Acta medica (Hradec Kralove)最新文献_第2页

Two World Wars and Belgium: Missing Births and Birth Sex Ratio Changes. 两次世界大战与比利时：缺失出生和出生性别比变化。

Acta medica (Hradec Kralove) Pub Date : 2024-01-01 DOI: 10.14712/18059694.2024.15

Victor Grech, Tania Borg

{"title":"Two World Wars and Belgium: Missing Births and Birth Sex Ratio Changes.","authors":"Victor Grech, Tania Borg","doi":"10.14712/18059694.2024.15","DOIUrl":"https://doi.org/10.14712/18059694.2024.15","url":null,"abstract":"Introduction: The sex ratio at birth (male/total births, M/T) is expected to approximate 0.515. M/T is influenced by many factors including stress. Both World Wars have been implicated as influencing birth rates and M/T. This study was carried out to analyse the effects of two World Wars on Belgium vis-à-vis missing births as well as M/T changes.Methods: Belgian male and female births were available for 1830-2019 and annual population was available from Statista. ARIMA models were used to estimate and project birth losses. The effect of wars was assumed to begin in the years following the commencement of each war and extend to the year after cessation of hostilities i.e., 1915-1919 and 1940-1946 for the First and Second World Wars respectively.Results: This study included 27,346,178 live births for 1830-2019, M/T 0.5124. There was a decreasing trend in births for 1830-2019, significant for 1950-2019. There were dips in births in association with both Wars resulting in over 440,000 missing births, 3.80% of the Belgian population for the First World War and 1.91% for the Second World War. M/T rose non-significantly for the First World War and significantly for the Second World War.Discussion: The declining birth rate and M/T in developed countries is a recognised phenomenon. The missing births in relation to wars are of demographic importance but are often overlooked with emphasis usually on casualties and deaths. M/T may rise in wars, possibly due to increased coital activity as well as other factors.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 1","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts from 20th International Medical Doctoral Conference (2023) - New Horizons for PhD Students in Medical Research. 第20届国际医学博士会议摘要（2023年）-医学研究博士生的新视野。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2023.20

引用次数: 0

COVID-19 Can Unveil Brugada: A Rare Case. 新冠肺炎可能揭开布鲁加达的面纱：罕见病例。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2023.18

Savalan Babapoor, Zachary Port, Philip C Wiener, Roozbeh Tarighati Rasekhi, Ali Babapour Farrokhran, Sumeet K Mainigi

引用次数: 0

Comparison of Short and Long-Term Results after Injection Laryngoplasty with Radiesse® Voice and Thyroplasty Type I in Unilateral Vocal Fold Palsy. 单侧声带褶皱麻痹患者使用 Radiesse® Voice 和 I 型胸廓成形术进行注射喉成形术后的短期和长期效果比较。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2024.2

Katarína Smatanová, András Burián, Jakub Dršata, Jana Krtičková, Anikó Kőnig-Péter, Jan Mejzlík, Viktor Chrobok

{"title":"Comparison of Short and Long-Term Results after Injection Laryngoplasty with Radiesse® Voice and Thyroplasty Type I in Unilateral Vocal Fold Palsy.","authors":"Katarína Smatanová, András Burián, Jakub Dršata, Jana Krtičková, Anikó Kőnig-Péter, Jan Mejzlík, Viktor Chrobok","doi":"10.14712/18059694.2024.2","DOIUrl":"10.14712/18059694.2024.2","url":null,"abstract":"Objectives: Unilateral vocal fold palsy independently of etiology results in glottic insufficiency leading to unfavorable short or long-term impact on voice quality. Our aim was to evaluate the effect of injection laryngoplasty using Radiesse® Voice and thyroplasty type I on glottic closure, voice quality and aerodynamics by comparing preoperative, short- and long-term results.Materials and methods: Data of 32 consent patients were reviewed between 2012 and 2023. All patients underwent either injection laryngoplasty (14 patients) or thyroplasty type I (18 patients) under local anesthesia. Maximum phonation time, glottic closure based on videolaryngostroboscopy, VHI-30 values and GRBAS scale were recorded prior, short-term (3 month) and long-term (12 months) after procedures for statistical comparison. Friedman test, Mann-Whitney test and Wilcoxon signed rank tests were used for statistical analysis.Results: In injection laryngoplasty group, we found significant improvement in maximum phonation time (p = 0.002), grade of hoarseness (p = 0.002) and breathiness (p = 0.000) when comparing results before and short-term after procedure. In thyroplasty type I group we saw significant improvement of maximum phonation time (p = 0.000), glottic insufficiency (p = 0.000), all three VHI-30 components (p = 0.000), as well as grade of hoarseness, breathiness (both p = 0.000) and roughness (p = 0.011) of GRBAS scale when comparing voice outcome before and short-term after procedure. There was no significant difference in voice outcome results neither between short and long-term results nor between the two groups in any parameter.Conclusion: These results demonstrate both short and long-term efficiency of injection laryngoplasty and thyroplasty type I in the improvement of voice quality and glottic closure.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"66 3","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival Analysis of Newly Diagnosed Multiple Myeloma Patients after Frontline Autologous Stem Cell Transplantation in a Real-Life Setting. 新诊断的多发性骨髓瘤患者在前线自体干细胞移植后的实际生存情况分析。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2024.4

David Garrido, Virginia Bove, Fiorella Villano, Eloísa Riva

{"title":"Survival Analysis of Newly Diagnosed Multiple Myeloma Patients after Frontline Autologous Stem Cell Transplantation in a Real-Life Setting.","authors":"David Garrido, Virginia Bove, Fiorella Villano, Eloísa Riva","doi":"10.14712/18059694.2024.4","DOIUrl":"10.14712/18059694.2024.4","url":null,"abstract":"Introduction: Autologous stem cell transplantation (ASCT) is the standard consolidation option for transplant-eligible patients with multiple myeloma (MM). The aim of this study is to report the overall survival (OS) and progression-free survival (PFS) outcomes after frontline ASCT in newly-diagnosed MM (NDMM) patients in a real-world setting.Methods: We conducted a retrospective, survival analysis of all NDMM patients included in the MM Uruguayan Registry.Results: We included 151 NDMM patients treated with induction therapy followed by high-dose melphalan and ASCT as consolidation. The median age at diagnosis was 59 years, and the international staging system (ISS) risk groups were ISS-III 32.9%, ISS-II 37.8%, and ISS-I 29.4%. Frontline induction regimens included bortezomib in 61.6% of cases, and maintenance therapy was used in 63.9% of reported cases. With a median follow-up of 42 months, the 36-month OS and PFS for the whole group were 82.4% (95% CI 75.9% to 89.4%) and 63.8% (95% CI 55.6% to 73.3%), respectively, median OS of 98 months and median PFS of 47 months. The 100-month OS and PFS for the entire group were 48.0% (95% CI 34.9% to 66.0%) and 17.3% (95% CI 8.4% to 35.8%), respectively.Conclusion: ASCT is a feasible, safe, and potent strategy that provides a prolonged median OS and PFS in NDMM patients. This approach can be implemented in low-income countries.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"66 3","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tortuosity and Pulsatility of the Tibial Artery - Two Case Reports of a Rare Etiology of Tarsal Tunnel Syndrome. 胫动脉迂曲和搏动--跗骨隧道综合症罕见病因的两个病例报告。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2024.12

Márcio Luís Duarte, Mayara Oliveira da Silva, Ocacir de Souza Reis Soares

引用次数: 0

Sodium-Hyaluronate Cystic-like Lesion in the Anterior Chamber Following Cataract Surgery: A Case Report. 白内障手术后前房透明质酸钠囊状病变一例报告。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2023.19

Christina Mitsi, Minas Bakirtzis, Eirini-Kanella Panagiotopoulou, Georgios Labiris

引用次数: 0

Triple Combination with Direct Acting Antivirals in the Treatment of Hepatitis C Does not Prolong the QT Interval. 三联直接作用抗病毒药物治疗丙型肝炎不会延长 QT 间期。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2024.1

Jakub Šimka, Radek Pudil, Monika Fialová, Filip Varhaník, Stanislav Plíšek, Petr Pařízek

{"title":"Triple Combination with Direct Acting Antivirals in the Treatment of Hepatitis C Does not Prolong the QT Interval.","authors":"Jakub Šimka, Radek Pudil, Monika Fialová, Filip Varhaník, Stanislav Plíšek, Petr Pařízek","doi":"10.14712/18059694.2024.1","DOIUrl":"10.14712/18059694.2024.1","url":null,"abstract":"Aims: Antiviral drugs are considered as potentially cardiotoxic, due to prolongation of QT interval which may affect incidence of severe ventricular arrhythmias. The main aim of this retrospective study was to assess the influence of treatment by three antiviral drugs on QT interval and to find patients who are at an increased risk of developing malignant ventricular arrhythmias.Methods: The study included 23 patients (14 men, 9 women) who were treated with a combination of interferon alpha, ribavirin, and an NS3/4A protease inhibitor. The parameters from the 12 leads electrocardiograms were evaluated before treatment, and then 3 ± 1 and 6 ± 1 months after treatment.Results: Heart rate (HR) 69 ± 12 / min and corrected QT interval (QTc) 412 ± 35 ms were obtained before the treatment and there was not observed a significant prolongation of intervals after 3 months (HR 72 ± 11 / min, QTc 412 ± 33 ms) and after 6 months (HR 64 ± 12 / min, QTc 405 ± 28 ms) respectively. In total QTc interval was prolonged from the baseline in 53% and in 43% of the patients 3 months respectively 6 months after treatment. A QTc prolongation over of 450 ms and new treatment-related repolarization change was noted in 1 (4%) patient.Conclusion: The study demonstrates that a combination therapy of 3 antiviral drugs does not significantly prolong the QTc interval and does not cause severe pathological changes on the ECG. Patients undergoing this treatment are not at risk of developing heart disease as an undesirable side effect.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"66 3","pages":"101-106"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-reported Side Effects of SARS-CoV-2 Vaccination. 自我报告的 SARS-CoV-2 疫苗副作用。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2024.10

Josef Finsterer, Danice Hertz

{"title":"Self-reported Side Effects of SARS-CoV-2 Vaccination.","authors":"Josef Finsterer, Danice Hertz","doi":"10.14712/18059694.2024.10","DOIUrl":"https://doi.org/10.14712/18059694.2024.10","url":null,"abstract":"SARS-CoV-2 vaccines are often promoted as safe. However, real world data tell a different story. The aim of this study is to investigate the type and frequency of adverse reactions to SARS-CoV-2 vaccination in a randomly selected cohort of unrelated individuals. Adverse reactions to the first/second dose of a SARS-CoV-2 vaccine were recorded using an online reporting system called \"Pabbly\". Patients were asked via social media to report any symptoms temporarily associated with vaccination. One hundred subjects were enrolled. The mean age was 42.6 years (range: 12-74 years). Ninety-one percent were female. The latency period between vaccination and onset of symptoms ranged from zero to 18 days. The most commonly reported symptoms were tingling/vibration/tremor (79%), numbness (57%), heart problems (53%), muscle weakness/muscle pain (45%), dizziness (44%), headache (44%) and fatigue (43%). Three patients developed small fiber neuropathy. Three patients had COVID-19 prior to vaccination. Of the included subjects, 37% had to be hospitalized. Overall, SARS-CoV-2 vaccination is not without side effects, regardless of the product used. In most cases, the reported side effects were not life-threatening, but one third of study participants experienced serious side effects requiring hospitalization and intensive care. Manufacturers of SARS-CoV-2 vaccines should respond appropriately to reports of adverse reactions associated with SARS-CoV-2 vaccination.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"66 4","pages":"154-157"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of Serum Total Homocysteine Levels with Various Demographic, Clinical and Genetic Characteristics in Healthy Greek Adults. 健康希腊成年人血清总同型半胱氨酸水平与各种人口统计学、临床和遗传特征的相关性。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2023.17

Elias E Mazokopakis, Maria G Papadomanolaki, John A Papadakis

{"title":"Associations of Serum Total Homocysteine Levels with Various Demographic, Clinical and Genetic Characteristics in Healthy Greek Adults.","authors":"Elias E Mazokopakis, Maria G Papadomanolaki, John A Papadakis","doi":"10.14712/18059694.2023.17","DOIUrl":"https://doi.org/10.14712/18059694.2023.17","url":null,"abstract":"Aim: The aim of this study was to investigate the association of serum total Hcy (tHcy) levels with various demographic, clinical and genetic characteristics in healthy Greek adults.Methods: Anthropometric characteristics (height, weight), systolic and diastolic blood pressure, complete blood count and biochemical assessments, were recorded and measured among 383 Greek adults (199 men). Serum folate, Cobalamin (Cbl) and tHcy levels were determined using immunoassays methods. The MTHFR C677T and A1298C gene polymorphisms were genotyped using polymerase chain reaction and reverse hybridization.Results: MTHFR C677T gene polymorphism, serum folate and Cbl levels were correlated with serum tHcy levels independently. The individuals with 677TT genotype had significantly higher serum tHcy levels than individuals with 677 CC or CT genotypes. Regarding the MTHFR C677T gene polymorphism, the existence of the T allele was associated with statistically significantly lower serum folate and higher serum tHcy levels than C allele. Regarding the MTHFR A1298C gene polymorphism, the existence of the C allele was associated with statistically significant lower serum tHcy levels than A allele. Furthermore, there was no significant correlation between the serum tHcy levels and demographic (except age) or clinical characteristics (sex, BMI, smoking status, SBP, DBP, HGB, HCT, TC, TG, HDL-C, LDL-C, TC/HDL-C).Conclusions: Serum tHcy levels are influenced by the existence of MTHFR C677T gene polymorphism (mainly 677TT genotype), serum folate and Cbl levels. Individuals with hyperhomocysteinemia should be further investigated for the existence of MTHFR C677T gene polymorphism, with the aim to determine the suitable treatment.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"66 2","pages":"61-67"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71490950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0