A Rising Crisis: Escalating Burden of Diabetes Mellitus and Hypertension-Related Mortality Trends in the United States, 2000–2023

IF 2.4 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Hibah Siddiqui, Zahra Imran, Dua Ali, Maryam Sajid, Taimor Mohammed Khan, Hussain Salim, Muhammad Salik Uddin, Shaheer Qureshi, Muzammil Farhan, Saad Ahmed Waqas
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Abstract

Introduction

Diabetes mellitus and hypertension are major contributors to cardiovascular and renal disease mortality, yet their combined long-term impact on mortality trends in the United States remains underexplored. This study evaluates national trends in DM and hypertension-related mortality from 2000 to 2023, analyzing disparities across sex, age groups, race/ethnicity, urbanization, and geographic regions.

Methods

We analyzed mortality data from the CDC-WONDER database, identifying deaths with DM and hypertension as listed causes among adults aged 25 and older. Age-adjusted mortality rates (AAMRs) per 100,000 were calculated, and temporal trends were assessed using Joinpoint regression to determine annual percentage changes.

Results

A total of 2,742,668 DM and hypertension-related deaths were recorded. The AAMR nearly doubled from 33.7 per 100,000 in 2000 to 66.2 per 100,000 in 2023. A sharp increase was observed from 2018 to 2021 (APC: 16.3 [95% CI: 11.8–19.6]), followed by a decline through 2023. Men had consistently higher mortality rates than females. Mortality rates were highest among older adults (65+ years), Non-Hispanic Black individuals, and nonmetropolitan populations. The South had the highest mortality rates, with Mississippi and the District of Columbia reporting the greatest burden.

Conclusions

DM and hypertension-related mortality has significantly increased over the past two decades, with notable demographic and geographic disparities. Public health interventions should prioritize high-risk populations to mitigate mortality trends and improve health equity.

Abstract Image

一个上升的危机:2000-2023年美国糖尿病和高血压相关死亡率趋势的不断上升的负担
糖尿病和高血压是心血管和肾脏疾病死亡的主要原因,但它们对美国死亡率趋势的综合长期影响仍未得到充分探讨。本研究评估了2000年至2023年糖尿病和高血压相关死亡率的全国趋势,分析了性别、年龄组、种族/民族、城市化和地理区域之间的差异。方法分析来自CDC-WONDER数据库的死亡率数据,确定25岁及以上成人中糖尿病和高血压的死亡原因。计算每10万人的年龄调整死亡率(AAMRs),并使用连接点回归评估时间趋势,以确定年度百分比变化。结果共记录了2,742,668例糖尿病和高血压相关死亡。AAMR从2000年的33.7 / 10万增加到2023年的66.2 / 10万,几乎翻了一番。从2018年到2021年急剧增加(APC: 16.3 [95% CI: 11.8-19.6]),随后到2023年下降。男性的死亡率始终高于女性。老年人(65岁以上)、非西班牙裔黑人和非大都市人口的死亡率最高。南方的死亡率最高,密西西比州和哥伦比亚特区的负担最重。结论糖尿病和高血压相关死亡率在过去20年中显著增加,且存在明显的人口和地理差异。公共卫生干预措施应优先考虑高危人群,以减缓死亡率趋势并改善卫生公平性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Cardiology
Clinical Cardiology 医学-心血管系统
CiteScore
5.10
自引率
3.70%
发文量
189
审稿时长
4-8 weeks
期刊介绍: Clinical Cardiology provides a fully Gold Open Access forum for the publication of original clinical research, as well as brief reviews of diagnostic and therapeutic issues in cardiovascular medicine and cardiovascular surgery. The journal includes Clinical Investigations, Reviews, free standing editorials and commentaries, and bonus online-only content. The journal also publishes supplements, Expert Panel Discussions, sponsored clinical Reviews, Trial Designs, and Quality and Outcomes.
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