{"title":"Opening a New Path to Explore With Molecular Imaging: The Adrenal-Cardiac Axis!","authors":"Fabien Hyafil, James T Thackeray","doi":"10.1161/CIRCIMAGING.126.020109","DOIUrl":"10.1161/CIRCIMAGING.126.020109","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e020109"},"PeriodicalIF":9.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter by Chen et al Regarding Article, \"Quantitative Coronary Atherosclerotic Plaque Burden From CCTA and the Benefit From Lipid-Lowering Medication\".","authors":"Lin Chen, Hua Yan, Jun Fu","doi":"10.1161/CIRCIMAGING.126.019975","DOIUrl":"10.1161/CIRCIMAGING.126.019975","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e019975"},"PeriodicalIF":9.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter Regarding Article, \"Quantitative Coronary Atherosclerotic Plaque Burden From CCTA and the Benefit From Lipid-Lowering Medication\".","authors":"Teemu Maaniitty, Sarah Bär, Antti Saraste","doi":"10.1161/CIRCIMAGING.126.019999","DOIUrl":"10.1161/CIRCIMAGING.126.019999","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e019999"},"PeriodicalIF":9.1,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Promise and Practical Limits of Multimodal AI for Cardiac Amyloidosis Detection.","authors":"Arielle Abovich, Sarah A M Cuddy","doi":"10.1161/CIRCIMAGING.126.020031","DOIUrl":"10.1161/CIRCIMAGING.126.020031","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e020031"},"PeriodicalIF":9.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prognostic Impact of LGE Granularity Using CMR in End‑Stage Hypertrophic Cardiomyopathy.","authors":"Julien Hudelo, Jérôme Garot, Solenn Toupin, Suzanne Duhamel, Francesca Sanguineti, Philippe Garot, Thomas Hovasse, Stéphane Champagne, Thierry Unterseeh, Mariama Akodad, Antoinette Neylon, Trecy Gonçalves, Alexandre Unger, Jeremy Florence, Jean-Guillaume Dillinger, Christophe Tribouilloy, Alexis Hermida, Valérie Bousson, Théo Pezel, Yohann Bohbot","doi":"10.1161/CIRCIMAGING.125.019408","DOIUrl":"10.1161/CIRCIMAGING.125.019408","url":null,"abstract":"<p><strong>Background: </strong>End-stage hypertrophic cardiomyopathy (HCM) is a distinct and advanced form of HCM, defined by a left ventricular ejection fraction <50% and associated with a markedly poor prognosis. Evidence on the prognostic relevance of late gadolinium enhancement (LGE) and its key features in end-stage HCM remains limited. The aim of our study was to evaluate the prognostic value of the LGE granularity model, including its location, extent, and pattern in patients with end-stage HCM.</p><p><strong>Methods: </strong>All patients referred for cardiovascular magnetic resonance assessment of HCM at 3 French tertiary university hospitals between 2008 and 2024 were retrospectively screened, and all patients with a left ventricular ejection fraction <50% were included. The LGE granularity model was defined as a model combining LGE extent (unique versus multiple involvement), location (septal versus other), and pattern (subepicardial versus midwall). The primary end point was all-cause mortality.</p><p><strong>Results: </strong>Among 2873 patients with HCM, 691 (24%) with end-stage HCM were included (52±7 years, 54% male). After a median follow-up of 9 years (interquartile range, 6-11), 226 patients died (33%). LGE was observed in 259 (37%) patients and was associated with mortality, even after adjustment for classical prognostic factors (hazard ratio, 1.52 [95% CI, 1.07-2.18]; <i>P</i>=0.02). Each LGE granularity component was independently associated with mortality after adjustment: LGE extent (hazard ratio, 2.85 [95% CI, 1.03-7.85]; <i>P</i>=0.02), septal location (hazard ratio, 1.73 [95% CI, 1.10-2.73]; <i>P</i><0.001), and midwall pattern (hazard ratio, 4.15 [95% CI, 1.79-9.61]; <i>P</i><0.001).</p><p><strong>Conclusions: </strong>In this large multicenter cohort of patients with end-stage HCM, the LGE granularity model integrating LGE extent, location, and pattern provided strong and independent prognostic value.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e019408"},"PeriodicalIF":9.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nancy Herrera-Leaño, Bettia Celestin, Everton J Santana, Ryan Sandoval, Gracia Fahed, Patrick Khoury, Jack W O'Sullivan, Tatiana Kuznetsova, Nicholas Cauwenberghs, Kenneth W Mahaffey, Pamela S Douglas, Melissa M Daubert, Francois Haddad
{"title":"Impact of the 2025 ASE Guidelines on the Classification of LV Diastolic Dysfunction in the Community: A Project Baseline Health Study.","authors":"Nancy Herrera-Leaño, Bettia Celestin, Everton J Santana, Ryan Sandoval, Gracia Fahed, Patrick Khoury, Jack W O'Sullivan, Tatiana Kuznetsova, Nicholas Cauwenberghs, Kenneth W Mahaffey, Pamela S Douglas, Melissa M Daubert, Francois Haddad","doi":"10.1161/CIRCIMAGING.125.019402","DOIUrl":"10.1161/CIRCIMAGING.125.019402","url":null,"abstract":"<p><strong>Background: </strong>The 2016 American Society of Echocardiography (ASE) guidelines for left ventricular diastolic dysfunction (LVDD) classification resulted in a significant proportion of indeterminate classifications and grades. To address these limitations and incorporate new evidence, the ASE updated its recommendations in 2025. The impact of these revisions in community cohorts remains unclear.</p><p><strong>Methods: </strong>We studied 1953 Project Baseline Health Study participants who underwent comprehensive transthoracic echocardiography. LVDD was classified using the 2016 and 2025 ASE recommendations. For the 2025 recommendations, fixed and age-specific thresholds were evaluated separately. We compared LVDD prevalence, reclassification patterns, associations with cardiovascular risk factors, and prognostic value for major adverse cardiovascular events over a median follow-up of 4.3 years.</p><p><strong>Results: </strong>Median patient age was 50.6 years (Q1-Q3: 36.3-64.2); 56.3% of patients were female, 35.3% had hypertension, and 14.2% had diabetes. The prevalence of LVDD was higher with the 2025 recommendations than with the 2016 algorithm: fixed criteria 308 (15.8%), age-specific criteria 220 (11.3%) versus ASE 2016 154 (8.0%). Among 119 (6.1%) participants classified as indeterminate by the 2016 algorithm, the 2025 recommendations reclassified 51.2% as no LVDD and 31.8% as Grade 2 LVDD. Participants reclassified as no LVDD had event-free survival that was not statistically different from those without LVDD (<i>P</i>=0.26), whereas those reclassified as Grade 2 had higher event rates (12.5% versus 3.8%; <i>P</i>=0.02). Major adverse cardiovascular events occurred in 98 (5.0%) participants over the follow-up period. LVDD by all classification approaches was independently associated with major adverse cardiovascular events after adjustment for baseline risk factors.</p><p><strong>Conclusions: </strong>The 2025 ASE recommendations identified more participants with LVDD than the 2016 algorithm without indeterminate classification or grading. LVDD by the 2025 classification was significantly associated with major adverse cardiovascular events, supporting the clinical relevance of the revised framework.</p>","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e019402"},"PeriodicalIF":9.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response by Bak et al to Letter Regarding Article, \"Left Atrial Strain Predicts Cardiac Outcomes in Moderate Aortic Stenosis\".","authors":"Minjung Bak, Sang Yoon Lee, Sung-Ji Park","doi":"10.1161/CIRCIMAGING.126.019953","DOIUrl":"10.1161/CIRCIMAGING.126.019953","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e019953"},"PeriodicalIF":9.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147926811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neonatal Sepsis With Pericardial Involvement: Serial Echocardiography Reveals the Evolution of Pericarditis.","authors":"Jiao Yang, Ning Ma","doi":"10.1161/CIRCIMAGING.126.019533","DOIUrl":"10.1161/CIRCIMAGING.126.019533","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e019533"},"PeriodicalIF":9.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Felipe I Contreras-Yametti, Annalisa Filtz, Sanjana Nagraj, Daniel Lorenzatti, Kirtipal Bhatia, Franco J Cossettini, Aldo L Schenone, Leandro Slipczuk, Mario J Garcia
{"title":"Advanced Imaging in Loeffler Endocarditis in the Setting of Dupilumab-Associated Hypereosinophilia: Diagnostic Utility of Cardiac MRI.","authors":"Felipe I Contreras-Yametti, Annalisa Filtz, Sanjana Nagraj, Daniel Lorenzatti, Kirtipal Bhatia, Franco J Cossettini, Aldo L Schenone, Leandro Slipczuk, Mario J Garcia","doi":"10.1161/CIRCIMAGING.126.019739","DOIUrl":"10.1161/CIRCIMAGING.126.019739","url":null,"abstract":"","PeriodicalId":10202,"journal":{"name":"Circulation: Cardiovascular Imaging","volume":" ","pages":"e019739"},"PeriodicalIF":9.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}