Clinical Cardiology最新文献

{"title":"Advancing Equity in Left Atrial Appendage Occlusion Outcomes for Hispanic/Latino Patients","authors":"Syed Muhammad Rayyan, Bakhtiyar Ameer, Mueed Iqbal, Muhammad Abdul Haseeb Khan, Farmanullah Khan","doi":"10.1002/clc.70176","DOIUrl":"https://doi.org/10.1002/clc.70176","url":null,"abstract":"<p>We read with great interest the article published by Fleurestil and his colleagues. Fleurestil and colleagues have provided valuable insights into in-hospital outcomes after left atrial appendage occlusion (LAAO) among Hispanic/Latino patients using the National Inpatient Sample (NIS). Yet, in striving for equitable stroke prevention, several further considerations merit attention [<span>1</span>].</p><p>While the authors note absence of echocardiographic and catheterization details, they do not address variability in device selection (e.g., Watchman vs. Amplatzer), catheter access routes, or operator experience. Each device has distinct learning curves and complication profiles, and proficiency varies markedly across centers. Future studies should partner with the NCDR LAAO Registry—which captures device type, sheath size, fluoroscopy time, and operator volume—to determine whether specific techniques or low-volume operators disproportionately contribute to the elevated infectious and vascular complications seen in Hispanic/Latino groups [<span>2</span>].</p><p>By design, NIS only captures index hospitalization events. Yet device-related thrombus, late pericardial effusions, and stroke recurrence often manifest weeks to months later. Incorporating linkage to claims data (e.g., Medicare Part A/B) or designing a prospective, multicenter registry with mandatory 12-month follow-up would illuminate whether early in-hospital disparities translate into divergent long-term safety and efficacy outcomes.</p><p>Though Fleurestil et al. briefly cite insurance status and language barriers, they do not quantify health literacy, immigration status, or neighborhood deprivation. Embedding validated instruments—such as the Rapid Estimate of Adult Literacy in Medicine (REALM) [<span>3</span>] or Area Deprivation Index [<span>4</span>]—into future LAAO registries would allow risk adjustment for social determinants and guide culturally tailored peri-procedural education.</p><p>Administrative coding cannot verify periprocedural anticoagulation regimens or post-implant adherence. Given that suboptimal anticoagulant use may drive both bleeding and thrombotic events, prospective studies should incorporate pharmacy fill data and wearable adherence monitors. Moreover, qualitative interviews could uncover patient-level barriers to compliance, enabling development of targeted interventions (e.g., bilingual mobile reminders).</p><p>With only 6814 Hispanic/Latino cases (4.9%), the study risks type II error for less frequent outcomes and cannot explore heterogeneity within the Hispanic/Latino umbrella (e.g., Caribbean vs. Central American ancestry). Pooling data across international centers, or applying Bayesian hierarchical models, would enhance power and allow disaggregation by cultural background, socioeconomic bracket, and comorbidity clusters.</p><p>Clinical endpoints—mortality, bleeding, vascular complications—while critical, overlook quality-of-life and patient satisf","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Patients With Acute Coronary Syndrome Face Higher Mortality on Weekends Versus Weekdays? A Comprehensive Analysis of Demographic, Geographic, and Temporal Trends in the United States","authors":"Abdalhakim Shubietah,&nbsp;Abubakar Nazir,&nbsp;Mohamed S. Elgendy,&nbsp;Ameer Awashra,&nbsp;Jehad Zeidalkilani,&nbsp;Mohammad Alqadi,&nbsp;Suleiman Khreshi","doi":"10.1002/clc.70175","DOIUrl":"https://doi.org/10.1002/clc.70175","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The impact of a “weekend effect” on US acute coronary syndrome (ACS) mortality remains uncertain. We compared weekend and weekday age-adjusted mortality rates (AAMRs) and analyzed demographic, geographic, and temporal trends from 1999 to 2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a national analysis of ACS deaths (age ≥ 25 years) using CDC WONDER (ICD-10: I20.0; I21.0–I21.4; I21.9; I22.0–I22.9; I24.8; I24.9). Crude and AAMRs (per 100 000; 2000 U.S. standard) were calculated, and trends were assessed by joinpoint regression to estimate annual percent changes (APCs) and average APCs (AAPCs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 1999 to 2020, there were 3, 101, 451 ACS deaths: 2, 222, 468 on weekdays (AAMR 46.4; 95% CI 46.39–46.51) and 878, 983 on weekends (AAMR 18.4), a 2.5:1 ratio. Both periods saw two-phase declines—APCs of ≈ –6.4%/year before 2009–2010 and –3.3 to –3.7%/year thereafter (all <i>p</i> &lt;  0.001). Disparities persisted: Black adults had the highest AAMRs (20.9 weekend; 53.2 weekday), rural rates exceeded urban (28.7 vs. 15.8; 72.0 vs. 40.2), men exceeded women (23.8 vs. 14.0; 60.2 vs. 35.4), and rates rose steeply with age (weekend 0.3–223.0; weekday 0.7–561.0). After 2009, declines slowed, and weekday deaths in Black adults rose after 2018.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The weekend effect on ACS mortality is minimal, with weekday deaths far outnumbering weekend deaths. Persistent—and sometimes widening—disparities by race, rurality, sex, and age highlight the need for equity-focused interventions, strengthened rural cardiac care, and targeted prevention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Educational Inequality and Income Inequality With Metabolic Diseases and Cause-Specific Mortality","authors":"Jingya Niu,&nbsp;Xiaotong Li,&nbsp;Qiaoyun Chen,&nbsp;Wei Yang,&nbsp;Lixia Suo,&nbsp;Zhu Chen","doi":"10.1002/clc.70173","DOIUrl":"https://doi.org/10.1002/clc.70173","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Educational attainment and economic status are important socioeconomic characteristics and are associated with metabolic diseases and premature death risk. However, their relative importance and contributions to premature death remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were collected from ten survey waves of the National Health and Nutrition Examination Survey from 1999 to 2018. Deaths before age 75 from all-cause and cause-specific mortality were ascertained from linkage to the National Death Index with follow-up through 2019. Weighted Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CI) for death by educational attainment and income level. Population-attributable fractions (PAFs) were calculated to quantify the proportional contributions of low income and low educational attainment to mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over an average of 10.1 years of follow-up, 4310 premature deaths were confirmed from 43 637 participants. Low income and low educational attainment were associated with increased risks of all-cause and cause-specific mortality, respectively. The associations between low educational attainment and mortality risk disappeared after mutual adjusting for income and education. However, among those with high school education or above, the adjusted HRs of middle income and low income were 1.81 (95% CI, 1.48–2.21) and 2.88 (95% CI, 2.31–3.59) for all-cause mortality. The PAF showed that low educational attainment did not contribute to mortality, while 33.0% of premature deaths were attributable to low income.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Income had a greater impact on mortality risk than education. The disparities in mortality risk could be reduced by narrowing the income differentials.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial Fat Thickness as a Marker of Coronary Artery Disease in Diabetics: A Single Center Study","authors":"Abdul Nadeem Akhter,&nbsp;Fnu Aisha,&nbsp;Aimen Binte Moazzam,&nbsp;Sardar Humayun Babar Khan,&nbsp;Jahanzeb Malik,&nbsp;Abida Parveen","doi":"10.1002/clc.70171","DOIUrl":"https://doi.org/10.1002/clc.70171","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Epicardial fat thickness (EFT) is a visceral fat depot with pro-inflammatory properties, located adjacent to coronary vessels, and has been proposed as a marker of coronary artery disease (CAD). This study aimed to evaluate the association between EFT and the presence and severity of CAD in patients with type 2 diabetes mellitus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study was conducted at the Abbas Institute of Medical Sciences (AIMS) between January 2020 and March 2025 (Study ID: AIMS/25/007). A total of 2340 diabetic patients (mean age: 58.3 ± 9.6 years) were included. EFT was measured using transthoracic echocardiography, and CAD presence and severity were assessed via coronary angiography. Logistic regression analysis was used to evaluate associations, with results expressed as odds ratios (OR) with 95% confidence intervals (CI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Elevated EFT (≥ 5 mm) was observed in 1281 patients (54.7%). CAD was present in 1121 individuals (47.9%), with significantly higher rates in those with elevated EFT (65.7% vs. 26.3%, <i>p</i> &lt; 0.001). EFT ≥ 5 mm was associated with a 5.38-fold increased odds of CAD (95% CI: 4.59–6.30, <i>p</i> &lt; 0.001). Moreover, patients with elevated EFT had a significantly higher prevalence of multi-vessel CAD, indicating a correlation between EFT and disease severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In diabetic patients, elevated EFT is significantly associated with both the presence and severity of CAD. EFT measurement via echocardiography may serve as a simple, noninvasive tool for cardiovascular risk stratification and early intervention planning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70171","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rising Crisis: Escalating Burden of Diabetes Mellitus and Hypertension-Related Mortality Trends in the United States, 2000–2023","authors":"Hibah Siddiqui,&nbsp;Zahra Imran,&nbsp;Dua Ali,&nbsp;Maryam Sajid,&nbsp;Taimor Mohammed Khan,&nbsp;Hussain Salim,&nbsp;Muhammad Salik Uddin,&nbsp;Shaheer Qureshi,&nbsp;Muzammil Farhan,&nbsp;Saad Ahmed Waqas","doi":"10.1002/clc.70167","DOIUrl":"https://doi.org/10.1002/clc.70167","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Diabetes mellitus and hypertension are major contributors to cardiovascular and renal disease mortality, yet their combined long-term impact on mortality trends in the United States remains underexplored. This study evaluates national trends in DM and hypertension-related mortality from 2000 to 2023, analyzing disparities across sex, age groups, race/ethnicity, urbanization, and geographic regions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed mortality data from the CDC-WONDER database, identifying deaths with DM and hypertension as listed causes among adults aged 25 and older. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated, and temporal trends were assessed using Joinpoint regression to determine annual percentage changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 2,742,668 DM and hypertension-related deaths were recorded. The AAMR nearly doubled from 33.7 per 100,000 in 2000 to 66.2 per 100,000 in 2023. A sharp increase was observed from 2018 to 2021 (APC: 16.3 [95% CI: 11.8–19.6]), followed by a decline through 2023. Men had consistently higher mortality rates than females. Mortality rates were highest among older adults (65+ years), Non-Hispanic Black individuals, and nonmetropolitan populations. The South had the highest mortality rates, with Mississippi and the District of Columbia reporting the greatest burden.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DM and hypertension-related mortality has significantly increased over the past two decades, with notable demographic and geographic disparities. Public health interventions should prioritize high-risk populations to mitigate mortality trends and improve health equity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Prognostic Value of Kansas City Cardiomyopathy Questionnaire (KCCQ) Scores for 6-Month Readmissions in Southeast Asian Populations With Heart Failure","authors":"Jeanne SY Ong,&nbsp;Ming Fatt Kham,&nbsp;Jonah Goh,&nbsp;Francis Phng,&nbsp;Po Fun Chan,&nbsp;Poay Huan Loh,&nbsp;Christine Wu","doi":"10.1002/clc.70136","DOIUrl":"https://doi.org/10.1002/clc.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Heart failure (HF) is a prevalent cause of hospital readmissions. Our study aims to determine the correlation between the Kansas City Cardiomyopathy Questionnaire (KCCQ) scores and 6-month readmission in our Southeast Asian population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We evaluated KCCQ-12 in a cohort of 180 patients at first post-discharge visit after a recent hospitalization for HF with reduced ejection fraction (HFrEF). Logistic regression was used to determine the predictive significance of the KCCQ scores for 6-month HF readmission. The selection of predictive parameters was performed using Stepwise Akaike Information Criterion (StepAIC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 180 patients, 52 (29%) were readmitted for HF within 6 months. The mean KCCQ score was higher in the non-readmitted group (78.5) compared to the readmitted group (69.7, <i>p</i> = 0.0129). Multivariate analysis indicated a significant association between higher KCCQ scores (better health status) and lower HF readmission rates (adjusted OR = 0.929, <i>p</i> = 0.0255). The initial predictive model, using patient demographic data, had an AUC score of 0.64. Integrating KCCQ scores with demographics, length of stay (LOS), medical history and discharge medication variables raised the AUC score to 0.82.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>KCCQ scores recorded at first post-discharge encounter were found to have a significant relationship with 6-month readmissions in our cohort, suggesting that KCCQ scores can serve as an effective clinical indicator of 6 month readmissions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primordial Symptoms and ECG Among Sudden Cardiac Death Victims Due to Primary Myocardial Fibrosis","authors":"H. Silvola,&nbsp;L. Pakanen,&nbsp;L. Holmström,&nbsp;J. S. Perkiömäki,&nbsp;M. A. E Eskuri,&nbsp;H. V. Huikuri,&nbsp;M. J. Junttila","doi":"10.1002/clc.70057","DOIUrl":"https://doi.org/10.1002/clc.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sudden cardiac death (SCD) remains a major cause of death despite progress in prevention and intervention of cardiac diseases. The most common cause of nonischemic SCD in young individuals in Northern Finland is primary myocardial fibrosis (PMF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fingesture study consists of 5869 prospectively collected subjects with SCD from Northern Finland collected from 1998 to 2017. Nonischemic etiology was the cause of SCD in 1477 (25%) subjects out of which primary myocardial fibrosis was the cause of SCD in 184 (12%) subjects (65% men, median age 55 ± 16 years). We examined the ante mortem ECG and medical history of the subjects to discover preceding symptoms and ECG changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Prior health care contact in electronic health record system (EHR) was found for 89 (48%) subjects and ECG was available for 52 (28%) subjects. Both medical history and ECG were available for 20 subjects (11%). We observed that transient loss of consciousness (TLOC) was the most common <i>symptom</i> recorded and was reported by 33 (37%) subjects. ECG was abnormal in 38 (73%) subjects. Fragmented QRS (fQRS) complex was found in 26 (50%) subjects. Vast majority, 87% of subjects had either TLOC or abnormal ECG. Only seven subjects with ECG or EHR history available had normal ECG and did not have TLOC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Many SCD victims with primary myocardial fibrosis had abnormal ECG or history of TLOC. The results suggest that the combination should generate careful cardiovascular examination to detect underlying myocardial disease and possibly prevent SCD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144520089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Statin Intensity on Cardiovascular Outcomes and Survival Following Coronary Artery Bypass Grafting","authors":"Iftikhar Ali Ch,&nbsp;Khurram Nasir,&nbsp;Uzair Majeed,&nbsp;Azhar Chaudhry,&nbsp;Muhammad Abdullah,&nbsp;Ali Haider,&nbsp;Asadullah Jamal,&nbsp;Anum Hussain,&nbsp;Hammad Iftikhar,&nbsp;Salman Khalid,&nbsp;Pei-Tzu Wu,&nbsp;Yusuf Shah,&nbsp;Arham Niaz,&nbsp;Muhammad Siddique,&nbsp;Naeem Tahirkheli","doi":"10.1002/clc.70170","DOIUrl":"https://doi.org/10.1002/clc.70170","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>High-intensity statins are recommended for patients with chronic coronary artery disease, with reports suggesting improved clinical outcomes. However, recent findings in coronary artery bypass graft (CABG) patients question whether a treat-to-target low density lipoprotein (LDL) approach is non-inferior to high-intensity statin therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center observational study analyzed all CABG only (<i>n</i> = 1854) procedures performed between 2013 and 2015. Patients were divided into three groups based on statin prescription: high-intensity statin therapy (atorvastatin ≥ 40 mg or rosuvastatin ≥ 20 mg), low/moderate-intensity statin therapy, and a no-statin group. The primary outcome measured was major adverse cardiovascular events (MACE), a composite of post-CABG acute coronary syndrome, cerebrovascular accident and cardiovascular mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No-Statin group had significantly higher incidence of MACE compared to statin group (14.2% vs 8.9%; odds ratio (OR) 1.60, 95% confidence interval (CI) 1.055–2.427, <i>p</i> = 0.029). Low/moderate-intensity therapy (<i>n</i> = 1301) was associated with a numerically higher overall rate of MACE compared to high-intensity therapy (<i>n</i> = 397) but was not statistically significant (9.6% vs 6.6%; OR 1.45, CI 0.961–2.172, <i>p</i> = 0.073). Beyond 2 years post-CABG, low/moderate intensity statin use was associated with a significant higher incidence of MACE (9.1% vs 5.3%; OR 1.72, 95% CI 0.993–2.978, <i>p</i> = 0.047) compared to high intensity statins.</p>\u0000 \u0000 <p>Patients who received high-intensity statin therapy had the lowest LDL levels (82.21 ± 41.85 mg/dL), compared to those on low/moderate-intensity statins (90.84 ± 45.89 mg/dL) and no-statin group (104.83 ± 38.93 mg/dL, <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>High-intensity statin therapy following CABG is associated with improved long-term clinical outcomes compared to low- or moderate-intensity statin regimens.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Trends in Mortality Due to Cardiovascular Diseases Among Patients With Parkinson's Disease in the United States: A Retrospective Analysis”","authors":"","doi":"10.1002/clc.70168","DOIUrl":"https://doi.org/10.1002/clc.70168","url":null,"abstract":"<p>Akhtar M, Farooqi HA, Nabi R, et al. Trends in mortality due to cardiovascular diseases among patients with Parkinson's disease in the United States: a retrospective analysis. <i>Clinical Cardiology</i> 48, no. 1 (2025): e70079. doi:10.1002/clc.70079</p><p>The <i>y</i>-axis label of Figures 1-3 and 5 should read “AAMR per 100,000 individuals” (not “AAMR per 100,000 deaths”). Additionally, in the color key section of Figure 1, the text next to the blue circle should state: “Overall 1999 to 2003 APC: −5.13 (95% CI: −5.44 to −4.86); 2003 to 2014 APC: −6.30”. The corrected figures appear below.</p><p>The authors would like to clarify that these revisions are typographical oversights and do not affect the integrity of their findings.</p>","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70168","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between F-SIRI and Adverse Prognosis in Patients With Chronic Heart Failure","authors":"Xiaoli Liu,&nbsp;Heyu Chu,&nbsp;Guo Song,&nbsp;Yi Wang,&nbsp;Junfeng Duan,&nbsp;Xi Tan,&nbsp;Xue Bao,&nbsp;Biao Xu,&nbsp;Rong Gu","doi":"10.1002/clc.70166","DOIUrl":"https://doi.org/10.1002/clc.70166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>High plasma fibrinogen and systemic inflammation response index (F-SIRI) has been proposed as a novel prognostic factor in resectable gastric cancer. However, available data on the prognostic value of F-SIRI in chronic heart failure (CHF) patients is limited. We aimed to conduct a retrospective cohort study exploring the correlation between F-SIRI and prognosis in CHF individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We consecutively enrolled 1589 hospitalized patients (aged 66 ± 8 years, 32.9% women) with CHF from January 1, 2019 to August 31, 2022 in this single-center retrospective study. SIRI was calculated with the formula (monocyte count*neutrophil count/lymphocyte count). The primary endpoints encompassed all-cause death, the major adverse cardiac and cerebral events (MACCEs) and cardiovascular death. The association between F-SIRI and the risk of developing adverse outcomes were explored using four multivariate-adjusted Cox proportional hazard models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During a median follow-up of 687 days, 207 all-cause deaths, 462 MACCEs and 136 cardiovascular deaths were recorded. After adjusting for potential confounding factors, only risk of all-cause death remained significantly associated with higher levels of F-SIRI. The hazard ratios (HRs) for the highest F-SIRI group (F-SIRI = 2) versus the lowest F-SIRI group (F-SIRI = 0) were 2.37 (95% confidence interval [CI], 1.46−3.83; <i>p</i> &lt; 0.001) for all-cause death. The addition of F-SIRI could increase the prognostic ability for all-cause death on the basis of traditional risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>F-SIRI is a significant predictor of all-cause death but has limited predictive value for MACCEs and cardiovascular death in CHF patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"48 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clc.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}