医学应该把衰老当作一种疾病来对待吗?]

Harefuah Pub Date : 2025-07-01
Yuval Heled, Ayelet Shachar
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引用次数: 0

摘要

导读:衰老是发生在每一个生物体中并影响所有身体系统的生物过程。许多慢性疾病,如心血管疾病、糖尿病和中枢神经系统的神经退行性疾病,被认为是衰老过程的一个组成部分,甚至被称为“与衰老有关的疾病”。这些疾病是长期发展的,通常只有在已经表现出来或被诊断出来后才能得到治疗,主要是用药物治疗,而且它们不能完全治愈。近几十年来,越来越多的观点认为衰老本身的机制是一种促进疾病发展的病理过程。因此,干预这些机制,如果不能阻止,至少可以显著延缓其进展。这就提出了一个问题:医学是否应该将衰老过程本身视为一种疾病,甚至将衰老定义为一种疾病?这个问题的答案是复杂的,特别是考虑到任何医疗都需要明确界定和商定的医学指征。本文将通过回顾衰老的生物学机制、衰老与慢性疾病的关系、直接治疗衰老的现有潜力以及将衰老视为一种疾病所面临的挑战来探讨这一问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[SHOULD MEDICINE TREAT AGING AS A DISEASE?]

Introduction: Aging is a biological process that occurs in every living organism and affects all bodily systems. Many chronic diseases, such as cardiovascular diseases, diabetes, and neurodegenerative diseases of the central nervous system, are perceived as an integral part of the aging process and are even referred to as "aging-related diseases." These diseases develop over long periods of time and are typically treated only after they have already manifested or been diagnosed, primarily with medications, and they cannot be completely cured. In recent decades, a growing perspective views the mechanisms of aging themselves as a pathological process that facilitates the development of diseases. Consequently, intervening in these mechanisms may, if not prevent, at least significantly delay their progression. This raises the question: 'Should medicine regard the aging process itself as a disease and even define aging as a disease?' The answer to this question is complex, particularly given the necessity of a clearly defined and agreed-upon medical indication for any medical treatment. This article explores this issue by reviewing well-known biological mechanisms of aging, the relationship between aging and chronic diseases, the existing potential to treat aging directly, and the challenges associated with considering aging as a disease.

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