Harefuah最新文献_第2页

[INNOVATIONS IN THERAPIES FOR BACILLUS CALMETTE-GUERIN (BCG) FAILURE NON-MUSCLE INVASIVE PATIENTS]. [卡介苗失效（bcg）非肌肉侵入性患者的治疗创新]。

Harefuah Pub Date : 2025-09-01

Nicola Fazaa, Reut Shashar, Kamil Malshy, Gilad Amiel, Azik Hoffman

{"title":"[INNOVATIONS IN THERAPIES FOR BACILLUS CALMETTE-GUERIN (BCG) FAILURE NON-MUSCLE INVASIVE PATIENTS].","authors":"Nicola Fazaa, Reut Shashar, Kamil Malshy, Gilad Amiel, Azik Hoffman","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Bladder cancer is categorized into invasive cancer, which pathologically infiltrates the muscle layer of the bladder, and non-muscle invasive bladder cancer that does not penetrate this layer. Non-muscle-invasive bladder cancer is further stratified into risk groups based on the likelihood of disease recurrence and progression. High-risk non-muscle-invasive tumors typically undergo conventional treatment with intravesical Bacillus Calmette-Guerin (BCG) instillations. However, it is anticipated that thirty to fifty percent of patients will experience treatment failure, leading to disease recurrence or progression, necessitating radical cystectomy as the subsequent therapeutic step. Extensive endeavors are underway to explore novel treatment modalities aiming to reduce the necessity for bladder removal. Diverse treatments, both systemic and local, administered directly into the bladder, have been investigated in recent years to mitigate the need for cystectomy. This review article provides an overview of current approved therapeutic options such as combined intravesical chemotherapy with gemcitabine and docetaxel, systemic therapy with pembrolizumab, intravesical therapy with nadofaragene firadenovec, and innovative investigational treatments including TAR-200 drug-releasing supplement therapy and novel viral therapy, cretostimogene grenadenorepvec.","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 8","pages":"524-528"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[MASSIVE TUMOR INSIDE A GIANT BLADDER DIVERTICULUM]. [巨大膀胱憩室内的巨大肿瘤]。

Harefuah Pub Date : 2025-09-01

Israel Benzekry, Ilan Klein, Alex Pavlov, Yoram Dekel

引用次数: 0

[PREVALENCE OF BENIGN PROSTATIC HYPERPLASIA IN SPINA BIFIDA PATIENTS]. [脊柱裂患者前列腺增生的患病率]。

Harefuah Pub Date : 2025-09-01

Hila Noyman, Emmanuel Kornitzer, Shachar Aharoni, Yuval Bar-Yosef, Vladimir Yutkin, Fred Carroll, Mordechai Duvdevani, Ofer Gofrit, Guy Hidas

{"title":"[PREVALENCE OF BENIGN PROSTATIC HYPERPLASIA IN SPINA BIFIDA PATIENTS].","authors":"Hila Noyman, Emmanuel Kornitzer, Shachar Aharoni, Yuval Bar-Yosef, Vladimir Yutkin, Fred Carroll, Mordechai Duvdevani, Ofer Gofrit, Guy Hidas","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: In recent decades, with improvement in therapy, men born with spina bifida (myelomeningocele) live longer and reach adulthood. This raises the question whether they develop age-related benign prostatic hyperplasia (BPH). We recently found that low spinal cord injuries reverse age-related prostatic growth, suggesting that continuous nervous system support is essential for sustaining BPH.Objectives: This study aimed to examine if patients born with spina bifida develop BPH as they age.Methods: This was a multi-center study. The prostate volume (PV) of 24 spina bifida patients older than 35 years were documented from recent available imaging, or from ultrasound testing conducted as part of the research. Each patient's measured volume was compared to expected age-adjusted average volumes of healthy men. Additional clinical variables were collected.Results: Patients' median age was 46 years, with a range of 35-61 years. The prostate volume of spina bifida patients was on average 18% smaller than age-expected volume (P<0.005). The most common level of injury was lumbar; however, no significant correlation was found between the level of injury and PV. Non-parametric statistical tests did not show a significant correlation between PV and other clinical variables, probably due to the small sample size.Conclusions: Spina bifida patients have smaller PV than age expected, and do not commonly develop BPH. This information is beneficial for clinicians counselling spina bifida patients. Moreover, it provides additional evidence of the nervous system's role in developing BPH and raises the possibility of finding a non-hormonal pharmacological intervention for reversing BPH.","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 8","pages":"483-487"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[SHOULD MEDICINE TREAT AGING AS A DISEASE?] 医学应该把衰老当作一种疾病来对待吗？］

Harefuah Pub Date : 2025-07-01

Yuval Heled, Ayelet Shachar

{"title":"[SHOULD MEDICINE TREAT AGING AS A DISEASE?]","authors":"Yuval Heled, Ayelet Shachar","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Aging is a biological process that occurs in every living organism and affects all bodily systems. Many chronic diseases, such as cardiovascular diseases, diabetes, and neurodegenerative diseases of the central nervous system, are perceived as an integral part of the aging process and are even referred to as \"aging-related diseases.\" These diseases develop over long periods of time and are typically treated only after they have already manifested or been diagnosed, primarily with medications, and they cannot be completely cured. In recent decades, a growing perspective views the mechanisms of aging themselves as a pathological process that facilitates the development of diseases. Consequently, intervening in these mechanisms may, if not prevent, at least significantly delay their progression. This raises the question: 'Should medicine regard the aging process itself as a disease and even define aging as a disease?' The answer to this question is complex, particularly given the necessity of a clearly defined and agreed-upon medical indication for any medical treatment. This article explores this issue by reviewing well-known biological mechanisms of aging, the relationship between aging and chronic diseases, the existing potential to treat aging directly, and the challenges associated with considering aging as a disease.","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 7","pages":"447-451"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[RIGHT AORTIC ARCH]. [右主动脉弓]。

Harefuah Pub Date : 2025-07-01

Emil Sameyah, Gil Bachar

引用次数: 0

[THE EFFECTS OF PHYSICAL ACTIVITY ON FIBROMYALGIA]. [运动对纤维肌痛的影响]。

Harefuah Pub Date : 2025-07-01

Daphna Israeli, Yehuda Shoenfeld

{"title":"[THE EFFECTS OF PHYSICAL ACTIVITY ON FIBROMYALGIA].","authors":"Daphna Israeli, Yehuda Shoenfeld","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Fibromyalgia syndrome is defined as chronic widespread pain associated with sleep disorders, chronic fatigue, cognitive dysfunction, and other somatic and psychological symptoms. Psychological symptoms can include mood disorders, anxiety and depression. Physical activity can be considered a safe non-pharmacological tool to alleviate fibromyalgia's physical and psychological symptoms. Physical activity that includes aerobic exercises such as swimming, walking, and dancing, combined with strength training, flexibility training and other mind-body exercises, have been proven to alleviate pain, and improve quality of sleep, cognitive functions, mood and health-related quality of life. As a general guideline, all physical activity protocols for fibromyalgia patients should be gradual and incremental, starting with low intensity and duration, and increased gradually to avoid injuries, fatigue and drop-outs. Additionally, physical activity should be personalized according to each patient's fitness level, pain levels, physical limitations, personal preferences, goals and socio-economical barriers. It is recommended that a physical activity protocol should lapse 8-12 weeks, in order to see improvement and to instill healthy lifestyle habits. It is recommended to exercise 2-3 times per week, for 40-50 minutes in each session. A physical activity protocol should combine aerobic exercises, strength training, flexibility and mind-body exercises, such as Yoga, Pilates and Tai-chi, that involve balance, flexibility and breathing techniques.","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 7","pages":"436-440"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Steroid IV administration in coeliac attack: a case report]. [腹腔发作时静脉注射类固醇1例]。

Harefuah Pub Date : 2025-07-01

Chaim Chaimoff, Boris Sapojnikov, Eduard Reiss, Rotem Chaimoff

引用次数: 0

[ROBOTIC ORTHOPEDIC SURGERY - WHERE ARE WE STANDING TODAY?] 机器人整形外科——我们今天的进展如何？］

Harefuah Pub Date : 2025-07-01

Yaniv Steinfeld, Yaniv Yonai, Yaron Berkovich

{"title":"[ROBOTIC ORTHOPEDIC SURGERY - WHERE ARE WE STANDING TODAY?]","authors":"Yaniv Steinfeld, Yaniv Yonai, Yaron Berkovich","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: The use of robotic and semi-robotic systems in surgery was introduced back in the 1980s, and in orthopedic surgery in the 1990s, but many years passed before it became a significant part of orthopedic surgery. In recent years, robotic surgery, robotic-assisted surgery and advanced technologies have gained popularity and have been integrated as a fundamental part of orthopedic surgery. Adult limb reconstruction, Total Knee Replacement in particular, is probably the highest volume surgery performed in a robotic assisted manner in orthopedic surgery. However, advanced technologies are not limited to knee replacement surgeries. Spine surgery is the second sub-specialty in orthopedics using robotic assistance and navigation in surgery. In recent years we have seen the introduction of advanced technologies into many fields of orthopedic surgery, including foot and ankle surgery, trauma surgery and other subspecialties. In most cases the use of robotic systems is safe, but there are no prospective, long-term high quality studies that indicate a significant advantage for one of the options. There is an abundance of researchers currently investigating this topic. In this article we review the latest uses and developments of robotics and advanced technologies in orthopedic surgery.","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 7","pages":"452-455"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[THERAPY IN PATIENTS AFFECTED BY BREAST AND PROSTATE CANCER]. [乳腺癌和前列腺癌患者的治疗方法]。

Harefuah Pub Date : 2025-07-01

Adi David, Sharon Eilon, Shaked Lev-Ari, Moshe Frenkel

{"title":"[THERAPY IN PATIENTS AFFECTED BY BREAST AND PROSTATE CANCER].","authors":"Adi David, Sharon Eilon, Shaked Lev-Ari, Moshe Frenkel","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: This study aims to identify and evaluate the treatment gaps in patients undergoing endocrine therapy for breast and prostate tumors, and to propose integrative solutions for unmet needs.Methods: The article provides a narrative review of three significant side effects of endocrine therapy among breast and prostate cancer patients: vasomotor effects, joint pain and stiffness, and sexual disorders. It also offers treatment options for these effects from the field of complementary and integrative medicine.Results: The adverse consequences of endocrine treatments in breast and prostate cancer patients reduce treatment compliance and significantly impair the patients' quality of life. Evidence-based complementary and integrative medicine modalities, including nutritional counseling, dietary supplements, homeopathic remedies, touch therapies, acupuncture, and mind-body treatments, may improve the patients' quality of life and alleviate the burden of side effects.Conclusions: There is a need to improve the management of side effects unique to endocrine therapy. Integrating supportive care with complementary and integrative medicine offers a viable option to enhance the quality of life for these patients.","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 7","pages":"441-446"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[ASSESSMENT OF THE EFFECT OF THE CORONA PANDEMIC LOCKDOWNS IN 2020 ON THE AMOUNT AND NATURE OF REFERRALS FOR URGENT PSYCHIATRIC HELP IN THE EMERGENCY DEPARTMENT AT THE ZIV MEDICAL CENTER]. [评估2020年冠状病毒大流行封锁对ziv医疗中心急诊科紧急精神病帮助转诊数量和性质的影响]。

Harefuah Pub Date : 2025-07-01

Viktoriya Gershman, Vladimir Zlidennyy, Lidia Izackson, Salman Zarka

{"title":"[ASSESSMENT OF THE EFFECT OF THE CORONA PANDEMIC LOCKDOWNS IN 2020 ON THE AMOUNT AND NATURE OF REFERRALS FOR URGENT PSYCHIATRIC HELP IN THE EMERGENCY DEPARTMENT AT THE ZIV MEDICAL CENTER].","authors":"Viktoriya Gershman, Vladimir Zlidennyy, Lidia Izackson, Salman Zarka","doi":"","DOIUrl":"","url":null,"abstract":"Background: On January 30, 2020, the World Health Organization declared a public health emergency of international concern and on March 11, 2020, it declared the Corona epidemic (COVID-19). Governments around the world have adopted a series of procedures to reduce the spread of the pandemic (eg, lockdowns, social distancing and isolation) affecting over half of the world's population. The population of the mentally challenged may be among the most vulnerable populations affected by the COVID-19 pandemic.Methods: The study is a retrospective study. The information was extracted from existing medical files of patients in the \"Ziv\" Medical Center Emergency Department, who applied for psychiatric help in 2016 and in 2020. The data from the source documents was collected and processed through SPSS software.Results: Data was received for about 958 patients who applied to the psychiatric emergency room in 2016 and for 1565 patients who applied in 2020.Conclusions: The results of the study strengthen the hypothesis that the Corona epidemic (COVID-19) had a cumulative negative effect on mental health and caused dramatic consequences for the mental health of the population. An increase was observed in the number of patient applications to the psychiatric emergency room, including repeated referrals, referrals in more unusual situations such as accompanied by violence or suicidality, as well as an increase in the number of forced hospitalizations.","PeriodicalId":101459,"journal":{"name":"Harefuah","volume":"164 7","pages":"430-435"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0