Clinical Cardiology最新文献

Safety and Feasibility of a CT-Based Pathway for Left Atrial Appendage Assessment Prior to Inpatient Cardioversion: A Single-Center Experience. 住院患者转复前左心耳ct评估路径的安全性和可行性：单中心经验。

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70323

Ariel Furer, Maxim Perelman, Yafim Brodov, Orly Goitein, Sagit Ben Zikri, Rafael Kuperstein, Edward Itelman, Elad Maor, Eyal Nof, Roy Beinart, Shlomi Matetzky, Roy Beigel

{"title":"Safety and Feasibility of a CT-Based Pathway for Left Atrial Appendage Assessment Prior to Inpatient Cardioversion: A Single-Center Experience.","authors":"Ariel Furer, Maxim Perelman, Yafim Brodov, Orly Goitein, Sagit Ben Zikri, Rafael Kuperstein, Edward Itelman, Elad Maor, Eyal Nof, Roy Beinart, Shlomi Matetzky, Roy Beigel","doi":"10.1002/clc.70323","DOIUrl":"https://doi.org/10.1002/clc.70323","url":null,"abstract":"Background: Transesophageal echocardiography (TEE) for left atrial appendage (LAA) thrombus exclusion before cardioversion faces logistical barriers including limited availability, patient intolerance, and procedural delays. We evaluated the feasibility and short-term safety of a cardiac CT-based alternative pathway in hospitalized patients with atrial fibrillation (AF).Methods: This retrospective single-center study included 408 consecutive AF inpatients planned for cardioversion. The primary endpoint was the composite of stroke/TIA or systemic embolism within 48 h post-cardioversion. Secondary endpoints included 30-day thromboembolic events, acute kidney injury, and all-cause mortality at 30 days and 1 year. Imaging modality selection was based on availability, clinical factors, and contraindications.Results: Among 74 patients undergoing CT-guided cardioversion and 206 undergoing TEE-guided cardioversion, no strokes or TIAs occurred within 48 h in either group (0/74 CT vs. 0/206 TEE, p = 1.0). By 30 days, one TIA occurred in the CT group (1.4%) and none in the TEE group (0%), representing an absolute risk difference of +1.4% (95% CI: -0.8% to +7.3%; p = 0.26). Acute kidney injury occurred in 8.1% of CT patients compared with 3.9% in the TEE group (absolute risk difference +4.2%, 95% CI: -1.4% to +12.9%; OR 2.18, 95% CI: 0.60-7.45; p = 0.21). No mortality was observed at 30 days or 1 year.Conclusions: In this single-center feasibility analysis, a CT-based imaging pathway for LAA assessment prior to cardioversion was associated with no periprocedural thromboembolic events and acceptable short-term safety. Prospective randomized trials are needed to define the clinical role of CT as an alternative to TEE.","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"49 5","pages":"e70323"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological Concerns Regarding a Recent Meta-Analysis of Direct Oral Anticoagulants Versus Vitamin K Antagonists in Non-Valvular Atrial Fibrillation. 近期一项关于直接口服抗凝剂与维生素K拮抗剂治疗非瓣膜性心房颤动的meta分析的方法学关注。

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70341

Omar Khalid Samir, Nikita Datta

引用次数: 0

Methodological Considerations in Interpreting Mortality Trends in Aortic Dissection Among Hypertensive Adults. 解释高血压成人主动脉夹层死亡率趋势的方法学考虑。

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70340

Hamna Bibi, Saad Arif

引用次数: 0

Methodological Concerns Regarding the Meta-Analysis of Cranberry Consumption and Blood Pressure. 食用蔓越莓与血压meta分析的方法学问题。

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70339

Shaher Yar, Muhammad Touseef, Ishvah Shashwat Nag

引用次数: 0

Comment on "Mortality Due to Aortic Dissection in Adults With Primary Hypertension: A Nationwide Analysis Over Two Decades". 对“成人原发性高血压主动脉夹层死亡率：近20年的全国分析”的评论。

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70320

Muhammad Faizan Khan, Muhammad Imran

引用次数: 0

Reconsidering the Prognostic Role of the HALP Score in Rheumatic Mitral Stenosis. 重新考虑HALP评分在风湿性二尖瓣狭窄中的预后作用。

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70334

Muhammad Talha, Sawera Gul, Muhammad Faizan Khan

引用次数: 0

The Correlations and Predictive Capabilities of the "Life's Essential 8" With Respect to All-Cause Mortality and Cardiovascular Disease Mortality Risks in Individuals Experiencing Sleep Disorders: A Prospective Cohort Study From the NHANES (2005-2014). 睡眠障碍患者的“生命要素8”与全因死亡率和心血管疾病死亡率风险的相关性和预测能力：一项来自NHANES的前瞻性队列研究（2005-2014）。

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70336

Jia Wei, Tengfei Ji, Yide Yuan, Su Liu, Qing Yan, YuYang Zhao, Lan Yang, Jiahong Xue

{"title":"The Correlations and Predictive Capabilities of the \"Life's Essential 8\" With Respect to All-Cause Mortality and Cardiovascular Disease Mortality Risks in Individuals Experiencing Sleep Disorders: A Prospective Cohort Study From the NHANES (2005-2014).","authors":"Jia Wei, Tengfei Ji, Yide Yuan, Su Liu, Qing Yan, YuYang Zhao, Lan Yang, Jiahong Xue","doi":"10.1002/clc.70336","DOIUrl":"10.1002/clc.70336","url":null,"abstract":"Background: Life's Essential 8 (LE8) is a framework for assessing cardiovascular health (CVH). Individuals with sleep disorders face an elevated risk of cardiovascular disease (CVD). This study aims to investigate the prognostic value of the LE8 score in predicting mortality among individuals with sleep disorders.Methods: The prospective cohort study included 1606 adults (aged ≥ 20 years) diagnosed with sleep disorders from the National Health and Nutrition Examination Survey (NHANES) 2005-2014. LE8 scores were categorized into three groups: Low CVH (0-49), Moderate CVH (50-79), and High CVH (80-100). Kaplan-Meier survival curves were used to compare mortality across these groups. Weighted multivariable Cox proportional hazards models were employed to investigate the relationship between LE8 scores with all-cause and CVD mortality. The Boruta algorithm was applied for feature selection, and six machine learning (ML) algorithms were utilized to predict all-cause mortality.Results: During a median follow-up of 103 months, 282 deaths occurred, including 66 CVD-related deaths. The weighted multivariable Cox models revealed that higher LE8 scores were significantly associated with a lower risk for both all-cause mortality (HR = 0.85, 95% CI, 0.73-0.99) and CVD mortality (HR = 0.72, 95% CI, 0.56-0.93). Among the evaluated ML algorithms, the Gradient Boosting Decision Tree (GBDT) model exhibited the highest area under the curve (AUC) for predicting all-cause mortality.Conclusion: Higher LE8 scores are independently associated with a decreased risk of all-cause and CVD mortality among patients with sleep disorders. These findings highlight the importance of optimizing overall CVH in the clinical management of sleep disorders.","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"49 5","pages":"e70336"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma EDA2R and Risk of Cardiovascular Diseases and All-Cause Mortality: Analysis of the UK Biobank Cohort. 血浆EDA2R与心血管疾病和全因死亡率的风险：英国生物银行队列分析

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70314

Ziqing Ruan, Jiabin Tu, Hongli Xu, Yupeng Zhi, Chun Chen, Kaiyang Lin, Yansong Guo

{"title":"Plasma EDA2R and Risk of Cardiovascular Diseases and All-Cause Mortality: Analysis of the UK Biobank Cohort.","authors":"Ziqing Ruan, Jiabin Tu, Hongli Xu, Yupeng Zhi, Chun Chen, Kaiyang Lin, Yansong Guo","doi":"10.1002/clc.70314","DOIUrl":"https://doi.org/10.1002/clc.70314","url":null,"abstract":"Background: Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Ectodysplasin A2 receptor (EDA2R), a newly identified member of the tumor necrosis factor receptor superfamily, has been implicated in metabolic and inflammatory processes, but its role in CVD is unknown.Objective: To examine the associations of plasma EDA2R levels with incident CVD and all-cause mortality.Methods: A total of 45,305 UK Biobank participants with baseline plasma proteomics measured by Olink were included. EDA2R expression levels in the UKB have been converted to normalized protein expression (NPX). Cox proportional hazards models were used to assess the relationships between EDA2R and CVD, as well as all-cause mortality. Temporal trajectories of EDA2R before events were examined using a nested case-control design with LOESS smoothing. Causal mediation and GO enrichment analyses were performed to identify mediating proteins and underlying pathways.Results: Over a median follow-up of 15 years, 8667 participants (19.1%) developed CVD, and 3988 (8.8%) died. After fully adjusted, each 1 NPX increase in plasma EDA2R was associated with a 74% higher risk of CVD and a 177% higher risk of all-cause mortality, with risks increasing monotonically across the entire distribution. Mediation analysis identified 302 proteins for CVD and 482 for mortality, enriched in death receptor activity, tumor necrosis factor receptor activity, cytokine and growth factor binding, and immune receptor activity.Conclusion: Elevated plasma EDA2R is strongly associated with long-term risks of CVD and all-cause mortality, suggesting its potential as a novel prognostic biomarker and therapeutic target.","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"49 5","pages":"e70314"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to Editor "Melatonin as a Novel Drug to Improve Cardiac Function and Quality of Life in Heart Failure Patients: A Systematic Review and Meta-Analysis". 致编辑的信“褪黑素作为一种改善心力衰竭患者心功能和生活质量的新药：一项系统综述和荟萃分析”。

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70325

Neda Roshanravan, Sina Pakkhesal, Faezeh Tarighat, Samad Ghaffari

引用次数: 0

Note for Male Smokers: The Healthy Eating Index Associated With the Risk of Subclinical Myocardial Injury. 男性吸烟者注意事项：健康饮食指数与亚临床心肌损伤风险相关。

IF 2.3 3区医学

Clinical Cardiology Pub Date : 2026-05-01 DOI: 10.1002/clc.70330

Zhi-Jin Li, Bin-Gui Li

{"title":"Note for Male Smokers: The Healthy Eating Index Associated With the Risk of Subclinical Myocardial Injury.","authors":"Zhi-Jin Li, Bin-Gui Li","doi":"10.1002/clc.70330","DOIUrl":"https://doi.org/10.1002/clc.70330","url":null,"abstract":"Objectives: To investigate the associations of the healthy eating index (HEI) and subclinical myocardial injury (SCMI) in different smoking statuses (current smokers, former smokers, and never smokers) based on the National Health and Nutrition Examination Survey (NHANES) III.Methods: SCMI was defined as a cardiac infarction injury score (CIIS) ≥ 10. The HEI was compared between individuals with and without SCMI across different smoking status categories. Logistic regression analysis was used to investigate the association between HEI and SCMI stratified by smoking status, as well as in subgroups defined by sex and smoking status. Restricted cubic spline (RCS) modeling was applied to assess the nonlinear relationship between HEI and SCMI risk among male participants. Logistic regression-based classification was further employed to explore the contribution of individual HEI components to SCMI risk in male smokers.Results: A total of 7256 participants (without SCMI group: 5389; SCMI group: 1867) were included. After stratifying by smoking status, a significant difference in HEI was found between the two groups among smokers. Multivariable logistic regression analysis revealed that HEI was inversely associated with the odds of SCMI in smokers. This association was particularly pronounced in male smokers. RCS analysis revealed a negative linear association between HEI and SCMI risk in male smokers. Diet variety and saturated fats were major contributors to this relationship.Conclusion: This study demonstrated that in male smokers, HEI scores negatively correlated with SCMI risk, with diet variety and saturated fats being major contributors in the late 1980s to early 1990s.","PeriodicalId":10201,"journal":{"name":"Clinical Cardiology","volume":"49 5","pages":"e70330"},"PeriodicalIF":2.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0