Acta medica (Hradec Kralove)最新文献

{"title":"Beyond the Algorithm: The ERC Guidelines 2025 and the Maturity of Resuscitation Medicine.","authors":"Roman Škulec","doi":"10.14712/18059694.2026.17","DOIUrl":"https://doi.org/10.14712/18059694.2026.17","url":null,"abstract":"<p><p>The European Resuscitation Council Guidelines 2025, officially launched as the Guidelines on Cardiopulmonary Resuscitation 2025 on 22 October 2025 in Rotterdam and published in Resuscitation (1) as a thematic collection of guideline papers, represent far more than a scheduled update of resuscitation algorithms. That reading would be too narrow. The ERC Guidelines 2025 are better understood as a portrait of a discipline that has entered a new phase in its understanding of the continuum of resuscitation care. In these guidelines, resuscitation medicine is not reduced to the dramatic moment of cardiac arrest. It is presented as a continuum of knowledge, decision-making, technical skill, system organization, ethical responsibility, and longterm outcome. The algorithm retains its grammar, but not the whole language of care. This is what makes the 2025 guidelines important. They document the transformation of resuscitation from an acute technical intervention into a mature clinical discipline situated at the intersection of time, pathophysiology, teamwork, system design, and value-based decision-making. Resuscitation remains inseparable from urgency, but contemporary resuscitation medicine shows that speed without structure, technical correctness without a functioning system, and intensity of treatment without an ethical frame are not enough. Saving life in a critical moment requires not only hands capable of performing the correct intervention, but also an environment in which that intervention can be delivered early, reliably, in the appropriate clinical context, and with a clear pathway to subsequent care.This shift from algorithm to system is visible throughout the guidelines. Resuscitation is no longer merely a question of what happens in the minutes after collapse. It is shaped by how the system works before cardiac arrest, during cardiac arrest, and after return of spontaneous circulation. Recognition of deterioration, activation of help, first aid, basic life support, automated external defibrillation, dispatcher assistance, emergency medical service organization, in-hospital rapid response systems, advanced life support, post-resuscitation care, registries, and audit all form a single clinical and organizational continuum. The chain of survival is therefore not only an educational metaphor. It is an operational responsibility. Survival after cardiac arrest is not the property of an isolated intervention; it is a property of the system.The concept of systems saving lives is consequently one of the central messages of the ERC Guidelines 2025. There is no isolated hero in resuscitation detached from the system. Citizens, dispatchers, first responders, ambulance crews, emergency departments, catheterization laboratories, intensive care units, rehabilitation professionals, and registries are all part of the same trajectory of care. Each enters at a different point, with different competencies, but in relation to the same outcome. Where one li","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 2","pages":"46-47"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Impacted Mandibular Third Molars: A Scoping Review of Surgical Extraction versus Orthodontic Traction and Nerve Injury Risk.","authors":"Angeliki Andreadou, Eleftheria Sipka, Vasiliki Zavogianni, Dimitra Papageorgiou, Loukia Ieronymou, Panagiotis Kafas, Theodoros Lillis, Nikolaos Dabarakis","doi":"10.14712/18059694.2026.12","DOIUrl":"10.14712/18059694.2026.12","url":null,"abstract":"<p><p>The management of impacted mandibular third molars can be a difficult clinical issue due to the proximity of the tooth to critical neurovascular structures. Surgical removal is routinely performed, but the technique carries a known risk of injury to the inferior alveolar and lingual nerves. The complication may induce temporary or permanent sensory impairment. Orthodontic traction can be an alternative to reposition the tooth in a more desirable location before surgical removal. The selection of the appropriate treatment is important to avoid a mechanical injury and to allow the adjacent bone and soft tissue to adapt, which may reduce the risk of nerve injury from compression or transection. This review discusses the anatomy of the inferior alveolar canal and the lingual nerve route, describes the known mechanisms and classifications of nerve injury, and outlines how orthodontic traction may diminish these risks. Technical aspects of traction, including the surgical exposure with coronectomy or not, force application, anchorage methods, and radiographic observation, are reviewed. Potential complications, including root resorption and unwanted tooth movement, were also explained. Criteria for patient selection are discussed, with emphasis on age, root morphology, eruption space, and imaging findings that indicate proximity to neurovascular structures. The purpose of this scoping review was to compare orthodontic traction and complete surgical extraction of mandibular impacted third molars with respect to injury of the inferior alveolar nerve (IAN) and lingual nerve (LN). The limited but growing evidence allows us to identify gaps in long-term outcome data and calls for further prospective studies. Orthodontic traction cannot replace extraction in every case, but for carefully chosen patients, it may offer a practical treatment option for preserving neurosensory function. The approach requires interdisciplinary collaboration, precise biomechanical planning, and a clear explanation of treatment goals to support informed decision-making.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 1","pages":"19-25"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Changing Comorbidity Burden and its Association with Outcomes in Acute NIV: A Charlson Comorbidity Index-Based Analysis.","authors":"Aylin Ozsancak Ugurlu, Alastair Watson, Barea Tanveer, Syed Abid, Giselle Pereira, Rahul Mukherjee","doi":"10.14712/18059694.2026.21","DOIUrl":"10.14712/18059694.2026.21","url":null,"abstract":"<p><p>Acute non-invasive ventilation (NIV) is a lifesaving treatment for acute hypercapnic respiratory failure, particularly during exacerbations of chronic obstructive pulmonary disease (COPD), and is also an established therapy that improves outcomes in acute cardiogenic pulmonary oedema. Decisions regarding NIV initiation are complex and require careful consideration of patient-specific factors. With an aging population, with increasing multimorbidity, understanding the evolving acute NIV patient characteristics is critical to optimize NIV delivery. We audited all adult acute NIV patients at a tertiary centre, pre-COVID (April 2019-March 2020) and post-COVID (April 2023-March 2024) and performed a retrospective observational cohort analysis. We compared the Charlson Comorbidity Index (CCI) scores and outcomes using Chi-squared or Mann-Whitney U. Three hundred and twelve patients received acute NIV, 171 pre-COVID and 141 post-COVID. Post-COVID patients had higher comorbidity burden vs pre-COVID (median CCI 5 vs 4, p=0.002), and ward-based NIV ceiling of care frequency (83% vs 66%, p=0.009). Across the entire cohort, higher CCI score associated with increased NIV failure (p=0.007) and in-hospital mortality (p<0.001). Our demonstration of increasing multimorbidity in a real-world cohort, and the association of multimorbidity with NIV failure, provides insights to guide optimization strategies for acute NIV services. Further understanding the evolving patient characteristics and their impact on outcome is essential to determine how best to incorporate comorbidity assessment into clinical decision making for improved NIV delivery.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 2","pages":"72-74"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural and Functional Determinants of Oxygen Transport in Exercise: The Role of Total Hemoglobin Mass.","authors":"Jiří Dostal","doi":"10.14712/18059694.2026.10","DOIUrl":"10.14712/18059694.2026.10","url":null,"abstract":"<p><p>Cardiac hemodynamics during exercise depend on both structural and functional adaptations of the oxygen transport system. This narrative review summarizes the knowledge on total hemoglobin mass (tHbmass) as a structural determinant of convective oxygen transport, and cardiac output and hemodynamic responses as key functional determinants, with attention to sex-related differences and clinical translation. We describe carbon monoxide rebreathing as the preferred method for quantifying tHbmass, outline typical values in untrained and endurance-trained men and women, and discuss the contributions of genetics, training, altitude exposure, and blood manipulation to inter-individual variation. The association between tHbmass and maximal oxygen uptake, its sport-specific distribution, and emerging clinical applications in the differential diagnosis of anemia and risk stratification are highlighted. We then review the regulation of cardiac output and arteriovenous oxygen difference during dynamic exercise, compare invasive and noninvasive techniques for their assessment, and summarize consistent sex differences in stroke volume, cardiac output, blood volume, and oxygen-carrying capacity. Across both domains, major gaps remain, particularly in the paucity of data in women and elite athletes studied at or near their physiological limits. Integrative assessments combining tHbmass, blood volume, and exercise hemodynamics may improve the understanding of both normal performance and cardiovascular pathology.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 1","pages":"3-10"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth Hormone-Mediated Diabetic Ketoacidosis: A Rare Presentation of Acromegaly.","authors":"Waraporn Polamuang, Thanyaporn Angsuwatcharakorn, Sakun Santisukwongchote, Sarat Sunthornyothin, Thiti Snabboon","doi":"10.14712/18059694.2026.14","DOIUrl":"10.14712/18059694.2026.14","url":null,"abstract":"<p><p>Acromegaly is a chronic disorder caused by pathological hypersecretion of growth hormone (GH), most commonly due to pituitary somatotroph adenomas. Excess GH leads to elevated insulin-like growth factor 1 (IGF-1) levels, which together mediate progressive physical changes and a wide range of systemic complications. A key metabolic abnormality in acromegaly is impaired glucose metabolism, which may result in diabetes through mechanisms of insulin resistance. This report describes a case of diabetic ketoacidosis (DKA), a severe complication of relative insulin deficiency, presenting as a rare initial manifestation of acromegaly. Following surgical intervention and remission of acromegaly, the glycemic control of the patient significantly improved, underscoring the importance of addressing the underlying endocrinopathy. This report highlights the critical need for comprehensive clinical evaluations in patients with common metabolic disorders, such as diabetes mellitus, to identify rare underlying causes and ensure timely diagnosis. Furthermore, it examines potential mechanisms of ketosis in acromegaly and reviews current approaches to glycemic management in this population, where evidence-based guidelines remain limited.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 1","pages":"32-36"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CTCAE-Guided Management of Cytotoxic Chemotherapy Toxicity in Uro-Oncology: A Contemporary Narrative Review.","authors":"Minh Nguyet Tranová, Oleg Izmaylov, Hanka Princlová, Pavel Navrátil","doi":"10.14712/18059694.2026.20","DOIUrl":"https://doi.org/10.14712/18059694.2026.20","url":null,"abstract":"<p><p>Cytotoxic chemotherapy remains integral to contemporary uro-oncology despite the rapid expansion of targeted therapy, antibody-drug conjugates, and immunotherapy. Its role is especially critical where therapeutic success depends on maintaining adequate dose intensity, most notably in metastatic testicular germ cell tumours and in cisplatin-based perioperative treatment for muscle-invasive bladder cancer. In metastatic prostate cancer and selected penile squamous cell carcinoma, taxane- and platinum-based regimens also retain clinical value but are constrained by hematologic, neurologic, renal, pulmonary, and gastrointestinal toxicities. This narrative review summarises current evidence and guideline recommendations for Common Terminology Criteria for Adverse Events (CTCAE)-guided management of chemotherapy toxicity across major uro-oncologic disease settings. A practical emphasis is placed on pretreatment risk stratification, cycle-by-cycle surveillance, supportive care, and intent-adapted treatment modification. Across tumour types, early recognition of grade 2 toxicity, urgent management of febrile neutropenia and organ toxicity, and thoughtful preservation of dose intensity when cure is realistic are the central management principles. In older, frail, immunosuppressed, heavily pretreated, or organ-limited patients, CTCAE grades must be interpreted against baseline reserve and cumulative toxicity.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 2","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Emerging Role and Clinical Impact of Vitamin D Supplementation in Breast Cancer Patients Undergoing Chemotherapy: A Systematic Review.","authors":"I Wayan Gede Sutadarma, Putu Anda Tusta Adiputra, I Wayan Weta, Desak Made Wihandani, I Gede Putu Supadmanaba, Putri Ayu Wulandari","doi":"10.14712/18059694.2026.19","DOIUrl":"https://doi.org/10.14712/18059694.2026.19","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer is the most common cancer in women and is often diagnosed at an advanced stage. Chemotherapy plays a crucial role in disease control but is limited by toxicity and response variability. Vitamin D, with its biological functions and the high prevalence of deficiency in patients, has potential as an adjuvant therapy to improve treatment response and clinical outcomes.</p><p><strong>Objective: </strong>To integrate existing evidence on the role of vitamin D supplementation in breast cancer patients undergoing chemotherapy, focusing on its impact on treatment response and clinical outcomes.</p><p><strong>Methods: </strong>This systematic review followed PRISMA guidelines and included RCTs, cohort, and case-control studies evaluating vitamin D supplementation in adult women with breast cancer undergoing chemotherapy. A comprehensive search across five databases up to June 2025 was conducted, applying the pre-established PICOS criteria, with filtering, data extraction, and quality assessment performed. This systematic review has been prospectively registered in the PROSPERO database (CRD420251142938).</p><p><strong>Results: </strong>This systematic review identified six eligible studies involving breast cancer patients undergoing chemotherapy, with interventions ranging from low- to high-dose vitamin D, either alone or in combination with synbiotics. Vitamin D supplementation in breast cancer patients undergoing chemotherapy has been associated with improved clinical outcomes, including enhanced nutritional status, reduced inflammatory and cardiotoxic biomarkers, and increased pathological complete response (pCR) and disease-free survival (DFS).</p><p><strong>Conclusion: </strong>Vitamin D supplementation during chemotherapy shows potential benefits in breast cancer patients, but large-scale standardized trials with long-term follow-up are needed to confirm its impact on survival outcomes.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 2","pages":"55-64"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Middle Meningeal Artery Embolization (MMAE) Versus Surgical Evacuation for Recurrent and Refractory Chronic Subdural Hematoma: A Systematic Review and Meta-Analysis.","authors":"Bhavya Pahwa, Nishtha Pahwa, Sangeeta Pahwa, Rajkumar Pahwa, Luis Ab Borba, Mirza Khinikadze, Ismail Bozkurt, Tural Rajabov, Kanav Gupta, Bipin Chaurasia","doi":"10.14712/18059694.2026.18","DOIUrl":"10.14712/18059694.2026.18","url":null,"abstract":"<p><strong>Background: </strong>Recurrent and refractory chronic subdural hematoma (cSDH) remains a significant neurosurgical challenge due to high recurrence rates and morbidity associated with repeated surgical interventions. Middle meningeal artery embolization (MMAE) has recently emerged as a minimally invasive alternative, but its efficacy compared to surgical evacuation in this specific subgroup has not been systematically evaluated.</p><p><strong>Methodology: </strong>A systematic search of Pubmed was conducted to identify studies reporting outcomes of MMAE and surgical evacuation in recurrent or refractory cSDH cases. Pooled efficacy rates and complication rates were extracted and analyzed using fixed-effects meta-analysis. Statistical significance was assessed with a p-value threshold of 0.05.</p><p><strong>Results: </strong>Sixteen studies were included in the meta-analysis. 181 patients underwent surgical evacuation while 97 patients underwent MMAE for recurrent and refractory cSDH. MMAE demonstrated significantly higher efficacy with a pooled success rate of 95% versus 84% for surgery (p=0.002, I2=0). Complication rates were lower in the MMAE group (6%) versus the surgical group (10%), though the difference was not statistically significant (p=0.06, I2=0).</p><p><strong>Conclusions: </strong>MMAE shows promise as a highly effective and safe treatment modality for recurrent and refractory cSDH, potentially surpassing surgical evacuation in both efficacy and safety. Given these findings, MMAE should be strongly considered not only as a salvage therapy but also as a frontline treatment option in this challenging patient population. Further high-quality randomized controlled trials are warranted to confirm these results and refine patient selection criteria.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 2","pages":"48-54"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Occlusion of the Central Retinal Artery in a Patient with Granulomatosis with Polyangiitis.","authors":"Minas Bakirtzis, Aikaterini Giannoukaki, Eirini-Kanella Panagiotopoulou, Tryfon Rotsos, Doukas Dardabounis, Georgios Labiris","doi":"10.14712/18059694.2026.15","DOIUrl":"10.14712/18059694.2026.15","url":null,"abstract":"<p><p>The purpose of this report is to document the occurrence of transient central retinal artery occlusion (CRAO) as a rare and serious ocular complication in a patient with granulomatosis with polyangiitis (GPA), emphasizing the potential vision-threatening nature of this condition. A 49-year-old male with a known diagnosis of GPA presented with transient CRAO. The case was analyzed to understand the ocular manifestations associated with GPA and the challenges in its management. The patient exhibited a transient CRAO, highlighting the potential for severe ocular complications in the context of GPA. Transient CRAO is a rare but serious vision-threatening complication of GPA. This case underscores the importance of early diagnosis and timely management in patients with ocular manifestations of GPA. Financial disclosure: No financial support was received for this case report. None of the authors has any proprietary interests or conflicts of interest related to this submission. It is not simultaneously being considered for publication at any other journal.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Occasion of the 80th Anniversary of the Faculty of Medicine of Charles University in Hradec Králové.","authors":"Roman Chlíbek, Leo Klein","doi":"10.14712/18059694.2026.16","DOIUrl":"https://doi.org/10.14712/18059694.2026.16","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Last autumn we commemorated the 80th anniversary of the founding of the Faculty of Medicine of Charles University in Hradec Králové. A number of events were held and several publications were released, including a special issue of the Časopis lékařů českých entirely dedicated to this anniversary and to the faculty. At the ceremonial assembly of the academic community on 8 October 2025, the dean of the faculty, Professor Manďák, delivered an extensive speech in which he clearly described the historical circumstances of the faculty's foundation, its beginnings, development, and growth through various stages up to the present day.Despite the many difficulties and changes related to both international and domestic political developments and the broader social climate over the past eight decades, the faculty has consistently fulfilled its main missions in student education, research, and scientific work. Outstanding physicians, teachers, and researchers have worked and continue to work here. Over the course of a demanding 80-year journey, the faculty has evolved into a modern educational and scientific research institution respected both nationally and internationally.Throughout this development - one that was not always without challenges - an important role was played by the exceptionally supportive environment and conditions created by the authorities of the city of Hradec Králové and the entire East Bohemian region. Even before the faculty itself was established after the end of the Second World War, efforts had been made to build a regional university. The critical shortage of physicians after the war, together with the possibility of utilizing a well-functioning modern hospital staffed by many top specialists in Hradec Králové, were among the main reasons for choosing this city.The excellent cooperation between the district hospital (later the University Hospital), the faculty, and the municipal and regional authorities has historically been one of the valuable attributes of mutual collaboration - something not entirely common elsewhere in the country. The spirit of interdisciplinary cooperation in Hradec Králové was further strengthened in 1969 with the establishment of the Faculty of Pharmacy of the university.In this article we would also like to recall another unique and very important characteristic of the Hradec Králové Faculty of Medicine. Within the framework of interministerial cooperation, it prepares - as the only institution in former Czechoslovakia and now in the Czech Republic - prepares physicians for the needs of the Czech Armed Forces, within a joint study programme with the Military Medical Faculty of the University of Defence. This extremely significant and today highly relevant role represents a unique chapter and a distinctive feature in the faculty's history.At the turn of the 1940s and 1950s, the international situation deteriorated with the emergence of two political-military blocs and the threat of a new conflict, ","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"69 2","pages":"43-45"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148709019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}