Acta medica (Hradec Kralove)最新文献_第2页

Visual Acuity Screening of Refugees and Immigrants with a Web-Based Digital Test: A Pilot Study.

Acta medica (Hradec Kralove) Pub Date : 2024-01-01 DOI: 10.14712/18059694.2025.2

Minas Bakirtzis, Eirini Michaleakou, Maria-Eleni Martidou, Eleni Lahana, Petros Kostagiolas, Dimitris Niakas, Georgios Labiris

{"title":"Visual Acuity Screening of Refugees and Immigrants with a Web-Based Digital Test: A Pilot Study.","authors":"Minas Bakirtzis, Eirini Michaleakou, Maria-Eleni Martidou, Eleni Lahana, Petros Kostagiolas, Dimitris Niakas, Georgios Labiris","doi":"10.14712/18059694.2025.2","DOIUrl":"https://doi.org/10.14712/18059694.2025.2","url":null,"abstract":"Purpose: To screen visual acuity in two refugee camps in Greece and explore the feasibility of replicating these methods on a nationwide scale.Methods: Visual acuity was assessed in all participants using web-based Democritus Digital Acuity & Reading Test (DDART). Furthermore, the immigrants responded to a structured questionnaire regarding their demographics and medical history.Results: A total of 330 adult refugees and immigrants were recruited. A total of 47.3% of the patients had never undergone ophthalmological examination. A significant negative correlation was detected between age (r = -0.207, p < 0.001) and educational background (r = -0.135, p = 0.014), suggesting that younger immigrants who had attended compulsory education were more likely to have their eyes checked in their home country. A total of 6.97% of patients presented with impaired vision and were referred for further care. All remote DDART measurements presented no differences from the corresponding hospital-based data in the referred cases.Conclusions: Visual acuity screening using DDART provides valuable information regarding the visual capacity of refugees. The study outcomes suggest that pilot methods can be replicated on a nationwide scale.Clinical trials: Gov number NCT05209581; date of registration: January 13, 2022. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The authors have no funding or conflicts of interest to disclose. Patients Consent Statement: The patients sign written consent form.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 3","pages":"79-86"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical Manifestation of X-linked Agammaglobulinemia - the Importance of Genetic Testing. X 连锁阿加球蛋白血症的非典型表现--基因检测的重要性。

Acta medica (Hradec Kralove) Pub Date : 2024-01-01 DOI: 10.14712/18059694.2024.21

Adam Markocsy, Daniela Kapustová, Andrej Čereš, Eva Froňkova, Miloš Jeseňák

{"title":"Atypical Manifestation of X-linked Agammaglobulinemia - the Importance of Genetic Testing.","authors":"Adam Markocsy, Daniela Kapustová, Andrej Čereš, Eva Froňkova, Miloš Jeseňák","doi":"10.14712/18059694.2024.21","DOIUrl":"10.14712/18059694.2024.21","url":null,"abstract":"X-linked agammaglobulinemia (XLA) was one of the first inborn errors of immunity to be described. It is caused by pathogenic variants in the gene for Bruton tyrosine kinase (BTK), which has important functions in B cell development and maturation. Recurrent bacterial infections in the first two years of life and hypogammaglobulinemia with absent B cells in male patients are the most common symptoms. A four-month-old male patient underwent surgical removal of urachus persistens complicated with recurrent scar abscesses. Hypogammaglobulinemia (IgG, IgA, and IgM), low phagocytic activity, mild neutropenia, and a normal percentage of B cells were observed in the patient's immune laboratory profile. Over time, he suffered recurrent respiratory infections (otitis media and rhinosinusitis) and developed B cell depletion, but interestingly, this was with a normalisation of IgG and IgA levels along with undetectable IgM. Molecular-genetic testing confirmed the presence of the pathogenic variant c.1843C>T in the BTK gene, which is associated with a milder phenotype of XLA. Molecular-genetic testing uncovers the variability of clinical and laboratory features of apparently well-known inherited disorders. Patients with mild \"leaky\" XLA may have normal levels of non-functional or oligoclonal immunoglobulins.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 2","pages":"60-63"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zirconia Ceramics. 氧化锆陶瓷。

Acta medica (Hradec Kralove) Pub Date : 2024-01-01 DOI: 10.14712/18059694.2024.18

Bedirhan Savas Yigit, Marwan Al-Akkad, Radek Mounajjed

引用次数: 0

Sensorineural Hearing Loss in Otosclerosis Surgery. 耳硬化症手术中的感音神经性听力损失。

Acta medica (Hradec Kralove) Pub Date : 2024-01-01 DOI: 10.14712/18059694.2025.1

Kristýna Néma, Viktor Chrobok, Jan Mejzlík, Vladimír Pavlík, Lukáš Školoudík

{"title":"Sensorineural Hearing Loss in Otosclerosis Surgery.","authors":"Kristýna Néma, Viktor Chrobok, Jan Mejzlík, Vladimír Pavlík, Lukáš Školoudík","doi":"10.14712/18059694.2025.1","DOIUrl":"https://doi.org/10.14712/18059694.2025.1","url":null,"abstract":"Background: During otosclerosis surgery, operative trauma can lead to decreased bone conduction.Aims: The study aims to observe the bone conduction changes after otosclerosis operations and analyse possible factors affecting the postoperative decrease in bone conduction.Material and methods: Authors retrospectively processed the data of 109 patients and evaluated pure tone audiometry before surgery and consequently 2 days, 1 month and 1 year after surgery.Results: We noted a deterioration of bone conduction >5 dB on the second postoperative day in 28% (30/109) of patients, which persisted one year after the surgery in 9% (10/109) cases. Analysis of individual factors affecting bone conduction loss revealed a higher risk of permanent loss of bone conduction in patients with early postoperative loss in higher frequencies, in older patients and patients with a preoperative threshold of bone conduction >20 dB. Revision surgery was not a statistically significant factor.Conclusion and significance: The bone conduction decrease after otosclerosis surgery is usually temporary. The recovery of bone conduction is influenced by the age of patients and the level of bone conduction before the surgery. The early postoperative decrease of bone conduction in higher frequencies is a negative predictive factor for permanent hearing loss.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 3","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colloid Cyst of the Third Ventricle: A Case Report. 第三脑室胶体囊肿：病例报告

Acta medica (Hradec Kralove) Pub Date : 2024-01-01 DOI: 10.14712/18059694.2025.4

Aleš Kopal, Jiří Preis, Leoš Ungermann, Edvard Ehler, Ivana Štětkářová

引用次数: 0

Two World Wars and Belgium: Missing Births and Birth Sex Ratio Changes. 两次世界大战与比利时：缺失出生和出生性别比变化。

Acta medica (Hradec Kralove) Pub Date : 2024-01-01 DOI: 10.14712/18059694.2024.15

Victor Grech, Tania Borg

{"title":"Two World Wars and Belgium: Missing Births and Birth Sex Ratio Changes.","authors":"Victor Grech, Tania Borg","doi":"10.14712/18059694.2024.15","DOIUrl":"https://doi.org/10.14712/18059694.2024.15","url":null,"abstract":"Introduction: The sex ratio at birth (male/total births, M/T) is expected to approximate 0.515. M/T is influenced by many factors including stress. Both World Wars have been implicated as influencing birth rates and M/T. This study was carried out to analyse the effects of two World Wars on Belgium vis-à-vis missing births as well as M/T changes.Methods: Belgian male and female births were available for 1830-2019 and annual population was available from Statista. ARIMA models were used to estimate and project birth losses. The effect of wars was assumed to begin in the years following the commencement of each war and extend to the year after cessation of hostilities i.e., 1915-1919 and 1940-1946 for the First and Second World Wars respectively.Results: This study included 27,346,178 live births for 1830-2019, M/T 0.5124. There was a decreasing trend in births for 1830-2019, significant for 1950-2019. There were dips in births in association with both Wars resulting in over 440,000 missing births, 3.80% of the Belgian population for the First World War and 1.91% for the Second World War. M/T rose non-significantly for the First World War and significantly for the Second World War.Discussion: The declining birth rate and M/T in developed countries is a recognised phenomenon. The missing births in relation to wars are of demographic importance but are often overlooked with emphasis usually on casualties and deaths. M/T may rise in wars, possibly due to increased coital activity as well as other factors.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"67 1","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abstracts from 20th International Medical Doctoral Conference (2023) - New Horizons for PhD Students in Medical Research. 第20届国际医学博士会议摘要（2023年）-医学研究博士生的新视野。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2023.20

引用次数: 0

COVID-19 Can Unveil Brugada: A Rare Case. 新冠肺炎可能揭开布鲁加达的面纱：罕见病例。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2023.18

Savalan Babapoor, Zachary Port, Philip C Wiener, Roozbeh Tarighati Rasekhi, Ali Babapour Farrokhran, Sumeet K Mainigi

引用次数: 0

Comparison of Short and Long-Term Results after Injection Laryngoplasty with Radiesse® Voice and Thyroplasty Type I in Unilateral Vocal Fold Palsy. 单侧声带褶皱麻痹患者使用 Radiesse® Voice 和 I 型胸廓成形术进行注射喉成形术后的短期和长期效果比较。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2024.2

Katarína Smatanová, András Burián, Jakub Dršata, Jana Krtičková, Anikó Kőnig-Péter, Jan Mejzlík, Viktor Chrobok

{"title":"Comparison of Short and Long-Term Results after Injection Laryngoplasty with Radiesse® Voice and Thyroplasty Type I in Unilateral Vocal Fold Palsy.","authors":"Katarína Smatanová, András Burián, Jakub Dršata, Jana Krtičková, Anikó Kőnig-Péter, Jan Mejzlík, Viktor Chrobok","doi":"10.14712/18059694.2024.2","DOIUrl":"10.14712/18059694.2024.2","url":null,"abstract":"Objectives: Unilateral vocal fold palsy independently of etiology results in glottic insufficiency leading to unfavorable short or long-term impact on voice quality. Our aim was to evaluate the effect of injection laryngoplasty using Radiesse® Voice and thyroplasty type I on glottic closure, voice quality and aerodynamics by comparing preoperative, short- and long-term results.Materials and methods: Data of 32 consent patients were reviewed between 2012 and 2023. All patients underwent either injection laryngoplasty (14 patients) or thyroplasty type I (18 patients) under local anesthesia. Maximum phonation time, glottic closure based on videolaryngostroboscopy, VHI-30 values and GRBAS scale were recorded prior, short-term (3 month) and long-term (12 months) after procedures for statistical comparison. Friedman test, Mann-Whitney test and Wilcoxon signed rank tests were used for statistical analysis.Results: In injection laryngoplasty group, we found significant improvement in maximum phonation time (p = 0.002), grade of hoarseness (p = 0.002) and breathiness (p = 0.000) when comparing results before and short-term after procedure. In thyroplasty type I group we saw significant improvement of maximum phonation time (p = 0.000), glottic insufficiency (p = 0.000), all three VHI-30 components (p = 0.000), as well as grade of hoarseness, breathiness (both p = 0.000) and roughness (p = 0.011) of GRBAS scale when comparing voice outcome before and short-term after procedure. There was no significant difference in voice outcome results neither between short and long-term results nor between the two groups in any parameter.Conclusion: These results demonstrate both short and long-term efficiency of injection laryngoplasty and thyroplasty type I in the improvement of voice quality and glottic closure.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"66 3","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival Analysis of Newly Diagnosed Multiple Myeloma Patients after Frontline Autologous Stem Cell Transplantation in a Real-Life Setting. 新诊断的多发性骨髓瘤患者在前线自体干细胞移植后的实际生存情况分析。

Acta medica (Hradec Kralove) Pub Date : 2023-01-01 DOI: 10.14712/18059694.2024.4

David Garrido, Virginia Bove, Fiorella Villano, Eloísa Riva

{"title":"Survival Analysis of Newly Diagnosed Multiple Myeloma Patients after Frontline Autologous Stem Cell Transplantation in a Real-Life Setting.","authors":"David Garrido, Virginia Bove, Fiorella Villano, Eloísa Riva","doi":"10.14712/18059694.2024.4","DOIUrl":"10.14712/18059694.2024.4","url":null,"abstract":"Introduction: Autologous stem cell transplantation (ASCT) is the standard consolidation option for transplant-eligible patients with multiple myeloma (MM). The aim of this study is to report the overall survival (OS) and progression-free survival (PFS) outcomes after frontline ASCT in newly-diagnosed MM (NDMM) patients in a real-world setting.Methods: We conducted a retrospective, survival analysis of all NDMM patients included in the MM Uruguayan Registry.Results: We included 151 NDMM patients treated with induction therapy followed by high-dose melphalan and ASCT as consolidation. The median age at diagnosis was 59 years, and the international staging system (ISS) risk groups were ISS-III 32.9%, ISS-II 37.8%, and ISS-I 29.4%. Frontline induction regimens included bortezomib in 61.6% of cases, and maintenance therapy was used in 63.9% of reported cases. With a median follow-up of 42 months, the 36-month OS and PFS for the whole group were 82.4% (95% CI 75.9% to 89.4%) and 63.8% (95% CI 55.6% to 73.3%), respectively, median OS of 98 months and median PFS of 47 months. The 100-month OS and PFS for the entire group were 48.0% (95% CI 34.9% to 66.0%) and 17.3% (95% CI 8.4% to 35.8%), respectively.Conclusion: ASCT is a feasible, safe, and potent strategy that provides a prolonged median OS and PFS in NDMM patients. This approach can be implemented in low-income countries.","PeriodicalId":101400,"journal":{"name":"Acta medica (Hradec Kralove)","volume":"66 3","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0