The Turkish journal of pediatrics最新文献

{"title":"Before attributing Guillain-Barré syndrome to an adenovirus infection, alternative causes must be thoroughly ruled out.","authors":"Josef Finsterer","doi":"10.24953/turkjpediatr.2026.8396","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.8396","url":null,"abstract":"","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"717-718"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenovirus as a plausible trigger of Guillain-Barré syndrome: response to the letter to the editor.","authors":"Gulrukh Tuychiboeva, İbrahim Öncel, Gökçen Çoban Çifçi, Ali Bülent Cengiz, Kübra Aykaç","doi":"10.24953/turkjpediatr.2026.8561","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.8561","url":null,"abstract":"","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"719-720"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal bacterial meningitis.","authors":"Amar Taksande","doi":"10.24953/turkjpediatr.2026.8627","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.8627","url":null,"abstract":"","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"721-722"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between obesity, digital game addiction, and sleep quality in secondary school students: a cross-sectional study.","authors":"Mehmet Önlü, Selma Pekgör, Sümeyye Koç","doi":"10.24953/turkjpediatr.2026.8311","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.8311","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine the prevalence of obesity and to examine the associations between digital game addiction, sleep quality, and body mass index (BMI) among secondary school students.</p><p><strong>Materials and methods: </strong>This cross-sectional study included 902 students in grades 6-8 in Konya, a central province of Türkiye. Data were collected using a sociodemographic questionnaire, the Digital Game Addiction Scale (DGAS), and the Pittsburgh Sleep Quality Index (PSQI). Anthropometric measurements were performed, and BMI percentiles were calculated according to national reference charts.</p><p><strong>Results: </strong>The prevalence rates of overweight and obesity were 13.2% and 3.8%, respectively. High-risk digital game addiction patterns (risky, addicted, or highly addicted) were identified in 50.8% of the cohort, and 72.2% of participants were classified as having poor sleep quality (PSQI > 5). No statistically significant associations were observed between BMI measures and either DGAS or PSQI scores (p > 0.05). In multivariable linear regression analysis, higher DGAS scores were significantly associated with poorer sleep quality (higher PSQI scores) (B = 0.049, 95% confidence interval: 0.037-0.062, p <0.001; adjusted R2 = 0.138).</p><p><strong>Conclusion: </strong>Digital game addiction was not directly associated with weight status in this adolescent population, but it was significantly associated with poorer sleep quality. These findings highlight the potential role of problematic gaming behaviors in adolescent sleep health. Targeted school-based interventions addressing digital gaming behaviors may help improve sleep outcomes in early adolescence.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"566-578"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognizing Stuve-Wiedemann syndrome in childhood: clinical insights from 11 patients with founder and novel <i>LIFR</i> variants.","authors":"Gizem Ürel Demir, Nazlı Büşra Açıkgöz, Gülen Eda Utine, Pelin Özlem Şimşek Kiper","doi":"10.24953/turkjpediatr.2026.8259","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.8259","url":null,"abstract":"<p><strong>Background: </strong>Stuve-Wiedemann syndrome is a rare autosomal recessive bent-bone dysplasia characterized by dysautonomia and distinctive skeletal abnormalities, most commonly caused by biallelic LIFR variants.</p><p><strong>Methods: </strong>Eleven patients from ten unrelated families with molecularly confirmed Stuve-Wiedemann syndrome were evaluated. Detailed demographic, perinatal, clinical, radiographic, and molecular data were collected. All patients underwent Sanger sequencing of LIFR.</p><p><strong>Results: </strong>Respiratory problems and episodic hyperthermia were present in all patients, while feeding difficulties, hypotonia, growth failure, developmental delay, craniofacial dysmorphism, oral abnormalities, and ocular involvement were also common. All patients demonstrated long-bone bowing, cortical thickening, and flared metaphyses. A biallelic LIFR variant was identified in all patients, occurring in the homozygous state in nine patients and in the compound heterozygous state in two patients. The recurrent c.2074C>T; p.(Arg692Ter) variant was homozygous in seven patients and compound heterozygous in one patient. Three novel LIFR variants were also identified.</p><p><strong>Conclusion: </strong>Stuve-Wiedemann syndrome is characterized by a high mortality rate during the first two years of life due to severe dysautonomia, and orthopedic complications worsen progressively with age; therefore, early diagnosis and lifelong multidisciplinary follow-up are essential. Furthermore, the high rate of consanguinity in Türkiye, together with the recurrent p.(Arg692Ter) variant in LIFR identified in multiple unrelated families, supports the possibility of a founder effect and suggests that the frequency of Stuve-Wiedemann syndrome in our population may be higher than expected. Our findings further characterize the previously reported clinical manifestations of Stuve-Wiedemann syndrome while expanding the molecular spectrum through the identification of three novel LIFR variants.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"639-648"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esophageal atresia and nutritional outcomes: the influence of anastomotic stricture and gastroesophageal reflux.","authors":"Paula Salcedo Arroyo, Paolo Bragagnini Rodríguez, Rafael Fernández Atuan, Ruth García Romero, Paulina Vargova, Ignacio Ros Arnal, Carolina Corona Bellostas","doi":"10.24953/turkjpediatr.2026.6347","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.6347","url":null,"abstract":"<p><strong>Background: </strong>Esophageal atresia (EA) is a congenital malformation often associated with long-term gastrointestinal complications and impaired growth. This study aimed to evaluate anthropometric outcomes in children with EA, with particular attention to the impact of associated conditions such as anastomotic stricture and gastroesophageal reflux (GER).</p><p><strong>Methods: </strong>We conducted a retrospective analysis of patients with type C EA who underwent primary anastomosis between 2005 and 2021. Anthropometric data were collected at four age intervals (<1 year, 1-4 years, 5-11 years, >11 years) and standardized using validated growth charts. Associations between anthropometric parameters and the presence of stricture or GER were analyzed.</p><p><strong>Results: </strong>Fifty-seven patients met the inclusion criteria. Stricture and GER were identified in 32% and 30% of patients, respectively. Infants (<1 year) with stricture had significantly lower BMI Z-scores -2.5 ± 0.7 than those without stricture (-1.1 ± 1.1; p=0.0093), while those with GER had significantly lower weight Z-scores (-2.1 ± 1.0) than those without GER (-1.2 ± 1.1; p=0.0443). Although most patients showed improvement in anthropometric parameters with age, early growth impairment was consistently observed in association with these complications.</p><p><strong>Conclusions: </strong>Children with EA are at risk of impaired growth during early childhood, particularly when stricture or GER is present. Regular anthropometric monitoring and early nutritional intervention are crucial, especially within the first year of life. Long-term multidisciplinary follow-up is recommended to optimize developmental outcomes.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"662-671"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply: methodological considerations in evaluating outcomes of neonatal bacterial meningitis.","authors":"Feng Li","doi":"10.24953/turkjpediatr.2026.8797","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.8797","url":null,"abstract":"","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"723-724"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of suspected scoliosis in fifth-grade students: a population-based school screening study.","authors":"Sevil Aydoğan Gedik, Şebnem Eker Güvenç, Burcu Işıktekin Atalay, Yaşar Bildirici, Babur Mimtaş","doi":"10.24953/turkjpediatr.2026.7846","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.7846","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to conduct school-based scoliosis screening among fifth-grade students and to determine the rate of screening positivity for suspected scoliosis.</p><p><strong>Methods: </strong>During the 2024-2025 academic year, scoliosis screening was conducted among 6,587 students attending all middle schools in Eskişehir province, Türkiye. Data were collected through scoliosis screening examinations performed by physiotherapists and a questionnaire administered to the students. The screening examinations included visual inspection, the forward bending test, and measurements using a scoliometer. Students with a trunk rotation ≥5° on scoliometer assessment and/or with physical signs such as visual asymmetry, scapular, shoulder, or pelvic imbalance, or apparent leg length discrepancy were referred for specialist evaluation. Chi-square test and logistic regression analysis were performed.</p><p><strong>Results: </strong>The ages of the students ranged between 10-11 years (mean ± standard deviation: 10.26±0.44). According to the assessments performed by physiotherapists, visual asymmetry suggestive of scoliosis was observed on inspection in 240 students (3.6%). Scoliometer measurements showed trunk rotation angles of 5 degrees or greater in 355 students (5.4%). As a result of the screening examinations, 725 students (11.0%) were screening-positive for suspected scoliosis and were referred to higher-level healthcare facilities for further evaluation. Risk factors were more prevalent among female students. In multivariate analysis, screening positivity for suspected scoliosis was significantly associated with female sex, low body mass index, a family history of scoliosis in first-degree relatives, chest stabbing sensation or pain during breathing, and skin findings on the back (discoloration, large nevi, or localized hypertrichosis).</p><p><strong>Conclusions: </strong>This study determined that the screening positivity rate for suspected scoliosis among fifth-grade students was 11.0%. Factors that may be associated with scoliosis were found to be more common in female students; however, the multifactorial nature of scoliosis suggests that screening positivity may be influenced by a complex interaction of biological, anthropometric, familial, and postural factors. The findings also highlight the importance of early recognition and risk-based approaches in school-aged populations, and underscore the public health relevance of awareness and screening practices integrated within existing school health services and primary care.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"579-593"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infection-triggered neurological deterioration and immunodeficiency in a case of RNU4ATAC-opathy.","authors":"Deniz Yaşar, Mustafa Kılıç, Abdülkerim Kolkıran, Ayşe Kaçar Bayram, Özlem Sarıtaş Nakip, Berna Uçan, Hüsniye Yücel, Elif Soyak Aytekin","doi":"10.24953/turkjpediatr.2026.6568","DOIUrl":"10.24953/turkjpediatr.2026.6568","url":null,"abstract":"<p><strong>Introduction: </strong>RNU4ATAC-opathy is a rare autosomal recessive disorder characterized by a wide clinical spectrum, including brain anomalies, seizures, strokes, immunodeficiency, and cardiac defects. Other manifestations include ophthalmologic, dermatologic, renal, gastrointestinal, auditory, and endocrine involvement. Here, we report the identification of pathogenic RNU4ATAC variants through whole exome sequencing in an infant presenting with microcephaly, growth failure, and immunodeficiency.</p><p><strong>Case presentation: </strong>We describe an 11-month-old infant who had been followed since 4 months of age for growth failure and developmental delay. During follow-up, the patient experienced episodes of neurological deterioration triggered by febrile illnesses associated with SARS-CoV-2 and respiratory syncytial virus infections (RSV) at 9 and 11 months of age, respectively. Immunological evaluation showed normal immunoglobulin levels, a marked reduction in switched memory and memory B cells, impaired T-cell activation, and decreased T-cell subpopulations, suggesting combined immunodeficiency that may have contributed to increased susceptibility to viral infections. Whole exome sequencing subsequently identified compound heterozygous pathogenic variants in the RNU4ATAC gene, confirming the diagnosis of RNU4ATAC-opathy.</p><p><strong>Discussion: </strong>RNU4ATAC-opathy should be considered in cases with microcephaly, growth failure, immunodeficiency, and skeletal abnormalities. Our case shows that RNU4ATAC-opathy may present as infection-related encephalopathy, together with combined T- and B-cell dysfunction. Early immunological assessment and timely initiation of prophylactic therapy could play a key role in improving survival. Genetic and immunological evaluations are essential for accurate diagnosis, early intervention, and effective management. Further research is needed to clarify the syndrome's impact on immune function and guide targeted therapies.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"700-709"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth and development in children with periodic fever, aphthous stomatitis, pharyngitis, lymphadenitis syndrome: a case-control study.","authors":"Çağla Bağçalı, Yavuz Demircelik, Mine İnal Akkaya, Hacer Örsdemir Hortu, Belde Kasap Demir, Ali Kanık","doi":"10.24953/turkjpediatr.2026.6925","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2026.6925","url":null,"abstract":"<p><strong>Background: </strong>Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome is the most common cause of recurrent fever in childhood. Although normal growth and development are included in the diagnostic criteria, this assumption has not been systematically evaluated in controlled studies. This study aimed to compare growth patterns and developmental screening outcomes between children with PFAPA and healthy controls.</p><p><strong>Methods: </strong>A total of 138 children were enrolled, including 69 patients diagnosed with PFAPA according to the modified Marshall criteria and 69 age- and sex-matched healthy controls. The PFAPA group consisted of 26 females (37.7%) and 43 males (62.3%), while the control group included 26 females (37.7%) and 43 males (62.3%). The mean age was 52.1 ± 13.86 months in the PFAPA group and 50.28 ± 13.70 months in the control group. Growth was assessed using anthropometric parameters, including height, weight, body mass index (BMI), weight-for-height, and mid-upper arm circumference. The primary outcome was overall growth pattern, assessed by anthropometric measures, with particular attention to BMI. Developmental screening was performed using the Denver II Developmental Screening Test.</p><p><strong>Results: </strong>Mean anthropometric measures, including height, weight, and BMI, were comparable between patients with PFAPA and controls. However, overweight/obesity was more prevalent in the PFAPA group than in controls (18.8% vs. 5.8%; odds ratio [OR] 3.77, 95% confidence interval [CI] 1.16-12.24, p=0.020). Patients with PFAPA who were overweight/obese had received a higher number of corticosteroid treatments (p=0.046). Developmental screening outcomes did not differ significantly between groups.</p><p><strong>Conclusion: </strong>In this case-control study, children with PFAPA demonstrated overall growth patterns and developmental screening results similar to those of healthy peers, although a higher prevalence of overweight/obesity was observed. These findings support, but do not definitively establish, the assumption of preserved growth and development in PFAPA and underscore the need for further longitudinal studies.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"68 4","pages":"619-626"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149032476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}