Beyond the Headlines: Why Henipaviruses Warrant Our Attention.

Biplab Adhikari
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Abstract

Henipaviruses, including Hendra and Nipah viruses, represent significant zoonotic threats with higher mortality rates. Due to limited therapeutic interventions, poses substantial challenges. These bat-borne pathogens were first identified in Australia (Hendra, 1994) and Malaysia (Nipah, 1998-1999), with subsequent multiple outbreaks. The recent discovery of Camp Hill virus in North American shrews, suggest broader geographic distribution than previously recognized. Transmission occurs primarily through contact with reservoir hosts, though human-to-human spread has been documented in Nipah outbreaks. Initial non-specific febrile symptoms can progress to fatal encephalitis with distinctive pathological findings including syncytia formation and vasculitis. A concerning feature is the potential for relapsing encephalitis months or years after initial infection. Management remains predominantly supportive, highlighting the urgent need for effective antivirals, vaccines, and enhanced surveillance. Expanded research into therapeutic countermeasures is essential to address this emerging global public health threat.

标题之外:为什么亨尼帕病毒值得我们关注
亨尼帕病毒,包括亨德拉病毒和尼帕病毒,是具有较高死亡率的重大人畜共患威胁。由于有限的治疗干预,提出了实质性的挑战。这些蝙蝠传播的病原体最初是在澳大利亚(亨德拉,1994年)和马来西亚(尼帕,1998-1999年)发现的,随后发生了多次暴发。最近在北美鼩鼱中发现了坎普希尔病毒,这表明该病毒的地理分布比以前认识到的要广泛。传播主要通过与水库宿主接触发生,尽管在尼帕疫情中有人际传播的记录。最初的非特异性发热症状可发展为致命的脑炎,具有独特的病理表现,包括合胞体形成和血管炎。一个值得关注的特征是在初次感染后数月或数年脑炎复发的可能性。管理仍然主要是支持性的,强调迫切需要有效的抗病毒药物、疫苗和加强监测。扩大对治疗对策的研究对于应对这一新出现的全球公共卫生威胁至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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