Acta medica (Hradec Kralove)最新文献

Two Hurt More Than One: Severe Hyponatraemia and Rhabdomyolysis as Presenting Features of Addison's Disease. 两害大于一害：严重低钠血症和横纹肌溶解是艾迪生病的表现特征。

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.16

Luca Foppiani, Christian Cascio, Paola Pesce, Giancarlo Antonucci

引用次数: 0

Eyelid Radiotherapy-Treated Basal and Squamous Cell Carcinomas: A Case Series. 眼睑放射治疗基底细胞癌和鳞状细胞癌：一个病例系列。

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.20

Ioannis Athanasiadis, Aristeidis Konstantinidis, Eirini-Kanella Panagiotopoulou, Minas Bakirtzis, Michael Koukourakis, Georgios Labiris

{"title":"Eyelid Radiotherapy-Treated Basal and Squamous Cell Carcinomas: A Case Series.","authors":"Ioannis Athanasiadis, Aristeidis Konstantinidis, Eirini-Kanella Panagiotopoulou, Minas Bakirtzis, Michael Koukourakis, Georgios Labiris","doi":"10.14712/18059694.2025.20","DOIUrl":"https://doi.org/10.14712/18059694.2025.20","url":null,"abstract":"Introduction: This case report aims to showcase the successful application of electron hypofractionated radiotherapy in the treatment of eyelid basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).Cases presentation: Two cases are presented involving a 91-year-old Greek female with nodular BCC and an 88-year-old Greek male with ulcerative SCC. Both cases were treated with electron 10MeV irradiation using an ELEKTA 5-15MV linear accelerator. In the first case, a patient with advanced dementia presented with left-upper-eyelid nodular BCC. Following confirmation through biopsy and imaging, hypofractionated electron-beam radiotherapy was chosen, leading to gradual recession of the lesion and no recurrence at the one-year follow-up. In the second case, an elderly male with comorbidities had right-upper-eyelid ulcerative SCC. After systemic evaluation ruled out metastasis, the patient underwent hypofractionated radiotherapy, resulting in unexpected lesion shrinkage, resolution, and absence of recurrence at the 6-month and one-year follow-ups.Conclusions: Hypofractionated electron-beam radiotherapy emerges as an effective and well-tolerated alternative for eyelid tumors, particularly in cases where surgical excision is challenging or contraindicated.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"68 2","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Headlines: Why Henipaviruses Warrant Our Attention. 标题之外：为什么亨尼帕病毒值得我们关注

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.11

Biplab Adhikari

引用次数: 0

Intra-Operative and Post-Operative Impact of Body Weight on Total Hip Arthroplasty: Are We Approaching It Correctly? 术中及术后体重对全髋关节置换术的影响：我们是否正确处理？

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.15

Edoardo Ipponi, Sara Barderi, Elena Bechini, Belinda Misso, Luca Orsetti, Lorenzo Andreani, Nicola Piolanti, Enrico Bonicoli, Paolo Domenico Parchi

{"title":"Intra-Operative and Post-Operative Impact of Body Weight on Total Hip Arthroplasty: Are We Approaching It Correctly?","authors":"Edoardo Ipponi, Sara Barderi, Elena Bechini, Belinda Misso, Luca Orsetti, Lorenzo Andreani, Nicola Piolanti, Enrico Bonicoli, Paolo Domenico Parchi","doi":"10.14712/18059694.2025.15","DOIUrl":"https://doi.org/10.14712/18059694.2025.15","url":null,"abstract":"Background: To this date, the impact of body weight on total hip arthroplasty is still debated. The literature lacks evidence on the impact of body weight on surgical times and complications.Methods: We retrospectively evaluated all the patients who underwent primary total hip arthroplasty (THA), collecting patients' pre-operative BMI before surgery. We recorded the surgical approach performed (anterior or posterolateral), and their duration. All the major complications were recorded.Results: Seven-hundred-thirty-two cases were included (627 posterolateral and 105 anterior approach). The mean BMI was 27.3. The mean surgical time was 90.8 minutes (104.9 for anterior and 88.5 for posterolateral approach). We found a significant positive relationship between BMI and surgical times for both cases treated with a posterolateral approach, and (even more remarked) in case anterior approach. Thirty-nine cases (5.3%) had major complications; 27 of them (69.2%) were overweight or obese. The surgical times of those who had complications were significantly higher compared to others.Conclusions: Patients' body weight, and in particular their Body Mass index, has a direct impact on the duration of THA surgical procedures, particularly if performed using an anterior approach, and an indirect effect on complication rates.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"68 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of Chondral Defect of the Knee Joint - Current Methods, Possibilities of Using Cultured Mesenchymal Stem Cells. 膝关节软骨缺损的治疗-现有方法，利用培养间充质干细胞的可能性。

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.12

Libor Prokeš, Tomáš Kučera

引用次数: 0

Clinical Evaluation of Oxidized Cellulose Powder and Endoscopic Applicator in Multicenter Trial. 氧化纤维素粉及内镜下涂抹器在多中心试验中的临床评价。

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.13

Petr Habal, Veronika Sívková, Zdeněk Šorm, Milan Chobola, Jiří Feix, Igor Slaninka, Jiřina Habalová, Tomáš Hosszú, Jaroslav Pacovský

{"title":"Clinical Evaluation of Oxidized Cellulose Powder and Endoscopic Applicator in Multicenter Trial.","authors":"Petr Habal, Veronika Sívková, Zdeněk Šorm, Milan Chobola, Jiří Feix, Igor Slaninka, Jiřina Habalová, Tomáš Hosszú, Jaroslav Pacovský","doi":"10.14712/18059694.2025.13","DOIUrl":"10.14712/18059694.2025.13","url":null,"abstract":"Purpose: Oxidized cellulose-based haemostatic agents are widely used for managing bleeding in various surgical procedures. This study evaluates the efficacy and safety of oxidized cellulose powder and an endoscopic applicator across a broad spectrum of surgical settings.Methods: This was a prospective, multicentre study involving 99 evaluable patients undergoing surgeries with varying bleeding severities and surgical approaches (open, laparoscopic, or thoracoscopic). The primary endpoint was achieving haemostasis within 3 minutes and avoiding revision surgery within 12 hours. The time to haemostasis (TTH) and complications were recorded, and statistical comparisons were made using a paired and unpaired t-test, with a significance threshold of P < 0.05. Data from this study were compared to historical results from fibrillar haemostats.Results: Haemostasis was achieved within 3 minutes in 61.6% (95% CI [52.0, 71.2]) of patients and within 5 minutes in 99.0% (95% CI [97.0, 100.0]) of patients. The overall mean TTH was 153.8 seconds (95% CI: 141.5-166.1), with shorter TTH observed in minimally invasive procedures using the endoscopic applicator. Subgroup analysis revealed higher success rates for patients with mild bleeding (78%) compared to moderate bleeding (50%).Conclusion: Oxidized cellulose powder demonstrates reliable haemostatic performance across diverse surgical applications. The endoscopic applicator enhances precision and applicability, particularly in minimally invasive settings, making it a valuable tool in modern surgical practice.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"68 1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peritendinitis of the Fourth Dorsal Compartment Due to Anomalous Extensor Indicis Proprius: A Case Report and Review of Anatomical Variations. 指固有伸肌异常致第四背隔室腹膜炎：1例报告及解剖变异回顾。

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.23

Dimas Drummond, José Luiz Masson de Almeida Prado, Henrique Shimidu, Márcio Luís Duarte

{"title":"Peritendinitis of the Fourth Dorsal Compartment Due to Anomalous Extensor Indicis Proprius: A Case Report and Review of Anatomical Variations.","authors":"Dimas Drummond, José Luiz Masson de Almeida Prado, Henrique Shimidu, Márcio Luís Duarte","doi":"10.14712/18059694.2025.23","DOIUrl":"https://doi.org/10.14712/18059694.2025.23","url":null,"abstract":"Anomalous extensor indicis proprius (EIP) tendons are rare anatomical variations that can cause wrist pain and dysfunction due to tendon compression and inflammation. These variations, though often asymptomatic, are implicated in conditions such as fourth extensor compartment peritendinitis, requiring accurate diagnosis and tailored treatment. We report the case of a 56-year-old man with chronic right wrist pain lasting eight months, primarily aggravated by finger extension. Physical examination revealed a tender nodule on the dorsum of the wrist and pain elicited by the Spinner test, indicating involvement of the fourth dorsal compartment. Magnetic resonance imaging (MRI) showed an anomalous, thickened EIP tendon with peritendinitis. The patient opted for conservative management, including nonsteroidal anti-inflammatory drugs (NSAIDs) and activity modification, which led to complete symptom resolution within two weeks. This case highlights the clinical relevance of EIP tendon anomalies, which can mimic other wrist pathologies. The Spinner test and imaging modalities such as MRI are essential for diagnosis. While conservative treatment is often sufficient, surgical decompression may be necessary in refractory cases. Awareness of these rare anatomical variations is crucial for accurate diagnosis and effective management, ensuring better outcomes for patients with wrist pain.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"68 2","pages":"73-75"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EUS Guided FNA Cell Block Cytology and Intraoperative Squash Cytology in the Diagnostic Approach of Unfamiliar Malignant Neoplastic Disorders. EUS引导下FNA细胞阻滞细胞学和术中挤压细胞学在不熟悉的恶性肿瘤疾病诊断中的应用。

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.22

Alexandra Kalogeraki, Dimitrios Tamiolakis, Eleni Moustou, Evangelos Kalaitzakis

引用次数: 0

Comparative Analysis of Immaturity CD Markers Expression between Pediatric and Adult Acute Lymphoblastic Leukemia: Insights and Implications for Diagnostic and Therapeutic Strategies. 儿童和成人急性淋巴细胞白血病不成熟CD标志物表达的比较分析：诊断和治疗策略的见解和意义。

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.19

Ihsan Mardan Al-Badran, Ahmed Mardan Al-Badran

{"title":"Comparative Analysis of Immaturity CD Markers Expression between Pediatric and Adult Acute Lymphoblastic Leukemia: Insights and Implications for Diagnostic and Therapeutic Strategies.","authors":"Ihsan Mardan Al-Badran, Ahmed Mardan Al-Badran","doi":"10.14712/18059694.2025.19","DOIUrl":"https://doi.org/10.14712/18059694.2025.19","url":null,"abstract":"Objective: The objective of this study is to assess the expression levels of different immaturity CD markers in diverse subtypes of Acute Lymphoblastic Leukemia (ALL) among children and adults, and determine any statistically significant variations in marker expression between these two groups.Methods: This dataset included CD marker expressions (CD34, HLA-DR, TdT, and CD38) for 130 ALL patients (51 pediatric B-ALL, 16 pediatric T-ALL, 44 adult B-ALL, and 19 adult T-ALL patients). The Shapiro-Wilk test analysis was conducted to check for normality distribution in all data points before proceeding with the statistical analysis test. As a result for each marker within these subtypes, descriptive statistics were calculated. Independent samples t-tests were initially conducted to compare mean expression levels of CD markers between groups. Moreover, since non-normal distributions are likely to occur, Mann-Whitney U tests were used for Pediatric T-ALL and Adult T-ALL.Results: Descriptive analysis indicated variability in CD marker expression levels among the different subtypes of ALL. Both t-tests and Mann-Whitney U tests revealed statistically significant differences (p < 0.05) in the expression levels of CD markers between pediatric and adult groups, or between B-ALL and T-ALL groups.Conclusion: Significant differences have been identified using different analysis methods across the studied groups. The investigation analyzes the expression levels of CD34, HLA-DR CD38, and TdT within pediatric B-ALL patients and pediatric T-ALL patients along with adult B-ALL patients and adult T-ALL patients. The patterns need appreciation because they might reveal biological differences at their base which influence disease development and both treatment results and patient survival outcomes.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"68 2","pages":"50-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between XRCC1 Arg399gln Polymorphism and Risk of Luminal Subtype Breast Cancer in Bali, Indonesia. 印尼巴厘岛地区XRCC1 Arg399gln多态性与Luminal亚型乳腺癌发病风险的关系

Acta medica (Hradec Kralove) Pub Date : 2025-01-01 DOI: 10.14712/18059694.2025.14

I Wayan Gede Sutadarma, I Gede Putu Supadmanaba, Putu Anda Tusta Adiputra, Anggi Amanda Triana Devy, Anak Agung Bagus Putra Indrakusuma, I Gede Aswin Parisya Sasmana

{"title":"Relationship Between XRCC1 Arg399gln Polymorphism and Risk of Luminal Subtype Breast Cancer in Bali, Indonesia.","authors":"I Wayan Gede Sutadarma, I Gede Putu Supadmanaba, Putu Anda Tusta Adiputra, Anggi Amanda Triana Devy, Anak Agung Bagus Putra Indrakusuma, I Gede Aswin Parisya Sasmana","doi":"10.14712/18059694.2025.14","DOIUrl":"https://doi.org/10.14712/18059694.2025.14","url":null,"abstract":"Background: Breast cancer is the second leading cause of cancer-related death and the most common type of cancer in women. Recent studies have shown that the development of carcinogenesis is influenced by impaired XRCC1 expression. Therefore, research on the relationship between the XRCC1 Arg399Gln polymorphism and the luminal subtype of breast cancer is important so that it can be used as a reference for further research development.Methods: This study lasted for 12 months at the Integrated Biomedical Laboratory and Biochemistry Laboratory, Faculty of Medicine, Udayana University. The samples consisted of 30 samples of stored biological material from previous studies with a case-control study design. The status of the XRCC1 Arg399Gln polymorphism was determined by performing PCR on blood samples. Furthermore, the samples were analyzed with SPSS version 25.0.Results: The number of samples in this study was 15 cases and 15 controls with the majority aged > 50 years. The results of the analysis showed that differences in age groups, menstrual status, and cancer grade were significantly associated with breast cancer subtypes (p < 0.05). Based on the results of sequencing and bivariate analysis, the XRCC1 Arg399Gln polymorphism acted as a protective risk factor for the development of luminal subtype breast cancer (OR = 0.182; p = 0.028).Conclusion: XRCC1 Arg399Gln polymorphism is associated with the risk of luminal subtype breast cancer in Bali.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"68 1","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0