Z Scores for Pediatric Echocardiography Dimensions Adjusted for Body Size, BMI, and Age.

IF 6.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Circulation: Cardiovascular Imaging Pub Date : 2025-07-09 DOI:10.1161/CIRCIMAGING.124.017944

Jonathan Lauzon-Schnittka, Virginie Plante, Nagib Dahdah, Steven C Greenway, Christian Drolet, Kenny Wong, Andrew S Mackie, Luc Mertens, Tiscar Cavallé-Garrido, Joshua Penslar, Derek Wong, Luis Martín Garrido-García, Frédéric Dallaire

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引用次数: 0

Abstract

Background: Cardiovascular dimensions measured during pediatric echocardiograms must be normalized for body size. However, other variables may confound their interpretation, such as age and abnormal body habitus. This retrospective cross-sectional study of the Canadian Congenital and Pediatric Cardiology Research Network aimed to create Z score equations for commonly measured dimensions in pediatric 2-dimensional echocardiography that were free of residual confounding effects of body size, body mass index, and age.

Methods: The reference sample consisted of >20 000 children without heart disease from 9 institutions who underwent clinical echocardiography that was reported as normal. A generalized additive model for location, scale, and shape (GAMLSS) was used to model the expected distributions of measurements as a function of sex, height, weight, body mass index, and age.

Results: Compared with a model that only considered body surface area, the proposed Z scores demonstrated less bias in subgroups of overweight, young, and early school-aged children.

Conclusions: The proposed Z score equations may improve diagnostic and therapeutic accuracy by ensuring that body size, body mass index, and age do not confound the interpretation of measurements.

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儿童超声心动图维度的Z分校正了身体尺寸、BMI和年龄。

背景：在儿童超声心动图中测量的心血管尺寸必须与身体尺寸标准化。然而，其他变量可能会混淆他们的解释，如年龄和不正常的身体习惯。这项对加拿大先天性和儿童心脏病学研究网络的回顾性横断面研究旨在为儿童二维超声心动图中常用测量维度创建Z分数方程，该方程不受身体尺寸、体重指数和年龄的残留混淆影响。方法：参考样本为来自9个医疗机构的20万名无心脏病的儿童，均行临床超声心动图检查，报告正常。一个广义的位置、尺度和形状加性模型（GAMLSS）被用来模拟测量的预期分布，作为性别、身高、体重、身体质量指数和年龄的函数。结果：与只考虑体表面积的模型相比，提出的Z分数在超重、年幼和早期学龄儿童亚组中显示出更小的偏差。结论：所提出的Z分数方程可以通过确保身体尺寸、身体质量指数和年龄不会混淆测量结果的解释来提高诊断和治疗的准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Circulation: Cardiovascular Imaging 医学-核医学

CiteScore

6.30

自引率

2.70%

发文量

225

审稿时长

6-12 weeks

期刊介绍： Circulation: Cardiovascular Imaging, an American Heart Association journal, publishes high-quality, patient-centric articles focusing on observational studies, clinical trials, and advances in applied (translational) research. The journal features innovative, multimodality approaches to the diagnosis and risk stratification of cardiovascular disease. Modalities covered include echocardiography, cardiac computed tomography, cardiac magnetic resonance imaging and spectroscopy, magnetic resonance angiography, cardiac positron emission tomography, noninvasive assessment of vascular and endothelial function, radionuclide imaging, molecular imaging, and others. Article types considered by Circulation: Cardiovascular Imaging include Original Research, Research Letters, Advances in Cardiovascular Imaging, Clinical Implications of Molecular Imaging Research, How to Use Imaging, Translating Novel Imaging Technologies into Clinical Applications, and Cardiovascular Images.