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[SILENT SINUS SYNDROME]. [沉默性鼻窦综合征]。
Harefuah Pub Date : 2025-03-01
Ben Gvili, Arkadi Yakirevitch
{"title":"[SILENT SINUS SYNDROME].","authors":"Ben Gvili, Arkadi Yakirevitch","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Silent sinus syndrome (SSS) is a rare condition, usually consisting of asymptomatic spontaneous collapse of the sinus walls and orbit floor. It is often found incidentally on MRI or CT imaging for other pathology work-up. The etiology of SSS remains controversial. Patients typically deny preexisting sinus disease or orbitofacial trauma. Clinical appearance usually consists of asymptomatic enophthalmos and altered facial appearance. Nevertheless, diplopia, nasal discharge, post-nasal drip, facial pressure, or pain may also be present. Most authors postulate that the collapse of the inferior orbital wall is induced by negative pressure generated by the resorption of gas after a natural ostium occlusion.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"143-144"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[COGAN SYNDROME - CASE PRESENTATION WITH PROGRESSIVE OCULAR INVOLVEMENT]. [cogan综合征-伴有进行性眼部受累的病例]。
Harefuah Pub Date : 2025-03-01
Amir Abd Elkader, Irit Bahar, Eitan Livny
{"title":"[COGAN SYNDROME - CASE PRESENTATION WITH PROGRESSIVE OCULAR INVOLVEMENT].","authors":"Amir Abd Elkader, Irit Bahar, Eitan Livny","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>A 74-year-old female patient suffering from Cogan's syndrome, presented to our department with slow progression bilateral corneal clouding, leading to reduced vision in her right eye. Recently, the patient underwent combined surgery of penetrating keratoplasty with cataract extraction, which improved her vision significantly. Cogan syndrome is a rare progressive systemic disease with potentially severe visual impairment. Disease diagnosis is challenging and is conducted by exclusion. Patients can benefit from keratoplasty in progressive disease manifestation.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"158-162"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[OCULAR MANIFESTATION OF STEVENS-JOHNSON SYNDROME]. [史蒂文斯-约翰逊综合征的眼部表现]。
Harefuah Pub Date : 2025-03-01
Noa Kapelushnik, Asaf Achiron, Irit Barequet
{"title":"[OCULAR MANIFESTATION OF STEVENS-JOHNSON SYNDROME].","authors":"Noa Kapelushnik, Asaf Achiron, Irit Barequet","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Steven Johnson Syndrome (SJS) is a syndrome with a wide range of severity, primarily affecting the body's mucous membranes, including the eyes. Ocular involvement is common and typically consists of an acute phase followed by chronic complications. This article describes a case of a young 7-year-old patient who developed SJS and presented with numerous ocular complications associated with the disease. Additionally, a literature review of the ocular manifestations of the disease and their treatment is provided. This case demonstrates how timely and appropriate treatment of SJS, involving a multidisciplinary team, is essential. There are several treatment approaches for ocular involvement and ways to manage chronic complications; however, the most crucial aspect is the early identification and optimal treatment during the acute phase of the disease to prevent future chronic complications.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"153-157"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[VOGT-KOYANAGI-HARADA SYNDROME]. (VOGT-KOYANAGI-HARADA综合症)。
Harefuah Pub Date : 2025-03-01
Dana Cohen, Yael Ben-Arie-Weintrob, Tamar Hareuveni-Blum, Efrat Naaman
{"title":"[VOGT-KOYANAGI-HARADA SYNDROME].","authors":"Dana Cohen, Yael Ben-Arie-Weintrob, Tamar Hareuveni-Blum, Efrat Naaman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Vogt-Koyanagi-Harada (VKH) syndrome is an autoimmune disease characterized at its acute stage by pan-ocular granulomatous inflammation. Systemic symptoms may develop, including hearing impairment, neurologic disorders, and loss of pigment in the skin and hair. Ocular complications occur during the chronic stage or secondary to flare-ups and may result in substantial vision loss due to the intraocular inflammation. This manuscript presents a case report and literature review of the ocular and systemic manifestations, diagnostic criteria, differential diagnosis and treatment considerations in VKH. We describe a case of a 14-year-old patient who presented with bilateral granulomatous uveitis with optic nerve and central retinal edema, with no other complaints. She underwent workup to rule out a systemic disease including an infectious and rheumatologic disease, which was unremarkable. She was treated with systemic steroids but suffered from worsening of her symptoms. She subsequently developed imaging manifestations consistent with VKH. Therefore, she was also treated with immunosuppressants including Imuran and Cyclosporin, as well as biological therapy due to recurring flare-ups, with good response. Early diagnosis and appropriate treatment of VKH is important to minimize ocular and extraocular complications.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"183-187"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[BIRDSHOT CHORIORETINOPATHY]. (网CHORIORETINOPATHY)。
Harefuah Pub Date : 2025-03-01
Shani Barenboim, Raz Gepstein
{"title":"[BIRDSHOT CHORIORETINOPATHY].","authors":"Shani Barenboim, Raz Gepstein","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Birdshot chorioretinopathy, also known as \"Birdshot uveitis\" is a binocular, chronic disease, as a result of inflammation in the posterior segment of the eye. The hallmarks of the disease are multiple white-creamy choroidal ovoid lesions. The symptoms of the disease range from good visual acuity with only mild symptoms, to a significant and permanent decrease in vision. This review aims to provide information about the course, clinical presentation, diagnosis and treatment for Birdshot chorioretinopathy. The initial diagnosis is made through fundus examination, in addition to support of positive HLA-A29 results and imaging modalities such as FA, ICG and OCT which are used as tools for initial diagnosis, response to treatment and monitoring the course of the disease. The treatment depends on the inflammatory activity and includes steroids (mainly systemic), and different types of immunosuppressive medications.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"193-196"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[MEDICATIONS AND VACCINE-ASSOCIATED UVEITIS]. [药物和疫苗相关的葡萄膜炎]。
Harefuah Pub Date : 2025-03-01
Shaul Sar, Oren Yovel, Oren Tomkins-Netzer
{"title":"[MEDICATIONS AND VACCINE-ASSOCIATED UVEITIS].","authors":"Shaul Sar, Oren Yovel, Oren Tomkins-Netzer","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Uveitis describes intra-ocular inflammation involving any ocular structure, related to either infectious or non-infectious etiologies. Non-infectious uveitis may be associated with systemic autoimmune diseases or be isolated to the eyes. Rarely, uveitis can be drug-induced. Vaccine-associated uveitis has been reported following different vaccines. It is mostly anterior, mild and resolves following topical treatment. Current medical recommendations are to receive timely vaccinations according to local guidelines. Uveitis patients and physicians should be aware of symptoms suggesting disease relapse.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"188-192"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[OCULAR CICATRICIAL PEMPHIGOID].
Harefuah Pub Date : 2025-03-01
Ofri Rimoni, Wallid Ghanem, Arie Marcovich, Adi Einan-Lifshitz
{"title":"[OCULAR CICATRICIAL PEMPHIGOID].","authors":"Ofri Rimoni, Wallid Ghanem, Arie Marcovich, Adi Einan-Lifshitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Ocular cicatricial pemphigoid (OCP) is considered to be a subtype of Mucous Membrane Pemphigoid (MMP). OCP is a type of autoimmune conjunctivitis that leads to scarring of the conjunctiva. Untreated OCP can lead to irreversible ophthalmic damage, to the point of blindness. In this article, we will discuss the case of a patient who has been under follow-up for over a decade at a corneal clinic due to OCP disease and as a result underwent various treatments. Prior to that, a short literature review will be presented on the subject including the etiology, pathophysiology, epidemiology, presentation, diagnosis, differential diagnosis, treatments available and complications that may occur during follow-up.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"163-168"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[VEXAS- NEWLY REPORTED SYNDROME WITH OCULAR MANIFESTATIONS: CASE REPORT]. [vexas -新报道的伴有眼部表现的综合征：1例报告]。
Harefuah Pub Date : 2025-03-01
Muhammad Abumanhal, Ran Ben Cnaan, Igal Leibovitch
{"title":"[VEXAS- NEWLY REPORTED SYNDROME WITH OCULAR MANIFESTATIONS: CASE REPORT].","authors":"Muhammad Abumanhal, Ran Ben Cnaan, Igal Leibovitch","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>VEXAS syndrome (VEXAS - Vascular E, X-linked, A Autoinflammatory, S Somatic) is an adult-onset autoinflammatory disease caused by a somatic mutation in the E1 enzyme of the ubiquitin, encoded by the UBA1 gene, primarily affecting males. The syndrome is typically accompanied by hematologic disorders, mainly myelodysplastic syndrome. Additionally, it includes systemic manifestations such as lung nodules inflammation (alveolitis), recurrent infections, systemic fever, sinus and ear inflammations, and skin rashes. In this article, we present a case of a patient diagnosed with VEXAS syndrome following ocular involvement. Furthermore, we will review ocular manifestations described in the literature.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"175-178"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[GENOMIC CANCER TESTS AND MEDICAL DECISION-MAKING: HOW DO LARGE LANGUAGE MODELS HANDLE INFORMATION GAPS?] 基因组癌症测试和医疗决策：大型语言模型如何处理信息差距？］
Harefuah Pub Date : 2025-03-01
Arni Gershman, Or Degany, Rotem Sisso-Avron
{"title":"[GENOMIC CANCER TESTS AND MEDICAL DECISION-MAKING: HOW DO LARGE LANGUAGE MODELS HANDLE INFORMATION GAPS?]","authors":"Arni Gershman, Or Degany, Rotem Sisso-Avron","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Clinicians and patients are offered a variety of genomic tests intended to assess the prognosis of cancer. Among these is the \"Decipher\" test for prostate cancer. A 71-year-old patient with prostate cancer was referred for testing by his treating doctor. The test results suggested reclassification of the patient from the intermediate-risk group for death and disease complications to the high-risk group.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"140-142"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[SOLVING A MEDICAL MYSTERY THROUGH THE EYES OF A YOUNG PATIENT WITH MULTIPLE TATTOOS]. [通过一个有多处纹身的年轻病人的眼睛解决一个医学之谜]。
Harefuah Pub Date : 2025-03-01
Shai Cohen, Zohar Habot-Wilner
{"title":"[SOLVING A MEDICAL MYSTERY THROUGH THE EYES OF A YOUNG PATIENT WITH MULTIPLE TATTOOS].","authors":"Shai Cohen, Zohar Habot-Wilner","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Tattoos have been an integral aspect of human cultural heritage for centuries, and gained vast popularity in recent years among different cultures, being part of the mainstream culture. To date, it is even very common to perform many tattoos in various sizes over the body. However, many tattooed people are not aware of tattoo-related side effects. Several reports have emerged in recent years regarding the association between tattoos and autoimmune diseases. Sarcoidosis is a systemic inflammatory disease of unknown etiology, characterized by non-caseating granulomas, and may involve many body organs, including the eyes. The most common ocular manifestation is uveitis, which may be the first sign of the disease.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 3","pages":"169-174"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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