Circulation: Cardiovascular Imaging最新文献

{"title":"Predicting Late Adverse Events in Uncomplicated Stanford Type B Aortic Dissection: Results From the ROADMAP Validation Study.","authors":"Dominik Fleischmann, Domenico Mastrodicasa, Martin J Willemink, Valery L Turner, Virginia Hinostroza, Nicholas S Burris, Bo Yang, Kate Hanneman, Maral Ouzounian, Daniel Ocazionez Trujillo, Rana O Afifi, Anthony L Estrera, Joan M Lacomis, Ibrahim Sultan, Thomas G Gleason, Davide Pacini, Gianluca Folesani, Luigi Lovato, Arthur E Stillman, Carlo N De Cecco, Edward P Chen, Ricarda Hinzpeter, Hatem Alkadhi, Sandeep Hedgire, Thoralf M Sundt, Sander M J van Kuijk, Geert Willem H Schurink, Anne S Chin, Marina Codari, Anna M Sailer, Gabriel Mistelbauer, Mohammad H Madani, Kathrin Bäumler, Jody Shen, Kendrick M Lai, Michael P Fischbein, D Craig Miller","doi":"10.1161/CIRCIMAGING.124.016766","DOIUrl":"10.1161/CIRCIMAGING.124.016766","url":null,"abstract":"<p><strong>Background: </strong>Risk stratification is highly desirable in patients with uncomplicated Stanford type B aortic dissection but inadequately supported by evidence. We sought to validate externally a published prediction model for late adverse events (LAEs), consisting of 1 clinical (connective tissue disease) and 4 imaging variables: maximum aortic diameter, false lumen circumferential angle, false lumen outflow, and number of identifiable intercostal arteries.</p><p><strong>Methods: </strong>We assembled a retrospective multicenter cohort (ROADMAP [Registry of Aortic Diseases to Model Adverse Events and Progression]) of 401 patients with uncomplicated Stanford type B aortic dissection presenting to 1 of 8 aortic centers between 2001 and 2013, followed until 2020. LAEs were defined as fatal or nonfatal aortic rupture, new refractory hypertension or pain, organ or limb ischemia, aortic aneurysm formation (≥6 cm), or rapid growth (≥1 cm per year). We applied the original model parameters to the validation cohort and examined the effect on risk categorization using LAE end points.</p><p><strong>Results: </strong>One hundred and seventy-six patients (44%) with incomplete imaging or clinical data were excluded. Of 225 patients in the final cohort, 90 (40%) developed LAEs, predominantly driven by aneurysm formation. Baseline maximum aortic diameter was significantly larger in patients with (42.6 [95% CI, 39.1-45.8] mm) compared with patients without LAEs (39.9 [95% CI, 36.3-44.2] mm; <i>P</i>=0.001). A multivariable Cox regression model indicated that only maximum diameter was associated with LAEs (hazard ratio, 1.07 [95% CI, 1.03-1.11] per mm; <i>P</i><0.001), while the other parameters were not (<i>P</i>>0.05). Applying the original prediction model to the validation cohort resulted in a poor 5-year sensitivity (38%) and specificity (69%).</p><p><strong>Conclusions: </strong>A clinical and imaging-based prediction model performed poorly in the ROADMAP cohort. Maximum aortic diameter remains the strongest predictor of LAEs in uncomplicated Stanford type B aortic dissection.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":"18 2","pages":"e016766"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Seemann et al, \"Noninvasive Quantification of Pressure-Volume Loops From Brachial Pressure and Cardiovascular Magnetic Resonance\".","authors":"","doi":"10.1161/HCI.0000000000000087","DOIUrl":"https://doi.org/10.1161/HCI.0000000000000087","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":"18 2","pages":"e000087"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Assessment of Subclinical Arterial Inflammation in Patients Receiving Immune Checkpoint Inhibitors by Sequential [¹⁸F]FDG PET Scans.","authors":"Lucas Bacmeister, Niklas Hempfling, Alexander Maier, Susanne Weber, Annette Buellesbach, Adrian Heidenreich, Istvan Bojti, Mark Colin Gissler, Ingo Hilgendorf, Constantin von Zur Muehlen, Dirk Westermann, Philipp Tobias Meyer, Christian Goetz, Dennis Wolf","doi":"10.1161/CIRCIMAGING.124.016851","DOIUrl":"10.1161/CIRCIMAGING.124.016851","url":null,"abstract":"<p><strong>Background: </strong>Immune checkpoint inhibitors (ICIs), though revolutionary in cancer treatment, may accelerate atherosclerosis by inducing arterial inflammation. Due to a lack of controlled studies, the capacity of arterial 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) uptake in patients with cancer to detect this arterial inflammation remains unclear.</p><p><strong>Methods: </strong>Arterial [¹⁸F]FDG uptake at 6 anatomic landmarks was assessed on serial positron emission tomography scans in patients with cancer treated at a German University Hospital between January 2010 and May 2023. Patients aged ≥65 years with at least 4 sequential scans within 30 months were included. Linear mixed regression analyses were used to evaluate the change in arterial tracer uptake in patients who received ICI or not.</p><p><strong>Results: </strong>Of the 156 patients included, 50 (30.1%) received ICIs after the baseline scan. Baseline arterial [¹⁸F]FDG uptake correlated with traditional cardiovascular risk factors, such as body mass index and male sex. Cross-sectional analyses suggested a negative effect of cholesterol-lowering medication on arterial [¹⁸F]FDG uptake at follow-up. In a time-dependent interaction analysis, arterial [¹⁸F]FDG uptake increased by 0.8% annually in patients without ICIs (95% CI, 0.2%-1.4%), potentially reflecting the background progression of arterial inflammation in patients with cancer. In ICI users, [¹⁸F]FDG uptake increased by 2.5% annually (95% CI, 1.7%-3.3%; <i>P</i>=0.001 for interaction with no ICI). Higher annual increase rates in ICI users were consistent across several anatomic landmarks, preexisting cardiovascular disease status, arterial calcification status, and concomitant chemotherapy or steroid use. However, this effect did not reach statistical significance in patients with melanoma and those with prior irradiation therapy.</p><p><strong>Conclusions: </strong>This is the first controlled clinical study supporting the role of ICIs in accelerating atherosclerosis through low-grade arterial inflammation. However, although detectable by repeated [¹⁸F]FDG scans, the increase in tracer uptake associated with ICI use was modest compared with individual variability, questioning whether [¹⁸F]FDG captures the full pathophysiological process of ICI-induced, lymphocyte-driven inflammation.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e016851"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Myocarditis: Exploring the Vascular Impact of Immune Checkpoint Inhibitors.","authors":"Brett W Sperry, Patrick J Miller","doi":"10.1161/CIRCIMAGING.125.017937","DOIUrl":"10.1161/CIRCIMAGING.125.017937","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017937"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-In-Human Study of [⁶⁴Cu]Cu-DOTATATE PET/CT in Infective Endocarditis: A Prospective Head-to-Head Comparison With [¹⁸F]FDG.","authors":"Katra Hadji-Turdeghal, Marie Øbro Fosbøl, Philip Hasbak, Johan Löfgren, Ida Bull Rasmussen, Henning Bundgaard, Kasper Iversen, Niels Eske Bruun, Christian H Møller, Christian Tuxen, Helle Hjorth Johannesen, Lars Køber, Andreas Kjær, Rasmus Sejersten Ripa, Emil Loldrup Fosbøl","doi":"10.1161/CIRCIMAGING.124.017156","DOIUrl":"10.1161/CIRCIMAGING.124.017156","url":null,"abstract":"<p><strong>Background: </strong>Infective endocarditis (IE) can be challenging to diagnose. Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[¹⁸F]-fluoro-d-glucose ([¹⁸F]FDG) is recommended as a diagnostic tool in the guidelines, but holds limitations. The aim of this study was to compare the tracer uptake between the novel [⁶⁴Cu]Cu-DOTATATE, which has low cardiac uptake and does not require fasting or dietary restrictions, and [¹⁸F]FDG in patients with IE and examine the sensitivity and specificity.</p><p><strong>Methods: </strong>The CuDOS study (Cu-Dotatate Positron Emissions Tomography in Infective Endocarditis) was a prospective study including 20 patients with IE (10 with prosthetic valve endocarditis and 10 with native valve endocarditis) and 20 controls. All participants underwent [⁶⁴Cu]Cu-DOTATATE and [¹⁸F]FDG PET/CT. Scans were read blinded to clinical data. Tracer uptakes were measured as maximum standardized uptake values in each heart valve. Differences were tested with Wilcoxon rank tests.</p><p><strong>Results: </strong>The median age of the cases and controls was 68 years (interquartile range [IQR], 55.0-75.5) and 61 years (IQR, 57.0-69.5), respectively. [⁶⁴Cu]Cu-DOTATATE uptake (median maximum standardized uptake value [IQR]) in patients with IE was higher than in controls (2.34 [1.40-3.23] versus 1.44 [1.21-1.60]; <i>P</i> =0.008), although this difference was mainly driven by prosthetic valve endocarditis cases (3.23 [2.02-3.86]; <i>P</i> <0.001) and not between native valve endocarditis cases and controls (1.51 [1.23-2.58]; <i>P</i>=0.428). The sensitivity of [⁶⁴Cu]Cu-DOTATATE and [¹⁸F]FDG PET/CT in 20 cases versus 20 controls were equal, and the specificity was 90% and 75%, respectively. The analysis of prosthetic valve endocarditis versus the 20 controls showed equal sensitivity (80%), and a specificity of 90% and 75%, respectively (<i>P</i> =0.38). In addition, a greater proportion of scans achieved diagnostic certainty with [⁶⁴Cu]Cu-DOTATATE PET/CT compared with [¹⁸F]FDG PET/CT for native valve endocarditis, prosthetic valve endocarditis, and controls.</p><p><strong>Conclusions: </strong>[⁶⁴Cu]Cu-DOTATATE PET/CT showed uptake in the infected valve in patients with IE, and has major advantage as it does not require any preparation compared with [¹⁸F]FDG. [⁶⁴Cu]Cu-DOTATATE had a numerically higher specificity than [¹⁸F]FDG, although the difference was not statistically significant. Both tracers were limited in the detection of native valve endocarditis.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT05432427. www.clinicaltrialsregister.eu; Unique identifier: 2021-005501-27.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017156"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Usual Suspects: Myocardial Infarction Triggered by Coronary Vasculitis in a Young Patient With Systemic Lupus Erythematosus.","authors":"Maria Jose Santa Ana-Bayona, Pavel Martinez-Dominguez, Oscar Perez-Orpinel, Enrique C Guerra, Nilda Espinola-Zavaleta","doi":"10.1161/CIRCIMAGING.124.017009","DOIUrl":"10.1161/CIRCIMAGING.124.017009","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017009"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Natale et al Regarding Article, \"Association of Lipoprotein(a) With Changes in Coronary Atherosclerosis in Patients Treated With Alirocumab\".","authors":"Francesco Natale, Paolo Golino, Giovanni Cimmino","doi":"10.1161/CIRCIMAGING.124.017942","DOIUrl":"10.1161/CIRCIMAGING.124.017942","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017942"},"PeriodicalIF":6.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Left Ventricular Remodeling in Fabry Cardiomyopathy: The Key Diagnostic Role of T1 Mapping.","authors":"Stefano Censi, Giada De Angeli, Federico Pieruzzi, Lara Tondi, Gianluigi Guida, Giandomenico Disabato, Andrea Attanasio, Pietro Spagnolo, Gianpaolo Carrafiello, Massimo Lombardi, Antonia Camporeale","doi":"10.1161/CIRCIMAGING.124.017640","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017640","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017640"},"PeriodicalIF":6.5,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cave Under the Aortic Valve: The Rare Left Ventricular Outflow Tract Pseudoaneurysm With Thrombosis.","authors":"Shuang Wang, Wanwan Song, Wenjun Yu, Jinping Liu, Bin Wang","doi":"10.1161/CIRCIMAGING.124.017574","DOIUrl":"https://doi.org/10.1161/CIRCIMAGING.124.017574","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e017574"},"PeriodicalIF":6.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study.","authors":"Luca Cristin, Shalini Dixit, Dwight Bibby, Janet J Tang, Qizhi Fang, Lionel Tastet, Amy H Rich, Rohit Jhawar, Yasufumi Nagata, Satoshi Higuchi, Robert A Levine, Henry H Hsia, Zian H Tseng, Nelson B Schiller, Francesca N Delling","doi":"10.1161/CIRCIMAGING.124.017051","DOIUrl":"10.1161/CIRCIMAGING.124.017051","url":null,"abstract":"<p><strong>Background: </strong>A subset of patients with mitral valve prolapse (MVP), a highly heritable condition, experience sudden cardiac arrest (SCA) or sudden cardiac death (SCD). However, the inheritance of phenotypic imaging features of arrhythmic MVP remains unknown.</p><p><strong>Methods: </strong>We recruited 23 MVP probands, including 9 with SCA/SCD and 14 with frequent/complex ventricular ectopy. Participants underwent interviews, 2-dimensional and speckle-tracking echocardiography, and 48-hour Holter/event monitoring. Each individual was categorized as having a normal mitral valve, MVP, or borderline MVP. We assessed mitral annular disjunction, curling, global longitudinal strain, segmental peak longitudinal strain, electrical/mechanical dispersion, and the postsystolic shortening index in family members and unrelated healthy controls.</p><p><strong>Results: </strong>We enrolled 23 pedigrees (14 extended pedigrees, 4 trios, and 5 duos) with a total of 121 participants (mean age 45 years, 50% women). Multigenerational SCA/SCD occurred in 2 of 14 extended pedigrees (14%) with an SCA/SCD proband. Mitral annular disjunction was present in 2 generations among 3 families (13%) and absent in 3 of 9 (33%) SCA/SCD cases. Compared with nonarrhythmic cases, arrhythmic MVP cases had more bileaflet involvement, mitral annular disjunction, curling, and abnormal valvular-myocardial mechanics, as expressed by a higher mid-inferior/inferolateral postsystolic shortening index (<i>P</i><0.05). Among arrhythmic MVP cases, those with SCA had the highest mechanical dispersion (<i>P</i>=0.04). Family members with normal valves had lower global longitudinal strain and greater mechanical dispersion compared with nonpedigree controls (both <i>P</i><0.05).</p><p><strong>Conclusions: </strong>In the context of familial MVP, SCA/SCD is rarely observed in multiple generations and is not consistently linked to mitral annular disjunction. Instead, SCA may result from combination of abnormal valvular-myocardial mechanics and a substrate of increased mechanical/electrical dispersion. Family members with normal mitral valves also exhibit mildly abnormal global strain parameters, suggesting an underlying myopathy independent of MVP expression. Future studies are needed to determine whether SCA/SCD in MVP requires the concomitant presence of abnormal mechanics and a primary genetic myopathy.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":"18 1","pages":"e017051"},"PeriodicalIF":6.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}