{"title":"[ASSOCIATION BETWEEN TREATMENT FOR DIABETES MELLITUS AND HYPOGLYCEMIA AMONG HOSPITALIZED PATIENTS WITH HYPOALBUMINEMIA TREATED WITH MEDICAL FOOD].","authors":"Israel Khanimov, Eyal Leibovitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Hypoglycemia may be related to malnutrition or treatment of diabetes. An association between treatment with medical food and lower incidence of hypoglycemia among patients with diabetes and hypoalbuminemia has recently been shown.</p><p><strong>Aims: </strong>To study the association between hypoglycemia incidence and medical and nutrition treatment for diabetes.</p><p><strong>Methods: </strong>In this observational study, data was collected from electronic medical records. Included were patients with type 2 diabetes, admitted to internal medicine \"E\" at the Edith Wolfson Medical Center between 1.6.2016-31.5.2017. Logistic regression was implemented to assess the association between treatment for diabetes and hypoglycemia. Linear regression models were built to examine the association between treatment for diabetes and the number of hypoglycemic events.</p><p><strong>Results: </strong>Included were 221 patients (62.4% females, mean age 77.4 ± 12.0 years), 52 of them (23.5%) had hypoglycemia. The proportion of patients on medical food was 69.5±37.1%. According to logistic regression model, age (OR 1.034, CI 1.002-1.068, p=0.038), male sex (OR 2.941, CI 1.454-5.945, p=0.003) and treatment with insulin (OR 3.778, CI 1.831-7.794, p<0.001) were associated with hypoglycemia, while treatment with medical food was associated with less hypoglycemia (OR 0.352, CI 0.145-0.857, p=0.022). The linear regression model showed that metformin was associated with fewer hypoglycemic events (beta=-0.352 CI -1.391- -0.704, p<0.001). Nutrition was not found to be associated with the number of hypoglycaemic events.</p><p><strong>Conclusions: </strong>Treatment with oral nutrition supplements and metformin is associated with reduced incidence of hypoglycemia.</p><p><strong>Discussion: </strong>Oral nutrition is crucial for preventing hypoglycaemia during hospitalizations, regardless of the treatment for glucose control. Metformin is also beneficial.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 10","pages":"650-654"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Riham Kheir, Vera Sorin, Dana Stav, Tal Paz, Roy Raphael, Amit Shemesh, Shirley Greenbaum
{"title":"[The winning works of the Scientific Council of the Israel Medical Association (IMA) Award for Excellence in Basic Sciences for 2024].","authors":"Riham Kheir, Vera Sorin, Dana Stav, Tal Paz, Roy Raphael, Amit Shemesh, Shirley Greenbaum","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The winning works of the Scientific Council of the Israel Medical Association (IMA) Award for Excellence in Basic Sciences for 2024.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 10","pages":"616-620"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shay Ofir-Geva, Isaac Meilijson, Silvi Frenkel-Toledo, Nachum Soroker
{"title":"[IDENTIFYING BRAIN STRUCTURES THAT CONTRIBUTE TO UPPER-LIMB RECOVERY POST STROKE USING THREE DIFFERENT METHODS OF LESION-SYMPTOM MAPPING].","authors":"Shay Ofir-Geva, Isaac Meilijson, Silvi Frenkel-Toledo, Nachum Soroker","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Aims: </strong>The identification of brain structures that are critical for upper limb residual motor function following stroke is an essential step towards the development of advanced treatment modalities for improving rehabilitation outcomes among brain-injured patients, such as non-invasive brain stimulation techniques, which aim to induce neuroplasticity in motor-critical brain regions. In the current study we attempted to identify the critical brain regions for upper limb motor function among stroke patients, using three different methods of lesion-symptom mapping (LSM).</p><p><strong>Methods: </strong>Brain imaging data and Fugl-Meyer Assessment for upper-limb (FMA) scores for 107 patients admitted to the neurological rehabilitation department at Loewenstein Rehabilitation Medical Center, were analyzed using 3 LSM methods: Voxel-based Lesion-Symptom Mapping (VLSM), Region-based Lesion-Symptom Mapping (RLSM), and Multi-perturbation Shapley-value Analysis (MSA).</p><p><strong>Results: </strong>In left-hemispheric damaged (LHD) patients only a relatively small number of brain regions were found, in comparison with right-hemispheric damaged (RHD) patients. For LHD, two regions important for movement planning were found to be critical - the supplementary motor area and the premotor area. For RHD, parts of the temporal, frontal and insular cortices, as well as the cingulate gyrus were exclusively detected as critical. Sub-cortical brain structures (basal ganglia, corona radiata, internal capsule and superior longitudinal fasciculus) were detected in both hemispheres.</p><p><strong>Conclusions: </strong>Despite the variability between different LSM methods, all methods have consistently shown a difference between the critical brain-regions for upper-limb function following LHD vs. RHD. These findings support previous works suggesting that the left (motor-dominant) hemisphere is more inter-connected, thus it has higher redundancy and decreased vulnerability to focal damage.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 9","pages":"552-557"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[THE CONTRIBUTION OF INPATIENT REHABILITATION IN ISRAEL TO THE IMPROVEMENT OF DAILY FUNCTIONING AFTER SPINAL CORD LESIONS].","authors":"Yaron Watts, Lilach Front, Dianne Michaeli, Elena Aidinoff, Amiram Catz, Vadim Bluvshtein","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal cord lesions (SCL) are usually followed by neurological and functional improvement. The neurological improvement is natural and improves the functional potential of the patients, while rehabilitation improves the realization of that potential. The functional change depends on the neurological change, and usually does not represent the contribution of rehabilitation alone to the functional improvement.</p><p><strong>Aims: </strong>To evaluate the net contribution of inpatient rehabilitation in Israel to functioning after SCL, and the ability to predict this contribution, which reflects the success of rehabilitation.</p><p><strong>Methods: </strong>Demographic and clinical data of SCL patients admitted to rehabilitation between 2011 and 2020 were collected retrospectively. The data were used to calculate Spinal Cord Injury Ability Realization Measurement Index (SCI-ARMI) scores, isolating the effect of neurologic status on functioning, its change during rehabilitation, and factors affecting it. Data were analyzed using t-tests, Pearson correlations, ANOVA, and ANCOVA.</p><p><strong>Results: </strong>A total of 1,433 patients were included in the study. Their age was 54±17 years, 32% were females, and 37.2% had traumatic injuries. American Spinal Injury Association Impairment Scale (AIS) grades were A in 11% of the patients, B in 4.8%, C in 17.3% and D in 65.9%. SCI-ARMI was 52±24 at admission to rehabilitation, and 73.5±19 at discharge (41% improvement, p<0.001). Likewise, the neurological motor status and function significantly improved. SCI-ARMI improvement increased with lower admission SCI-ARMI values (r=-0.654, p<0.001) and younger age (r=-0.122, p<0.001), and correlated with longer stay in rehabilitation (r=0.261, p<0.001).</p><p><strong>Conclusions: </strong>Inpatient rehabilitation in Israel made a substantial contribution to functional improvement. Lower realization of the functional potential at admission to rehabilitation predicted greater success in the process of SCL rehabilitation.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 9","pages":"564-570"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jana Landa, Tamar Silberg, Maya Gerner, Etzyona Eisenstein, Sharon Barak
{"title":"[COMPLEX REGIONAL PAIN SYNDROME AND FUNCTIONAL NEUROLOGICAL DISORDER IN CHILDREN AND ADOLESCENTS: UNITY IN DIVERSITY].","authors":"Jana Landa, Tamar Silberg, Maya Gerner, Etzyona Eisenstein, Sharon Barak","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Functional neurological disorder (FND) and complex regional pain syndrome (CRPS) are disorders that affect quality of life. CRPS diagnosis is based on Budapest criteria that include various signs/symptoms. Despite the similarity in the etiology/pathophysiology of FND and CRPS, the joint prevalence of these two conditions in youth has not yet been reported. Given that both phenomena are less familiar among pediatric patients, it is crucial to thoroughly characterize them and establish a clear differential diagnosis. This, in turn, holds significant implications for guiding therapeutic interventions.</p><p><strong>Objectives: </strong>We aimed to examine: 1) the clinical profile of children with FND; 2) the prevalence of CRPS among children with FND; and 3) differences in clinical characteristics and in Budapest's symptoms/signs between children with FND and those with a co-diagnosis of FND and CRPS.</p><p><strong>Methods: </strong>Sixty-one children (mean age: 13.70+2.93 years; 75.4% females) diagnosed with FND were studied. Sample's demographic, clinical characteristics and the Budapest CRPS classification criteria were collected from medical files.</p><p><strong>Results: </strong>Most children with FND reported sensory (67%) and motor (88%) symptoms. Forty-four percent had a co-diagnosis of FND and CRPS. Among these children, 100% reported sensory and motor/tropical, 74% vasomotor, and 65% sudomotor symptoms. The prevalence of Budapest symptoms, except for motor-function impairment, was significantly higher among children with a co-diagnosis compared to children with FND alone.</p><p><strong>Conclusions: </strong>The high frequency of symptoms and clinical signs in children with co-incidence of CRPS and FND may indicate a shared developmental mechanism and is important for the development of appropriate rehabilitation interventions.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 9","pages":"571-578"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[WHAT IS \"PHYSICAL MEDICINE\" - THE FIELD OF PHYSICAL MEDICINE AND REHABILITATION IN ISRAEL?]","authors":"Michal E Eisenberg, Iuly Treger, Alan Friedman","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The field of Physical Medicine and Rehabilitation is as diverse and broad as any field in medicine. The two, seemingly different, fields developed separately and over time (as later presented) merged into one specialty. This resulted in an initial asymmetry of focus amongst training programs - and indeed countries. In Israel, although rehabilitation medicine is on par with the highest levels in the world, its partner, physical medicine (PM) has suffered to the extent that it is practically invisible in some of the training hospitals in our country.</p><p><strong>Objectives: </strong>We will define PM, explain why it is less developed in Israel, and present the methods being employed to rectify the training imbalance.</p><p><strong>Methods: </strong>A systematic literature review was performed for prior descriptions and issues in PM in Israel. The search was conducted using four databases (PubMed, Google Scholar, ScienceDirect and the Cochrane Library). Searches were not limited by language or date, reflecting all available data.</p><p><strong>Results: </strong>No articles were identified. This was anticipated as the field of PM is in the process of development in Israel.</p><p><strong>Conclusions: </strong>Whereas PM has been an official partner of rehabilitation medicine in Israel and prominently featured in academic syllabi, the reality has been otherwise. Our article delineates why this developed and the plans and methods on how it is changing, allowing Israel to be a world leader in all aspects of Physical Medicine and Rehabilitation.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 9","pages":"594-599"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[REHABILITATION MEDICINE IN DEPTH AND WIDTH].","authors":"Iuly Treger","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Modern rehabilitation medicine focuses on evaluating and treating patients whose quality of life has been compromised by medical conditions. This field endeavors to enhance well-being and independence levels by adopting a comprehensive approach that addresses physical, mental, psychological, and social aspects, while incorporating advancements in medical research. Grounded in the International Classification of Functioning, Disability, and Health (ICF) model by the World Health Organization, rehabilitation targets diverse levels of functional impairment. A collaborative effort among professionals from various disciplines characterizes the rehabilitative process, guided by an Individual Rehabilitation Project, and oversight by a specialist in physical medicine and rehabilitation. Through initiated prompt post-injury, rehabilitation progresses through hospital-based interventions and extends to community-based therapies upon the patient's return home. In this special edition of \"Harefuah\" readers will find profound scientific articles and literature reviews spanning a breadth of topics within the realm of physical medicine and rehabilitation. These insights offer a glimpse into the expansive domain of rehabilitation medicine.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 9","pages":"548-551"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[OCULAR DISEASES, FALLS AND HIP FRACTURES].","authors":"Atzmon Tsur, Gershon Volpin, Zvi Segal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Falls occur among old people and sometimes cause fractures in the hip. There are many reasons for falls.</p><p><strong>Objectives: </strong>To examine which ocular diseases are frequent among old people who fell and had hip fractures; to verify whether the use of glasses can prevent fall events.</p><p><strong>Methods: </strong>A survey was conducted on a sample of 100 patients, 63 women and 37 men, who fell and broke their hip between the years 2008 - 2012, were operated on and hospitalized for rehabilitation. Their mean age was 78+8.4 years old and mean weight, 69+14.4 kg. All these patients were examined by an ophthalmologist to detect ocular diseases.</p><p><strong>Results: </strong>Only 67% of them suffered from ophthalmic disease. Among them, 49.3% suffered from problems in the anterior compartment of at least one eye, 32.8% in the posterior compartment and 17.9% in both compartments. The cataract was the most frequent disease (42%), and the second, was the retinopathy. We must mention that 77.6% of the patients who needed glasses were not using them at the time of the fall. The mean age of the patients who had no ocular disease was 4 years younger than the age of those who suffered from it (Independent t-test, p=0.0115 1-side).</p><p><strong>Conclusions: </strong>Treatment for optic diseases and the use of glasses are important factors in falls prevention among the elderly.</p><p><strong>Discussion: </strong>Elderly people are more prone to fall and break their hip than younger people. Even though it was not statistically proved, disorders in visual acuity and in the visual field, can cause falls among old people.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 9","pages":"585-588"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[APPLICATIONS OF ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING IN REHABILITATION].","authors":"Orit Mazza, Amir Haim, Shay Ofir-Geva","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The use of artificial intelligence applications in medicine has been common in recent decades. Machine learning, a subfield of artificial intelligence, is a methodology that allows computers to learn from examples and draw conclusions about new data. Advances in artificial intelligence and machine learning may play a central role in making clinical decisions in rehabilitation, diagnosing functional impairments, developing, improving existing protocols and building personalized rehabilitation programs. In addition, artificial intelligence applications in rehabilitation will be integrated into rehabilitation treatment for the purpose of improving impairments in body functions and compensating for body functions that cannot be restored (using human-machine interfaces).</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 9","pages":"600-608"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amit Kosto, Dor Vadas, Lena Lutsky, Leonid Kalichman, Iuly Treger
{"title":"[COMMUNITY-BASED REHABILITATION: IMPORTANCE, PRINCIPLES AND ADVANCEMENT IN ISRAEL].","authors":"Amit Kosto, Dor Vadas, Lena Lutsky, Leonid Kalichman, Iuly Treger","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Medical rehabilitation is developing rapidly in Israel and around the world due to the aging of the population, improvement of results of medical care, and growing awareness of the importance of rehabilitation medicine. An option of comprehensive community rehabilitation treatment is also developing quickly, both in the model of replacing hospitalization and as a professional treatment after early discharge from an inpatient program. Rehabilitation in the community has many benefits, including financial, high patient satisfaction, and in some cases even more successful results of rehabilitation. The key to successful community rehabilitation lies in team cooperation and synchronization and in transferring the weight of rehabilitation from the inpatient department to rehabilitation in the community by the rehabilitation doctor as a team manager and the multi-disciplinary team. A 2018 Ministry of Health document defines home rehabilitation as \"An orderly, multi-professional and vigorous program, intended for all ages, to achieve goals in rehabilitation according to a functional assessment and a rehabilitation plan, in the patient's home.\" In writing this article we defined two main goals. The first is to review current data, which can be found in the scientific literature on community rehabilitation. The second goal was to define the principles and systems of community rehabilitation, relevant to the State of Israel.</p>","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"163 9","pages":"589-593"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}