{"title":"Inflammatory marker comparison in childhood brucellosis: predicting osteoarticular involvement.","authors":"Elif Böncüoğlu, Şadiye Kübra Tüter Öz, Zafer Bağcı","doi":"10.24953/turkjpediatr.2025.5811","DOIUrl":"10.24953/turkjpediatr.2025.5811","url":null,"abstract":"<p><strong>Background: </strong>Although the use of inflammatory markers in diagnosing Brucella-related complications has been the subject of research, studies on osteoarticular disease are insufficient, especially in children. This study aimed to compare inflammatory markers in children diagnosed with brucellosis, distinguishing between those with and without osteoarticular involvement (OI).</p><p><strong>Methods: </strong>In this retrospective study, patients diagnosed with brucellosis from 1 month to 18 years of age were evaluated. Data collected included age, gender, OI, treatment duration, complete blood count, inflammatory markers including neutrophil-monocyte ratio (NMR), monocyte-lymphocyte ratio, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and Brucella serum agglutination test (SAT) results. OI was confirmed by MRI in symptomatic patients. The results of patients with and without OI were compared.</p><p><strong>Results: </strong>The study included 38 patients, 23.7% having OI (8 with sacroiliitis and 1 with spondylitis). The median age of patients with OI was significantly higher than those without (p=0.037). All patients with OI (n = 9, 100%) had an SAT titer ≥ 1/640. Among patients without OI, 62% (n = 18) had an SAT titer ≥1/640. This difference was statistically significant (p = 0.028). Patients with OI had higher CRP levels (p=0.038) but similar ESR levels compared to those without. WBC levels were significantly lower in the group with OI (p=0.015). NMR was significantly higher in those with OI (p=0.012).</p><p><strong>Conclusions: </strong>Lower WBC counts and higher CRP and NMR levels can predict OI in children with brucellosis at the time of admission. However, our findings should be validated through prospective studies involving larger patient groups.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"248-253"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cornell Assessment of Pediatric Delirium: Turkish translation and validation.","authors":"Emel Uyar, Nurettin Onur Kutlu, Elif Akçay, Gülser Dinç, Merve Onat, Esra Koçkuzu, Yavuz Meral, Chani Traube","doi":"10.24953/turkjpediatr.2025.5237","DOIUrl":"10.24953/turkjpediatr.2025.5237","url":null,"abstract":"<p><strong>Background: </strong>Hypoactive delirium may go unrecognized unless routinely screened. At present, there is no valid screening tool for delirium in the Turkish language. This study was conducted to translate the Cornell Assessment of Pediatric Delirium (CAPD) into Turkish and to evaluate its validity and reliability.</p><p><strong>Methods: </strong>In this is validation study, CAPD assessments were conducted by pediatric intensive care unit nurses and compared with assessments by a child psychiatrist.</p><p><strong>Results: </strong>A total of 76 patients were included, 37 participants (48.6%) were younger than 24 months, and 22 participants (28.9%) had developmental disabilities. Prevalence of delirium was 25.0% (n=19). Inter-rater agreement for the identification of delirium by psychiatrists was strong and reliable, with a Cohen's kappa value of 0.86 (95% confidence interval [CI]: 0.72-0.99). Inter-rater reliability for nurses was also significant, with a Cohen's kappa of 0.74 (95% CI, 0.57-0.91). Inter-rater reliability ranged from 0.64 to 0.84 for each CAPD item except item 6, indicating reliable scoring. Sensitivity and specificity improved when the CAPD cut-off score was increased from 9 (100% and 95%, respectively) to 11 (100% and 98.02%, respectively). Subgroup analyses showed high sensitivity and specificity in patients with developmental delay (96%) and in patients under 2 years of age (96%) when the CAPD cut-off score was 9. However, specificity decreased slightly to 93% in patients under 6 months of age.</p><p><strong>Conclusion: </strong>The Turkish CAPD, the first delirium screening scale translated into Turkish, has demonstrated validity and reliability in screening for delirium in children of all ages, including those with developmental disabilities.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"221-229"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hong Qiu, Xiaojun Wang, Yanhong Li, Renping Mao, Qin Lv
{"title":"Association of miR-149 gene rs2292832 polymorphism with necrotizing enterocolitis in preterm infants.","authors":"Hong Qiu, Xiaojun Wang, Yanhong Li, Renping Mao, Qin Lv","doi":"10.24953/turkjpediatr.2025.5653","DOIUrl":"10.24953/turkjpediatr.2025.5653","url":null,"abstract":"<p><strong>Background: </strong>Necrotizing enterocolitis (NEC) is a prevalent and challenging intestinal disease in premature infants, lacking a specific pathogen consistently associated with its occurrence. Effectively preventing and treating NEC to reduce mortality rates remains a significant contemporary challenge. The present study aimed to explore the correlation between microRNA-149 gene polymorphism and NEC in premature infants in a Chinese Han population.</p><p><strong>Methods: </strong>The expression levels of serum miR-149 were determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Polymorphism detection of the miR-149 gene rs2292832 polymorphism was performed by polymerase chain reaction. Multivariate logistic regression analysis was employed to investigate the association between the rs2292832 polymorphism and risk factors for NEC in preterm infants.</p><p><strong>Results: </strong>General clinical data were compared between 102 preterm infants diagnosed with NEC and 263 preterm infants without NEC. Significant differences were observed in gestational age and birth weight. However, no significant differences were found in antenatal steroid use, sex, or feeding patterns between the two groups. The expression level of serum miR-149 was significantly reduced in premature infants with NEC, and there were differences in the allele frequency of the miR-149 rs2292832 polymorphism between the NEC group and control group. Specifically, the T allele and TT genotype of rs2292832 were associated with an increased susceptibility to NEC. Furthermore, both gestational age and the rs2292832 polymorphism showed a significant association with NEC risk, with the rs2292832 polymorphism of miR-149 being identified as the most prominent risk factor for NEC development in preterm infants.</p><p><strong>Conclusions: </strong>The rs2292832 gene polymorphism of miR-149 may potentially exert an influence on susceptibility to NEC.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"144-152"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Duchenne muscular dystrophy with Kocher-Debre-Semelaigne syndrome: a double jeopardy.","authors":"Arumugom Archana, Pediredla Karunakar, Vaishnavi Sreenivasan, Reena Gulati","doi":"10.24953/turkjpediatr.2025.5488","DOIUrl":"10.24953/turkjpediatr.2025.5488","url":null,"abstract":"<p><strong>Background: </strong>Duchenne muscular dystrophy (DMD) is a progressive X-linked dystrophinopathy with onset in early childhood. Affected individuals present predominantly with proximal lower limb weakness and pseudohypertrophy of calf musculature being a prominent sign, heralding the onset of contractures in the large joints of lower limbs. Kocher-Debre-Semelaigne syndrome (KDSS) refers to the muscular pseudohypertrophy that develops in children with long-standing hypothyroidism.</p><p><strong>Case presentation: </strong>We present an 11-year-old boy with progressive walking difficulty for two years and associated decrease in appetite and chronic constipation. Physical examination revealed mild soft goitre, proximal lower limb weakness, areflexia (except for preserved weak ankle reflex), soft hypertrophy of bilateral calf muscles and latissimus dorsi, with bilateral dynamic ankle joint contractures. Investigations showed moderately elevated total serum creatine phosphokinase (CPK) levels, elevated serum thyroid stimulating hormone (TSH), low free T4, normal free T3 and elevated serum anti-thyroid peroxidase and anti-thyroglobulin antibody titers. A diagnosis of hypothyroidism secondary to Hashimoto's thyroiditis with Kocher-Debre-Semelaigne syndrome (KDSS) (thyroid myopathy) was made while multiplex ligation-dependent probe amplification confirmed DMD. He was started on steroids and levothyroxine. On follow up, he had improvement in activity, appetite and motor movements (North Star Ambulatory Assessment score 3 to 7).</p><p><strong>Conclusion: </strong>As a very rare coincidence, our patient suffered from two different diseases with similar presentation which are DMD and KDSS. Subtle clinical clues of joint contractures and goitre helped us identify these unrelated co-existing diseases. An alternate diagnosis must be thought of when all clinical findings cannot be explained by a single disease.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"268-272"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abid Ali, Laxman Basany, G Naga Priyanka, Ravinder Reddy Lotkal
{"title":"Blocked D phenomenon implicated in a diagnostic dilemma in RhD-hemolytic disease affecting twins: case report and review of literature.","authors":"Abid Ali, Laxman Basany, G Naga Priyanka, Ravinder Reddy Lotkal","doi":"10.24953/turkjpediatr.2025.5786","DOIUrl":"10.24953/turkjpediatr.2025.5786","url":null,"abstract":"<p><strong>Background: </strong>The Rh blood group system is the most common cause of hemolytic disease of the fetus and newborn (HDFN). Rh antigens are fully expressed at birth unlike ABO antigens which are weakly expressed. Sensitization to the D antigen can occur with exposure to < 0.1 mL of fetal blood. In rare cases of HDFN, these passively transferred IgG anti-D antibodies coat the D antigens on the newborn's red blood cells and interfere with the agglutination of D-positive red cells when tested with IgM anti-D typing reagents, resulting in false-negative Rh(D) typing. This \"blocked D phenomenon,\" can pose a diagnostic challenge.</p><p><strong>Case presentation: </strong>This case report describes twins with HDFN born to a Rh(D) negative mother. Both cord blood and neonatal blood were incorrectly typed as Rh(D) negative using routine typing reagents, creating a diagnostic dilemma. The combination of a positive direct antiglobulin test (DAT), the mother's RhD-negative status, a positive indirect antiglobulin test (IAT), and discordant or unexpected RhD typing in the neonate raised suspicion of blocked D phenomenon. Paired samples from the parents and neonates were analysed. Following gentle heat elution at 45°C for 10 minutes, the neonatal red cells were re-typed as RhD positive using the conventional tube technique with monoclonal IgM anti-D. At the 6-month follow-up, both infants were phenotyped as O RhD positive.</p><p><strong>Conclusions: </strong>The possibility of the blocking phenomenon should be considered while interpreting blood group results from fetal or neonatal samples in an alloimmunized pregnancy with potent antibodies. All pregnant women, regardless of their RhD type, should be tested for clinically significant unexpected serum antibodies during pregnancy. Elution methods help in identifying correct D antigen when Rh(D) typing gives uncertain results. Antiglobulin testing with anti-IgG should be performed to detect antibodies causing hemolytic disease of the fetus and newborn (HDFN).</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"259-267"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burcu Parlak, Sevliya Öcal Demir, Seyhan Yılmaz, Sevgi Aslan Tuncay, Pınar Canizci Erdemli, Aylin Dizi Işık, Nazlı Pazar, Işıl Küçüker, Zeynep Ergenç, Hüseyin Bilgin, Feyza İnceköy Girgin, Gülşen Akkoç, Eda Kepenekli
{"title":"An <i>Escherichia coli</i> pseudo-outbreak in the intensive care units of a university hospital.","authors":"Burcu Parlak, Sevliya Öcal Demir, Seyhan Yılmaz, Sevgi Aslan Tuncay, Pınar Canizci Erdemli, Aylin Dizi Işık, Nazlı Pazar, Işıl Küçüker, Zeynep Ergenç, Hüseyin Bilgin, Feyza İnceköy Girgin, Gülşen Akkoç, Eda Kepenekli","doi":"10.24953/turkjpediatr.2025.5347","DOIUrl":"10.24953/turkjpediatr.2025.5347","url":null,"abstract":"<p><strong>Background: </strong>The term 'pseudo-outbreak' refers to a condition in which a microorganism is found in cultures at a greater rate than expected due to contamination of materials that would normally be sterile. This situation cannot be clinically correlated with the infection suggested by the culture results. This can be confusing depending on the patient's clinical condition, especially in intensive care units (ICU). The pseudo-outbreak with Escherichia coli in patients in ICUs will be discussed in this study to emphasize the importance of strict adherence to microbiology policies and procedures.</p><p><strong>Methods: </strong>In September 2022, growths of Escherichia coli were found in the endotracheal aspirate cultures of six children and eighteen adults in the ICU.</p><p><strong>Results: </strong>The identification of the same microbial agent in 24 patients prompted an investigation into a potential outbreak. The infection control committee compiled a comprehensive patient list to facilitate the assessment. Given that the healthcare personnel and infrastructure of each ICU were distinct and functioned independently, the possibility of cross-contamination within these units was deemed unlikely. Consequently, attention was directed toward the microbiology laboratory as a potential source of the outbreak. A thorough review of culture processing steps and laboratory equipment was conducted. This investigation revealed that the saline solution used for the passage of endotracheal aspiration cultures was contaminated, suggesting a laboratory-associated contamination event as the probable cause.</p><p><strong>Conclusions: </strong>By strictly adhering to the latest protocols, the disinfection and sterilization chain can ensure the safe use of both invasive and non-invasive medical equipment. This manuscript aims to raise awareness among pediatricians and pediatric infectious disease specialists regarding the occurrence of pseudo-outbreaks. A pseudo-outbreak is indicative of a disruption in the sterilization chain.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"242-247"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing clinical decision-making: a scenario-based patient simulation study using QR code-based algorithms for the management of acute intoxication-type inborn errors of metabolism.","authors":"Merve Koç Yekedüz, Gülçin Bilicen Yarenci, Muhammet Taş, Nilüfer Okur, Fatma Tuba Eminoğlu","doi":"10.24953/turkjpediatr.2025.5208","DOIUrl":"10.24953/turkjpediatr.2025.5208","url":null,"abstract":"<p><strong>Background: </strong>Acute intoxication-type inborn errors of metabolism (IEMs) present significant challenges in pediatric care. Prompt recognition and appropriate management are essential to prevent serious complications and reduce mortality. Recent studies increasingly highlight the use of quick response (QR) code-based tools to facilitate rapid intervention, particularly in emergency departments and primary healthcare settings. In this study, the effectiveness of a newly developed QR code-based algorithm, designed to support the accurate recognition and effective management of acute intoxication-type IEMs and, indirectly, to reduce sequelae and mortality, was evaluated for the first time.</p><p><strong>Methods: </strong>This study included 113 pediatric residents from two centers, one with (Group 1, n=77) and one without (Group 2, n=36) a mandatory pediatric metabolism rotation. All participants completed a scenario-based simulation with 10 clinical questions on a standardized patient case of acute intoxication-type inborn errors of metabolism, both before and after using the QR code-based algorithm. The algorithm, developed in accordance with international guidelines, was accessed via mobile devices. Pre- and post-intervention responses were compared using appropriate statistical tests. The effectiveness of the QR code in guiding the management of a simulated patient was analyzed.</p><p><strong>Results: </strong>Of the participants, 73 (64.6%) were female and 40 (35.4%) male; the median age was 28.0 years. Forty-two residents (37.2%) had previous experience in a pediatric metabolism unit. Correct identification of urgent treatment increased from 77.9% to 97.3% (p.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"162-174"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic persistence, autistic traits, and resilience in youth and adolescents with attention deficit hyperactivity disorder.","authors":"Buket Kılıç, Dilek Ünal, Muhammed Enes Bingöl","doi":"10.24953/turkjpediatr.2025.5460","DOIUrl":"10.24953/turkjpediatr.2025.5460","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine whether children diagnosed with attention deficit hyperactivity disorder (ADHD) continue to receive this diagnosis during adolescence and young adulthood, and to examine the relationships between autistic traits, psychological resilience, emotion regulation levels, and the continuity of diagnosis.</p><p><strong>Methods: </strong>In the initial evaluations conducted between 2012 and 2013, 121 children diagnosed with ADHD began medication treatment. From this group, 20 participants aged 13 to 25 who agreed to participate in the second evaluation, conducted between 2020 and 2022, were included in this study. The presence of ADHD in their second evaluation was determined using the DSM-5 criteria. Psychiatric comorbidities in adolescents were screened using the Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version, 2016 Turkish Adaptation of the DSM-5, while for adults, the DSM-5 criteria were utilized. Parents completed the Social Responsiveness Scale and the Family Assessment Device, while the young participants completed the Child and Youth Resilience Measure and the Difficulties in Emotion Regulation Scale.</p><p><strong>Results: </strong>Among the participants, 10 individuals (50%) continued to have an ADHD diagnosis, exhibiting lower psychological resilience and significantly more autistic traits. No difference in emotional dysregulation was observed between those with and without an ADHD diagnosis, and a negative relationship between autistic traits and psychological resilience was identified.</p><p><strong>Conclusion: </strong>The continuity of an ADHD diagnosis during adolescence and young adulthood may be associated with psychological resilience and autistic traits. However, the limited number of participants and the cross-sectional design highlight the need for larger longitudinal studies to further explore the cause-and-effect relationships.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"208-220"},"PeriodicalIF":0.0,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Şebnem Çalkavur, Oğuz Han Kalkanlı, Tuna Ketenci, Nazan Kavas, Miray Yılmaz Çelebi, Arzu Bayram, İlker Devrim
{"title":"Effectiveness of a blood culture bundle in reducing contamination rates in a neonatal intensive care unit.","authors":"Şebnem Çalkavur, Oğuz Han Kalkanlı, Tuna Ketenci, Nazan Kavas, Miray Yılmaz Çelebi, Arzu Bayram, İlker Devrim","doi":"10.24953/turkjpediatr.2025.5613","DOIUrl":"10.24953/turkjpediatr.2025.5613","url":null,"abstract":"<p><strong>Background: </strong>Isolating microorganisms from blood cultures is the gold standard for identifying the cause of sepsis. However, contamination of the blood culture is a significant barrier to the blood culture's utility. In this study, we aimed to evaluate the impact of blood culture bundles on the incidence of contamination in the neonatal intensive care unit (NICU).</p><p><strong>Methods: </strong>A prospective research to compare pre-bundle and bundle periods was created. During the bundle period, a bundle for blood culture sampling was implemented. The numbers of unnecessary antibiotic days and hospital stay following a false positive blood culture were used to calculate costs.</p><p><strong>Results: </strong>A total of 320 neonatal blood culture procedures were included. The rate of blood culture contamination was 3.8% in the bundle and 12.5% in the pre-bundle period, this was significantly higher in the pre-bundle period (p.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"135-143"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İsmail Yıldız, Erdem Gönüllü, Sıla Yılmaz, Elvan Zengin, Osman Yeşilbaş, Ahmet Soysal
{"title":"Turkish pediatricians' knowledge, attitudes, and awareness of respiratory syncytial virus (RSV) infection and immunization strategies: a cross-sectional study.","authors":"İsmail Yıldız, Erdem Gönüllü, Sıla Yılmaz, Elvan Zengin, Osman Yeşilbaş, Ahmet Soysal","doi":"10.24953/turkjpediatr.2025.5528","DOIUrl":"10.24953/turkjpediatr.2025.5528","url":null,"abstract":"<p><strong>Background: </strong>This study aims to assess Turkish pediatricians' knowledge and attitudes regarding respiratory syncytial virus (RSV) infection and its current immunization strategies.</p><p><strong>Methods: </strong>From May 10 to June 4, 2024, we invited 1603 pediatricians who subscribed to the website of The Turkish Pediatrics Atelier via e-mail to respond to an online questionnaire. A total of 401 pediatricians responded.</p><p><strong>Results: </strong>Of pediatricians, 11% stated that they routinely use chest X-ray (CXR) for diagnosing RSV illness. When managing RSV-positive patients, while 44.4% of pediatricians indicated that they need a CXR if there are lung auscultation findings, the rate of routine CXR usage was 22.7%. While most pediatricians (74.8%) stated that they prefer nebulized salbutamol and/or corticosteroid; 43.4% used hypertonic saline; and 22.7% used nebulized epinephrine as a treatment option. While 60.3% of pediatricians had no information about the maternal RSV vaccine; 58.1% stated that they would recommend it to only willing women; 16% stated that they would not recommend it; and 25.9% indicated that they would recommend it to every pregnant individual. While most pediatricians (79.8%) had knowledge about nirsevimab; 14% indicated that it was not approved in children worldwide; 49.1% stated that it is more effective than palivizumab; and 37.9% indicated that they would start administrating it immediately after its approval and availability in Türkiye.</p><p><strong>Conclusions: </strong>The use of CXR and administration of non-evidence-based therapies in diagnosing and managing RSV illness were relatively high. Additionally, there is a notable gap in knowledge and awareness regarding the maternal RSV vaccine and nirsevimab.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 2","pages":"153-161"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}