印尼巴厘岛地区XRCC1 Arg399gln多态性与Luminal亚型乳腺癌发病风险的关系

I Wayan Gede Sutadarma, I Gede Putu Supadmanaba, Putu Anda Tusta Adiputra, Anggi Amanda Triana Devy, Anak Agung Bagus Putra Indrakusuma, I Gede Aswin Parisya Sasmana
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引用次数: 0

摘要

背景:乳腺癌是癌症相关死亡的第二大原因,也是女性中最常见的癌症类型。最近的研究表明,XRCC1表达受损会影响癌变的发生。因此,研究XRCC1 Arg399Gln多态性与乳腺癌腔内亚型的关系具有重要意义,可为进一步的研究开发提供参考。方法:在乌达亚那大学医学院生物医学综合实验室和生物化学实验室进行为期12个月的研究。样本包括来自以往研究的30份储存生物材料样本,采用病例对照研究设计。通过对血样进行PCR检测XRCC1 Arg399Gln多态性的状态。此外,使用SPSS 25.0版本对样本进行分析。结果:本组病例15例,对照组15例,年龄以50 ~ 50岁为主。分析结果显示,年龄、月经状况和癌症分级的差异与乳腺癌亚型有显著相关性(p < 0.05)。基于测序和双变量分析结果,XRCC1 Arg399Gln多态性是发生腔型乳腺癌的保护性危险因素(OR = 0.182;P = 0.028)。结论:XRCC1 Arg399Gln多态性与巴厘地区腔室亚型乳腺癌发病风险相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship Between XRCC1 Arg399gln Polymorphism and Risk of Luminal Subtype Breast Cancer in Bali, Indonesia.

Background: Breast cancer is the second leading cause of cancer-related death and the most common type of cancer in women. Recent studies have shown that the development of carcinogenesis is influenced by impaired XRCC1 expression. Therefore, research on the relationship between the XRCC1 Arg399Gln polymorphism and the luminal subtype of breast cancer is important so that it can be used as a reference for further research development.

Methods: This study lasted for 12 months at the Integrated Biomedical Laboratory and Biochemistry Laboratory, Faculty of Medicine, Udayana University. The samples consisted of 30 samples of stored biological material from previous studies with a case-control study design. The status of the XRCC1 Arg399Gln polymorphism was determined by performing PCR on blood samples. Furthermore, the samples were analyzed with SPSS version 25.0.

Results: The number of samples in this study was 15 cases and 15 controls with the majority aged > 50 years. The results of the analysis showed that differences in age groups, menstrual status, and cancer grade were significantly associated with breast cancer subtypes (p < 0.05). Based on the results of sequencing and bivariate analysis, the XRCC1 Arg399Gln polymorphism acted as a protective risk factor for the development of luminal subtype breast cancer (OR = 0.182; p = 0.028).

Conclusion: XRCC1 Arg399Gln polymorphism is associated with the risk of luminal subtype breast cancer in Bali.

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