Updated Meta-Analysis of VDR FokI and TaqI Variants and Their Association with Melanoma Risk.

Nazila Farnoush, Mehdi Khosravi-Mashizi, Amirhossein Rahmani, Maedeh Barahman, Sepideh Soleymani, Fatemeh Asadian, Ahmad Shirinzadeh-Dastgiri, Mohammad Vakili-Ojarood, Seyed Masoud HaghighiKian, Amirhosein Naseri, Maryam Aghasipour, Amirmasoud Shiri, Kazem Aghili, Hossein Neamatzadeh
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Abstract

Background: Research suggests that melanoma patients with low vitamin D levels exhibit a higher risk of tumor ulceration and increased tumor mitotic rates. This has led to investigations into the vitamin D receptor (VDR) gene concerning its potential link to melanoma susceptibility. This meta-analysis aims to explore the association between VDR FokI and TaqI polymorphisms and melanoma risk, with an emphasis on the need for research in diverse populations to enhance our conclusions regarding interactions between skin phenotypes and VDR variations.

Methods: A comprehensive literature search was conducted in databases, including PubMed, Scopus, and Web of Science, for studies linking VDR polymorphisms to melanoma risk, up to February 1, 2024. Keywords used included "Melanoma", "VDR", and various genetic terms. Quantitative synthesis was performed with Comprehensive Meta-Analysis (Version 4.0) and a significance threshold set at p < 0.05.

Results: A total of twenty-one case-control studies involving 8,813 melanoma cases and 7,973 controls were included. Twelve studies on FokI had 4,642 cases and 4,534 controls, while nine TaqI studies included 4,171 cases and 3,439 controls. The results show a significant association between the VDR FokI polymorphism and increased melanoma risk across four genetic models (allele model: OR = 1.128, 95% CI 1.026-1.241; P = 0.013; homozygote model: OR = 1.166, 95% CI 1.020-1.332; P = 0.025; heterozygote model: OR = 1.255, 95% CI 1.046-1.507; P = 0.015; dominant model: OR = 1.243, 95% CI 1.052-1.470; P = 0.011). In contrast, the TaqI polymorphism showed no significant association with melanoma risk in the general population.

Conclusions: This meta-analysis suggests that the VDR FokI polymorphism is linked to an increased susceptibility to melanoma, while the TaqI variant does not show a significant association. Future research should explore the interactions between VDR polymorphisms, skin phenotypes, and melanoma risk in diverse populations, with larger and more varied studies needed to confirm these findings and enhance our understanding of genetic factors affecting melanoma susceptibility.

VDR FokI和TaqI变异及其与黑色素瘤风险关联的最新meta分析
背景:研究表明,维生素 D 水平低的黑色素瘤患者肿瘤溃疡的风险更高,肿瘤有丝分裂率也更高。因此,人们开始研究维生素 D 受体(VDR)基因与黑色素瘤易感性的潜在联系。本荟萃分析旨在探讨 VDR FokI 和 TaqI 多态性与黑色素瘤风险之间的关联,重点是需要对不同人群进行研究,以加强我们对皮肤表型与 VDR 变异之间相互作用的结论:对截至 2024 年 2 月 1 日 VDR 多态性与黑色素瘤风险相关的研究进行了全面的文献检索,数据库包括 PubMed、Scopus 和 Web of Science。使用的关键词包括 "黑色素瘤"、"VDR "和各种基因术语。使用综合元分析(4.0 版)进行定量综合,显著性阈值设定为 p <0.05:共纳入 21 项病例对照研究,涉及 8813 例黑色素瘤病例和 7973 例对照。其中,12 项关于 FokI 的研究涉及 4642 例病例和 4534 例对照,而 9 项关于 TaqI 的研究涉及 4171 例病例和 3439 例对照。结果显示,在四种遗传模型中,VDR FokI 多态性与黑色素瘤风险增加之间存在明显关联(等位基因模型:OR = 1.128,95% CI 1.026-1.241;P = 0.013;等位基因模型:OR=1.166,95% CI 1.020-1.332;P=0.025;杂合子模型:OR = 1.255,95% CI 1.046-1.507;P = 0.015;显性模型:OR = 1.243,95% CI 1.052-1.470;P = 0.011)。相比之下,在普通人群中,TaqI 多态性与黑色素瘤风险没有显著关联:这项荟萃分析表明,VDR FokI多态性与黑色素瘤易感性的增加有关,而TaqI变异与黑色素瘤的易感性并无显著关联。未来的研究应探索不同人群中 VDR 多态性、皮肤表型和黑色素瘤风险之间的相互作用,需要更大规模和更多样的研究来证实这些发现,并加深我们对影响黑色素瘤易感性的遗传因素的了解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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