The Turkish journal of pediatrics最新文献

{"title":"Effective interleukin-6 inhibition in a pediatric patient with mevalonate kinase deficiency and chronic nonbacterial osteomyelitis-like bone lesions under interleukin-1 blockade.","authors":"Eray Tunce, Sıla Atamyıldız Uçar, Sevinç Taşar, Metin Eser, Betül Sözeri","doi":"10.24953/turkjpediatr.2026.7588","DOIUrl":"10.24953/turkjpediatr.2026.7588","url":null,"abstract":"<p><strong>Background: </strong>Mevalonate kinase deficiency (MKD) is a rare autosomal recessive autoinflammatory disease. Chronic nonbacterial osteomyelitis (CNO) represents another autoinflammatory disorder characterized by sterile bone inflammation. Although musculoskeletal pain is common in MKD, CNO-like bone lesions have rarely been described. Tocilizumab has been used separately in MKD / hyper-IgD syndrome (HIDS) and in CNO; however, pediatric cases showing both conditions together and responding completely to IL-6 blockade have not been previously reported.</p><p><strong>Case presentation: </strong>We present a 16-year-old boy born to consanguineous parents who experienced early-onset recurrent fever episodes with abdominal pain, maculopapular rash, oral ulcers, and conjunctival injection. He was initially misdiagnosed with FMF and IgA vasculitis and treated with colchicine with partial improvement. Persistent systemic inflammation prompted referral to our tertiary center at age 9. A periodic fever gene panel revealed a homozygous MVK p.V377I mutation, confirming MKD. Anakinra therapy was initiated. Although no attacks occurred during the first month, flares characterized by fever, abdominal pain, rash, and elevated acute-phase reactants recurred in the second and third months, reflecting a partial response. Consequently, treatment was switched to canakinumab. Toward the end of the second year of IL-1 blockade, attack frequency increased to once every three months, and at age 12 he developed diffuse musculoskeletal pain. Whole-body magnetic resonance imaging demonstrated multifocal metaphyseal bone marrow edema compatible with CNO-like lesions. Sulfasalazine was added but discontinued after drug-induced pancreatitis. Given persistent systemic inflammation and inadequate response to IL-1 inhibitors, canakinumab was replaced with weekly subcutaneous tocilizumab, resulting in rapid improvement in bone pain and systemic inflammation. Since the third month of tocilizumab therapy, he has remained clinically stable with normalized inflammatory markers and only a single mild flare over the last year.</p><p><strong>Conclusion: </strong>This case highlights the potential role of IL-6 inhibition in complicated MKD presenting with autoinflammatory bone disease refractory to standard therapies.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"358-363"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza vaccination rates in children: a multicenter nationwide study.","authors":"Hacer Yakın, Kübra Aykaç, Sultan İçöz, Halit Kolukırık, Gülce Gerçek, Ece Arslan, Osman Oğuz Demir, Elif Güdeloğlu Çetiz, Muhammed Selçuk Sinanoğlu, Pelin Kaçar, Mustafa Gülderen, Arife Özer, Dilan Demir Gümüş, Şeyma Erdem Torun, Burcu Ceylan Cura Yayla, Önder Kılıçaslan, Adem Karbuz, Dicle Şener Okur, Mustafa Genceli, Özge Metin Akcan, Didem Büyüktaş Aytaç, Gülsen Akkoç, Sare İlbay, Latife Güder, Tuğba Bedir Demirdağ, Anıl Tapısız, Eda Şahin İzci, Nazan Dalgıç, Fatma Dilşad Aksoy, Esra Çiftçi, Solmaz Çelebi, Neslihan Mete Atasever, Ayper Somer, Esra Çakmak Taşkın, Merve İşeri Nepesov, Özlem Erdede, Derya İlhan, Soner Sertan Kara, Gülsüm Alkan, Büşra Özyalvaç, Melike Emiroğlu, Ayşe Çakıl Güzin, Eda Karadağ Öncel, Gülben Özgül Postuk, Zeynep Gökçe Gayretli Aydın, Belma Yaşar, Zuhal Ümit, Semra Bayturan Şen, Coşkun Ekemen, Gülhadiye Avcu, Hatice Sınav Utku, Selim Öncel, Aslıhan Şahin, Yıldız Ekemen Keleş, Elif Kıymet, Oben Gözde Şenkon, Ayşe Hitay Telefon, Merve Kılıç Çil, Ümit Çelik, Nahida Gökay, Edanur Yeşil, Necdet Kuyucu, Ayşenur Bostan, Gizem Mardinoğlu, Ömer Kılıç, Benhur Çetin, Mesut Kara, Nurettin Erdem, Şahika Şahinkaya, Zehra Nihan Coşkun, Hatice Kübra Konca, Saliha Kanık-Yüksek, Hatice Karaoğlu Asrak, Hakan Tanrıkulu, Canan Özlü, Ayşe Sena Dönmez, Gülizar Toy Usta, Kıvanç Çelikkan, Özlem Çakıcı, Ezgi Avcı, Aysel Hacısoy, Halise Mercan, Hanife Avcı, Ali Bülent Cengiz, Yasemin Özsürekci","doi":"10.24953/turkjpediatr.2026.6651","DOIUrl":"10.24953/turkjpediatr.2026.6651","url":null,"abstract":"<p><strong>Background: </strong>Influenza remains a major cause of morbidity and mortality in children worldwide, yet vaccination coverage is still suboptimal in many countries. We aimed to understand parental awareness, attitudes, and determinants of vaccine uptake to guide effective strategies for increasing coverage and protecting vulnerable pediatric populations.</p><p><strong>Method: </strong>A cross-sectional study was conducted between October 2023 and May 2024 in 38 hospitals across 23 provinces in Türkiye. Data were collected from 5002 families through face-to-face interviews, with 4404 valid responses analyzed.</p><p><strong>Results: </strong>The overall influenza vaccination rate among children was 4.4% (n=195/4404). Vaccination coverage was slightly higher in high-risk groups compared to non-high-risk groups (5.2% vs. 3.5%, p=0.003). Factors positively associated with vaccination uptake included the presence of chronic illness in the child (15.1% in vaccinated vs. 4.7% in unvaccinated, p<0.001), higher parental education levels, and parental history of influenza vaccination (42.8% vs. 4.4%, p<0.001). Logistic regression identified poor attendance at routine pediatric check-ups, lack of awareness of influenza vaccination, and absence of private vaccination as the strongest predictors of non-vaccination.</p><p><strong>Conclusion: </strong>The overall influenza vaccination rate among children was 4.4% (n=195/4404). Vaccination coverage was slightly higher in high-risk groups compared to non-high-risk groups (5.2% vs. 3.5%, p=0.003). Factors positively associated with vaccination uptake included the presence of chronic illness in the child (15.1% in vaccinated vs. 4.7% in unvaccinated, p<0.001), higher parental education levels, and parental history of influenza vaccination (42.8% vs. 4.4%, p<0.001). Logistic regression identified poor attendance at routine pediatric check-ups, lack of awareness of influenza vaccination, and absence of private vaccination as the strongest predictors of non-vaccination.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"190-209"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three cases of tufting enteropathy and review of literature.","authors":"Aslı Noyan, Ersin Gümüş, Hayriye Hızarcıoğlu Gülşen, Hülya Demir, Diclehan Orhan","doi":"10.24953/turkjpediatr.2026.5607","DOIUrl":"10.24953/turkjpediatr.2026.5607","url":null,"abstract":"<p><strong>Background: </strong>Congenital tufting enteropathy (CTE) is a rare autosomal recessive enteropathy characterized by intractable watery diarrhea independent of feeding, electrolyte imbalances and severe malnutrition. The aim of this case series is to highlight the characteristic yet easily overlooked histological features of tufting enteropathy, especially in cases where initial biopsies may be reported as nonspecific, and to emphasize the importance of clinicopathological correlation and genetic confirmation.</p><p><strong>Case presentation: </strong>Here we report 3 patients with tufting enteropathy who have the characteristic histological findings and demonstrate the use of EpCAM (epithelial cell adhesion molecule) immunohistochemistry. One case was diagnosed by histopathological examination, while the other 2 were diagnosed by genetic analysis.</p><p><strong>Conclusions: </strong>These cases illustrate that the histopathological features of CTE, though subtle, are usually present from the outset and can be recognized when specifically sought. Correlation with genetic testing is essential for confirmation, but increased awareness of the characteristic epithelial tufts may reduce diagnostic delay and improve patient management.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"337-344"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When a handle bar accident leads to hernia: report of three cases.","authors":"Hayet Zitouni, Wiem Rhaiem","doi":"10.24953/turkjpediatr.2026.6207","DOIUrl":"10.24953/turkjpediatr.2026.6207","url":null,"abstract":"<p><strong>Introduction: </strong>Blunt impact-induced traumatic abdominal wall hernia (TAWH) is classically associated with handlebar injury caused by direct trauma to the anterior abdominal wall, hence the term \"handlebar hernia.\" It is uncommon in children and associated with significant morbidity if diagnosis is delayed. The aim of this study is to present our experience in treating bicycle handlebar-associated TAWH, highlight the likelihood of associated intra-abdominal injuries, and emphasize the importance of early imaging and surgical intervention when necessary.</p><p><strong>Case presentation: </strong>Three cases of abdominal wall hernia were included. All patients were boys, with a mean age of 8.6 years (range: 7-11 years). All patients presented with swelling in the iliac fossa (right n= 2 and left n= 1). Emergency computed tomography (CT) was performed in all cases: two revealed a muscular defect, while the third showed pneumoperitoneum. The musculoaponeurotic defect was surgically repaired in each case. In the third patient, a small intestinal perforation was also identified and sutured. All patients recovered uneventfully.</p><p><strong>Conclusion: </strong>TAWH is a rare clinical entity that may signal more significant associated injuries, such as hollow viscus perforation, which often requires urgent surgery. A high index of suspicion is necessary in children presenting with bruising, abrasions, ecchymosis, hematoma, or peritoneal signs following blunt abdominal trauma, and there should be a low threshold for additional imaging.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"352-357"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic dilemmas of child sexual abuse.","authors":"Roland Csorba, Zeynep Atas Elfrink","doi":"10.24953/turkjpediatr.2026.7133","DOIUrl":"10.24953/turkjpediatr.2026.7133","url":null,"abstract":"<p><p>Globally, an estimated 12-13% of children experience sexual abuse, with prevalence rates of approximately 18% among girls and 8% among boys. Clinicians evaluating pediatric patients who present with anogenital complaints or lesions face considerable diagnostic challenges. The purpose of this narrative review is to outline the most frequently encountered conditions that can mimic child sexual abuse (CSA), thereby raising clinical awareness and helping to minimize both false-positive and false-negative diagnoses. We conducted a semi-systematic literature search in PubMed covering the period from 2000 to 2025, using the search terms \"child sexual abuse,\" \"differential diagnosis,\" \"mimics,\" and \"mimickers,\" supplemented by the German interdisciplinary guideline on child abuse and neglect. Notably, the vast majority of children who have been sexually abused present without detectable physical abnormalities. Conversely, an erroneous diagnosis of abuse-or the failure to identify a treatable underlying condition-can carry severe consequences. Many practitioners in primary care lack sufficient training to distinguish the wide range of dermatologic and systemic disorders that may affect the anogenital region. Precise recognition, careful documentation, and scientifically grounded interpretation of physical findings are critical to ensue child protection. Optimal medical care for suspected CSA victims requires that clinicians possess expertise in pediatric and adolescent gynecology and forensic medicine, recognize the constraints inherent to physical examination findings, and consistently employ up-to-date classification frameworks and clinical guidelines. Heightened awareness of CSA mimickers is essential both to prevent unfounded allegations and to ensure timely, appropriate management of genuine abuse.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"179-189"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of mesenchymal stem cell treatment on retinopathy of prematurity in patients with bronchopulmonary dysplasia: experience of a tertiary center.","authors":"Esen Cakmak-Cengiz, Canan Seren, Ozlem Eski Yucel","doi":"10.24953/turkjpediatr.2026.6933","DOIUrl":"10.24953/turkjpediatr.2026.6933","url":null,"abstract":"<p><strong>Background: </strong>Retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) share overlapping mechanisms involving oxidative stress, inflammation, and aberrant angiogenesis. Mesenchymal stem cell (MSC) therapy has shown promise in the treatment of BPD through paracrine modulation and anti-inflammatory effects, but its influence on retinal vascular development remains uncertain.</p><p><strong>Case presentation: </strong>This retrospective case series included five extremely low birth weight (ELBW) infants (<1000 g) who received allogeneic umbilical cord–derived MSC therapy for severe BPD between October 2021 and May 2023. Each infant received intravenous (2 × 10⁶ cells/kg) and intratracheal (1 × 10⁷ cells/kg) MSC administration in a single session. ROP screening and treatment were conducted in accordance with national guidelines. Clinical data and ocular outcomes were analyzed descriptively.</p><p><strong>Conclusions: </strong>The mean gestational age was 26²/₇ weeks (range, 25–28³/₇) and the mean birth weight was 810 g (580–1060 g). MSC therapy was given between postnatal days 36–126 (mean, 74 days). No systemic or ocular complications occurred during hospitalization or follow-up. One infant had no ROP, one developed Type 2 ROP with spontaneous regression, and three developed Type 1 ROP requiring intravitreal bevacizumab. All treated cases achieved complete regression after a single intravitreal bevacizumab injection, without recurrence, repeat injection, or need for laser therapy. MSC therapy appeared clinically safe in ELBW infants with BPD, with no adverse ocular effects. However, ROP developed in most infants despite MSC treatment, suggesting that MSCs do not prevent disease onset. The potential modulatory role of MSCs on retinal angiogenesis warrants further investigation through larger, controlled trials.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"345-351"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric pulmonologists' current practices and variations in flexible bronchoscopy: a national survey study from Türkiye.","authors":"Ece Ocak, Erdem Başaran, Erkan Çakır, Nazan Çobanoğlu, Pınar Ergenekon, Sanem Eryılmaz Polat, Saniye Girit, Gökçen Kartal Öztürk, Ayşe Ayzıt Kılınç, Mehmet Köse, Ali Özdemir, Beste Özsezen, Sevgi Pekcan, Velat Şen, Tuğba Şişmanlar Eyüboğlu, Zeynep Seda Uyan, Füsun Ünal, Ebru Yalçın, Hasan Yüksel, Figen Gülen","doi":"10.24953/turkjpediatr.2026.6624","DOIUrl":"10.24953/turkjpediatr.2026.6624","url":null,"abstract":"<p><strong>Background: </strong>Flexible bronchoscopy (FB) is a critical diagnostic and therapeutic tool in respiratory diseases, enabling airway assessment, sample collection, and therapeutic interventions. Despite international guidelines, practices vary widely across centers. This study aimed to assess current FB practices and to identify variations among pediatric pulmonologists in Türkiye.</p><p><strong>Methods: </strong>A descriptive cross-sectional survey was distributed via email to clinical directors of 19 centers performing FB in March 2023. The survey comprised 80 questions across seven domains: demographics, patient preparation, bronchoscopy procedure, sedation/anesthesia, discharge, bronchoscope cleaning, and respondent comments. Participants were asked to provide accurate and objective data on FB practices at their centers.</p><p><strong>Results: </strong>All 19 centers participated in the survey, achieving a 100% response rate. The median FB experience was 12.5 years (IQR: 1-30), with a median 210 procedures per year per center (min-max: 30-500; IQR: 80-250). The most frequently reported indications were atelectasis (84.2%), bronchiectasis (78.9%), suspected foreign body aspiration (52.6%), and to obtain bronchoalveolar lavage (BAL) in patients with immunodeficiency (52.6%). Nine centers (47.4%) indicated performing advanced bronchoscopic procedures, including endobronchial biopsy (31.6%), bronchoscopic intubations (26.3%), and tracheal/bronchial stent insertion (10.5%). General anesthesia (84.2%) was the predominant sedation method, and propofol (89.5%) the most frequently used agent. Premedication was used in 13 centers (68.4%), with midazolam being the most commonly used agent (76.9%). Twelve centers (63.2%) also used topical lidocaine for local anesthesia. Respondents reported the need for developing interventional procedures and increasing the number of trained bronchoscopy teams.</p><p><strong>Conclusions: </strong>This first comprehensive national survey of pediatric FB practices in Türkiye, encompassing all relevant centers, revealed significant heterogeneity in procedural approaches, particularly regarding sedation protocols, BAL techniques, and interventional capabilities. The findings underscore the importance of developing interventional procedures and enhancing the training of pediatric pulmonologists and interdisciplinary teams practicing pediatric bronchoscopy to improve patient outcomes and procedural consistency.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"261-276"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memory of Prof. Enver Hasanoğlu: Honoring a legacy.","authors":"Ali Düzova, Sinem Akgül, Eda Utine, Yılmaz Yıldız, Özge Başaran, Leman Akcan Yıldız, Esra Serdaroğlu, Yağmur Ünsal","doi":"10.24953/turkjpediatr.2026.8601","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.8601","url":null,"abstract":"","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"175"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prof. Dr. Enver Hasanoğlu (1946-2026).","authors":"Ayhan Dağdemir, Aysun Bideci, Elif N Özmert, İlyas Okur, Koray Boduroğlu","doi":"10.24953/turkjpediatr.2026.8602","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.8602","url":null,"abstract":"","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"176-178"},"PeriodicalIF":0.0,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid-femoral pulse wave velocity and strain echocardiography in neonates: impact of maternal diabetes and hypertension.","authors":"Umut Berk Mercan, Şule Yiğit, Tevfik Karagöz, Hayrettin Hakan Aykan","doi":"10.24953/turkjpediatr.2026.7901","DOIUrl":"10.24953/turkjpediatr.2026.7901","url":null,"abstract":"<p><strong>Background: </strong>The arterial wall tends to stiffen owing to prolonged exposure to cardiovascular disease risk factors such as high blood pressure, hyperglycemia, and chronic inflammation. Epidemiological research has demonstrated that maternal factors, demographic characteristics, and clinical data influence arterial stiffness and echocardiographic findings. This study aimed to evaluate the association between arterial stiffness and echocardiographic findings with maternal factors and demographic and clinical characteristics in infants of mothers with gestational diabetes or hypertension during the neonatal period.</p><p><strong>Methods: </strong>A total of 67 newborns between 12-29 days of age, including 15 neonates of hypertensive mothers, 26 neonates of diabetic mothers, and 26 neonates in the control group, were included. Carotid-femoral pulse wave velocity (cfPWV) was used as a marker of arterial stiffness and measurements were performed using echocardiography. Basic echocardiographic evaluations and atrial and ventricular strain assessments were performed.</p><p><strong>Results: </strong>The mean cfPWV value of infants of diabetic mothers (6.34 m/s) was significantly higher than that of infants of hypertensive mothers (4.65 m/s) and the control group (4.56 m/s) (p<0.001). Multivariate linear regression analysis revealed that increasing maternal age and the presence of diabetes in the mother were predictors of carotid-femoral pulse wave velocity values. The right ventricular free wall longitudinal strain z-scores were higher in hypertensive infants, while no significant difference was found in other strain measurements.</p><p><strong>Conclusion: </strong>The analysis of arterial stiffness in infants of diabetic mothers, infants of hypertensive mothers, and controls showed that advanced maternal age and maternal diabetes were particularly associated with increased cfPWV. This study highlights the potential influence of maternal metabolic status on neonatal cardiac morphology and vascular function. Based on the data presented, further research is warranted to investigate whether the observed effects on arterial stiffness in infants of diabetic mothers persist into older ages and have long-term implications for the health of these patients.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 2","pages":"221-234"},"PeriodicalIF":0.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148008301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}