Surface triggering receptor expressed on myeloid cells-1 (sTREM1) in critically ill children: a prospective observational controlled study.

Elsaeed Rashad Fouda, Sara Hosny Abd Elghany, Thoria Ahmed Omar, Alyaa Ahdy Abdelaziz
{"title":"Surface triggering receptor expressed on myeloid cells-1 (sTREM1) in critically ill children: a prospective observational controlled study.","authors":"Elsaeed Rashad Fouda, Sara Hosny Abd Elghany, Thoria Ahmed Omar, Alyaa Ahdy Abdelaziz","doi":"10.24953/turkjpediatr.2025.5219","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In children admitted to the pediatric intensive care unit (PICU), early detection of risk factors and alarming indicators improves the prognosis and may even save lives. Several prognostic markers and scores have been studied in children who are seriously ill. Recently, surface triggering receptor expressed on myeloid cells-1 (sTREM1) has been studied in many infectious and non-infectious settings; however, there is little information on critically ill children. Our aim is to evaluate the sTREM1 level in critically ill children and assess its prognostic role.</p><p><strong>Method: </strong>A prospective observational study was conducted in a tertiary care hospital. 70 critically ill children and 50 healthy controls were enrolled in the study. Demographic, clinical, and laboratory data were obtained. sTREM1 level was assessed on admission to the PICU. Patients with conditions affecting immunity were excluded. The primary outcome was to assess the level of sTREM1 in both patients and controls. Secondary outcomes were mortality, morbidities as sepsis, need for mechanical ventilation, and PICU stay.</p><p><strong>Results: </strong>The level of sTREM1 was significantly higher in patients than in controls (850 pg/mL, interquartile range [IQR] 510.0- 1375.0 vs. 67.5 pg/mL, IQR 40.0- 85.0; p.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"67 1","pages":"1-10"},"PeriodicalIF":0.0000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Turkish journal of pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24953/turkjpediatr.2025.5219","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Background: In children admitted to the pediatric intensive care unit (PICU), early detection of risk factors and alarming indicators improves the prognosis and may even save lives. Several prognostic markers and scores have been studied in children who are seriously ill. Recently, surface triggering receptor expressed on myeloid cells-1 (sTREM1) has been studied in many infectious and non-infectious settings; however, there is little information on critically ill children. Our aim is to evaluate the sTREM1 level in critically ill children and assess its prognostic role.

Method: A prospective observational study was conducted in a tertiary care hospital. 70 critically ill children and 50 healthy controls were enrolled in the study. Demographic, clinical, and laboratory data were obtained. sTREM1 level was assessed on admission to the PICU. Patients with conditions affecting immunity were excluded. The primary outcome was to assess the level of sTREM1 in both patients and controls. Secondary outcomes were mortality, morbidities as sepsis, need for mechanical ventilation, and PICU stay.

Results: The level of sTREM1 was significantly higher in patients than in controls (850 pg/mL, interquartile range [IQR] 510.0- 1375.0 vs. 67.5 pg/mL, IQR 40.0- 85.0; p.

危重儿童骨髓细胞表面触发受体表达-1 (sTREM1):一项前瞻性观察对照研究
背景:在儿科重症监护病房(PICU)的儿童中,早期发现危险因素和预警指标可以改善预后,甚至可以挽救生命。对患有严重疾病的儿童进行了一些预后指标和评分研究。最近,骨髓细胞表面触发受体表达-1 (sTREM1)在许多感染性和非感染性环境中被研究;然而,关于危重儿童的信息却很少。我们的目的是评估重症儿童的sTREM1水平并评估其预后作用。方法:在某三级医院进行前瞻性观察研究。70名重症儿童和50名健康对照者参加了这项研究。获得了人口统计学、临床和实验室数据。入住PICU时评估sTREM1水平。排除了影响免疫力的患者。主要结果是评估患者和对照组中sTREM1的水平。次要结局是死亡率、败血症发病率、机械通气需求和PICU住院时间。结果:患者的sTREM1水平显著高于对照组(850 pg/mL,四分位数范围[IQR] 510.0 ~ 1375.0 vs. 67.5 pg/mL, IQR 40.0 ~ 85.0;p。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信