B O Somsen, Ruben W de Winter, Ruurt A Jukema, Jos W Twisk, Pieter G Raijmakers, Ibrahim Danad, Juhani Knuuti, Paul Knaapen, Pepijn A van Diemen, Roel S Driessen","doi":"10.1161/CIRCIMAGING.125.018574","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The relative flow reserve (RFR) derived from quantitative myocardial perfusion imaging is the ratio of absolute myocardial perfusion in a stenotic to normally perfused area and is considered the noninvasive equivalent of fractional flow reserve (FFR). In patients with prior coronary artery disease (CAD), detecting hemodynamically significant CAD using hyperemic myocardial blood flow (hMBF) is complicated by diffuse CAD and microvascular disease. In these patients, RFR may improve the diagnostic performance of myocardial perfusion imaging. Therefore, we studied the diagnostic value of RFR over hMBF in patients with prior CAD.</p><p><strong>Methods: </strong>The PACIFIC-2 trial included symptomatic patients with prior myocardial infarction and percutaneous coronary intervention who prospectively underwent [<sup>15</sup>O]H<sub>2</sub>O positron emission tomography perfusion imaging and invasive coronary angiography with 3-vessel FFR. RFR was assessed using positron emission tomography in an overall cohort incorporating all trial patients, and an optimal cohort of patients with angiographic 1- or 2-vessel disease (diameter stenosis ≥50%) and a nonstenotic reference vessel (diameter stenosis <30%). RFR was calculated as the ratio between the lowest to highest regional hMBF (overall cohort), or the lowest hMBF of a stenotic to the reference area (optimal cohort). Position emission tomography-derived flow indices were referenced by invasive FFR (≤0.80 deemed hemodynamically significant).</p><p><strong>Results: </strong>The overall cohort included 187 patients (63±9.3 years, 36 [19%] female), and the optimal cohort 80 patients (62±9.6 years, 19 [24%] female). Significant CAD was present in 87 (47%) and 43 (54%) patients, respectively. Correlations between RFR and FFR were 0.42 and 0.52 (<i>P</i><0.001 for both). C statistics for hMBF and RFR were comparable in the overall (0.81 versus 0.78; <i>P</i>=0.288) and the optimal cohort (0.79 versus 0.82; <i>P</i>=0.512).</p><p><strong>Conclusions: </strong>RFR proves clinically applicable, even without specific patient selection and knowledge of the coronary anatomy. However, RFR does not outperform absolute hyperemic myocardial perfusion for detecting FFR-defined significant CAD in patients with prior CAD and recurrence of symptoms.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e018574"},"PeriodicalIF":7.0000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic Value of Relative Flow Reserve in Patients With Prior Coronary Artery Disease: A Post Hoc Analysis of the PACIFIC-2 Trial.\",\"authors\":\"Roel Hoek, Yvemarie B O Somsen, Ruben W de Winter, Ruurt A Jukema, Jos W Twisk, Pieter G Raijmakers, Ibrahim Danad, Juhani Knuuti, Paul Knaapen, Pepijn A van Diemen, Roel S Driessen\",\"doi\":\"10.1161/CIRCIMAGING.125.018574\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The relative flow reserve (RFR) derived from quantitative myocardial perfusion imaging is the ratio of absolute myocardial perfusion in a stenotic to normally perfused area and is considered the noninvasive equivalent of fractional flow reserve (FFR). In patients with prior coronary artery disease (CAD), detecting hemodynamically significant CAD using hyperemic myocardial blood flow (hMBF) is complicated by diffuse CAD and microvascular disease. In these patients, RFR may improve the diagnostic performance of myocardial perfusion imaging. Therefore, we studied the diagnostic value of RFR over hMBF in patients with prior CAD.</p><p><strong>Methods: </strong>The PACIFIC-2 trial included symptomatic patients with prior myocardial infarction and percutaneous coronary intervention who prospectively underwent [<sup>15</sup>O]H<sub>2</sub>O positron emission tomography perfusion imaging and invasive coronary angiography with 3-vessel FFR. RFR was assessed using positron emission tomography in an overall cohort incorporating all trial patients, and an optimal cohort of patients with angiographic 1- or 2-vessel disease (diameter stenosis ≥50%) and a nonstenotic reference vessel (diameter stenosis <30%). RFR was calculated as the ratio between the lowest to highest regional hMBF (overall cohort), or the lowest hMBF of a stenotic to the reference area (optimal cohort). Position emission tomography-derived flow indices were referenced by invasive FFR (≤0.80 deemed hemodynamically significant).</p><p><strong>Results: </strong>The overall cohort included 187 patients (63±9.3 years, 36 [19%] female), and the optimal cohort 80 patients (62±9.6 years, 19 [24%] female). Significant CAD was present in 87 (47%) and 43 (54%) patients, respectively. Correlations between RFR and FFR were 0.42 and 0.52 (<i>P</i><0.001 for both). C statistics for hMBF and RFR were comparable in the overall (0.81 versus 0.78; <i>P</i>=0.288) and the optimal cohort (0.79 versus 0.82; <i>P</i>=0.512).</p><p><strong>Conclusions: </strong>RFR proves clinically applicable, even without specific patient selection and knowledge of the coronary anatomy. However, RFR does not outperform absolute hyperemic myocardial perfusion for detecting FFR-defined significant CAD in patients with prior CAD and recurrence of symptoms.</p>\",\"PeriodicalId\":10202,\"journal\":{\"name\":\"Circulation: Cardiovascular Imaging\",\"volume\":\" \",\"pages\":\"e018574\"},\"PeriodicalIF\":7.0000,\"publicationDate\":\"2025-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Circulation: Cardiovascular Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1161/CIRCIMAGING.125.018574\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Circulation: Cardiovascular Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1161/CIRCIMAGING.125.018574","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Diagnostic Value of Relative Flow Reserve in Patients With Prior Coronary Artery Disease: A Post Hoc Analysis of the PACIFIC-2 Trial.
Background: The relative flow reserve (RFR) derived from quantitative myocardial perfusion imaging is the ratio of absolute myocardial perfusion in a stenotic to normally perfused area and is considered the noninvasive equivalent of fractional flow reserve (FFR). In patients with prior coronary artery disease (CAD), detecting hemodynamically significant CAD using hyperemic myocardial blood flow (hMBF) is complicated by diffuse CAD and microvascular disease. In these patients, RFR may improve the diagnostic performance of myocardial perfusion imaging. Therefore, we studied the diagnostic value of RFR over hMBF in patients with prior CAD.
Methods: The PACIFIC-2 trial included symptomatic patients with prior myocardial infarction and percutaneous coronary intervention who prospectively underwent [15O]H2O positron emission tomography perfusion imaging and invasive coronary angiography with 3-vessel FFR. RFR was assessed using positron emission tomography in an overall cohort incorporating all trial patients, and an optimal cohort of patients with angiographic 1- or 2-vessel disease (diameter stenosis ≥50%) and a nonstenotic reference vessel (diameter stenosis <30%). RFR was calculated as the ratio between the lowest to highest regional hMBF (overall cohort), or the lowest hMBF of a stenotic to the reference area (optimal cohort). Position emission tomography-derived flow indices were referenced by invasive FFR (≤0.80 deemed hemodynamically significant).
Results: The overall cohort included 187 patients (63±9.3 years, 36 [19%] female), and the optimal cohort 80 patients (62±9.6 years, 19 [24%] female). Significant CAD was present in 87 (47%) and 43 (54%) patients, respectively. Correlations between RFR and FFR were 0.42 and 0.52 (P<0.001 for both). C statistics for hMBF and RFR were comparable in the overall (0.81 versus 0.78; P=0.288) and the optimal cohort (0.79 versus 0.82; P=0.512).
Conclusions: RFR proves clinically applicable, even without specific patient selection and knowledge of the coronary anatomy. However, RFR does not outperform absolute hyperemic myocardial perfusion for detecting FFR-defined significant CAD in patients with prior CAD and recurrence of symptoms.
期刊介绍：
Circulation: Cardiovascular Imaging, an American Heart Association journal, publishes high-quality, patient-centric articles focusing on observational studies, clinical trials, and advances in applied (translational) research. The journal features innovative, multimodality approaches to the diagnosis and risk stratification of cardiovascular disease. Modalities covered include echocardiography, cardiac computed tomography, cardiac magnetic resonance imaging and spectroscopy, magnetic resonance angiography, cardiac positron emission tomography, noninvasive assessment of vascular and endothelial function, radionuclide imaging, molecular imaging, and others.
Article types considered by Circulation: Cardiovascular Imaging include Original Research, Research Letters, Advances in Cardiovascular Imaging, Clinical Implications of Molecular Imaging Research, How to Use Imaging, Translating Novel Imaging Technologies into Clinical Applications, and Cardiovascular Images.
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