{"title":"Left Ventricular Hypertrophy Following Aortic Valve Replacement: Bruce Banner or the Hulk?","authors":"Timothy C Wong","doi":"10.1161/CIRCIMAGING.124.017716","DOIUrl":"10.1161/CIRCIMAGING.124.017716","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017716"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is Right Ventricular Strain the New TAPSE to Estimate Right Ventricular Arterial Coupling in Children?","authors":"Matthew Henry, Lisa K Hornberger","doi":"10.1161/CIRCIMAGING.124.017715","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017715","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":"17 12","pages":"e017715"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristina Garcia-Sebastian, Ana García-Martín, Ángel Sánchez-Recalde, Paloma Remior-Pérez, Luisa Salido-Tahoces, Sara Fernandez-Santos, Covadonga Fernández-Golfin, José Luis Zamorano
{"title":"Eclipsed Mitral Regurgitation as an Early Sign of Myocardial Ischemia Due to Coronary Vasospasm.","authors":"Cristina Garcia-Sebastian, Ana García-Martín, Ángel Sánchez-Recalde, Paloma Remior-Pérez, Luisa Salido-Tahoces, Sara Fernandez-Santos, Covadonga Fernández-Golfin, José Luis Zamorano","doi":"10.1161/CIRCIMAGING.124.017521","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017521","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017521"},"PeriodicalIF":6.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhengyang Han, Suyun Hou, Yang Chen, Zhengguang Chen, Zhenxing Sun
{"title":"Climber in the Cardiovascular System: Intravenous Leiomyomatosis.","authors":"Zhengyang Han, Suyun Hou, Yang Chen, Zhengguang Chen, Zhenxing Sun","doi":"10.1161/CIRCIMAGING.124.017305","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017305","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017305"},"PeriodicalIF":6.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hongxia Ning, Jiajing Ouyang, Jun Yang, Zongyi Xiu, Tianxiang Gu, Yang Bai, Chunyan Ma
{"title":"Mechanical Mitral Valve Avulsion and Mitral-Aortic Junction Pseudoaneurysm Following Surgical Treatment of Mitral Valve Aneurysm and Severe Aortic Insufficiency in a Patient With Spondyloarthropathy: A Rarity With a Possible Association.","authors":"Hongxia Ning, Jiajing Ouyang, Jun Yang, Zongyi Xiu, Tianxiang Gu, Yang Bai, Chunyan Ma","doi":"10.1161/CIRCIMAGING.124.017449","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017449","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017449"},"PeriodicalIF":6.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omar Dzaye, Alexander C Razavi, Zeina A Dardari, Frances M Wang, Yasuyuki Honda, Khurram Nasir, Josef Coresh, Candace M Howard-Claudio, Jin Jin, Bing Yu, Paul S de Vries, Lynne Wagenknecht, Aaron R Folsom, Ron Blankstein, Tanika N Kelly, Seamus P Whelton, Martin Bødtker Mortensen, Ziqiao Wang, Nilanjan Chatterjee, Kunihiro Matsushita, Michael J Blaha
{"title":"Polygenic Risk Scores and Extreme Coronary Artery Calcium Phenotypes (CAC=0 and CAC≥1000) in Adults ≥75 Years Old: The ARIC Study.","authors":"Omar Dzaye, Alexander C Razavi, Zeina A Dardari, Frances M Wang, Yasuyuki Honda, Khurram Nasir, Josef Coresh, Candace M Howard-Claudio, Jin Jin, Bing Yu, Paul S de Vries, Lynne Wagenknecht, Aaron R Folsom, Ron Blankstein, Tanika N Kelly, Seamus P Whelton, Martin Bødtker Mortensen, Ziqiao Wang, Nilanjan Chatterjee, Kunihiro Matsushita, Michael J Blaha","doi":"10.1161/CIRCIMAGING.123.016377","DOIUrl":"10.1161/CIRCIMAGING.123.016377","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery calcium (CAC) is heterogeneous in older age and is incompletely explained by traditional atherosclerotic cardiovascular disease risk factors. The extremes of subclinical atherosclerosis burden are strongly associated with either a low or high 10-year risk of incident atherosclerotic cardiovascular disease, respectively. However, the genetic underpinnings of differences in arterial aging remain unclear. We sought to determine the independent association of 2 polygenic scores for coronary heart disease (CHD) with CAC in adults ≥75 years of age.</p><p><strong>Methods: </strong>There were 1865 ARIC (Atherosclerosis Risk in Communities) participants who underwent genetic testing at visit 1 (1987-1989) and CAC scans at visit 7 (2018-2019). In the primary analysis, an externally derived multi-ancestry polygenic CHD risk score was calculated for both White and Black participants. Results were confirmed using a separate ARIC-derived polygenic CHD risk score, including ≥6 million variants computed for White participants. We used multivariable logistic regression models to assess the association of polygenic CHD risk with CAC, after adjusting for baseline, time-averaged lifestyle, traditional risk factors, and local ancestry principal components.</p><p><strong>Results: </strong>In the primary analysis, the average age was 80.6 years old, 61.6% were women, and the median CAC score was 246 (189 participants with CAC=0, 364 participants with CAC≥1000). Compared with persons below the 20th percentile of polygenic CHD risk, persons with polygenic-CHD risk above the 80th percentile had 82% lower odds of having CAC=0 (odds ratio, 0.18 [95% CI, 0.09-0.37]) and had >4-fold higher odds of CAC≥1000 (odds ratio, 4.77 [95% CI, 2.88-7.88]). On a continuous scale, each SD increment increase in the polygenic risk score was associated with a 78% higher CAC score. Results were nearly identical using a second confirmatory polygenic CHD risk score in White participants.</p><p><strong>Conclusions: </strong>Polygenic CHD risk is robustly associated with a lower prevalence of CAC=0 and a higher prevalence of CAC≥1000 in adults ≥75 years of age, beyond lifestyle and traditional risk factors. These results suggest a heritable contribution to distinct healthy and unhealthy arterial aging phenotypes that persist throughout the life course.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e016377"},"PeriodicalIF":6.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emilia Zampella, Roberta Assante, Adriana D'Antonio, Teresa Mannarino, Valeria Gaudieri, Carmela Nappi, Parthiban Arumugam, Mariarosaria Panico, Pietro Buongiorno, Mario Petretta, Alberto Cuocolo, Wanda Acampa
{"title":"Prognostic Value of Coronary Flow Capacity by <sup>82</sup>Rb PET in Patients With Suspected Coronary Artery Disease and Normal Myocardial Perfusion at Semiquantitative Imaging Analysis.","authors":"Emilia Zampella, Roberta Assante, Adriana D'Antonio, Teresa Mannarino, Valeria Gaudieri, Carmela Nappi, Parthiban Arumugam, Mariarosaria Panico, Pietro Buongiorno, Mario Petretta, Alberto Cuocolo, Wanda Acampa","doi":"10.1161/CIRCIMAGING.124.016815","DOIUrl":"10.1161/CIRCIMAGING.124.016815","url":null,"abstract":"<p><strong>Background: </strong>Coronary flow capacity (CFC) is a measure that integrates hyperemic myocardial blood flow and myocardial flow reserve to quantify the pathophysiological impact of coronary artery disease on vasodilator capacity. We assessed the prognostic value of CFC derived from <sup>82</sup>Rb positron emission tomography/computed tomography in patients with suspected coronary artery disease and normal myocardial perfusion imaging.</p><p><strong>Methods: </strong>We studied 1967 patients with suspected coronary artery disease and normal myocardial perfusion at the semiquantitative analysis of stress/rest cardiac <sup>82</sup>Rb positron emission tomography/computed tomography imaging. Coronary artery calcium scores were calculated and categorized into 3 groups: 0, 0.1 to 99.9, and ≥100. Patients were classified as having myocardial steal, severely reduced CFC, moderately reduced CFC, mildly reduced CFC, minimally reduced CFC, or normal flow using previously defined thresholds. The outcome end points were myocardial infarction and cardiac death, whichever occurred first.</p><p><strong>Results: </strong>During a mean time of 41±27 months, 49 events occurred (2.5% cumulative event rate, with an annualized event rate of 0.5% person-years). At multivariable Cox analysis, coronary artery calcium score categories and impaired CFC resulted as independent predictors of events (both <i>P</i><0.001). The annualized event rate was higher in patients with impaired CFC compared with those with normal CFC (<i>P</i><0.05). Kaplan-Meier analysis showed that patients with impaired CFC were at the highest risk of events.</p><p><strong>Conclusions: </strong>In patients with suspected coronary artery disease and normal myocardial perfusion, impaired CFC is associated with a higher risk of cardiac events. Evaluating CFC can help identify patients' candidates for additional therapies to prevent future events.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e016815"},"PeriodicalIF":6.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11575911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strong Genes: Insights Into Polygenic Risk and Coronary Artery Calcium in Older Individuals.","authors":"Aniruddh P Patel","doi":"10.1161/CIRCIMAGING.124.017531","DOIUrl":"10.1161/CIRCIMAGING.124.017531","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017531"},"PeriodicalIF":6.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}