Acta medica (Hradec Kralove)最新文献

{"title":"Deleterious Effect of Fructose on the Heart Function of Hypertriglyceridemic Rats.","authors":"Vladimír Knezl, Ružena Sotníková, Karol Švík, Štefan Bezek, Zuzana Brnoliaková, Zdenka Gáspárová","doi":"10.14712/18059694.2025.7","DOIUrl":"https://doi.org/10.14712/18059694.2025.7","url":null,"abstract":"<p><p>A high-fructose intake (HFI) in food, sweetened beverages, and soft drinks appears to be one of the risk factors that worsens human metabolic and cardiovascular health, although the more accurate mechanism remains unclear. Hypertriglyceridemic (HTG) rats represent a suitable animal model of metabolic syndrome where the consumption of an HFI could have an additional aggravating impact. We aimed to study the effect of fructose on the heart functions. Male HTG rats had HFI or a standard diet for five weeks. Heart function was tested ex vivo on the perfused heart using the Langendorff technique. Isolated hearts underwent 25 min ischemia (I) and 30 min reperfusion (R). Left ventricular developed pressure (LVDP), ventricular premature beats, and dysrhythmias were monitored during R. At the end of the R, ventricular fibrillation (VF) was evoked electrically. Systolic blood pressure, glucose level, serum total cholesterol (TC), triglycerides (TAG), and thiobarbituric acid reactive substances (TBARS) in the kidney were determined. The LVDP showed a reduced return to the input values, the duration of VF in R increased, and the threshold for VF induction decreased. Serum TC, TAG, and kidney TBARS were increased. The effect of HFI on heart ventricular impairment was associated with the reduced threshold for induction of VF and aggravated dyslipidemia. The results point to the adverse impact of dietary high-fructose intake in rats with hypertriglyceridemia.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 4","pages":"107-112"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forecasting with Excel.","authors":"Victor Grech","doi":"10.14712/18059694.2025.3","DOIUrl":"https://doi.org/10.14712/18059694.2025.3","url":null,"abstract":"<p><strong>Introduction: </strong>Time series analysis is used by statisticians to make predictions from time-ordered data. This is crucial for planning for the future. The inclusion of little-known forecasting function in Excel™ has brought this type of analysis within the ability of less mathematically sophisticated individuals, including doctors. There are two main models for time series analysis: ARIMA (Autoregressive Integrated Moving Average) and exponential smoothing. This paper will demonstrate how the ubiquitous Excel facilitates a little-known sophisticated forecasting technique that employs the latter and presents a facilitating spreadsheet.</p><p><strong>Methods: </strong>Excel's FORECAST.ETS function was invoked with supporting macros.</p><p><strong>Results: </strong>A bespoke spreadsheet was created that would prompt for data to be pasted in columns A and B, formatted as a valid date in A and data in B. After error trapping and a horizon date, the FORECAST.ETS function calculates forecasts with 95% CI and a line graph. The FORECAST.ETS.CONFINT was also invoked using a macro to obtain a 95, 96, 97, 98 and 99% confidence intervals table.</p><p><strong>Discussion: </strong>Forecasting is vital in all fields, including the medical field, for innumerable reasons. Statisticians are capable of far more sophisticated time series analyses and techniques and may use multiple techniques that are beyond the competence of ordinary clinicians. However, the sophisticated Excel tool described in this paper allows simple forecasting by anyone with some knowledge of this ubiquitous software. It is hoped that the spreadsheet included with this paper helps to encourage colleagues to engage with this simple-to-use Excel function.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 3","pages":"87-90"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updated Meta-Analysis of VDR FokI and TaqI Variants and Their Association with Melanoma Risk.","authors":"Nazila Farnoush, Mehdi Khosravi-Mashizi, Amirhossein Rahmani, Maedeh Barahman, Sepideh Soleymani, Fatemeh Asadian, Ahmad Shirinzadeh-Dastgiri, Mohammad Vakili-Ojarood, Seyed Masoud HaghighiKian, Amirhosein Naseri, Maryam Aghasipour, Amirmasoud Shiri, Kazem Aghili, Hossein Neamatzadeh","doi":"10.14712/18059694.2025.8","DOIUrl":"10.14712/18059694.2025.8","url":null,"abstract":"<p><strong>Background: </strong>Research suggests that melanoma patients with low vitamin D levels exhibit a higher risk of tumor ulceration and increased tumor mitotic rates. This has led to investigations into the vitamin D receptor (VDR) gene concerning its potential link to melanoma susceptibility. This meta-analysis aims to explore the association between VDR FokI and TaqI polymorphisms and melanoma risk, with an emphasis on the need for research in diverse populations to enhance our conclusions regarding interactions between skin phenotypes and VDR variations.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in databases, including PubMed, Scopus, and Web of Science, for studies linking VDR polymorphisms to melanoma risk, up to February 1, 2024. Keywords used included \"Melanoma\", \"VDR\", and various genetic terms. Quantitative synthesis was performed with Comprehensive Meta-Analysis (Version 4.0) and a significance threshold set at p < 0.05.</p><p><strong>Results: </strong>A total of twenty-one case-control studies involving 8,813 melanoma cases and 7,973 controls were included. Twelve studies on FokI had 4,642 cases and 4,534 controls, while nine TaqI studies included 4,171 cases and 3,439 controls. The results show a significant association between the VDR FokI polymorphism and increased melanoma risk across four genetic models (allele model: OR = 1.128, 95% CI 1.026-1.241; P = 0.013; homozygote model: OR = 1.166, 95% CI 1.020-1.332; P = 0.025; heterozygote model: OR = 1.255, 95% CI 1.046-1.507; P = 0.015; dominant model: OR = 1.243, 95% CI 1.052-1.470; P = 0.011). In contrast, the TaqI polymorphism showed no significant association with melanoma risk in the general population.</p><p><strong>Conclusions: </strong>This meta-analysis suggests that the VDR FokI polymorphism is linked to an increased susceptibility to melanoma, while the TaqI variant does not show a significant association. Future research should explore the interactions between VDR polymorphisms, skin phenotypes, and melanoma risk in diverse populations, with larger and more varied studies needed to confirm these findings and enhance our understanding of genetic factors affecting melanoma susceptibility.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 4","pages":"113-124"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscope Assisted Microvascular Decompression for Trigeminal Neuralgia: Surgical Safety and Efficacy.","authors":"Ali Karadag, Muyassar Mirkhasilova, Omer Furkan Turkis, Mustafa Eren Yuncu, Andrew W Grande, Gilberto Gonzalez Lopez, Florian Roser, Marcos Tatagiba","doi":"10.14712/18059694.2024.14","DOIUrl":"10.14712/18059694.2024.14","url":null,"abstract":"<p><strong>Background: </strong>The cranial nerve (CN) V and adjacent neurovascular structures are crucial landmarks in microvascular decompression (MVD). MVD of CN V is the most effective treatment for patients with drug-resistant trigeminal neuralgia (TN) diagnosis. The endoscope-assisted retrosigmoid approach (RSA) provides better exposure and less cerebellar retraction in the corridor towards the cerebellopontine angle (CPA).</p><p><strong>Methods: </strong>Five adult cadaver heads (10 sides) underwent dissection of the MVD in park bench position. MVD was simulated using microsurgical RSA, and the anatomical landmarks were defined. Microsurgical dissections were additionally performed along the endoscopic surgical path. Additionally, we present an illustrative case with TN caused by anterior inferior cerebellar artery (AICA) compression. The CN V and its close relationships were demonstrated. Endoscopic and microscopic three-dimensional pictures were obtained.</p><p><strong>Results: </strong>This study increases the anatomical and surgical orientation for CN V and surrounding structures. The CN V arises from the lateral part of the pons and runs obliquely upward toward the petrous apex. It has motor roots that leave from pons antero-supero-medial direction to the sensory root. The endoscopic instruments provide perfect visualization with minimal cerebellar retraction during MVD.</p><p><strong>Conclusion: </strong>MVD surgically targets the offending vessel(s) leading to TN and aims to create a disconnected area. The combination of preoperative radiographic assessment with and anatomical correlation provides safe and effective application while facilitating selection of the most appropriate approach. The RSA allows satisfactory visualization for CN V. Endoscope-assisted microsurgery through the CPA is a challenge, it should be performed with advanced anatomical knowledge.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 1","pages":"12-20"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spotlight on Carcinosarcoma of the Ovary: A Scoping Review.","authors":"Martina Gauci, Jean Calleja-Agius","doi":"10.14712/18059694.2024.13","DOIUrl":"10.14712/18059694.2024.13","url":null,"abstract":"<p><p>Ovarian carcinosarcoma, also referred as malignant mixed Mullerian tumour, is an uncommon, highly aggressive and malignant neoplasm which makes up 1 to 4% of all ovarian tumours. It is biphasic involving both malignant sarcomatous (mesenchymal) and carcinomatous (epithelial) cells. There are various subtypes such as serous and endometrioid. However, the mesenchymal part is sarcomatous. About 90% of cases of ovarian carcinosarcoma spread outside the ovary. The two most accepted theories of origin for carcinosarcoma of the ovary are the collision and conversion theories. A third theory is the combination theory. Prognosis remains poor even when still localised in the ovary. In the last few years, there has been no change in the survival rate. The median survival rate is lower than 2 years. Clinical features mainly include lower abdominal pain and a palpable abdominal mass. Ovarian carcinosarcoma remains poorly understood and understudied. Being a rare tumour, elaborate therapeutic consensus is not available for ovarian carcinosarcoma. The main treatment involves cytoreductive surgery and then chemotherapy. The type of chemotherapy, role of radiotherapy and novel therapies need to be further studied. The main objective of this article is to review the current literature on carcinosarcoma of the ovary.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG4 Subclass of Immunoglobulins; Immunobiology and Roles in Relation to Human Diseases.","authors":"Eva Malá, Moeina Afshari, Jan Krejsek","doi":"10.14712/18059694.2025.6","DOIUrl":"https://doi.org/10.14712/18059694.2025.6","url":null,"abstract":"<p><p>IgG4, a subclass of antibodies known as immunoglobulins have unique structural features, in particular, their Fc regions, that prevents their interactions with other receptors on effector cells and thus disabling them of activating complements system. IgG4 antibodies can undergo a process called Fab-arm exchange, wherein they exchange half-molecules with other IgG4 antibodies, thus forming bispecific monovalent antibodies. Isotypic switch in mature B cells in germinal centres of secondary lymphoid organs is controlled by Tfh subset of T cells. Functionally IgG4 antibodies exert immunomodulatory and blocking activities, modulating protective inflammation evolved by parasitic invasion and allergic inflammation. From the pathophysiological point of view, IgG4 autoantibodies are prominently observed in autoimmune diseases under the umbrella of IgG4-autoimmune diseases (IgG4-AID). Furthermore, IgG4-related diseases (IgG4-RD) are affecting various organs characterized by lymphoplasmacytic infiltrates and storiform fibrosis in tissues, together with elevated IgG4 levels in the blood. A better understanding of IgG4 immunobiology helps us diagnose and treat patients suffering from these rare forms of diseases.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 4","pages":"101-106"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Digital Facebow for CAD/CAM Implant-Supported Crowns Workflow.","authors":"Lenka Vavřičková, Martin Kapitán, Jan Schmidt","doi":"10.14712/18059694.2024.16","DOIUrl":"10.14712/18059694.2024.16","url":null,"abstract":"<p><p>Recent advancements in digital technologies have transformed clinical workflows in dentistry, ensuring precise restorations. Custom-made crowns and fixed partial dentures (FPDs) now rely on virtual articulation. The digital facebow provides individualized data for CAD settings, streamlining the fabrication via digital workflow. For the purpose of demonstrating the differences observed during fabrication, we present a case report involving a 68-year-old patient seeking a replacement for missing teeth 24, 25, 26, and 27. The treatment plan involved the fabrication of an implant-supported FPD using monolithic zirconia (ZrO2). However, technical hurdles emerged during the planning phase, primarily due to spatial limitations posing a risk of mechanical failure over time. Consequently, we pivoted approach towards a porcelain fused to metal (PFM) FPD. For the PFM FPD, individual values from the digital facebow adjusted both virtual and conventional articulators. For comparison, two ZrO2 FPDs were milled-individual settings and average settings. All restorations underwent assessment for occlusion in maximal intercuspal position and eccentric mandible movements. In conclusion, the case report showed that individualized PFM FPD required minimal adjustments compared to milled ZrO2 restorations, whether using individual or average values. Utilizing individual values from the digital facebow reduced operator working time and minimized the intraoral adjustments.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 1","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VIPoma: An Unusual Cause of Chronic Diarrhea.","authors":"Sutharin Suteetorn, Krit Kitisin, Natcha Wanpiyarat, Supaksorn Kunjan, Thiti Snabboon","doi":"10.14712/18059694.2024.22","DOIUrl":"10.14712/18059694.2024.22","url":null,"abstract":"<p><p>Chronic diarrhea is a significant challenge in clinical practice because of its high prevalence and various causes. Comprehensive clinical assessment and stepwise laboratory approach are crucial for an accurate diagnosis. This report presents a case of an adult woman who experienced chronic watery diarrhea, complicated by renal impairment and multiple electrolyte imbalances, including hypokalemia, hypophosphatemia, and metabolic acidosis. The diagnosis of a vasoactive intestinal polypeptide-secreting tumor (VIPoma) with liver metastases was confirmed by elevated serum levels of a vasoactive intestinal polypeptide (VIP) and imaging findings of a pancreatic mass with multiple hepatic lesions. Preoperative management, including fluid rehydration, electrolyte correction, and somatostatin analog therapy, significantly improved her clinical symptoms. Subsequent surgical tumor removal and radiofrequency ablation of the hepatic lesions resulted in complete resolution of symptoms and normalized VIP levels. This case emphasizes the importance of early recognition of this rare tumor in patients with chronic diarrhea to improve clinical outcomes.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 2","pages":"64-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P(A)SH Syndrome: Case Presentation and Short Update of Related Disorders.","authors":"Simona Kordeva, Alice Hristova, Valentina Broshtilova, Georgi Tchernev","doi":"10.14712/18059694.2025.9","DOIUrl":"10.14712/18059694.2025.9","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a chronic inflammatory disease that is frequently associated with syndromes, such as those within the PAPA spectrum. Syndromic HS presents unique management challenges, as it often shows resistance to conventional therapies. Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis that is often seen in association within the spectrum of autoinflammatory diseases. The PAPA spectrum disorders include a group of autoinflammatory diseases characterized by mutations in the PSTPIP1 gene or by clinical manifestations that closely resemble or overlap with those of PAPA syndrome. Each syndrome (PASH, PAPASH, PsAPASH, PASS, PAC, and PAMI syndrome) in this spectrum highlights specific inflammatory pathways and symptoms, providing insight into targeted therapeutic approaches. Here, we present a rare case of incomplete PASH (pyoderma gangrenosum and hidradenitis suppurativa) syndrome successfully managed with a standard combination of antibiotics (ceftriaxone and metronidazole) and corticosteroids (methylprednisolone), followed by immunosuppressant (azathioprine) and corticosteroids (dexamethasone). We review both novel and established/standard treatment options, with an emphasis on treatment outcomes. Conventional therapies remain both effective and affordable, providing valuable alternatives for patients.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 4","pages":"125-132"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Findings of Solitary Fibrous Tumors of the Gallbladder.","authors":"Trinh Anh Tuan, Le-Thi Mai Huong, Nguyen Thu Minh Chau, Ngo Quang Duy, Nguyen-Thi Hai Anh, Nguyen Duy Hung, Luc Ceugnart, Nguyen Minh Duc","doi":"10.14712/18059694.2025.5","DOIUrl":"10.14712/18059694.2025.5","url":null,"abstract":"<p><p>Solitary Fibrous Tumor (SFT) is a rare mesenchymal tumor with a higher incidence of benign than malignant, most common location in the pleura. Although this tumor has been found in other locations in the body such as the head and neck region, retroperitoneal space, and intra-abdominal omentum, SFT of the gallbladder remains extremely rare in the medical literature. In this article, we present the imaging characteristics of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) of gallbladder SFT, thereby contributing to providing information in the study of this rare pathology.</p>","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 3","pages":"96-100"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}